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分子细胞生物学报:英文版 2015年第2期7卷 132-142页

作者： Simona Citro Claudia Miccolo Laura Meloni susanna Chiocca Department of Experimental Oncology European Institute of OncologyIFOM-IEO Campusvia Adamello 1620139 MilanItaly Department for Molecular Biomedical Research Technologiepark Zwijnaarde927 VIB west9052 GhentBelgium

Histone deacetylase 1(HDAC1)is an important epigenetic controller involvedin transcriptional regulation throughmodification of chromatin *** and epigenetic changes and deregulation of signal transduction pathways have been implicated in the development of breast *** of estrogen receptor a(ERa)expression is one of the mechanisms behind the acquisition of endocrine *** and increased hormone and growth factor receptor signaling in breast cancer cells contribute to resistance to endocrine *** HDACs and the PI3K/mTOR signaling pathway are becoming promising targets in breast cancer,reversing also acquired hormone *** we show how mitogens,activating the PI3K/mTOR pathway,trigger the phosphorylation of HDAC1 in breast cancer cells,which is completely dependent on the activity of the p70 S6 kinase(S6K1).Our findings show that S6K1,overexpressed in many breast cancers,controls HDAC1-dependent transcriptional regulation of ERa levels upon mitogenic stimuli,controlling HDAC1 recruitment to the ERa ***,cell treatment with both mTOR and HDACs inhibitors shows an additive effect in inhibiting breast cancer *** confirms the novel cross-talk between the HDAC1 and PI3K pathways with clinical implications towards the treatment of this malignant disease.

关键词： breast cancer estrogen receptor HDAC1/mTOR/PI3K/S6K1

Emotions,Perceptions and Health Behaviors of Adult Congenital Heart Disease Patients during COVID-19 in New York City

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Congenital Heart Disease 2022年第5期17卷 519-531页

作者： Jodi L.Feinberg Peter Sheng Stephanie Pena Adam J.Small susanna Wendelboe Katlyn Nemani Vikram Agrawal Dan G.Halpern Leon H.Charney Division of Cardiology NYU Grossman School of MedicineNew YorkUSA Department of Medicine NYU Grossman School of MedicineNew YorkUSA Department of Psychiatry NYU Grossman School of MedicineNew YorkUSA Department of Cardiology Mount Sinai MorningsideNew YorkUSA

Background:Adults with congenital heart disease(ACHD)have increased prevalence of mood and anxiety *** are limited data regarding the influence of the COVID-19 pandemic on the mental health and health behaviors of these ***:The purpose is to evaluate the perceptions,emotions,and health behaviors of ACHD patients during the COVID-19 ***:In this cross-sectional study of ACHD patients,we administered surveys evaluating self-reported emotions,perceptions and health *** regressions were performed to determine the adjusted odds of displaying each perception,emotion and health behavior based on predictor ***:Ninety-seven patients(mean age 38.3 years,46.4%female,85.6%moderate or complex lesion)completed the *** majority of patients reported feeling moderately or very sad(63.1%),and 48.4%of patients identified themselves as feeling moderately or very *** majority of patients perceived their risk of COVID-19 as moderate or *** were more likely to report feeling sad and anxious(95%CI 1.06–10.96,p-value 0.039,and 95%CI 1.44–15.30,p-value=0.012,respectively),and were associated with higher odds of having a perceived increased risk of COVID-19(95%CI 1.33–10.59,p-value 0.012).There was no association between ACHD anatomic or physiologic classification and perceptions,emotions and health ***:Females were more likely to report feeling sad,anxious and an increased risk of COVID-19 in comparison to *** findings indicate the need for mental health support and promotion of health behaviors during the pandemic amongst all ACHD patients,regardless of underlying condition.

关键词： Adult congenital heart disease COVID-19 health behaviors anxiety depression

Viral manipulation of cellular protein conjugation pathways: The SUMO lesson

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World Journal of Virology 2013年第2期2卷 79-90页

作者： Domenico Mattoscio Chiara V Segré susanna Chiocca Department of Experimental Oncology European Institute of Oncology Via Adamello 16 20139 Milan Italy

Small ubiquitin-like modifier(SUMO)ylation is a key posttranslational modification mechanism that controls the function of a plethora of proteins and biological processes. Given its central regulatory role, it is not surprising that it is widely exploited by viruses. A number of viral proteins are known to modify and/or be modified by the SUMOylation system to exert their function, to create a cellular environment more favorable for virus survival and propagation, and to prevent host antiviral responses. Since the SUMO pathway is a multi-step cascade, viral proteins engage with it at many levels, to advance and favor each stage of a typical infection cycle: replication, viral assembly and immune evasion. Here we review the current knowledge on the interplay between the host SUMO system and viral lifecycle.

关键词： Virus Small ubiquitin-like modifier Smal ubiquitin-like modifier-ylation Exploitation Virus assem bly Immune evasion Innate immunity

Characterization of the prefusion and transition states of SARS-CoV S2

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Characterization of the prefusion and transition states of S...

