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Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:In search of shared genetic markers

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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De Egea Alex Dominguez-vargas Jorg e l.velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del Toro-Camargo Leticia martinez-Ariza Tatiana Gonzalez-vargas susana Garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

Solar-driven CO_(2) conversion to methane and methanol using different nanostructured Cu_(2)O-based catalysts modified with Au nanoparticles

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Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian D.Moura Torquato Juliana Fde Brito Gustavo A.Andolpho Mateus A.Gonçalves Leonardo D.De Angelis Lucas D.Germano susana I.Córdoba de Torresi Teodorico C.Ramalho Maria v.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Department of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with Cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of CO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron *** highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μM cm^(-2))and 27.8%(50.4μM cm^(-2))for methanol and methane,*** performance of the photoelectrodes was shown to be Cu_(2)O facet-dependent,with cubic structures leading to greater conversion of CO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured Cu_(2)O surface was mainly important for *** functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PDA/Nc/Au40%electrode for CH4generation to the formation of an OCH3intermediate bonded to Au *** using isotope-labeling and analysis by gas chromatograph-mass(GC-MS)demonstrated that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and13CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polydopamine CO_(2) photoelectroreduction DFT calculations

Advanced Fiber-Optic Acoustic Sensors

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Photonic Sensors 2014年第3期4卷 198-208页

作者： Joao G. v. TEIXEIRA Ivo T. LEITE susana SILvA Orlando FRAZAO EQS Group Rua Joaquim Dias Rocha 354 4470-221 Maia Portugal lNESC TEC (coordinated by INESC Porto) Rua Campo Alegre 687 4169-007 Porto Portugal Department of Physics and Astronomy Faculty of Sciences- University of Porto Rua Campo Alegre 687 4169-007 Porto Portugal

Acoustic sensing is nowadays a very demanding field which plays an important role in modern society, with applications spanning from structural health monitoring to medical imaging. Fiber-optics can bring many advantages to this field, and fiber-optic acoustic sensors show already performance levels capable of competing with the standard sensors based on piezoelectric transducers. This review presents the recent advances in the field of fiber-optic dynamic strain sensing, particularly for acoustic detection. Three dominant technologies are identified - fiber Bragg gratings, interferometric Mach-Zehnder, and Fabry-Perot configurations - and their recent developments are summarized.

关键词： Acoustic sensors fiber optics optical fiber sensors

Chemical characterisation of particulate matter in urban transport modes

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Journal of Environmental Sciences 2021年第2期33卷 51-61页

作者： vania martins Carolina Correia Ines Cunha-Lopes Tiago Faria Evangelia Diapouli Manousos Ioannis Manousakas Konstantinos Eleftheriadis susana marta Almeida Centro de Ciencias e Tecnologias N ucleares Instituto Superior TecnicoLisbonPortugal Institute of Nuclear and Radiological Sciences and Technology Energy and SafetyN.C.S.R.'Demokritos'AthensGreece

Traffic is a main source of air pollutants in urban areas and consequently daily peak exposures tend to occur during *** exposure to particulate matter(PM)was monitored while cycling and travelling by bus,car and metro along an assigned route in Lisbon(Portugal),focusing on PM_(2.5) and PM_(1)0(PM with aerodynamic diametervely)mass concentrations and their chemical *** vehicles,the indoor-outdoor interplay was also *** PM_(2.5) mean concentrations were 28±5,31±9,34±9 and 38±21μg/m 3 for bus,bicycle,car and metro modes,*** carbon concentrations when travelling by car were 1.4 to 2.0 times higher than in the other transport modes due to the closer proximity to exhaust *** are marked differences in PM chemical composition depending on transport *** particular,Fe was the most abundant component of metro PM,derived from abrasion of rail-wheel-brake *** concentrations of Zn and Cu in cars and buses were related with brake and tyre wear particles,which can penetrate into the *** the motorised transport modes,Fe,Zn,Cu,Ni and K were correlated,evidencing their common traffic-related *** average,the highest inhaled dose of PM_(2.5) was observed while cycling(55μg),and the lowest in car travels(17μg).Cyclists inhaled higher doses of PM_(2.5) due to both higher inhalation rates and longer journey times,with a clear enrichment in mineral *** presented results evidence the importance of considering the transport mode in exposure assessment studies.

