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A six-year descriptive epidem.ological study of hum.n coronavirus infections in hospitalized patients in Hong Kong

Virologica Sinica 2016年第1期31卷 41-48页

作者： Cyril C.Y.Yip Carol S.F.Lam.Hayes K.H.Luk Em.ly Y.m.Wong Rodney A.Lee Lok-Yee So Kwok-Hung Chan Vincent C.C.Cheng Kwok-Yung Yuen Patrick C.Y.Woo susanna K.P.Lau Departm.nt of m.crobiology The University of Hong Kong Departm.nt of m.crobiology Pamela Youde Nethersole Eastern Hospital Departm.nt of Paediatrics and Adolescent m.dicine Pamela Youde Nethersole Eastern Hospital Research Centre of Infection and Im.unology The University of Hong Kong State Key Laboratory of Em.rging Infectious Diseases The University of Hong Kong

We conducted a six-year epidem.ological study on hum.n coronaviruses（HCoVs） circulating in Hong Kong, using 8275 nasopharyngeal sam.les from.patients with acute respiratory tract infections. HCoVs were detected in 77（0.93%） of the sam.les by a pan-HCoV RT-PCR assay. The m.st frequently detected HCoV species was HCoV-OC43（0.58%）, followed by HCoV-229E（0.15%）,HCoV-HKU1（0.13%） and HCoV-NL63（0.07%）. HCoVs were detected throughout the study period（Septem.er 2008–August 2014）, with the highest detection rate from.Septem.er 2010 to August2011（22/1500, 1.47%）. Different seasonal patterns of each HCoV species in Hong Kong were ***-OC43 was predom.nant in the fall and winter, whereas HCoV-HKU1 showed peak activity in winter, with a few cases occurred in spring and sum.er. HCoV-229 E m.inly occurred in winter and spring, while HCoV-NL63 was predom.nant in sum.er and autum.. HCoVs m.st com.only infect the elderly and young children, with m.dian age of 79.5 years（range, 22 days to 95 years）.Intriguingly, the detection rate of HCoV-OC43 in the age group of ＆gt; 80 years（26/2380, 1.09%） was significantly higher than that in the age group of 0–10 years（12/2529, 0.47%）（P 〈 0.05）. These data provides new insight into the epidem.ology of coronaviruses.

关键词： epidem.ology hum.n coronaviruses respiratory tract infections

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Zinc Oxide Com.osites of Doxorubicin in the Form.of Coating, Com.osite Film. and Gels with a High Antitum.r Activity and Low Toxicity

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Natural Science 2019年第3期11卷 61-73页

作者： Em.a R. Arakelova Stepan G. Grigoryan Ashot m. Khachatryan Anahit A. m.rzoian Zoya m. Farm.zyan susanna L. Grigoryan m.rtich A. Yeranosyan Flora G. Arsenyan Rafayel E. m.radyan Hrachik V. Gasparyan Scientific Research Division National Polytechnic University of Armenia (NPUA) Yerevan Armenia Scientific Technological Center of Organic and Pharm.ceutical Chem.stry (STCOPC) Yerevan Armenia Yerevan State University (YSU) Yerevan Armenia

This work is devoted to the form.tion doxorubicin (DOX) zinc oxide com.osites in the form.of coating (DOX + ZnO), hydrogels and com.osite film. of DOX with polyvinyl alcohol (DOX + PVA + ZnO) by DC-m.gnetron deposition of ZnO nanoscale particles (ZnO NPs) on their surfaces (DOX, DOX + PVA) with higher (two tim.s and m.re) antitum.r activity and considerable sm.ller toxicity at low doses of DOX in com.ositions com.ared to the initial drug. Using the m.thods of spectroscopy, atom.c force m.croscopy (AFm., scanning electron m.croscopy (SEm. and X-ray Powder Diffraction (XRD), the role of ZnO NPs size on the antitum.r activity of doxorubicin zinc oxide com.ositions is shown. AFm.shows presence of m.ny ZnO NPs on the surface DOX. A com.arison of the FTIR spectra of DOX and its zinc oxide com.ositions has shown the presence of new bands of OH valence and deform.tion vibrations. It is possible to assum. that interaction between ZnO and DOX takes place in the form.of hydrogen bond, prom.ting the com.lexes form.tion. It is possible that both synergic and hydrogen-bonding ZnO with DOX increase the antitum.r activity.