Educational Value of Doctor Trainee Employments (“Student Doctor”) —A Questionnaire Study

第3届新生病毒性疾病控制学术研讨会

作者： susanna McReynolds Michael Caffrey University of Illinois at Chicago ChicagoILUSA

The envelope glycoproteins of the classⅠfamily,which include human immunodeficiency virus(HIV),influenza,and severe acute respiratory syndrome coronavirus(SARS-CoV),mediate viral entry by first binding to their cellular

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International Journal of Clinical Medicine 2015年第7期6卷 469-474页

作者： Sven Wallerstedt Maria Odqvist susanna M. Wallerstedt Institute of Medicine Sahlgrenska Academy University of Gothenburg G&oumlteborg Sweden Södra Älvsborgs Sjukhus Bor&arings Sweden Department of Clinical Pharmacology Sahlgrenska University Hospital G&oumlteborg Sweden

Background: In Sweden, medical students can work as employed doctor trainees under supervision during medical school breaks. The aim of the present study was to evaluate the educational value of such employments, as well as to compare university and non-university positions. Method: A questionnaire was administered to all employed doctor trainees at Sahlgrenska University Hospital, Gothenburg, in 2003-2004 (n = 67) plus all students in last term medical school 2005 who had had such a position inside or outside this university hospital (n = 43). The questionnaire included questions on trainee position/s, as well as statements regarding the educational value. Result: 75 unique individuals returned a filled-in questionnaire (response rate: 78%). The respondents experienced the positions as valuable concerning gain in professional confidence (mean ± standard deviation: 3.9 ± 1.1;1 = total disagreement to 5 = total agreement) and independence (3.9 ± 1.1), subsequent learning in medical school (4.3 ± 0.9), and future professional work (4.2 ± 1.0). The gain in professional confidence and independence was greater for those who had worked in a non-university hospital (n = 17) than in a university hospital (n = 29): 4.4 ± 0.6 vs. 3.6 ± 3.6, P = 0.011;4.3 ± 0.7 vs. 3.6 ± 1.1, P = 0.038. Conclusion: Employment as a doctor trainee seems to facilitate subsequent learning in medical school and enhance professional progress;the latter is particularly prominent in non-university hospitals.

关键词： Doctor Trainee Education Medical Student Professional Progress Student Doctor

Two NGO-Run Youth-Centers in Multicultural, Socially Deprived Suburbs in Sweden—Who Are the Participants?

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Health 2015年第9期7卷 1158-1174页

作者： susanna Geidne Ingela Fredriksson Koustuv Dalal Charli Eriksson School of Health and Medical Sciences Orebro University Orebro Sweden

Objective: Leisure-time is an important part of young people’s lives. One way to reduce social differences in health is to improve adolescents’ living conditions, for example by enhancing the quality of after-school activities. Multicultural, socially deprived suburbs have less youth participation in organized leisure-time activities. This study explores who the participants are at two NGO-run youth-centers in multicultural, socially deprived suburbs in Sweden and whether socio-demographic, health-related, and leisure-time factors affect the targeted participation. Methods: The study can be seen as an explanatory mixed-methods study where qualitative data help explain initial quantitative results. The included data are a survey with youth (n = 207), seven individual interviews with staff, and six focus-groups interviews with young people at two youth-centers in two different cities. Results and Conclusions: The participants in the youth-centers are Swedish born youths having foreign-born parents who live with both parents, often in crowded apartments with many siblings. Moreover they feel healthy, enjoy school and have good contact with their parents. It seems that strategies for recruiting youths to youth-centers have a large impact on who participates. One way to succeed in having a more equal gender and ethnicity distribution is to offer youth activities that are a natural step forward from children’s activities. The youth-centers’ proximity is also of importance for participation, in these types of neighborhoods.

关键词： Youth-Center Leisure-Time Participation Suburbs NGO

The Joint Use of Electronic Nose and Electronic Tongue for the Evaluation of the Sensorial Properties of Green and Black Tea Infusions as Related to Their Chemical Composition

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Food and Nutrition Sciences 2013年第6期4卷 605-615页

作者： susanna Buratti Antonella Casiraghi Paola Minghetti Gabriella Giovanelli DeFENS Department of Food Environmental and Nutritional Sciences Università degli Studi di Milano Milano Italy Depart- ment of Pharmaceutical Sciences “Pietro Pratesi” Università degli Studi di Milano Milano Italy.

The objectives of the present study were to determine the effects of the brewing method on the amount of the major catechins, methylxanthines, total polyphenols and antioxidant capacity in green and black teas, and to correlate the chemical composition of tea infusions to their sensorial properties by the combined use of the electronic nose and tongue. For this purpose, tea infusions were prepared from 7 green teas and 6 black teas using different extraction times (3 - 5 and 10 min). The extraction of total polyphenols and catechins was increased by prolonging the infusion time from 3 - 5 to 10 min, while the caffeine amounts did not increase. The antioxidant activity of teas was well correlated with polyphenol content. Electronic tongue and electronic nose were able to discriminate green teas from black teas on the basis of their sensorial properties. Considering the taste, green teas were characterized by astringency and aftertaste-astringency and this sensation was increased by prolonging the infusion time;black teas were perceived as more bitter, sour, salty and the extraction time affected the astringent sensation. The aroma of green and black teas was discriminated by specific sensors and the increase of the extraction time produced more richly flavoured infusions. This work adds information about correlation between sensorial properties, antioxidant capacity and chemical composition of green and black teas.

