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Re.irculating IL-1R2^(+) Tre.s fine.tune.intrathymic Tre. de.e.opme.t unde. inflammatory conditions

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Ce.lular & Mole.ular Immunology 2021年第1期18卷 182-193页

作者： e.rini Nikolouli Yassin e.faki susanne He.ppich Carste. Sche.mbaue. Michae. De.ache. Christine.Falk Ilgiz A.Mufazalov Ari Waisman Markus Fe.e.e. Joche. Hue.n De.artme.t of e.pe.ime.tal Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Institute.for Mole.ular Me.icine University Medical Center of the Johannes Gutenberg-University MainzMainzGermany Re.e.sburg Ce.te. for Inte.ve.tional Immunology(RCI) Chair for ImmunologyUniversity Regensburg and University Hospital RegensburgRegensburgGermany Institute.of Transplant Immunology Integrated Research and Treatment Center TransplantationIFB-TxHannover Medical SchoolHannoverGermany Hannove. Me.ical School HannoverGermany

The.vast majority of Foxp3^(+)re.ulatory T ce.ls(Tre.s)are.ge.e.ate. in the.thymus,and se.e.al factors,such as cytokine. and unique.thymic antige.-pre.e.ting ce.ls,are.known to contribute.to the.de.e.opme.t of the.e.thymus-de.ive. Tre.s(tTre.s).He.e.we.re.ort the.e.iste.ce.of a spe.ific subse. of Foxp3^(+)Tre.s within the.thymus that is characte.ize. by the.e.pre.sion of IL-1R2,which is a de.oy re.e.tor for the.inflammatory cytokine.*** flow cytome.ric analysis of the.thymocyte. from Foxp3^(hCD2)xRAG1^(GFP) re.orte. mice.re.e.le. that the.IL-1R2^(+)Tre.s are.mainly RAG1^(GFP-)and CCR6^(+)CCR7^(-),de.onstrating that the.e.Tre.s are.re.irculating ce.ls e.te.ing the.thymus from the.pe.iphe.y and that the. have.an activate. *** the.sple.n,the.majority of IL-1R2^(+)Tre.s e.pre.s ne.ropilin-1(Nrp-1)and He.ios,sugge.ting a thymic origin for the.e.***,among all tissue. studie.,the.highe.t fre.ue.cy of IL-1R2^(+)Tre.s was obse.ve. in the.thymus,indicating pre.e.e.tial re.ruitme.t of this Tre. subse. by the.*** fe.al thymic organ culture.(FTOCs),we.de.onstrate. that incre.se. conce.trations of e.oge.ous IL-1β blocke. intrathymic Tre. de.e.opme.t re.ulting in a de.re.se. fre.ue.cy of CD25^(+)Foxp3^(+)tTre.s and an accumulation of CD25^(+)Foxp3^(-)Tre. ***,the.addition of IL-1R2^(+)Tre.s,but not IL-1R2^(+)Tre.s,to re.ggre.ate. thymic organ culture.(RTOCs)abrogate. the.IL-1β-me.iate. blockade.de.onstrating that the.e.re.irculating IL-1R2^(+)Tre.s can que.ch IL-1 signaling in the.thymus and the.e.y maintain thymic Tre. de.e.opme.t e.e. unde. inflammatory conditions.

关键词： Thymus Tre. de.e.opme.t Inflammation IL-1 syste.

Use.of routine.HIV te.ting data for e.rly de.e.tion of e.e.ging HIV e.ide.ics in high-risk subpopulations:A conce.t de.onstration study

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Infe.tious Dise.se.Mode.ling 2018年第1期3卷 373-384页

作者： Housse.n H.Ayoub susanne F.Awad Laith J.Abu-Raddad De.artme.t of Mathe.atics Statisticsand PhysicsQatar UniversityDohaQatar Infe.tious Dise.se.e.ide.iology Group Weill Cornell Medicine-QatarCornell UniversityQatar Foundation-Education CityDohaQatar De.artme.t of He.lthcare.Policy and Re.e.rch Weill Cornell MedicineCornell UniversityNew YorkUSA Colle.e.of He.lth and Life.Scie.ce. Hamad Bin Khalifa UniversityDohaQatar

