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Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities

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World Journal of Gastroenterology 2022年第31期28卷 4310-4327页

作者： Pedro Moutinho-Ribeiro Ines A Batista Sofia t Quintas Bárbara Adem Marco Silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-Moreira Renato Medas susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo Serviço de Gastrenterologia Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Faculty of Medicine University of PortoPorto 4200Portugal Instituto de Investigacao e Inovacao em Saúde(i3S) Universidade do PortoPorto 4200Portugal IPAtIMUP-Institute of Molecular Pathology and Immunology University of PortoPorto 4200Portugal Instituto de Ciencias Biomédicas Abel Salazar(ICBAS) University of PortoPorto 4050Portugal Servico de Cirurgia Geral Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Unidade de Saúde Familiar Serpa Pinto ACeS Porto OcidentalPorto 4250Portugal Serviço de Anatomia Patológica Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal

BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer *** ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion *** no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic *** to evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by *** this cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).the inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,*** patients provided written informed *** and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all ***-guided tissue acquisition was done whenever *** statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was *** graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULtS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(8

关键词： Glypican-1 Circulating exosomes Endoscopic ultrasound Pancreatic cancer risk groups Pancreatic cancer precursor lesions Genetic predisposition

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Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients

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World Journal of Hepatology 2020年第11期12卷 1076-1088页

作者： teresa Broquetas Montserrat Garcia-Retortillo Miquel Mico Lidia Canillas Marc Puigvehi Nuria Canete susana Coll Ana Viu Juan Jose Hernandez Xavier Bessa JoseA Carrion Department of Gastroenterology Liver SectionHospital del Mar Medical Research InstituteBarcelona 08003Spain Departament of de Medicina Universitat Autònoma de BarcelonaBarcelona 08003Spain Laboratori de Referencia de Catalunya El Prat de LlobregatBarcelona 08820Spain

BACKGROUND Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)*** to evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs *** Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in *** B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were *** with hepatitis C virus,hepatitis D virus or human immunodeficiency virus co-infection and liver transplanted patients were *** and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six *** loss rate was evaluated in both *** events were recorded in both *** kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression *** Sixty-five patients were enrolled,61%receiving tenofovir and 33%***-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA *** matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(Pthe slope of HBsAg decline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not ***(22%)patients discontinued Peg-IFN due to adverse *** HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA *** the addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to N

关键词： Chronic hepatitis B Hepatitis B e antigen-negative Hepatitis B surface antigen Hepatitis B core-related antigen Pegylated-interferon Nucleos(t)ids analogues©the Author(s)2020.Published by Baishideng Publishing Group Inc.All rights reserved

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Chemosensitizer Effect of Violacein on Cisplatin-treated Bladder Cancer Cells

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Clinical Complementary Medicine and Pharmacology 2022年第2期2卷 50-58页

作者： Diego Alem Lucía Canclini susana Castro-Sowinski Wilner Martínez-López Genetics Department Instituto de Investigaciones Biológicas Clemente EstableAv.Italia 331811600MontevideoUruguay Biochemistry and Molecular Biology Faculty of SciencesUniversidad de la RepúblicaIguá422511400MontevideoUruguay Biodosimetry Service Instituto de Investigaciones Biológicas Clemente EstableAv.Italia 331811600MontevideoUruguay Molecular Microbiology Instituto de Investigaciones Biológicas Clemente EstableAv.Italia 331811600MontevideoUruguay