关键词： Green Tea Black Tea Electronic Nose Electronic Tongue Chemical Composition Antioxidant Activity

Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain

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Journal of Oceanology and Limnology 2021年第6期39卷 2044-2052页

作者： Rozalyn A.SIMON Purnika Damindi RANASINGHE Nawroz BARAZANJI Malin Bergman JUNGESTRÖM Jie XU Olga BEDNARSKA Lena SERRANDER Maria ENGSTRÖM Dennis A.BAZYLINSKI Åsa V.KEITA susanna WALTER Center for Medical Image Science and Visualization(CMIV) Linköping UniversityLinköping 58183Sweden Department of Health Medicineand Caring SciencesLinköping UniversityLinköping 58183Sweden Division of Infection and Infl ammation Department of Biomedical and Clinical SciencesLinköping UniversityLinköping 58183Sweden Institute of Global Food Security School of Biological SciencesQueen’s University BelfastBelfast BT95DLUnited Kingdom School of Life Sciences University of Nevada at Las VegasLas VegasNevada 89154USA Division of Surgery Orthopedics and OncologyDepartment of Clinical and Experimental MedicineLinköping UniversityLinköping 58183Sweden

Magnetotactic bacteria(MTB),ubiquitous in soil and fresh and saltwater sources have been identified in the microbiome of humans and many *** endogenously produce magnetic nanocrystals enabling them to orient and navigate along geomagnetic *** magnetite deposits have been found throughout the tissues of the human brain,including brain regions associated with orientation such as the cerebellum and hippocampus,the origins of which remain *** over the role and source of MTB in humans,as well as any association with the brain,remain *** performed a metagenomic analysis of the gut microbiome of 34 healthy females as well as grey matter volume analysis in magnetite-rich brain regions associated with orientation and navigation with the goal of identifying specific MTB that could be associated with brain structure in orientation and navigation *** identified seven MTB in the human gut microbiome:Magnetococcus marinus,Magnetospira ***-2,Magnetospirillum magneticum,Magnetospirillum ***-1,Magnetospirillum ***-1,Magnetospirillum gryphiswaldense,and Desulfovibrio *** preliminary results show significant negative associations between multiple MTB with bilateral flocculonodular lobes of the cerebellum and hippocampus(adjusted for total intracranial volume,uncorrected P<0.05).These findings indicate that MTB in the gut are associated with grey matter volume in magnetite-rich brain regions related to orientation and *** preliminary findings support MTB as a potential biogenic source for brain magnetite in *** studies will be necessary to validate and elucidate the relationship between these bacteria,magnetite concentrations,and brain function.

关键词： magnetotactic bacteria human microbiome microbiota-gut-brain axis magnetoreception

Reminiscence Therapy is Benefit to Quality of Life of Elderly Residents

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Reminiscence Therapy is Benefit to Quality of Life of Elderl...

Men’s Experience of Difficulties during First Year Following Myocardial Infarction—Not Only Fatigue

2012亚洲华人生存质量学术研讨会暨第五届全国生存质量学术交流会

作者： TSANG SUET MUI susanna CHAN CHSEHIRE HOME SHATIN

Background Most elderly residents stay in Cheshire Home Shatin are suffer from dementia. In order to help demented residents to recall their long term memories. Activities in an environment with old-styled

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Health 2016年第15期8卷 1654-1667页

作者： Pia Alsén susanna Thörn Linnea Nordqvist Ina Berndtsson Department of Health Science University West Trollh&auml ttan Sweden Primary Health Care Sollentuna Sweden Primary Health Care Munkedal Sweden

Recovery from a myocardial infarction (MI) can be a very difficult process and some patients are also stricken by fatigue. The aim of the study was to describe the difficulties experienced by men with fatigue during the first year following their MI. The study was conducted using qualitative content analysis of semi-structured interviews with nine men in working age (mean age: 55 years) with verified fatigue (≥12 of 20 on the Multidimensional Fatigue Scale with a mean of 17) one year after their MI. During the first year after the MI the men suffering from fatigue experienced various difficulties in terms of both themselves and the care received. The analysis generated three themes with difficulties described by the interviewed men. 1) Going through involuntary change: not recognizing their body and the inability to recognize themselves. 2) Lacking individualized care: To be denied satisfactory health care treatment and to be denied respectful treatment. 3) Not being seen in the light of the social context: The MI affects the whole family and caregivers do not pay attention to the family. In order to make both the patient and relatives feel secure and cared for, it is essential that caregivers be aware of the importance of providing individualized care over time with particular attention for the patient’s social context.

关键词： Fatigue Men Myocardial Infarction