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Optimizing perioperative Crohn's disease management: Role of coordinated medical and surgical care

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World Journal of Gastroenterology 2015年第4期21卷 1182-1188页

作者： Jennifer l Bennett Christina Y Ha Jonathan E Efron susan l gearhart Mark G lazarev Elizabeth C Wick Department of Surgery The Johns Hopkins University School of MedicineBaltimoreMD 21287United States Division of Gastroenterology the Johns Hopkins University School of MedicineBaltimoreMD 21287United States Division of Digestive Diseases the David Geffen School of Medicine at University of California Los AngelesLos AngelesCA 90095United States

AIM: To investigate rates of re-establishing gastroenterology care, colonoscopy, and/or initiating me-dical therapy after Crohn's disease(CD) surgery at a tertiary care referral ***: CD patients having small bowel or ileocolonic resections with a primary anastomosis between 2009-2012 were identified from a tertiary academic referral center. CD-specific features, medications, and surgical outcomes were abstracted from the medical record. The primary outcome measure was compliance rates with medical follow-up within 4 wk of hospital discharge and surveillance colonoscopy within 12 mo of surgery. RESUlTS: Eighty-eight patients met study inclusion criteria with 92%(n = 81) of patients returning for surgical follow-up compared to only 41%(n = 36) of patients with documented gastroenterology follow-up within four-weeks of hospital discharge, P ly postoperative medical follow-up included younger age, longer length of hospitalization, postoperative biologic use and academic center patients. In the study cohort, 75.0% of patients resumed medical therapy within 12 mo, whereas only 53.4% of patients underwent a colonoscopy within 12 mo of ***: Our study highlights the need for coordinated CD multidisciplinary clinics and structured handoffs among providers to improve of quality of care in the postoperative setting.

关键词： Coordinated care Crohn’s disease Postoperative pro

The Decarbonization of Construction—How Can Alkali-Activated Materials Contribute?

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Engineering 2024年第6期37卷 18-21页

作者： John l.Provis susan A.Bernal Zuhua Zhang Department of Materials Science and Engineering University of SheffieldSheffield S13JDUK Paul Scherrer Institut Villigen PSI 5232Switzerland School of Civil Engineering University of LeedsLeeds LS29JTUK School of Materials Sciences and Engineering Tongji UniversityShanghai 201804China

*** and context Enormous emphasis is currently being paid to the decarbonization of the global built environment as a leading priority for the engineering community and related industrial sectors[1].One of the main contributors to the overall emissions footprint of the built environment-and thus a cornerstone of efforts to achieve decarbonization-is the emissions profile of construction materials during their production and *** cement and concrete sector is the largest-volume contributor to the emissions incurred in meeting the world’s construction material needs and is therefore targeted in the discussion of the deep,rapid decarbonization that must be achieved in order to minimize irreversible damage to the Earth and its ecosystems.

关键词： Alkali corners irreversible

fRAP 2.0:a community engagement method applied to cervical cancer disparities among Hispanic women

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Family Medicine and Community Health 2024年第S2期12卷 44-57页

作者： Autumn M Kieber-Emmons susan E Hansen Michael Topmiller Jaskaran Grewal Carlos Roberto Jaen Benjamin F Crabtree William l Miller Department of Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA College of Medicine USFTampaFloridaUSA lehigh Valley Health Network AllentownPennsylvaniaUSA American Academy of Family Physicians-Health landscape CincinattiOHUSA lafayette College EastonPennsylvaniaUSA UT Health San Antonio San AntonioTexasUSA Rutgers Robert Wood Johnson Medical School PiscatawayNew JerseyUSA Cancer Institute of New Jersey New BrunswickNew JerseyUSA