Background:Bladder cancer is the tenth most common cancer *** its high prevalence(vulnerability to multiple recurrences and progression despite local therapy),which leads to a substantial health service burden,it becomes necessary to develop new strategies to increase the effectiveness of bladder tumor *** compounds with antiproliferative effect on cancer cells could be a good choice for co-adjuvant *** are one of the main sources for natural *** extracted from the cold-adapted microorganisms can contribute to the development of a broader range of applications in *** is a purple pigment commonly produced by many bacterial *** have previously shown that very low concentrations of violacein extracted from Janthinobacterium *** an antiproliferative effect on HeLa ***:With the aim to determine if violacein has an antiproliferative activity on bladder cancer cells,as well as to test if it has synergistic effects on cisplatin treated cells in vitro,t24 and 253J cell lines(derived bladder cancer cells from carcinoma in situ and retroperitoneal metastasis,respectively)were exposed to different concentrations of violacein in the presence or absence of ***:i)Resazurin assay and flow cytometry were performed in two bladder cancer-derived cell lines,namely t24 and 253J,to see if violacein affects cell viability and induce cell ***)to find out whether violacein sensitizes bladder cancer cells to cisplatin,the drug interaction among different doses of cisplatin and violacein was analyzed,as well their combination index was ***)the effect of violacein to induce primary genetic damage was determined through the analysis of induced micronuclei frequency and𝛾H2AX foci,as well as performing the comet ***:the half-maximal inhibitory concentration of violacein at 24 h for both cell lines were around 500 nM,and decreased below 400 nM

关键词： Non-genotoxic Cytotoxic Natural product Violacein Cisplatin sensitization

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MR t2^(*)mapping成像技术定量评价腰椎小关节炎软骨损伤

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中国组织工程研究 2024年第30期28卷 4866-4870页

作者：陈吉张晨张濒黄磊涛南京医科大学第四附属医院骨科江苏省南京市210031

背景:腰椎小关节炎是引起下腰痛的一个主要原因,目前主要依靠MRI进行初步定性诊断,但仍有一定漏诊、误诊的概率发生,因此MR t2^(*)mapping成像技术有望成为定量检查腰椎小关节炎软骨损伤的重要检测手段。目的:探讨MR t2^(*)mapping成像... 详细信息

背景:腰椎小关节炎是引起下腰痛的一个主要原因,目前主要依靠MRI进行初步定性诊断,但仍有一定漏诊、误诊的概率发生,因此MR t2^(*)mapping成像技术有望成为定量检查腰椎小关节炎软骨损伤的重要检测手段。目的:探讨MR t2^(*)mapping成像技术在定量分析腰椎小关节炎软骨损伤退变中的应用价值。方法:收集南京医科大学第四附属医院2020年4月至2022年3月门诊或住院合并下腰痛共110例患者,设为病例组;同时招募无症状志愿者80例,设为对照组。对所有纳入对象L1-S1的小关节行3.0 t MR扫描,获取t2^(*)mapping横断位图像和t2WI图像,分别对所有小关节软骨进行Weishaupt分级及t2^(*)值测量,收集数据并行统计学分析。不同小关节Weishaupt分级之间小关节软骨t2^(*)值比较采用单因素方差分析。结果与结论:①经统计分析发现,病例组腰椎小关节软骨t2^(*)值(17.6±1.5)ms明显较对照组(21.4±1.3)ms降低,差异有显著性意义(Pt分级增加,小关节软骨t2^(*)值也呈逐渐下降趋势,且这种差异有显著性意义(Pt2^(*)mapping能够较好地显示腰椎小关节软骨损伤的早期病理变化,腰椎小关节软骨的t2^(*)值能够定量评估腰椎小关节的软骨损伤程度;t2^(*)mapping成像技术能为影像学诊断腰椎小关节炎软骨早期损伤提供很好的理论依据,具有重要的临床应用价值。

关键词：腰椎小关节炎 t2^(*)mapping t2^(*)值小关节软骨退变下腰痛

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taq1B CEtP Polymorphism and Cardiovascular Risk in an Endogamous Pop-ulation of Diabetic Men: A Study in Santa Rosa Del Conlara, San Luis, Argentina

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Journal of Diabetes Mellitus 2015年第2期5卷 123-134页

作者： susana Siewert Irma Gonzalez Sergio Filipuzzi Dario C. Ramirez Marta S. Ojeda Laboratory of Diabetes Department of Biochemistry and Biological Sciences School of Chemistry Biochemistry and Pharmacy National University of San Luis San Luis Argentina Hospital of Santa Rosa Government of the Province of San Luis Santa Rosa del Conlara Argentina Laboratory of Experimental Medicine and therapeutics IMIBIO-SL-National Bureau of Science and Technology (CONICET) & National University of San Luis San Luis Argentina

