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Evaluation of bone remodeling in regard to the age of scaphoid non-unions

World Journal of Orthopedics 2016年第7期7卷 418-425页

作者： susanne Rein Uwe Hanisch Hans-Eberhard Schaller Hans Zwipp Stefan Rammelt Stefan Weindel Department of Plastic and Hand Surgery Burn UnitTrauma Center Bergmannstrost Center of Orthopaedics and Traumatology University Medicine "Carl Gustav Carus" DresdenTechnicalUniversity Dresden Institute of Pathology "Carl Thiem" Hospital Deptartment of Plastic Hand Reconstructive and Burn SurgeryTrauma Center Tuebingen University Deptartment of Hand Aesthetic and Plastic SurgeryHospital of Linth

AIM: To analyse bone remodeling in regard to the age of scaphoid non-unions(SNU) with ***: Thirty-six patients with symptomatic SNU underwent surgery with resection of the pseudarthrosis. The resected material was evaluated histologically after staining with hematoxylin-eosin(HE), tartrate resistant acid phosphatase(TRAP), CD 68, osteocalcin(OC) and osteopontin(OP). Histological examination was performed in a blinded ***: The number of multinuclear osteoclasts in the TRAP-staining correlated with the age of the SNU and was significantly higher in younger SNU(P = 0.034; r = 0.75). A higher number of OP-immunoreactive osteoblasts significantly correlated with a higher number of OC-immunoreactive osteoblasts(P = 0.001; r = 0.55). Furthermore, a greater number of OP-immunoreactive osteoblasts correlated significantly with a higher number of OP-immunoreactive multinuclear osteoclasts(P = 0.008; r = 0.43). SNU older than 6 mo showed a signifi-cant decrease of the number of fibroblasts(P = 0.04). Smoking and the age of the patients had no influence on bone remodeling in ***: Multinuclear osteoclasts showed a significant decrease in relation to the age of SNU. However, most of the immunhistochemical findings of bone remodeling do not correlate with the age of the SNU. This indicates a permanent imbalance of bone formation and resorption as indicated by a concurrent increase in both osteoblast and osteoclast numbers. A clear histological differentiation into phases of bone remodeling in SNU is not possible.

关键词： Bone remodeling Histology Immunohistological staining Scaphoid non-union Scaphoid Wrist joint

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Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation

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World Journal of Gastroenterology 2015年第3期21卷 977-981页

作者： Anna Hüsing Holger Reinecke Vito R Cicinnati susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar Department of Transplant Medicine University Hospital Münster48149 MünsterGermany Division of Angiology Department of Cardiology and AngiologyUniversity Hospital Münster48149 MünsterGermany

AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March *** patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was ***-up was continued until 24 mo after the last ***:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of ***-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± *** failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent ***:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS.

关键词： Liver transplantation Anastomotic stricture Endosc

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Recirculating IL-1R2^(+) Tregs fine-tune intrathymic Treg development under inflammatory conditions

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Cellular & Molecular Immunology 2021年第1期18卷 182-193页

作者： Eirini Nikolouli Yassin Elfaki susanne Herppich Carsten Schelmbauer Michael Delacher Christine Falk Ilgiz A.Mufazalov Ari Waisman Markus Feuerer Jochen Huehn Department of Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-University MainzMainzGermany Regensburg Center for Interventional Immunology(RCI) Chair for ImmunologyUniversity Regensburg and University Hospital RegensburgRegensburgGermany Institute of Transplant Immunology Integrated Research and Treatment Center TransplantationIFB-TxHannover Medical SchoolHannoverGermany Hannover Medical School HannoverGermany