关键词： Traffic Commuting Air pollution Particle chemistry Indoor-outdoor interplay Inhaled dose

Recognition of a multiple antigen peptide containing sequence from mimotope of the dengue type 3 virus NS4B protein by human antibodies

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 126-129页

作者： Nevis Amin Maritza Pupo Alicia Aguilar susana vázquez Yamira Caballero Rolando Ochoa María G Guzmán Armando Acosta Implementation and Design of Clinical trials Clinical Research and Impact Evaluation Direction Finlay Institute ‘Pedro Kourí’Tropical Medicine Institute (IPK) PAHO/WHO Collaborating Center for the Study of Dengue and its Vector

Objective: To evaluate the recognition of NS4 B mimotope, as multiple antigen peptide(MAP), by dengue antibodies presents in serum samples from patients with different serotype infections. Methods: A MAP containing mimotope sequence was synthesized and used to evaluate the recognition of NS4 B mimotope as MAP by a panel of 66 human sera from dengue cases by an indirect ELISA assay. Results: The MAP differentiated between sera from dengue viruses infected patients and sera from healthy individuals and the best reactivity was shown by serum from dengue type 3 virus patients. The recognition was more intense with serum from patients with secondary infection. Conclusions: The findings suggest the potential use of NS4 B mimotope on the development of a multi-epitope diagnostic tool. These results are important for further immunogenicity studies.

关键词： MAP Antibodies NS4B Dengue virus

Epimorphisms between Finite 4-valued Modal Algebras

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Advances in Pure Mathematics 2014年第5期4卷 222-227页

作者： Aldo v. Figallo Elda Pick susana Saad Facultad de Ingeniería Universidad Nacional de San Juan San Juan Argentina Instituto de Ciencias Básicas Facultad de Filosofía Universidad Nacional de San Juan San Juan Argentina Instituto de Ciencias Básicas Universidad Nacional de San Juan San Juan Argentina

In this paper, we determine conditions for the existence of an epimorphism between two finite 4-valued modal algebras and state a method to obtain it. Furthermore, we obtain formulas which generalize those indicated by R. Sikorski for finite Boolean algebras [1] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300380037003200340036003100310038000000 , and by M. Abad and A. v. Figallo for finite 3-valued ukasiewicz algebras [2] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300380037003200340036003100320031000000 .

关键词： Four valued Modal Algebras Tetravalent Modal Algebras De Morgan Algebra Epimorphisms Automorphisms

Pre-fire aboveground biomass, estimated from LiDAR, spectral and field inventory data, as a major driver of burn severity in maritime pine (Pinus pinaster) ecosystems

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Forest Ecosystems 2022年第2期9卷 234-246页

作者： Jose Manuel Fernandez-Guisuraga susana Suarez-Seoane Paulo MFernandes victor Fernandez-Garcia Alfonso Fernandez-Manso Carmen Quintano Leonor Calvo Area of Ecology Department of Biodiversity and Environmental ManagementFaculty of Biological and Environmental SciencesUniversity of Leon24071LeonSpain Centro de Investigacao e de Tecnologias Agroambientais e Biologicas Universidade de Tras-os-Montes e Alto Douro5000-801Vila RealPortugal Department of Organisms and Systems Biology(Ecology Unit)and Research Unit of Biodiversity(IMIB UO-CSIC-PA)University of OviedoOviedoMieresSpain Agrarian Science and Engineering Department School of Agricultural and Forestry EngineeringUniversity of Leon24400PonferradaSpain Electronic Technology Department School of Industrial EngineeringUniversity of Valladolid47011ValladolidSpain Sustainable Forest Management Research Institute University of Valladolid-Spanish National Institute for Agriculture and Food Research and Technology(INIA)34004PalenciaSpain