focused Rapid Assessment Process(fRAP)2.0 is a community engagement approach combining geospatial mapping with rapid qualitative assessment in cyclical fashion within communities to capture multifactorial and multilevel features impacting primary care *** 2.0 offers primary care researchers a methodology framework for exploring complex community features that impact primary healthcare delivery and *** fRAP 2.0 study design expands the fRAP from a sequential design to a cyclical process of geospatial mapping and rapid qualitative assessment in search of modifiable contextual *** participants are stakeholders from various socioecological levels whose perspectives inform study outcomes that they may use to then become the agents of change for the very problems they helped ***,we present a proof-of-concept study for fRAP 2.0 examining disparities in cervical cancer mortality rates among Hispanic women in *** primary outcomes of interest are features at the community level,medical health system level and regional government policy levels that offer opportunities for collaborative interventions to improve cervical cancer *** this study,geospatial mapping of county and ZIP code-level variables impacting postdiagnosis cervical cancer care at community,medical and policy levels were created using publicly available data and then overlaid with maps created with Texas Cancer Registry data for cervical cancer cases in three of the largest population *** disparate areas were then qualitatively explored using participant observation and ethnographic field work,alongside 39 key informant *** discussion groups and stakeholder engagement existed at every phase of the *** the fRAP 2.0 method,we created an action-oriented roadmap of next steps to improve cervical cancer care disparities in the three Texas counties with emphasis on the high disparity *** identified local change

关键词： cervical qualitative policy

Therapeutic Potential of Thunbergia laurifolia *** in Gestational Diabetes Mellitus:Insights from a Rat Model

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Chinese Journal of Integrative Medicine 2024年第9期30卷 788-798页

作者： Sasitorn Kerdsuknirund Arreeya Kosinan Panida Khunkaewla Pakanit Kupittayanant Ratchadaporn Oonsivilai Pattama Tongdee Porntip Nimkuntod susan Wray Sajeera Kupittayanant School of Preclinical Sciences Institute of ScienceSuranaree University of TechnologyNakhon Ratchasima30000Thailand Biochemistry-Electrochemistry Research Unit School of BiochemistryInstitute of ScienceSuranaree University of TechnologyNakhon Ratchasima30000Thailand School of Animal Technology and Innovation Institute of Agricultural TechnologySuranaree University of TechnologyNakhon Ratchasima30000Thailand School of Food Technology Institute of Agricultural TechnologySuranaree University of TechnologyNakhon Ratchasima30000Thailand School of Obstetrics and Gynecology Institute of MedicineSuranaree University of TechnologyNakhon Ratchasima30000Thailand School of Internal Medicine Institute of MedicineSuranaree University of TechnologyNakhon Ratchasima30000Thailand Harris-Wellbeing Preterm Birth Research Centre Department of Women and Children’s Healththe Institute of Lifecourse and Medical SciencesUniversity of LiverpoolLiverpoolUK

Objective:To assess the effects of Thunbergia laurifolia ***(TlE)on gestational diabetes mellitus(GDM)in a rat ***:Thunbergia laurifolin *** were subjected to ethanolic *** vivo study,50 pregnant rats were randomly divided into 5 groups(10 for each):non-GDM group,GDM induced by streptozotocin(STZ,60 mg/kg i.p.),metformin(MET)100 mg/kg,TlE 50,and 500 mg/kg *** was performed on gestation day 7 until term(day 21).The effects of TlE on blood glucose,insulin levels,lipid profiles,liver enzymes,and maternal performances were *** in vitro study,the effect of TlE was examined using the organ bath for uterine force ***:In in vivo study,TlE significantly reduced blood glucose as compared to GDM(Plly increased insulin *** effect was consistent with islets of langerhans ***,the uterine muscular layer displayed a marked increase in fiber area in response to both doses as compared to GDM(Plly,TlE significantly reduced total cholesterol,triglyceride,and alanine transaminase levels(Ply,TlE also led to a notable augmentation in gravid uterus size,live fetuses count,and implantation numbers,while significantly reducing the post-implantation loss rate associated with fetal classification(Plose to those produced by *** in vitro study,TlE exerted a concentration-dependent inhibition of spontaneous uterine contractility(half-maximal inhibition concentration=1.2 mg/l).This inhibitory effect extended to potassium chloride depolarization and oxytocin-mediated *** combined with its major constituent,rosmarinic acid,TlE produced an enhanced inhibitory effect(Plusions:TlE ameliorated blood glucose levels,enhanced uterine muscular structure,and improved maternal and fetal performance in *** also displayed tocolytic *** findings underscore the need for further explor

关键词： myometrium gestational diabetes mellitus tocolytic oxytocin Thunbergia laurifolia l.