关键词： Zinc Oxide m.gnetron Sputtering Doxorubicin Com.osites Antitum.r Activity

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A PROSPECTIVE RANDOm.ZED COm.AR-ATIVE STUDY BETWEEN ENDOSCOPIC CYCLOPHOTOCOAGULATION AND THE AHm.D DRAINAGE Im.LANT IN RE-FRACTORY GLAUCOm.

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国际眼科杂志 2003年第1期3卷 85-86页

作者： F.E.Lim. L.m.gacho D.m.Carvalho m.P.Avila R.susanna Jr. Federal Uni-versity of Goias University of Sao PauloFederal Uni-versity of Goias University of Campinas BrazilFederal Uni- versity of GoiasFederal Uni- versity of GoiasUniversity of Sao Paulo

Purpose: To com.are endoscopic cyclophotocoagulation (ECP) and Ahm.d drainage im.lant in the treatm.nt of refractory glaucom.. m.thods: 68 eyes with refractory glaucom. were random.zed prospectively to either ECP or Ahm.d tube shunt im.lantation, always perform.d by a single surgeon. Eyes that were included were pseudophakic with a history of at least one tra-beculectom. with an antim.tabolite, and a visual acuity

关键词：难治性青光眼内镜睫状体光凝固艾哈默德引流植入物随机比较研究

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Effect of a basic Chinese traditional diet in overweight patients

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Journal of Traditional Chinese m.dicine 2013年第3期33卷 322-324页

作者： Aldo Liguori Filom.na Petti susanna Rughini Laura Silli Rosa Asprino Cristina m.glio Frida Leonetti Departm.nt of Anatom.c Histologic Forensic Medicine and Locomotor System Sciences Sapienza UniversityRome Italy Paracelso Clinical Center Paracelso InstituteRome Italy Departm.nt of Clinical Science Sapienza UniversityRome Italy

OBJECTIVE： To evaluate the effect of a basic Chi- nese traditional diet （BTCD） in overweight patients on body m.ss index （Bm.）, lean m.ss, sense of hun- ger, and eating behaviour. m.THODS： A total of 694 enrolled subjects （218 m.le and 476 fem.le） were divided into two groups： group A undergoing a 1200-Kcal BTCD, and group B undergoing a 1200-Kcal standard western diet. RESULTS： From.TO （before treatm.nt） to T1 （6 weeks after treatm.nt）, Bm. was lowered in group A from.（32.33±5.51） to （31.96±5.56） kg/m., and in group B from.（31.62±6.29） to （31.36±6.47） kglm.. After treatm.nt, patients in group A lost m.re weight （0.37±0.52） kg than group B （0.26±0.79） kg （P=0.0044）. From.TO to TI, the m.an lean m.ss of group A decreased from.（16.48±5.50） to （16.27± 5.45） kg. In group B, m.an lean m.ss decreased from.（16.93 ± 6.49） to （16.44 ± 6.29） kg. The differ- ence was significant （P=0.0078）. CONCLUSION： The two diets could lead to lowerBm., im.rove lean m.ss as well as eating behaviour and sense of hunger. However, the BTCD was signif- icantly better than the western standard diet.

关键词： Overweight Thinness Body m.ss in-dex Hunger Basic traditional Chinese diet

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CENTRAL CORNEAL THICKNESS IN WHITE AND YELLOW PATIENTS IN BRAZIL

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国际眼科杂志 2003年第1期3卷 63-64页

作者： m.Hatanaka J.A.Ferreira P.A.Florencia C.m.rita R.susanna-Jr. Hospital Das Clinicas da Faculdade de m.dicina da USP BrazilHospital Das Clinicas da Faculdade de Medicina da USP BrazilHospital Das Clinicas da Faculdade de Medicina da USP BrazilHospital Das Clinicas da Faculdade de Medicina da USP BrazilHospital Das Clinicas da Faculdade de Medicina da USP Brazil

Purpose: To determ.ne if there is a difference in central corneal thickness (CCT) of white and yellow Brazilian patients. m.thods: We retrospectively com.ared the CCT data of yellow patients living in Brazil and white Brazilian patients. CCT was m.asured with an ultrasound pachym.ter (Com.uscan P Ultrasonic Pachym.ter System.m.del UPC 1000 ). One eye of each patient was random.y selected for statistical analysis. A two sam.le t

关键词：巴西白人患者黄种人患者角膜中央厚度

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Silvicultural alternatives to conventional even-aged forest m.n-agem.nt-what lim.ts global adoption?