Objectives: type 2 diabetes mellitus (t2DM) patients are at increased risk of cardiovascular diseases (CVDs). Several polymorphisms in the cholesterol ester transfer protein (CEtP) gene have been reported. the aim of this study was to determine the distribution and effect of the taq1B polymorphism in the CEtP gene on clinical and biochemical indicators of CVD risk in a population of endogamous-t2DM men. Methods: 102 men (57.5 ± 9.3 years old) inhabitants of Santa Rosa del Conlara, San Luis, Argentina, were recruited and assigned into two groups (22 control and 80 t2DM). Further, these two groups were subdivided according to their taq1B CEtP gene genotypes (i.e., B1B1, B1B2 and B2B2). Clinical and fasting-plasma biochemical indicators of CVD risk were measured and their association with the B1 allele was determined. Results: Compared to control, t2DM men had more central obesity, hypertension, atherogenic index, insulin resistance and poorly controlled diabetes. Compared to t2DM men having the B2 allele, those t2DM men having the B1 allele have increased risk of CVD as assessed by systolic blood pressure (156 ± 16.0 vs 135.8 ± 19.2, p = 0.015), atherogenic index (6.15 ± 1.3 vs 4.4 ± 0.7, p = 0.0008), HDL-c levels (38.9 ± 5.3 vs 64.4 ± 8.2, p ± 3.0 vs 2.4 ± 0.78, p = 0.004). Interestingly, only body mass index (r = ﹣0.559, p = 0.01) and HDL-c concentration (r = ﹣0.492, p = 0.02) negatively correlated with CVD risk in the endogamous population of B1B1 and B1B2 t2DM men. Conclusion: the B1 allele of the CEtP gene predicts cardiovascular complications in an endogamous population of t2DM men.

关键词： Cholesteryl Ester transfer Protein taq1B Polymorphism Endogamous type 2 Diabetic Men Cardiovascular Disease Risk Santa Rosa del Conlara-San Luis-Argentina

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Zero-Order Release Profiles from A Multistimuli Responsive Electro-Conductive Hydrogel

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Journal of Biomaterials and Nanobiotechnology 2012年第2期3卷 262-268页

作者： Suelen H.takahashi Luiz M.Lira susana I.Córdoba de torresi Instituto de Química Universidade de Sao Paulo Brazil

Electroconductive hydrogels has been extensively studied in drug delivery systems because they combine the properties of hydogels with the conducting polymers in only one material. In this work, pyrrole was polymerized electrochemically into poly(acrylic acid) hydrogel. this material kept the swelling properties that are characteristic of hydrogels and the electroactivity of the conducting polymers. the hydrogel (with and without the conducting polymer) swelling degree depends on both the ionic strength and pH. As this material is responsive to changes in the electrical potential, pH and ionic strength, the safranin release presented different delivery profiles, in accordance to variations and combinations of these stimuli. the most interesting result was the achievement of the linear safranin release indicating a zero-order kinetics.

关键词： Hydrogels Conducting Polymers Controlled Release

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Alterations of Blood Immune Cells in Elderly Patients with COVID-19 and with or without Pre-Existing type 2 Diabetes

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Open Journal of Immunology 2022年第2期12卷 41-63页

作者： susana Salva Yanina Kolling Nicolás Argañaraz María Pía Rocchia Novillo María del Milagro Rocchia Novillo Leonardo Albarracin Jacqueline Charubi Alejandra Casen Nadia Gobbato Mirta Rachid susana Alvarez Haruki Kitazawa Julio Villena Juan Carlos Valdez Laboratory of Immunobiotechnology Reference Centre for Lactobacilli (CERELA-CONICET) Tucuman Argentina Laboratory of Immunology Faculty of Biochemistry Chemistry and Pharmacy National University of Tucuman Tucuman Argentina Hospital Centro de Salud “Zenon Santillan” Tucuman Argentina Instituto de Maternidad “Ntra. Sra. De las Mercedes” Tucuman Argentina Food and Feed Immunology Group Laboratory of Animal Food Function Graduate School of Agricultural Science Tohoku University Sendai Japan Livestock Immunology Unit International Education and Research Center for Food and Agricultural Immunology (CFAI) Graduate School of Agricultural Science Tohoku University Sendai Japan