The vast majority of Foxp3^(+)regulatory T cells(Tregs)are generated in the thymus,and several factors,such as cytokines and unique thymic antigen-presenting cells,are known to contribute to the development of these thymus-derived Tregs(tTregs).Here,we report the existence of a specific subset of Foxp3^(+)Tregs within the thymus that is characterized by the expression of IL-1R2,which is a decoy receptor for the inflammatory cytokine *** flow cytometric analysis of the thymocytes from Foxp3^(hCD2)xRAG1^(GFP) reporter mice revealed that the IL-1R2^(+)Tregs are mainly RAG1^(GFP-)and CCR6^(+)CCR7^(-),demonstrating that these Tregs are recirculating cells entering the thymus from the periphery and that they have an activated *** the spleen,the majority of IL-1R2^(+)Tregs express neuropilin-1(Nrp-1)and Helios,suggesting a thymic origin for these ***,among all tissues studied,the highest frequency of IL-1R2^(+)Tregs was observed in the thymus,indicating preferential recruitment of this Treg subset by the *** fetal thymic organ cultures(FTOCs),we demonstrated that increased concentrations of exogenous IL-1β blocked intrathymic Treg development resulting in a decreased frequency of CD25^(+)Foxp3^(+)tTregs and an accumulation of CD25^(+)Foxp3^(-)Treg ***,the addition of IL-1R2^(+)Tregs,but not IL-1R2^(+)Tregs,to reaggregated thymic organ cultures(RTOCs)abrogated the IL-1β-mediated blockade,demonstrating that these recirculating IL-1R2^(+)Tregs can quench IL-1 signaling in the thymus and thereby maintain thymic Treg development even under inflammatory conditions.

关键词： Thymus Treg development Inflammation IL-1 system

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Toward flexible visual analytics augmented through smooth display transitions

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Visual Informatics 2021年第3期5卷 28-38页

作者： Christian Tominski Gennady Andrienko Natalia Andrienko susanne Bleisch Sara Irina Fabrikant Eva Mayr Silvia Miksch Margit Pohl AndréSkupin University of Rostock RostockGermany Fraunhofer IAIS Sankt AugustinGermany City University of LondonUK FHNW University of Applied Sciences and Arts Northwestern Switzerland MuttenzSwitzerland University of Zurich ZurichSwitzerland Danube University Krems KremsAustria TU Wien ViennaAustria San Diego State University San DiegoUSA

Visualizing big and complex multivariate data is *** address this challenge,we propose flexible visual analytics(FVA)with the aim to mitigate visual complexity and interaction complexity challenges in visual analytics,while maintaining the strengths of multiple perspectives on the studied *** the heart of our proposed approach are transitions that fluidly transform data between userrelevant views to offer various perspectives and insights into the *** smooth display transitions have been already proposed,there has not yet been an interdisciplinary discussion to systematically conceptualize and formalize these *** a call to further action,we argue that future research is necessary to develop a conceptual framework for flexible visual *** discuss preliminary ideas for prioritizing multi-aspect visual representations and multi-aspect transitions between them,and consider the display user for whom such depictions are produced and made available for visual *** this contribution we aim to further facilitate visual analytics on complex data sets for varying data exploration tasks and purposes based on different user characteristics and data use contexts.

关键词： Visual analytics Animated transitions Multi-faceted data

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Effects of oral Shilajit tablets on sexual function and sexual quality of life among reproductive-aged women: a triple-blind randomized clinical trial

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Traditional Medicine Research 2023年第11期8卷 55-62页

作者： Sadiqa Mosavi Malihe Tabarrai Mojgan Tansaz Hamid Salehinia susanne Grylka-Baeschlin Azam Rahmani Shadab Shahali Department of Reproductive Health and Midwifery Faculty of Medical SciencesTarbiat Modares UniversityTehran 14115-111Iran Department of Traditional Medicine School of Persian MedicineTehran University of Medical Sciences(TUMS)Tehran ***Iran Traditional Medicine and Materia Medica Research Center Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Traditional Medicine School of Traditional MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Social Determinants of Health Research Center Birjand University of Medical SciencesBirjand ***Iran Research Institute of Midwifery and Reproductive Health Zurich University of Applied SciencesWinterthur CH-8400Switzerland Nursing and Midwifery Care Research Center School of Nursing and MidwiferyTehran University of Medical SciencesTehran ***Iran.

Background:Shilajit is mentioned in the“Kama Sutra”as a potent enhancer of sexual *** study aimed to investigate the effects of oral Shilajit tablets on sexual function and sexual quality of life among women of reproductive ***:Forty-eight reproductive-aged women participated in a placebo-controlled triple-blind clinical *** intervention group took oral Shilajit tablets(200 mg)twice daily for 60 days and the control group took the *** collection tools were Sexual Quality of Life-Female and Female Sexual Function *** were collected before the intervention,30,60,and 90 days after the start of the ***:Forty-three women completed the *** mean score of total sexual function in the intervention group was significantly higher than before the intervention(P<0.001).The mean score of sexual function was 28.93 after 90 days in the intervention group while it was 22.09 in the control *** finding was observed in most domains of the sexual function *** mean score of sexual quality of life increased after 60 days of intervention in both groups;however,the difference was not statistically significant(P=0.094).Conclusion:The study indicated that Shilajit,as a complementary therapy,may improve sexual function and most of its domains;while there was no effect on improving the quality of sexual life.