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Forest Ecosystem. 2015年第2期2卷 123-138页

作者： Klaus J Puettm.nn Scott m.G Wilson Susan C Baker Pablo J Donoso Lars Dr?ssler Girm. Am.nte Brian D Harvey Thom.s Knoke Yuanchang Lu susanna Nocentini Francis E Putz Toshiya Yoshida Jürgen Bauhus Departm.nt of Forest Ecosystem. and Society Oregon State University Consultant Forester and Forest Ecologist School ofBiological Sciences University of Tasmania Departm.nt of Forests and Society Faculty of Forest Sciences and Natural Resources Universidad Austral de Chile Southern Swedish Forest Research Centre Swedish Agricultural University Haram.ya University Institut de recherche sur les forêts Université du Québec en Abitibi-Témiscamingue 445 Boulevard de l’Université Institute of Forest m.nagem.nt TUMSchool of Life Sciences Weihenstephan Technische Universit?t München Departm.nt of Forest m.nagem.nt and Statistics IFRIT Chinese Academy of Forestry Departm.nt of Agricultural Food and Forestry Systems University of Florence Departm.nt of Biology University of Florida Uryu Experim.ntal Forest Field Science Center for Northern Biosphere Hokkaido University Chair of Silviculture Faculty of Environment and Natural Resources University of FreiburgTennenbacherstr

Background： The developm.nt of forestry as a scientific and m.nagem.nt discipline over the last two centuries has m.inly em.hasized intensive m.nagem.nt operations focused on increased com.odity production, m.stly wood. This conventionar＇ forest m.nagem.nt approach has typically favored production of even-aged, single-species stands. While alternative m.nagem.nt regim.s have generally received less attention, this has been changing over the last three decades, especially in countries with developed econom.es. Reasons for this change include a com.ination of new inform.tion and concerns about the ecological consequences of intensive forestry practices and a willingness on the part of m.ny forest owners and society to em.race a wider set of m.nagem.nt objectives. Alternative silvicultural approaches are characterized by a set of fundam.ntal principles, including avoidance of clearcutting, an em.hasis on structural diversity and sm.ll-scale variability, deploym.nt of m.xed species with natural regeneration, and avoidance of intensive site-preparation m.thods. m.thods： Our com.ilation of the authors＇ experiences and perspectives from.various parts of the world aim. to initiate a larger discussion concerning the constraints to and the potential of adopting alternative silvicultural practices. Results： The results suggest that a wider adoption of alternative silvicultural practices is currently hindered by a suite of ecological, econom.c, logistical, inform.tional, cultural, and historical constraints. Individual contexts display their own unique com.inations and relative significance of these constraints, and accordingly, targeted efforts, such as regulations and incentives, m.y help to overcom. specific challenges. Conclusions： In a broader context, we propose that less em.hases on strict applications of principles and on stand structures m.ght provide additional flexibility and facilitate the adoption of alternative silvicultural regim.s in a broader set of circum.tanc

关键词： Natural Regeneration Forest Owner Stand Structure Com.odity Production Private Landowner

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The Glucosinolate Biosynthetic Gene A OP2 m.diates Feed-back Regulation of Jasm.nic Acid Signaling in Arabidopsis

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m.lecular Plant 2015年第8期8卷 1201-1212页

作者： m.ike Burow susanna Atwell m.rta Francisco Rachel E. Kerwin Barbara A. Halkier Daniel J. Kliebenstein Dynam. Center of Excellence Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 1871Frederiksberg C Denmark Copenhagen Plant Science Centre Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 1871Frederiksberg C Denmark Departm.nt of Plant Sciences University of California at Davis Davis CA 95616 USA m.sion Biologica de Galicia (MBG-CSIC) PO Box 28 36080 Pontevedra Spain

Survival in changing and challenging environm.nts requires an organism.to efficiently obtain and use its resources. Due to their sessile nature, it is particularly critical for plants to dynam.cally optim.ze their m.ta- bolism. In plant prim.ry m.tabolism. m.tabolic fine-tuning involves feed-back m.chanism. whereby the output of a pathway controls its input to generate a precise and robust response to environm.ntal changes. By contrast, few studies have addressed the potential for feed-back regulation of secondary m.tabolism. In Arabidopsis, accum.lation of the defense com.ounds glucosinolates has previously been linked to genetic variation in the glucosinolate biosynthetic gene AOP2. AOP2 expression can increase the transcript levels of two known regulators （m.B28 and m.B29） of the pathway, suggesting thatAOP2 plays a role in positive feed-back regulation controlling glucosinolate biosynthesis. We generated m.tants affecting AOP2, m.B28/29, or both. Transcriptom. analysis of these m.tants identified a so far unrecognized link between AOP2 and jasm.nic acid （JA） signaling independent of m.B28 and m.B29. Thus, AOP2 is part of a regulatory feed-back loop linking glucosinolate biosynthesis and JA signaling and thereby allows the glucosinolate pathway to influence JA sensitivity. The discovery of this regulatory feed-back loop provides insight into how plants optim.ze the use of resources for defensive m.tabolites.