Introduction:HIV e.ide.ics in hard-to-re.ch high-risk subpopulations are.ofte. discove.e. ye.rs afte. e.ide.ic e.e.ge.ce.in se.tings with poor surve.llance.*** hypothe.is-ge.e.ation mode.ing,we.aime. to inve.tigate.and de.onstrate.the.conce.t of using routine.HIV te.ting data to ide.tify and characte.ize.hidde. e.ide.ics in high-risk *** also compare. this approach to surve.llance.base. on AIDS case.***:A de.e.ministic mathe.atical mode. was de.e.ope. to simulate.an e.e.ging HIV e.ide.ic in a high-risk subpopulation.A stochastic Monte.Carlo simulation was imple.e.te. on the.total population to simulate.the.sampling proce.s of ge.e.ating routine.HIV te.ting *** me.sure. we.e.e.timate. on the.simulate. e.ide.ic and on the.ge.e.ate. te.ting *** analyse. we.e.conducte. on the.***:In the.simulate. e.ide.ic,HIV pre.ale.ce.saturate. at 32%in the.high-risk subpopulation and at 0.33%in the.total *** e.ide.ic starte. its e.e.ginge.ide.ic phase.28 ye.rs afte. infe.tion introduction,and saturate. 67 ye.rs afte. infe.tion *** the.simulate. HIV te.ting sample.a significant time.tre.d in pre.ale.ce.was ide.tifie.,and the.ge.e.ate. me.rics of e.ide.ic e.e.ge.ce.and saturation we.e.similar to those.of the.simulate. *** e.ide.ic was ide.tifie. 4.0(95%CI 3.4e..6)ye.rs afte. e.ide.ic e.e.ge.ce.using routine.HIV te.ting,but 29.7(95%CI 15.8 e.2.1)ye.rs afte. e.e.ge.ce.using AIDS case.*** the.se.sitivity analyse.,none.of the.sampling biase. affe.te. the.conclusion of an e.e.ging e.ide.ic,but some.affe.te. the.e.timate. e.ide.ic growth ***:Routine.HIV te.ting data provide. a tool to ide.tify and characte.ize.hidde. and e.e.ging e.ide.ics in high-risk *** approach can be.spe.ially use.ul in re.ource.limite. se.tings,and can be.applie. alone.or along with othe. comple.e.tary data,to provide.a me.ningful characte.ization of e.e.

关键词： HIV High-risk subpopulation Surve.llance Mathe.atical mode.ing Monte.Carlo simulations e.ide.iology Se.ually transmitte. infe.tion

De.e.t re.onstruction of the.trochante. major afte. ne.rotizing fasciitis and multiple.ope.ations using an arte.iove.ous Ioop and Iatissimus dorsi fre. flap

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Plastic and Ae.the.ic Re.e.rch 2018年第9期5卷 40-45页

作者： Andre.s Arkudas susanne Re.us Ale.ande. Me.e. We.ne. Lang Marwe. Schmitz Raymund e.Horch De.artme.t of Plastic and Hand Surge.y University Hospital of ErlangenFriedrich-Alexander-University of Erlangen-Nürnberg(FAU)Erlangen 91054Germany De.artme.t of Vascular Surge.y University Hospital of ErlangenFriedrich-Alexander-University of Erlangen-Nürnberg(FAU)Erlangen 91054Germany

Ne.rotizing fasciitis (NF) is a se.e.e.soft tissue.infe.tion which has to be.tre.te. with a radical de.ride.e.t as the.ke. e.e.e.t. In the.furthe. course.ofte. large.tissue.de.e.ts occur, so that a long-te.m stable.de.e.t re.onstruction plays a crucial role.afte. any succe.sful de.ride.e.t. The.re.onstruction can include.split skin grafting or local and fre. flaps. He.e.we.pre.e.t a case.of a 41-ye.r-old male.patie.t with a NF in the.trochante. major re.ion afte. spondylode.is and spinal cord stimulation (SCS) de.ice.implantation. Afte. multiple.ope.ations including local and fre. flaps we.pe.forme. a de.e.t re.onstruction using an arte.iove.ous (AV) loop and subse.ue.t fre. latissimus dorsi transplantation le.ding to no furthe. ope.ations. This comple. re.onstruction can be.conside.e. as the.final stage.of any re.onstruction latte..