Background:The characterization of surface and canopy fuel loadings in fire-prone pine ecosystems is critical for understanding fire behavior and anticipating the most harmful ecological effects of ***,the joint consideration of both overstory and understory strata in burn severity assessments is often *** aim of this work was to assess the role of total,overstory and understory pre-fire aboveground biomass(AGB),estimated by means of airborne Light Detection and Ranging(LiDAR)and Landsat data,as drivers of burn severity in a megafire occurred in a pine ecosystem dominated by Pinus pinaster *** the western Mediterranean ***:Total and overstory AGB were more accurately estimated(R^(2) equal to 0.72 and 0.68,respectively)from LiDAR and spectral data than understory AGB(R^(2)=0.26).Density and height percentile LiDAR metrics for several strata were found to be important predictors of *** severity responded markedly and non-linearly to total(R^(2)=0.60)and overstory(R ^(2)=0.53)AGB,whereas the relationship with understory AGB was weaker(R ^(2)=0.21).Nevertheless,the overstory plus understory AGB contribution led to the highest ability to predict burn severity(RMSE=122.46 in dNBR scale),instead of the joint consideration as total AGB(RMSE=158.41).Conclusions:This study novelty evaluated the potential of pre-fire AGB,as a vegetation biophysical property derived from LiDAR,spectral and field plot inventory data,for predicting burn severity,separating the contri-bution of the fuel loads in the understory and overstory strata in Pinus pinaster *** evidenced relationships between burn severity and pre-fire AGB distribution in Pinus pinaster stands would allow the implementation of threshold criteria to support decision making in fuel treatments designed to minimize crown fire hazard.

关键词： Aboveground biomass Burn severity Landsat LiDAR Pinus pinaster

Proposal of a Conceptual Model to Analyse the Influence of LARG Practices on Manufacturing Supply Chain Performance

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Journal of Modern Accounting and Auditing 2012年第2期8卷 174-184页

作者： susana G. Azevedo Helena Carvalho v. Cruz-Machado University of Beira Interior Portugal Universidade Nova de Lisboa Portugal

The main objective of this paper is to propose a conceptual model about the influence of lean, agile, resilient, and green （LARG） practices on supply chain operational, economic and environmental performance. This model is based on the literature review about the four supply chain management paradigms and also performance measurement systems. This paper contributes to the literature by introducing a new model to improve the leanness, agility, resilience, and greenness of manufacturing supply chains. Among the suggested LARG practices, the ones influencing more the supply chain performance are the just in time and also the supplier relationships. Also the supply chain performance measures with more LARG practices influencing them are the inventory levels and the time, that is, the supply chain＇s operational performance is the most affected by the simultaneous paradigms deployment in the supply chain.

关键词： performance measurement LARG (lean agile resilient and green) supply chain manufacturing supplychain

NiFeRuO_(x)nanosheets on Ni foam as an electrocatalyst for efficient overall alkaline seawater splitting

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Frontiers of Chemical Science and Engineering 2023年第11期17卷 1698-1706页

作者： Yu Liu Lin Chen Yong Wang Yuan Dong Liang Zhou susana ICórdoba de Torresi Kenneth IOzoemena Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing&International School of Materials Science and Engineering&School of Materials Science and Engineering&Shenzhen Research Institute&Laoshan Laboratory Wuhan University of TechnologyWuhan 430070China Instituto de Química Universidade de São Paulo05508-080 São PauloBrazil Molecular Sciences Institute School of ChemistryUniversity of the WitwatersrandJohannesburg 2050South Africa

The electrocatalyst NiFeRuO_(x)/NF,comprised of NiFeRuO_(x)nanosheets grown on Ni foam,was synthesized using a hydrothermal process followed by thermal ***_(x)/NF displays high electrocatalytic activity and stability for overall alkaline seawater splitting:98 mv@10 mA∙cm^(−2)in hydrogen evolution reaction,318 mv@50 mA∙cm^(−2)in oxygen evolution reaction,and a cell voltage of 1.53 v@10 mA∙cm^(−2),as well as 20 h of durability.A solar-driven system containing such a bifunctional NiFeRuO_(x)/NF has an almost 100%Faradaic *** NiFeRuO_(x)coating around Ni foam is an anti-corrosion layer and also a critical factor for enhancement of bifunctional performances.

关键词： NiFeRuO_(x)nanosheets Ni foam electrocatalysis overall seawater splitting solar-driven system