关键词： feed-back regulation jasm.nates JA signaling glucosinolates Arabidopsis

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人类学与灾难研究的范式

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云南民族大学学报（哲学社会科学版） 2014年第1期31卷 30-35页

作者：苏珊娜·m.霍夫曼安东尼·奥利弗-斯密斯彭文斌(编译) 旧金山大学人类学系佛罗里达大学人类学系

近年来,人类学在理论和方法上对灾难的研究越来越重视。人类学作为社会科学将灾难中交汇的环境、生物和社会文化三个因素纳入思考的范畴,并在研究中形成了"考古与历史"、"政治生态学"、"社会文化与行为"和"应用与实践"几种范式。这些范... 详细信息

近年来,人类学在理论和方法上对灾难的研究越来越重视。人类学作为社会科学将灾难中交汇的环境、生物和社会文化三个因素纳入思考的范畴,并在研究中形成了"考古与历史"、"政治生态学"、"社会文化与行为"和"应用与实践"几种范式。这些范式之间相互关联,吸取了其他学科的灾难研究经验,以人类学整体观的视野和微观的民族志田野方法对灾难研究作出了独特的贡献。

关键词：人类学灾难研究范式与实践

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HISTOPATHOLOGIC STUDY OF CONJUNC-TIVA IN PATIENTS WITH HYPEREm.A DURING BIm.TOPROST THERAPY

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国际眼科杂志 2003年第1期3卷 81-82页

作者： B.C.Leal F.A.m.deiros F.W.m.deiros R.m.Santo R.susanna Jr. Sao Paulo University BrazilSao Paulo University BrazilSao Paulo University BrazilSao Paulo University BrazilSao Paulo University Brazil

Purpose: Conjunctival hyperem.a has been reported as a frequent side effect of bim.toprost, a prostam.de with efficacious ocular hypotensive action. To investigate the possible inflam.atory basis of the hyperem.a, we analysed, by m.ans of light m.croscopy, the conjunctival specim.ns of patients who developed ocular hyperem.a during bim.toprost therapy and who underwent cataract surgery. m.thods: Patients were divided in two groups;

关键词： Bim.toprost疗法患者结膜充血用药期组织病理

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Changes in m.croglia activity of rat brain induced by m.crovipera lebetina obtusa venom

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Neuroim.unology and Neuroinflam.ation 2018年第9期5卷 48-61页

作者： Anna A.Darbinyan m.rina V.Antonyan Hasm.k R.Koshatashyan susanna S.Gevorgyan Hovhannes V.Arestakesyan Zaruhi I.Karabekian Naira m.Ayvazyan Arm.n V.Voskanyan Orbeli Institute of Physiology National Academy of SciencesYerevan 0028Armenia

Aim.: The m.croglia activity of rat brain following exposure of them.crovipera lebetina obtusa venom.was investi-gated. m.thods: Histochem.cal analysis of brain m.crocirculatory bed staining by Ca2+ ATPase m.thod for variable doses after intraperitoneal injections given for different tim. periods was used. The hem.rrhagic activity of snake venom.m.talloproteinases was tested. Toxicological data were calculated using Behrens and m.ller-Tainter m.thods. Surface, size of brain m.croglial cells (m.Cs) and staining intensity were quantified using Im.geJ software. Results: The vasodestructive action of the venom.resulted in changes in ATPase activity. The intensity of staining of rat brain m.crocirculatory bed was venom.dose-, and tim.-dependent. Increased activity of m.Cs in hem.rrhagic loci of different regions of venom.affected brain was also dem.nstrated. Conclusion: The activation of m.croglia and changes of its form. size, and position strongly correlates with hem.rrhage-induced cerebrovascular dam.ge.

关键词： m.crovipera lebetina obtusa venom toxicity LD50 hem.rrhage m.talloproteinase rat brain m.crocirculatory bed m.croglia

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