关键词： Ne.rotizing fasciitis arte.iove.ous loop fre. Iatissimus dorsi flap transplantation

The.role.of polysulfide.saturation in e.e.trolyte. for high powe. applications of re.l world Li-S pouch ce.ls

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Nano Re.e.rch 2023年第6期16卷 8313-8320页

作者： Tom Boe.ke.Se.astian Kirchhoff Florian SRe.te. Florian Schmidt Christine.We.le. susanne Dörfle. Kai Schwe.tmann Paul Härte. Thomas Abe.droth Holge. Althue. Jan J.We.g Ste.an Kaske. Te.hnische.Unive.sität Dre.de. Chair of Inorganic Chemistry IBergstr.6601069 DresdenGermany Fraunhofe. Institute.for Mate.ial and Be.m Te.hnology(IWS) Winterbergstr.2801277 DresdenGermany Te.hnische.Unive.sität Dre.de. Chair of Inorganic Molecular ChemistryMommsenstraße 401069 DresdenGermany

The.lithium-sulfur(Li-S)te.hnology is the.most promising candidate.for ne.t-ge.e.ation batte.ie. due.to its high the.re.ical spe.ific e.e.gy and ste.dy progre.s for applications re.uiring lightwe.ght batte.ie. such as aviation or he.vy e.e.tric *** the.e.applications,howe.e.,the.rate.capability of Li-S ce.ls re.uire. significant *** e.e.trolyte.formulations in Li-S batte.ie. e.able.ne. pathways for ce.l de.e.opme.t and adjustme.t of all ***,the.r rate.capability at pouch ce.l le.e. is ofte. ne.the. e.aluate. nor compare. to state.of the.art(SOTA)LiTFSI/dime.hoxye.hane.dioxolane.LITFSI:lithium-bis(trifluorome.hylsulfonyl)imide.***,the.combination of the.sparingly polysulfide.PS)solvating he.ylme.hyle.he./1,2-dime.hoxye.hane.HMe.DMe.e.e.trolyte.and highly conductive.carbon nanotube.Buckypape.(CNT-BP)with low porosity was e.aluate. in both coin and pouch ce.ls and compare. to dime.hoxye.hane.dioxolane.re.e.e.ce.*** advance. sulfur transfe. me.t infiltration was e.ploye. for cathode.production with *** Li+ion coordination in the.HMe.DMe.e.e.trolyte.was inve.tigate. by nucle.r magne.ic re.onance.NMR)and Raman ***,ionic conductivity and viscosity was inve.tigate. for the.pristine.e.e.trolyte.and a polysulfide.stature. *** e.e.trolyte.,DMe.DOL-1/1(DOL:1,3-dioxolane.and HMe.DMe.8/2,are.the. combine. with CNT-BP and transfe.re. to multi-laye.e. pouch *** study re.e.ls that the.ionic conductivity of the.e.e.trolyte.incre.se. drastically ove. state.of(dis)charge.e.pe.ially for DMe.DOL e.e.trolyte.and le.n e.e.trolyte.re.ime.le.ding to a be.te. rate.capability for the.sparingly polysulfide.solvating *** e.aluation in prototype.ce.ls is an important ste. towards be.poke.adaption of Li-S batte.ie. for practical applications.

关键词： lithium-sulfur pouch ce.l polysulfide.solubility e.e.trolyte.characte.ization high powe.

Targe.ing TIGIT in NSCLC—Is The.e.Light on the.Horizon?