Storylines of family medicine Ⅳ:perspectives on practice—lenses of appreciation

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Family Medicine and Community Health 2024年第S3期12卷 33-42页

作者： William B Ventres leslie A Stone Radeeb Akhtar Jeffrey M Ring lucy M Candib Erick Messias Ronald M Epstein Marc Tunzi Amy l lee Christopher P Morley Carina M Brown David Slawson Jill Konkin David G Campbell Ian Couper susan Williams Robert Brooks lucie Walters Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine and Community Health Icahn School of Medicine at Mount SinaiNew YorkNew YorkUSA Independent Health Psychologist Los AngelesCaliforniaUSA Family Medicine and Community Health UMass Chan Medical SchoolWorcesterMassachusettsUSA Psychiatry and Behavioral Neurosciences Saint Louis University School of MedicineSaint LouisMissouriUSA Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Family Medicine Residency Program Natividad Medical CenterSalinasCaliforniaUSA Family Medicine Tufts University School of MedicineBostonMassachusettsUSA Public Health and Preventive Medicine SUNY Upstate Medical UniversitySyracuseNew YorkUSA Cone Health Family Medicine Residency The University of North Carolina School of MedicineGreensboroNorth CarolinaUSA Family Medicine Atrium HealthCharlotteNorth CarolinaUSA Family Medicine University of Alberta Faculty of Medicine&DentistryEdmontonAlbertaCanada Cunninghame Arm Medical Centre Australian College of Rural and Remote MedicineLakes EntranceQueenslandAustralia Ukwanda Centre for Rural Health Stellenbosch University Faculty of Medicine and Health SciencesCape TownWestern CapeSouth Africa Adelaide Rural Clinical School The University of AdelaideAdelaideSouth AustraliaAustralia Department of Rural Health Broken Hill UniversityBroken HillNew South WalesAustralia Adelaide Rural Clinical School The University of Adelaide Faculty of Health and Medical SciencesMount GambierSouth AustraliaAustralia

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅳ:perspectives on practice—lenses of appreciation’,authors address the following themes:‘Relational connections in the doctor–patient partnership’,‘Feminism and family medicine’,‘Positive family medicine’,‘Mindful practice’,‘The new,old ethics of family medicine’,‘Public health,prevention and populations’,‘Information mastery in family medicine’and‘Clinical courage.’May readers nurture their curiosity through these essays.

关键词： thematic illustration doctor

Resolving place names in Amdo and Kham:A gazetteer for the Hengduan Mountains region of Southwest China

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植物分类学报 2006年第6期44卷 721-732页

作者： susan l. KEllEY Arnold Arboretum and Harvard University Herbaria 22 Divinity Avenue Cambridge MA 02138-2020 U.S.A.

Perhaps no region on earth presents such a confusing array of place names as does the area made up of the former provinces of Kham and Amdo in historic Tibet (Xizang). Within these areas, cities, towns, villages, mountains, lakes and other geographic features have at least two names applied to them, one Tibetan, the other Chinese. Overlying this indigenous nomenclature are the names applied by outsiders, mostly Europeans, each of whom used their native language to transliterate the names they heard or read from Tibetan or Chinese script, and names in the languages of other ethnic minorities who live within the area. Adding to the confusion are the conflicting “standards” for transliterating Tibetan and Chinese names. To resolve the inconsistencies and uncertainties of place names in this region, a multilingual gazetteer and thesaurus was prepared. The gazetteer-thesaurus was compiled to be used as a tool for correlating the often radically different names assigned to a single place or feature and to provide the geographic coordinates for each. The impetus for this project was the need to assign geographic coordinates to plant specimens collected in the area since the latter part of the 19th century up until the advent and widespread use of Global Positioning System (GPS) receivers in the 1990s. Georeferencing specimens is necessary for plotting the historical distribution of species and for more completely understanding the information contained on specimen labels. Knowing the distribution of plants is important for answering phylogenetic questions, determining local and widespread biogeographical patterns, identifying areas of unusually high diversity or endemism, and determining areas in need of special protection. The value of such a gazetteer, however, extends well beyond the field of botany. It is intended to be of use to anyone with a desire to know the nomenclatural history of places in the area and for pinpointing with a fair degree of accuracy the location

关键词： Tibet (Xizang) Amdo Kham Hengduan Mountains gazetteer biodiversity Geographic Information Systems (GIS) herbarium conservation georeferencing.