Elderly individuals, especially those with pre-existing conditions like type 2 diabetes mellitus (t2DM), have a high risk for developing severe cases of COVID-19. the aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed SARS-CoV-2 infection, ≥60 years and who needed hospitalization in the Centro de Salud Hospital of tucuman, Argentina, during the second peak of the pandemic in Argentina. ten patients were enrolled from December 2020 to May 2021. Blood samples were taken at the time of admission (day 0) and five days after (day 5) for routine laboratory tests and the characterization of BIC by flow cytometry. Most of the patients were men (70%) aged between 60 and 78 years. the 70% of patients had t2DM while 50% had arterial hypertension. At day 0, all the patients had increased neutrophils and inflammatory markers (C reactive protein and D-dimers) and reduced numbers of lymphocytes, HLA-DRhi monocytes, CD16+CD56+ NK cells, CD3+HLA−DR+CD25+ cells, CD4+ and CD8+ t cells in blood. Patients received a standard treatment for COVID-19 care (O2, corticosteroids and antibiotics). the hospital treatment normalized the levels of BIC (day 5) in 30% of patients who were those with no comorbidities. In patients with t2DM, BIC recovery was variable. In t2DM patients who required administration of plasma (30%), prolonged O2 therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16+CD56+, CD3+HLA−DR+CD25+, CD4+ and CD8+ cells were observed between days 0 and 5. In line with previous studies, our results show that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease

关键词： COVID-19 SARS-CoV-2 Diabetes Elderly Blood Leukocytes Immune Response

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考虑定子外壳漏磁的同极式永磁偏置径向磁轴承磁路模型

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电工技术学报 2017年第11期32卷 118-125页

作者：吴磊涛王东苏振中张贤彪王抗海军工程大学舰船综合电力技术国防科技重点实验室武汉430033

同极式永磁偏置径向磁轴承的永磁偏置磁场在定子外壳内形成较大漏磁,而且外壳的有效面积相对工作气隙较大,即使在铁心与外壳间加入隔磁层的情况下,漏磁仍不可忽略,必须进行准确计算。首先直接求解拉普拉斯方程获得隔磁层内的磁场分布,... 详细信息

同极式永磁偏置径向磁轴承的永磁偏置磁场在定子外壳内形成较大漏磁,而且外壳的有效面积相对工作气隙较大,即使在铁心与外壳间加入隔磁层的情况下,漏磁仍不可忽略,必须进行准确计算。首先直接求解拉普拉斯方程获得隔磁层内的磁场分布,并结合保角变换计算漏磁区域的端部效应,然后求解工作气隙的永磁偏置磁场和电励磁控制磁场,最后建立完整磁路模型和电磁力解析模型。三维有限元仿真结果表明,所建立的磁路模型能准确计算磁轴承工作范围的电磁参数。依据飞轮储能系统的总体需求,设计了径向磁轴承系统,实验结果验证了所建立解析模型和有限元模型的准确性。

关键词：磁轴承解析模型漏磁磁路模型线性模型

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Downregulation of Nrf2 and HO-1 expression contributes to oxidative stress in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina

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Journal of Diabetes Mellitus 2013年第2期3卷 71-78页

作者： susana Siewert Irma González Lucas Santillán Roberto Lucero Marta S. Ojeda María S. Gimenez Juana Koslay Regional Center Ministry of Health of the Province of San Luis San Luis Argentina Laboratory of Diabetes Department of Biochemistry and Biological Sciences School of ChemistryBiochemistry and Pharmacy National University of San Luis San Luis Argentina Laboratory of Pathological & Biological Chemistry National University of San Luis & IMIBIO-SL-National Bureau of Science and Technology (CONICET) San Luis Argentina