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Advance. in Lung Cance. 2022年第4期11卷 51-60页

作者： susanne Re.the. Wolfram C. M. De.pke Me.ical Clinic III Campus Grosshadern University of Munich Munich Germany

Non-small ce.l lung cance.s (NSCLCs) re.re.e.t ove. 80% of all malignant lung tumours and are.one.of the.le.ding cause. of cance. de.th throughout the.world. First- and se.ond-line.tre.tme.t of advance. or me.astatic NSCLCs has change. dramatically during the.last two de.ade. with the.de.e.opme.t of nove. immunothe.apie. (e.g., che.kpoint inhibitors targe.ing PD-1, PD-L1, and CTLA-4) sparing NSCLC patie.ts from the.toxic e.fe.ts of che.othe.apy. Howe.e., only 15% - 20% of all patie.ts re.pond to tre.tme.t. In orde. to improve.re.ponse.rate., e.pe.ime.tal and clinical e.ide.ce.has provide. the.basis for furthe. e.aluating the.combination of co-stimulatory and inhibitory monoclonal antibodie. to improve.the.anti-tumour immune.re.ponse. Innovative.se.ond- and third-ge.e.ation immuno-oncology drugs are.curre.tly e.aluate. in ongoing phase.I-III trials (e.the. alone.or in combination) including the.ne. che.kpoint inhibitor targe. TIGIT (T ce.l immunore.e.tor with Ig and ITIM domains). TIGIT functions as an inhibitory immunoglobin re.e.tor which is ove.e.pre.se. by diffe.e.t immune.ce.ls including e.fe.tor and me.ory CD4+ T and CD8+ T ce.ls, re.ulatory T ce.ls (Tre.s), follicular T he.pe. ce.ls (Tfh), and natural kille. ce.ls. Targe.ing the.inte.action be.we.n the.re.e.tors of the.TIGIT re.e.tors (e.g., CD96, CD112R, CD226, TIGIT and the.r corre.ponding binding partne.s) has be.ome.an innovative.strate.y for the.ne.t conce.ts of cance. immunothe.apy that has the.pote.tial to syne.gize.with PD-1/PD-L1che.kpoint inhibition. Curre.tly, four anti-TIGIT monoclonal antibodie. are.curre.tly be.ng studie. in phase.III trials in NSCLCs: 1) tiragolumab (SKYSCRAPe. programme.;2) vibostolimab (Ke.VIVe.programme.;3) domvanalimab (ARC programme., and 4) ocipe.limab (AdvanTIG programme.. The.vast majority of the.e.studie. are.ongoing;howe.e., the.SKYSCRAPe.-01 trial (tiragolumab in NSCLC) and the.SKYSCRAPe.-02 trial (tiragolumab in SCLC) we.e

关键词： NSCLC TIGIT SKYSCRAPe. Trials Ke.VIVe.Studie. Domvanalimab Ocipe.limab

Could sport be.part of pe.iatric obe.ity pre.e.tion and tre.tme.t? e.pe.t conclusions from the.28th e.rope.n Childhood Obe.ity Group Congre.s

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Journal of Sport and He.lth Scie.ce 2019年第4期8卷 350-352页

作者： susanne Ring-Dimitriou Pe.e. Krustrup Manue. J Coe.ho-e.Silva Jorge.Mota Ande.a Se.bra Carla Re.o Artur Mazur e.pis Vlachopapadopoulou Marge.ita Caroli Marie.Laure.Fre.ut e.a e.hardt Ande.s Forslund e.a Boyland Danie. We.hube. David Thive. De.artme.t of Sport Scie.ce.and Kine.iology Paris Lo dron-UniversitySalzburg 5020Austria Pae.iatric Practice Albi 81000France De.artme.t of Pae.iatrics University of PecsPecs 7600Hungary De.artme.t of Wome.'s and Childre.'s He.lth Uppsala UniversityUppsala 74192Sweden Appe.ite.Obe.ity Re.e.rch Group Department of Psychological SciencesUniversity of LiverpoolLiverpoolL69 7ZAUK De.artme.t of Pe.iatrics Obesity Research UnitParacelsus Medical UniversitySalzburg 5020Austria Laboratory of the.Me.abolic Adaptations to e.e.cise.unde. Physiological and Pathological Conditions Auvergne Regional Center for Human NutritionClermont A uvergne UniversityClermont-Ferrand 63000France e.rope.n Childhood Obe.ity Group(e.OG) Brussels 1000Belgium De.artme.t of Sports Scie.ce.and Clinical Biome.hanics SDU Sport and Health Sciences Cluster(SHSC)University of Southern DenmarkOdense 5000Denmark Faculty of Sport Scie.ce. and Physical e.ucation University of CoimbraCoimbra 3000Portugal Re.e.rch Ce.tre.in Physical Activity Health and Leisure(CIAFEL)Faculty of SportUniversity of PortoPorto 4000Portugal Hospital Center for Research in Health Technologies and Information Systems(CINTESIS)Faculty of MedicineUniversity of PortoPorto 4000Portugal Pe.iatric De.artme.t Clinical Provincial Hospital No.2 in Rzesz6wFaculty of MedicineUniversity of RzeszowRzeszow 35-301Poland De.artme.t of e.docrinology Children's Hosp.P.&A.KyriakouAthens 10431Greece Pae.iatric De.artme.t Brindisi HospitalBrindisi 72100Italy

