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Interaction of a root-knot nematode (Meloidogyne hapla) and plant intraspecific diversity in clover-grass communities

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Journal of Plant Ecology 2019年第1期12卷 1-9页

作者： Xiaohui Guo Jana S.Petermann susanne Wurst Dahlem Centre of Plant Sciences Institute of BiologyFreie Universität BerlinKönigin-Luise-Str.1-3Berlin D-14195Germany Key Laboratory of Biological and Ecological Engineering Ministry of EducationInstitute of Biodiversity ScienceFudan UniversitySonghu Road 2005Shanghai 200438China Berlin-Brandenburg Institute of Advanced Biodiversity Research Altensteinstr.34Berlin D-14195Germany Department of Ecology and Evolution University of SalzburgHellbrunnerstr.34Salzburg 5020Austria

Aims Soil organisms can influence the plant diversity-productivity rela-tionship at species level;however,little is known about their role in the relationship at an intraspecific *** study aimed to investigate the interaction between the effects of plant intraspe-cific diversity and a root-knot nematode on primary production and community *** A greenhouse experiment was conducted by using intraspecific diversity of a clover-grass community through sowing 2-,4-,8-and 16-cultivar mixtures of Trifolium pratense *** Lolium perenne *** by adding the nematode Meloidogyne *** investigated the effects of plant intraspecific diversity and *** on biomass of plant community,biomass of cultivar individuals and community *** Findings We found that *** dominated the communities,yet its bio-mass was not affected by the *** hapla influ-enced the effect of plant intraspecific diversity on aboveground biomass of *** at the four-cultivar mixture level of plant intraspecific *** evenness increased linearly with increasing plant intraspecific diversity,and *** affected community evenness at the four-cultivar mixture *** ***-ense and *** cultivars differed in aboveground *** on plant intraspecific diversity and cultivar identity,nematode addition positively affected the aboveground biomass of *** *** response of *** cultivars to *** and to various plant intraspecific diversity levels influenced the intraspecific diversity-productivity *** study high-lights the influence of *** on the effect of plant intraspecific diversity on aboveground biomass of ***,suggesting that future research on the impact of intraspecific plant diversity on eco-system functions should consider the effects of soil organisms.

关键词： nematode diversity-productivity relationship biomass legume-grass community

Long-term effects of environmentally relevant concentrations of silver nanoparticles on microbial biomass, enzyme activity,and functional genes involved in the nitrogen cycle of loamy soil

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Journal of Environmental Sciences 2018年第7期30卷 12-22页

作者： Anna-Lena Grün susanne Straskraba Stefanie Schulz Michael Schloter Christoph Emmerling Faculty of Regional and Environmental Sciences Department of Soil Science University of Trier J.W.Goethe University Institute of Molecular Biosciences Research for Comparative Microbiome Analysis Helmholtz Zentrum München Chair for Soil Science Technische Universit?t München

The increasing production and use of engineered silver nanoparticles（AgNP） in industry and private households are leading to increased concentrations of AgNP in the environment. An ecological risk assessment of AgNP is needed, but it requires understanding the long term effects of environmentally relevant concentrations of AgNP on the soil microbiome. Hence, the aim of this study was to reveal the long-term effects of AgNP on soil microorganisms. The study was conducted as a laboratory incubation experiment over a period of one year using a loamy soil and AgNP concentrations ranging from 0.01 to 1 mg AgNP/kg soil. The short term effects of AgNP were, in general, ***, after one year of exposure to 0.01 mg AgNP/kg, there were significant negative effects on soil microbial biomass（quantified by extractable DNA; p = 0.000） and bacterial ammonia oxidizers（quantified by amo A gene copy numbers; p = 0.009）. Furthermore, the tested AgNP concentrations significantly decreased the soil microbial biomass, the leucine aminopeptidase activity（quantified by substrate turnover; p = 0.014）, and the abundance of nitrogen fixing microorganisms（quantified by nif H gene copy numbers; p = 0.001）. The results of the positive control with Ag NO3 revealed predominantly stronger effects due to Ag＋ion release. Thus, the increasing toxicity of AgNP during the test period may reflect the long-term release of Ag^＋ions. Nevertheless, even very low concentrations of AgNP caused disadvantages for the microbial soil community, especially for nitrogen cycling, and our results confirmed the risks of releasing AgNP into the environment.