关键词： sexual quality of life sexual function Shilajit mumie complementary medicine

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新标准德语强化教程

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作者： (德)巴尔默 (德)susanne·Schwalb (德)Dorte·Weers

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Telepsychiatry:The Evaluation and Treatment of Seniors in Rural Retirement Communities

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Journal of Geriatric Medicine 2019年第2期1卷 23-31页

作者： susanne Inez Steinberg Robert Gallop Medical Director&Psychiatrist Penn Med Princeton House Behavioral Health MoorestownNJ 08057United States Applied Statistics Program Department of MathematicsWest Chester UniversityWest ChesterPA 19383United States

Few studies examine the benefits from geriatric telepsychiatry in rural retirement ***:*** demonstrate that using telepsychiatry(a)standard approaches to psychiatric evaluation would yield diagnoses in Diagnostic and Statistical Manual of Mental Disorders(DSM-V);(b)psychotherapies and pharmacotherapy could be effectively *** examine the relationships among cognition,mood,agitation and functions at baseline and the response to treatment over ***:Prospective longitudinal ***:Geriatric Depression scale(GDS),Mini Mental State Exam(MMSE),Barthel Index(BI),Pittsburgh Agitation Scale(PAS).Setting:Video ***:Psychotherapy,***:428 Seniors over 55,met criteria for at least one DSM-V ***:Treatments were administered for a full range of psychiatric diagnoses and age-related medical *** most frequently prescribed pharmacological agents were:antidepressants(78%)antipsychotics(64%),memory enhancers(38%).Participants(66%)received psychotherapy:individual(31%),couple(7%),family(13%).Variation in the MMSE scores were observed:55%remained stable,11%declined,18%*** Scores improved from baseline to 26 weeks(p=0.02,d=0.99:95%CI 0.39-1.56).PAS scores declined from baseline to 52 weeks(McNemar’s S=11.27,p=0.0008,d=1.17:95%CI 0.63-1.68).Function(BI)at week 26 was not statistically significantly different from baseline(t(26)=1.66,p=0.11,d=0.65:95%CI-0.16-1.42).Participants maintained independence(64.5%)at 52 weeks(McNemar’s S=6.23,p=0.013,d=0.79:95%CI 0.19-1.36)Conclusion:This study demonstrates the feasibility and benefit of providing a full complement of services via telepsychiatry to seniors and provides a rationale for more comprehensive reimbursement plans.

关键词： Psychotherapy Psychopharmacology Telepsychiatry Seniors Retirement communities Nursing Homes

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高大冷杉温室Strophosoma象甲的微生物防治(英文)

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安徽农业大学学报 2007年第2期34卷 185-194页

作者：夏洛蒂.尼尔森 susanne Vestergaard susanne Harding JФrgen Eilenberg Department of Ecology Copenhagen UniversityFaculty of Life SciencesThorvaldsensvej 401871 Frederiksberg CDenmark

In Denmark,the weevils Strophosoma melanogrammum and *** cause economic damage in Noble fir due to the adult stage feeding on the *** chemical treatments of these weevils are allowed in Denmark,so biological control is an attractive *** evaluated the potential for microbial control of larvae of Strophosoma *** on laboratory bioassays and field applications,taking effect on both target and non-target into consideration,as well as persistence of the applied *** the laboratory Beauveria bassiana,Paecilomyces farinosus and Metarhizium anisopliae were able to infect and cause mycosis in Strophosoma *** the tested isolates the most virulent isolate was *** BIPESCO 5,which resulted in 80 % *** the field experiment ***,isolate BIPESCO 5,was applied to the soil as a conidial suspension against larvae of Strophosoma *** effect of the fungus on the target population was monitored at a weekly basis by counts of emerging adult weevils during their activity *** population of Strophosoma *** reduced by up to 60% in treated plots compared to control *** non-target effects of *** were studied by sampling insects and ticks from both treated and control *** days after treatment,two sampled insect orders(Hemiptera and Coleoptera)and ticks were found with prevalences of *** above 50%,compared to no infection in the insects collected from control *** in coccinellids were found as long as 277 days after ***,the effect on population level of non-target is still *** persistence of the fungus was documented by plating a soil suspension onto *** documented that conidia of *** could persist in the greenery plantation for at least 418 days after application.