The.pre.ale.ce.of pe.iatric obe.ity continue. to incre.se.worldwide.bringing with it various me.abolic,functional,social,and psychological complications.1 Both the.pre.e.tion and tre.tme.t of childhood obe.ity must be.base. on multidisciplinary approache. combining nutrition,physical activity(PA),and psychological support.2 As an e.se.tial e.e.e.t of the.e.multicompone.t strate.ie.,re.ular physical activity has be.n acknowle.ge. as having be.e.icial e.fe.ts on childre.'s and adole.ce.ts,body composition,physical fitne.s,and me.abolic profile.as we.l as on the.r he.lth-re.ate. quality of life.social and psychological he.lth,and acade.ic achie.e.e.t.3,4 Give. that only a re.ative.y small proportion of childre. and adole.ce.ts me.t the.public he.lth re.omme.dations for PA,5 and give. that we.ght loss e.e.cise.base. inte.ve.tions suffe. from a high attrition rate.the.e.is a cle.r ne.d for appropriate.PAs.

关键词： pe.iatric obe.ity pre.e.tion tre.tme.t 28th e.rope.n Childhood Obe.ity Group Congre.s

Post-Translational De.e.re.sion of Inve.tase.Activity in Source.Le.ve. via Down-Re.ulation of Inve.tase.Inhibitor e.pre.sion Is Part of the.Plant De.e.se.Re.ponse

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Mole.ular Plant 2010年第6期3卷 1037-1048页

作者： Katharina B. Bonfig Andre. Gable. Uwe.K. Simon Nora Luschin-e.e.gre.th Martina Hatz susanne Be.ge. Nase.m Muhammad Jurge. Ze.e. Alok K. Sinha Thomas Roitsch Julius-von-Sachs-Institut fue. Biowisse.schafte. Lehrstuhl for Pharmazeutische Biologie Universitaet Wuerzburg Julius-von-Sachs-Platz 2 97082 Wuerzburg Germany Institute.of Plant Scie.ce. Department of Plant Physiology University of Graz 8010 Graz Austria Ze.trum for rne.izinische.Grundlage.forschung (ZMF) Medizinische Universitat Graz Stiftingtalstraβe 24 A-8010 Graz De.artme.t of Biology Plant Biology Section University of Fribourg Route Albert Gockel 3 CH-1700 Fribourg Switzerland National Institute.for Plant Ge.ome.Re.e.rch Aruna Asaf Ali Road New Delhi 110067 India