关键词： Silver nanoparticles Soil Microbiome amoA nifH Leucine aminopeptidase activity AgPure

Reduced peripheral vascular reactivity in refractory angina pectoris:Effect of enhanced external counterpulsation

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Journal of Geriatric Cardiology 2011年第4期8卷 215-223页

作者： susanne M Bondesson Marie-Louise Edvinsson Thomas Pettersson Lars Edvinsson Department of Medicine Kristianstad HospitalSE-29185 KristianstadSweden Department of Health Sciences Lund Lund UniversitySE-22100 LundSweden Department of Emergency Medicine Lund University HospitalSE-22185 LundSweden

Objective To examine if the skin microvascular bed is altered and can be modified by enhanced external counterpulsation(EECP)in patients with chronic refractory *** Twenty patients diagnosed with refractory angina were divided into EECP(n=10)or no EECP(n=10)*** data were compared to matched healthy subjects(n=20).The cutaneous forearm microvascular blood flow was measured by Laser-Doppler *** vascular responsiveness to iontophoretic administration of acetylcholine(ACh),sodium nitroprusside(SNP)and local skin warming were *** of Canadian Cardiovascular Society(CCS)-class,blood pressure and plasma samples were *** EECP patients showed reduced CCS-class compared to no EECP(P<0.05).Both EECP and no EECP(P<0.05)groups had decreased systolic blood pressure(SBP)as compared to SBP at baseline(P<0.05).There was no difference in resting blood flow between the two refractory groups at baseline as well as after EECP and seven weeks of *** to heating,the responses to ACh and SNP in the cutaneous microcirculation were lower in both groups of refractory angina patients as compared to healthy subjects(P<0.05).EECP patients corresponded positively to the treatment shown by reduced plasma level of soluble interleukin-2 receptor and *** Refractory angina patients have reduced responsiveness in their cutaneous microcirculation to ACh,SNP and heat compared to healthy *** EECP reduced the CCS-class,this effect was not associated with improvements in responsiveness of the cutaneous microcirculation.

关键词： refractory angina pectoris flowmetry microcirculation enhanced external counterpulsation

Directional changes of species spatial dispersion and realized environmental niches drive plant community assembly during early plant succession

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Journal of Plant Ecology 2019年第3期12卷 409-418页

作者： Werner Ulrich Markus Klemens Zaplata susanne Winter Anton Fischer Department of Ecology and Biogeography Nicolaus Copernicus University in TorunLwowska 1PL 87-100 ToruńPoland Hydrology and Water Resources Management Brandenburg University of Technology Cottbus-SenftenbergSiemens-Halske-Ring 10D-03046 CottbusGermany Faculty of Forest and Environment Section of Applied Ecology and ZoologyEberswalde University of Sustainable DevelopmentAlfred-Möller-Str.5D-16225 EberswaldeGermany Department of Geobotany Center of Life and Food SciencesTechnische Universität MünchenHans-Carl-von-Carlowitz-Platz 2D-85354 FreisingGermany

Aims Probabilistic models of species co-occurrences predict aggre-gated intraspecific spatial distributions that might decrease the degree of joint species occurrences and increase community ***,little is known about the influence of intraspecific aggre-gation on the co-occurrence of species in natural,species-rich ***,we focus on early plant succession and ask how changes in intraspecific aggregation of colonizing plant spe-cies influence the pattern of species co-existence,richness and *** We studied the early vegetation succession in a six ha constructed catchment within the abandoned part of a lignite mine in NE *** two spatial scales(1-and 25-m2 plots),we compared for each pair of species the intraspecific degree of aggregation and the pattern of co-occurrence and compared observed rela-tionships with temporal changes in important species functional *** Findings The majority of species occurred in an aggregated manner,particu-larly in the first 2 years of *** pairwise comparisons,we found an excess of segregated species occurrences leading to a posi-tive link between intraspecific aggregation and pairwise species seg-regation as predicted by the aggregation hypothesis,particularly at the lower spatial *** degree of intraspecific aggregation was negatively correlated with the community-wide level of species spatial turnover and with plot species *** results are the first direct confirmation that increasing intraspecific aggregation and interspecific competitive interactions counteract in shaping plant community structure during *** respective effects of aggregation were strongest at intermediate states of early succession.

