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Human immunology and immunotherapy:main achievements and challenges

Cellular & Molecular Immunology 2021年第4期18卷 805-828页

作者： Jezabel Varade susana magadan Africa Gonzalez-Fernandez ONBIO Centro de Investigaciones BiomedicasUniversidade de VigoImmunology GroupCampus Universitario LagoasMarcosende36310 VigoSpain Instituto de Investigacidn Sanitaria Galicia Sur(IIS-Galicia Sur) ERGAS-UVIGOVigoSpain

The immune system is a fascinating world of cells,soluble factors,interacting cells,and tissues,all of which are *** highly complex nature of the immune system makes it difficult to view it as a whole,but researchers are now trying to put all the pieces of the puzzle together to obtain a more complete *** development of new specialized equipment and immunological techniques,genetic approaches,animal models,and a long list of monoclonal antibodies,among many other factors,are improving our knowledge of this sophisticated *** different types of cell subsets,soluble factors,membrane molecules,and cell functionalities are some aspects that we are starting to understand,together with their roles in health,aging,and *** knowledge is filling many of the gaps,and in some cases,it has led to changes in our previous assumptions;e.g.,adaptive immune cells were previously thought to be unique memory cells until trained innate immunity was observed,and several innate immune cells with features similar to those of cytokine-secreting T cells have been ***,we have improved our knowledge not only regarding immune-mediated illnesses and how the immune system works and interacts with other systems and components(such as the microbiome)but also in terms of ways to manipulate this system through *** development of different types of immunotherapies,including vaccines(prophylactic and therapeutic),and the use of pathogens,m onodonal antibodies,recombinant proteins,cytokines,and cellular immunotherapies,are changing the way in which we approach many diseases,especially cancer.

关键词： Vaccines CAR T cells Trained immunity Microbiota Cancer Monoclonal antibodies

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Residents'perception of sustainable tourism in protected mountain areas:the case of Asturias

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Journal of Mountain Science 2022年第12期19卷 3597-3614页

作者： magadan-DIAZ Marta RIVAS-GARCIA Jesus I. Faculty of Business and Communication Universidad Internacional de La RiojaAvda.de la Paz 137Logrono 26o06Spain

Spain is the country with the most Biosphere Reserves in the world,52,and Asturias,with 7,ranks first among the single-province Autonomous *** tourist interest in these natural spaces is increasing,but little or nothing is known about how the residents of these natural spaces perceive the tourist *** main objective of this research was to evaluate the residents’perceived changes in protected mountain areas in Asturias concerning the environmental,sociocultural,and economic dimensions related to tourism activity with survey methods and various quantitative *** findings obtained were the following:firstly,there were significant differences between the residents’sociodemographic characteristics and their perceptions of tourism impacts;secondly,there were positive relationships between the residents’perceived tourism economic,environmental and sociocultural impacts and their general attitude towards tourism development;and thirdly,the more positive the residents’attitude towards tourism development,the more likely residents actively support its further *** findings indicate the willingness of residents to get involved and participate in the tourism activity,so policymakers should implicate residents in decisionmaking on local tourism *** conclusion,long-term monitoring of residents’evolution of their perceptions and attitudes is necessary to achieve sustainable tourism development.

关键词： Sustainable tourism Tourists’perception Survey method Regression analysis Asturias

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Stem Population and Tissue Replacement of <i>Urochloa</i>in Different Phenological Stages

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American Journal of Plant Sciences 2020年第8期11卷 1296-1306页

作者： María de los Ángeles Maldonado Peralta Adelaido Rafael Rojas García Jessica Lizbeth Ruíz Clavel Herminio Aniano Aguirre Filiberto magadan Olmedo Leopoldo Jorge Castañeda Uriel Mondragón Calderón Universidad Autónoma de Guerrero Facultad de Medicina Veterinaria y Zootecnia Cuajinicuilapa Guerrero México Tecnológico Nacional de México Campus Instituto Tecnológico de Pinotepa Pinotepa Nacional Oaxaca México

The objective of the present investigation was to evaluate the Urochloa Insurgent, Piata and Signal grasses by varying the phenology in the attributes: stem population dynamics, tissue replacement, leaf:stem relation and weight per stem. The data were analyzed using a completely randomized block design with arrangement in divided plots and four replications, the procedure used was PROC GLM from SAS. The Signal grass presented higher stem density with an average of 450 m?2 stems, while the meadow with Insurgent grass registered the lowest stem density throughout the investigation, with an average of 320 m-2 stems;furthermore, in this treatment, the stem density tended to increase slowly over time (P = 0.05). The Insurgente and signal grasses showed rapid leaf elongation from day 21 of regrowth with 123 and 104 cm stem?1, while in Piata the accelerated leaf elongation was on day 14 with 113 cm stem?1 where it remained active its growth until day 56 (P > 0.05). As the regrowth age was increasing, the population dynamics of stems and weight per stem were increasing;in Insurgent and signal the leaf elongation and net growth increased to a maximum point to start declining;however, in Piata grass was increasing without decreasing. The trend of the leaf:stem relation was decreasing as the test progressed and senescence increased from day 21 of regrowth.

关键词： Urochloa Stem Population Leaf Elongation Weight Per Stem

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Optimization of a Classical Algorithm for the Alignment of Genomic Sequences with Artificial Bee Colony

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Journal of Mechanics Engineering and Automation 2022年第2期12卷 57-63页

作者： Raul Magdaleno Peñaloza Andrea magadan Salazar Gerardo Reyes Salgado Department of Computer Science Centro de Investigacion y Desarrollo TecnologicoCuernavaca Morelos 62490Mexico

This article shows genomic alignment methods using the classic“Needleman”and“Smith-Waterman”algorithms,the latter they were optimized by the ABC(artificial bee colony)*** the genomic alignment,a goal state is not presented,the experiments that are carried out show alternative alignments by ABC were *** types of alignments could exist within the classical algorithm,based on a horizontal,vertical,diagonal and inverse search mechanism on a match value *** ABC-Smith Waterman algorithm was generated from the genomic sequences written in rows and columns for the search for similarities that will provide values that ABC uses to process and provide more results of alignments that can be used by scientists for their experiments and research.

关键词： Algorithm genomic alignment ABC Needleman Smith-Waterman

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