The.e.is incre.sing e.ide.ce.that pathoge.s do not only e.icit dire.t de.e.se.re.ponse., but also cause.pronounce. change. in primary carbohydrate.me.abolism. Ce.l-wall-bound inve.tase. be.ong to the.ke. re.ulators of carbohydrate.partitioning and source.sink re.ations. Whe.e.s studie. have.focuse. so far only on the.transcriptional induction of inve.tase.ge.e. in re.ponse.to pathoge. infe.tion, the.role.of post-translational re.ulation of inve.tase.activity has be.n ne.le.te. and was the.focus of the.pre.e.t study. e.pre.sion analyse. re.e.le. that the.high mRNA le.e. of one.out of thre. prote.nace.us inve.tase.inhibitors in source.le.ve. of Arabidopsis thaliana is strongly re.re.se. upon infe.tion by a virule.t strain of Pse.domonas syringae.pv. tomato DC3000. This re.re.sion is paralle.e. by a de.re.se.in inve.tase.inhibitor activity. The.physiological role.of this re.ulatory me.hanism is re.e.le. by the.finding that in situ inve.tase.activity was de.e.table.only upon infe.tion by P. syringae. In contrast, a high inve.tase.activity could be.me.sure. in vitro in crude.and ce.l wall e.tracts pre.are. from both infe.te. and non-infe.te. le.ve.. The.discre.ancy be.we.n the.in situ and in vitro inve.tase.activity of control le.ve. and the.high in situ inve.tase.activity in infe.te. le.ve. can be.e.plaine. by the.pathoge.-de.e.de.t re.re.sion of inve.tase.inhibitor e.pre.sion and a concomitant re.uction in inve.tase.inhibitor activity. The.functional importance.of the.re.e.se.of inve.tase.from post-translational inhibition for the.de.e.se.re.ponse.was substantiate. by the.application of the.compe.itive.che.ical inve.tase.inhibitor acarbose. Posttranslational inhibition of e.trace.lular inve.tase.activity by infiltration of acarbose.in le.ve. was shown to incre.se.the.susce.tibility to P. syringae. The.impact of inve.tase.inhibition on spatial and te.poral dynamics of the.re.re.sion of photosynthe.is and promotion of bacte.ial growth during pathoge. infe.tion supports a

关键词： Acarbose Arabidopsis de.e.se.re.ponse. inve.tase.inhibitor prote.n inve.tase plant-microbe.inte.actions Pse.domonas syringae.

Transport in graphe.e.nanostructure.

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Frontie.s of physics 2011年第3期6卷 271-293页

作者： Christoph Stampfe. Ste.an Fringe. Johanne. Gfittinge. Francoise.Molitor Christian Yolk Be.nat Te.rds Jan Daube. Ste.han e.ge.s Ste.an Schne. Arnhild Jacobse. susanne Drosche. Thomas Ihn Klaus e.sslin JARA-FIT and II. Institute.of Physics B RWTH Aachen University 52074 Aachen and Peter Griinberg Institute （PCI-9） Forschungszentrum Jiilich 52425 Jiilich Germany Solid State.Physics Laboratory ETH Zurich 8093 Zurich Switzerland

Graphe.e.nanostructure. are.promising candidate. for future.nanoe.e.tronics and solid-state.quan- tum information te.hnology. In this re.ie. we.provide.an ove.vie. of a numbe. of e.e.tron transport e.pe.ime.ts on e.che. graphe.e.nanostructure.. We.brie.ly re.isit the.e.e.tronic prope.tie. and the.transport characte.istics of bulk, i.e., two-dime.sional graphe.e. The.fabrication te.hnique. for making graphe.e.nanostructure. such as nanoribbons, single.e.e.tron transistors and quantum dots, mainly base. on a dry e.ching ＂pape.-cutting＂ te.hnique.are.discusse. in de.ail. The.limitations of the.curre.t fabrication te.hnology are.discusse. whe. we.outline.the.quantum transport prope.tie. of the.nanostructure. de.ice.. In particular we.focus he.e.on transport through graphe.e.nanoribbons and constrictions, single.e.e.tron transistors as we.l as on graphe.e.quantum dots including dou- ble.quantum dots. The.e.quasi-one.dime.sional （nanoribbons） and quasi-ze.o-dime.sional （quantum dots） graphe.e.nanostructure. show a cle.r route.of how to ove.come.the.gaple.s nature.of graphe.e.allowing the.confine.e.t of individual carrie.s and the.r control by late.al graphe.e.gate. and charge.de.e.tors. In particular, wo e.phasize.that graphe.e.quantum dots and double.quantum dots are.ve.y promising syste.s for spin-base. solid state.quantum computation, since.the. are.be.ie.e. to have.e.ce.tionally long spin cohe.e.ce.time. due.to we.k spin-orbit coupling and we.k hype.flne.inte.action in graphe.e.

关键词： graphe.e nanostructure. e.e.tron transport quantum dots

e.olutionary Me.hods in Biote.hnology: Cle.e. Tricks for Dire.te. e.olution 1

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