关键词： primary succession spatial analysis environmental niche functional traits species aggregation

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话剧《禁闭》[奥]

上海戏剧 2024年第4期 F0004-F0004页

作者： susanne Hassler-Smith(摄影) 不详

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Killer on the road?—cells from pancreatic preneoplastic lesions disseminate through pancreatic ducts on their way to cancer

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 392-394页

作者： Heiner Schafer Arne Traulsen susanne Sebens Institute for Experimental Cancer Research Kiel University&University Hospital Schleswig-Holstein Campus KielKielGermany Max Planck Institute for Evolutionary Biology PlonGermany

Pancreatic ductal adenocarcinoma (PDAC) is ranked the fourth most common cause of cancer related deaths in western countries with a 5-year survival rate of less than 8% (1). It is estimated to be even the second most common cause by 2030 as there are no successful treatment options (2). Due to the lack of early and specific symptoms as well as non-invasive biomarkers, the majority of patients is diagnosed at an advanced and already metastasized disease stage, where palliative treatment remains the only option (3). Thus, in order to improve the dismal prognosis of PDAC patients, a much better understanding of PDAC evolution is urgently needed allowing earlier detection of the disease and providing novel therapeutic modalities. It is well appreciated that the most common precursor lesion of PDAC is the pancreatic intraepithelial neoplasia (PanIN) (4). According to the progression model (5,6) and supported by genetic studies, PanINs develop from low-grade to high-grade lesions finally leading to an invasive carcinoma. This progression is characterized and driven by the acquisition of genetic (and epigenetic) alterations. In fact, mutations in the oncogene kras, being one of the earliest genetic alterations, are present in 99% of even early low-grade PanINs (PanIN1) (5,6). In resected PDAC tissues, PanINs are often found in and around the tumor mass (7). Genetic analysis revealed that PanINs and adjacent carcinoma tissues share many common mutations albeit some mutations are apparently acquired not until the carcinoma stage (8,9). These data indicate that PDAC may;origin from neighboring PanINs. However, the biology and genetic relationship between PanINs and PDAC and thereby PDAC evolution is still poorly understood.

关键词： alterations Killer thereby

Piet Mondrian, 1872-1944

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Unexpected little helpers: microbiota stimulate systemic antiviral defenses

作者： susanne Deicher.

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4001-4002页

作者： susanne Klute Helene Hoenigsperger Konstantin M.J.Sparrer Institute of Molecular Virology Ulm University Medical CenterUlm89081Germany

In a recent study published in Immunity by Erttmann et al.,an unexpected beneficial role of gut microbiota in protecting mice against invading viruses by promoting low levels of systemic innate immune activation via t... 详细信息

关键词： al. interferon ed.

Uptake of citrate-coated iron oxide nanoparticles into atherosclerotic lesions in mice occurs via accelerated transcytosis through plaque endothelial cells

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Nano Research 2016年第11期9卷 3437-3452页

作者： Wolfram C. Poller Evelyn Ramberger Philipp Boehm-Sturm susanne Mueller Konstantin Moller Norbert Lowa Frank Wiekhorst susanne Wagner Matthias Taupitz Eyk Schellenberger Gert Baumann Karl Stangl Verena Stangl Antje Ludwig Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charite-Universitatsmedizin Berlin Campus Mitte Chariteplatz 1 10117 Berlin Germany Abteilung fur Experimentelle Neurologie Center for Stroke Research Charite-Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Charite Core Facility '7 T experimental MRIs' Charite-Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Physikalisch-Technische Bundesanstalt Abbestr. 2-12 10587Berlin Germany Institut fur Radiologie Charite-Universitatsmedizin Berlin Campus Mitte Charit@platz 1 10117 Berlin Germany DZHK (German Centre for Cardiovascular Research) partner site Berlin 10115 Berlin Germany Berlin Institute of Health (BIH) 10117 Berlin Germany

Very small superparamagnetic iron oxide nanoparticles （VSOPs） rapidly accumulate in atherosclerotic lesions, thereby enabling plaque visualization by magnetic resonance imaging （MRI）. This study was performed to identify the uptake mechanisms of VSOPs into atherosclerotic plaques. Low-density lipoprotein receptor-deficient （LDLR^-/-） mice with advanced atherosclerosis were analyzed using MRI and transmission electron microscopy （TEM） at various time points after intravenous administration of VSOPs. Post-mortem MRI detected VSOP labeling of atherosclerotic plaques 10 min after injection, and the signal increased over the first 3 h. TEM revealed that the intensive plaque labeling was mediated by accelerated transcytosis of VSOPs through endothelial cells overlaying atherosclerotic lesions. Experiments with endocytosis inhibitors and small interfering RNA （siRNA） revealed a dynamin-dependent mechanism involving both clathrin- and caveolin-mediated processes. In cell culture experiments, endothelial VSOP uptake was enhanced under proatherogenic flow and TNFα stimulation, conditions that are both present in plaque areas. Our study demonstrates that VSOPs enable non-invasive MRI assessment of accelerated endothelial transcytosis, an important pathomechanism in atherosclerotic plaque formation.

关键词： atherosclerosis,unstable plaques,magnetic resonanceimaging decreased endothelial barrier function,superparamagnetic ironoxide nanoparticles