关键词：高大冷杉温室微生物 Strophosoma象甲防治措施

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Shakespeare＇s Language Strategies in Hamlet

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Journal of Literature and Art Studies 2012年第10期2卷 911-924页

作者： Mufeed AI-Abdullah susanne Ramadan Dhofar University Salalah Oman Yarmouk University Irbid Jordan

This study investigates the language strategies used by Shakespeare in The Tragedy of Hamlet, Prince of Denmark （1603）. Emphasis is given to the type of language or register Shakespeare provides his characters with in order to give them genuine or assumed identities. The linguistic register of the three major characters of Claudius, the Ghost, and Hamlet is explored in light of the Elizabethan cultural context. This concern with these three characters stems from the basic assumption of the paper that the play is a struggle between Claudius and the Ghost over Hamlet. Claudius speaks the language of a monarch which is informed by the code of society; the Ghost, who used to speak such language of sovereignty while alive, speaks a language of the dead informed by a newly acquired experience not familiar to human beings. On the other hand, Hamlet＇s use of language is the most peculiar in the play. His register keeps changing according to his tragic growth and his readiness for action. The study indicates that the language functions Shakespeare utilizes in Hamlet are numerous. Language is used creatively for a variety of purposes in addition to communication. The playwright employs language as a shield for self-defense, a tool for defining and hiding identity and misleading and manipulating others, a means of search for reality, and a tool for punishment, among other functions. The study findings invite further research into Shakespeare＇s use of language in his plays. No detailed in-depth studies of Shakespearean language and its implications exist.

关键词： Shakespeare Hamlet language drama

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Case Studies on Acupuncture Principles in Headaches

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Chinese Medicine and Culture 2021年第2期4卷 93-98页

作者： Saroj Kumar Pradhan Andreas Rudolf Gantenbein Yi-Ming Li Sebastian Frese susanne Lehmann Felix Angst Department of Traditional Chinese Medicine Zurzach Care/TCM-Klinik Ming DaoBad Zurzach 5330Switzerland Department of Research Swiss TCM AcademyBad ZurzachSwitzerland in Collaboration with Department of ResearchNanjing University of Chinese MedicineNanjing 210029JiangsuChina Department of Neurology and Neurorehabilitation Zurzach CareBad Zurzach 5330Switzerland Department of Prevention Zurzach CareBad Zurzach 5330Switzerland Department of Research Zurzach CareBad Zurzach 5330Switzerland

Objective:This observational cohort pilot study aimed to evaluate the effects of the acupuncture methods,Jiu Cang Zhen(JCZ)and Huang Guan(HG),on changes in headache intensity in an inpatient,multimodal Zurzach Headache Programme(ZHP).Methods:Study participants consisted of patients diagnosed with chronic headache disorder(headache ds,30 days per month)or daily persistent *** patients received conventional therapies with active and passive *** patient group was treated with JCZ and HG acupuncture methods,receiving a total of six to eight acupuncture sessions of 50 to 60 minutes each,during a 3–4-week multimodal ZHP at the RehaClinic Bad *** intensity was quantified using a Numerical Rating Scale(NRS)before and after each acupuncture therapy ***:Ten patients were recruited,six women and four men,with a mean age of 41.7(standard deviation,[SD]=13.9).A reduction in headache intensity was reported by all patients in each of the *** average NRS for pain was 4.21(SD=1.44)before acupuncture and 1.24(SD=0.93)after acupuncture(means first by number of sessions,then per n=10 patients).This resulted in a mean difference of 2.97(SD=1.04),corresponding to a standardized response mean of 2.85(95%confidence interval:2.11–3.60,one-tailed P<0.001),meaning there was a large ***:This pilot study shows that JCZ and HG are suitable acupuncture methods for reducing headache intensity in the treatment of headaches.A comparison with the conventional classical acupuncture methods from the acupuncture textbook for traditional Chinese medicine students in China,exploration with a larger patient group,and prolonged monitoring of pain behavior could be foci of follow-up investigations.

关键词： Acupuncture headache migraine medication-overuse headache neurology

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