Oxidative stress is associated with diabetes mellitus, a condition characterized by increased prevalence and progression rate of cardiovascular disease. NFE2-related factor 2 (Nrf2) is a master regulator of cellular detoxification responses and redox status. the aim of this study was to examine associations between type 2 Diabetes Mellitus (t2DM), oxidative stress and the expression of NFE2-related factor 2 (Nrf2) in a population of diabetic patients living in Juana Koslay City, San Luis, Argentina. In addition, we evaluated the functional relevance of Nrf2 by measuring the HO-1 expression among persons with type 2 diabetes. We measured clinical and biochemical parameters related to lipid metabolism and oxidative stress in a population of type 2 Diabetes Mellitus patients (t2DM, n = 40) and controls (Co, n = 30). Compared to Co, t2DM patients had higher fasting serum glucose, glycated hemoglobin, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and thiobarbituric acid reactive substances and lower high-density lipoprotein cholesterol. t2DM individuals had also higher atherogenic index and body mass index than controls. We also founded that HO-1 mRNA in whole blood was lower in t2DM than controls, suggesting that t2DM may have an altered antioxidant response to oxidative stress. Interestingly, we found reduced Nrf2 mRNA in whole blood from t2DM compared to Co. the results from this study provide novel evidence that genes associated to antioxidant defense mechanisms are markedly reduced in patients with type 2 diabetes, and that the reduction in the expression of these genes could be associated to hyperglycemia and increased levels of MDA. Linear regression analysis revealed that there was a strong and positive correlation between the changes of Nrf2 and HO-1 expression levels.

关键词： type 2 Diabetes Mellitus HO-1 Nrf2 and tBAR’S

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腰椎小关节矢状化与退行性腰椎滑脱的相关性研究

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中国修复重建外科杂志 2017年第11期31卷 1354-1357页

作者：黄磊涛吴霞赖琦刘远戴闽张斌南昌大学第一附属医院骨科(江西省人工关节工程技术研究中心) 南昌330006 南昌大学医学部南昌330006 南昌大学第一附属医院心胸外科南昌330006

目的通过观察腰椎小关节角的改变,探讨腰椎小关节矢状化与退行性腰椎滑脱(degenerative lumbar spondylolisthesis,DLS)间的相关性。方法研究纳入2013年1月—2016年2月收治并符合选择标准的DLS患者57例(DLS组),其中男26例,女31例;年龄34... 详细信息

目的通过观察腰椎小关节角的改变,探讨腰椎小关节矢状化与退行性腰椎滑脱(degenerative lumbar spondylolisthesis,DLS)间的相关性。方法研究纳入2013年1月—2016年2月收治并符合选择标准的DLS患者57例(DLS组),其中男26例,女31例;年龄34~84岁,平均54.0岁。以40例同期收治的非DLS患者作为对照组,男23例,女17例;年龄29~82岁,平均55.6岁。两组患者性别及年龄比较,差异均无统计学意义(P>0.05)。两组行腰椎MRI扫描,测量并比较腰椎小关节角差异;DLS组常规摄腰椎正侧位X线片,参照Meyerding分度标准对腰椎滑脱进行分度,比较不同分度患者间腰椎小关节角差异。结果 DLS组腰椎小关节角为(34.18±4.81)°,显著小于对照组的(45.87±1.09)°,比较差异有统计学意义(t=15.073,P=0.000)。DLS组中Ⅰ度滑脱24例,Ⅱ度19例,Ⅲ度14例;其腰椎小关节角分别为(39.00±2.69)、(32.15±1.68)、(28.68±1.23)°;随滑脱程度增加,腰椎小关节角逐渐减小,比较差异有统计学意义(P<0.05)。结论腰椎小关节矢状化可能是发生DLS的风险因素之一。

关键词：退行性腰椎滑脱腰椎小关节矢状化

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