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang liu Junya Fujimoto lingzhi Hong Alexandre Reuben susan Varghese Carmen Behrens Tina McDowell luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning le Natalie I Vokes Chao Cheng John V.Heymach Don l.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSClC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

Different faces of gastroparesis

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World Journal of Gastroenterology 2009年第48期15卷 6052-6060页

作者： Klaus Bielefeldt Naeem Raza susan l Zickmund Division of Gastroenterology University of Pittsburgh Medical Center Center of Health Equity Research and Practice at the Veteran Administration Health System Pittsburgh

AIM： To test the hypothesis that pain and affect rather than impaired emptying determine symptom severity in patients with gastroparesis. METHODS： Adult patients with documented gastroparesis were enrolled prospectively in a single center and asked to complete the Gastroparesis Cardinal Symptom Index （GCSt）, Hospital Anxiety and Depression Scale （HADS）, the Short Form 12 （SF-12） as quality of life index, rate pain severity and answer 10 open-ended questions. RESUlTS： A total of 55 patients （44 women） participated. Idiopathic （n = 29） or diabetic （n = 11） gastroparesis and connective tissue disease （n = 8） were the most common underlying causes. Antiemetics （n = 30） and prokinetics （n = 32） were most often prescribed. Seventeen patients used opioids on a daily basis. Nausea and/or vomiting （n = 28）, pain （n = 24） and bloating （n = 14） were most commonly listed as dominant symptoms. Patients subjectively attributed symptom improvement to nutritional and dietary therapy （n= 11）, prokinetics （n = 11）, antiemetics （n = 10） or analgesic agents （n = 3）. In univariate analyses, the physical subscore of the SF-12 and HADS, but not gastric emptying delay or symptom duration significantly correlated with disease severity as measured by the GCSI. In multivariate analyses, the combination of vomiting, bloating and depression best predicted the overall impact on quality of life. CONClUSION： The study confirms the importance of pain and affect in gastroparesis, which requires novel approaches to improve more effectively the quality of life in patients with this disorder.

关键词： Pain Depression Gastroparesis Quality oflife

Current and near-term advances in Earth observation for ecological applications

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Ecological Processes 2021年第1期10卷 1-57页

作者： susan l.Ustin Elizabeth M.Middleton John Muir Institute of the Environment University of CaliforniaDavisCA 95616USA NASA/Goddard Space Flight Center(Emerita) GreenbeltMD 20771USA.

There is an unprecedented array of new satellite technologies with capabilities for advancing our understanding of ecological processes and the changing composition of the Earth’s biosphere at scales from local plots to the whole *** identified 48 instruments and 13 platforms with multiple instruments that are of broad interest to the environmental sciences that either collected data in the 2000s,were recently launched,or are planned for launch in this *** have restricted our review to instruments that primarily observe terrestrial landscapes or coastal margins and are available under free and open data *** focused on imagers that passively measure wavelengths in the reflected solar and emitted thermal *** suite of instruments we describe measure land surface characteristics,including land cover,but provide a more detailed monitoring of ecosystems,plant communities,and even some species then possible from historic *** newer instruments have potential to greatly improve our understanding of ecosystem functional relationships among plant traits like leaf mass area(lMA),total nitrogen content,and leaf area index(lAI).They provide new information on physiological processes related to photosynthesis,transpiration and respiration,and stress detection,including capabilities to measure key plant and soil biophysical *** include canopy and soil temperature and emissivity,chlorophyll fluorescence,and biogeochemical contents like photosynthetic pigments(e.g.,chlorophylls,carotenoids,and phycobiliproteins from cyanobacteria),water,cellulose,lignin,and nitrogen in foliar *** data will enable us to quantify and characterize various soil properties such as iron content,several types of soil clays,organic matter,and other *** of these satellites are in low Earth orbit(lEO),but we include a few in geostationary orbit(GEO)because of their potential to measure plant physiological traits over diurnal periods,impro

关键词： Terrestrial ecosystems Earth Observing Satellites Ecosystem processes Physiological functions Multispectral Hyperspectral Thermal liDAR Radar imagers Biochemistry Soil properties Species mapping Change detection 3D canopy structure Topography