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地磁亚暴期间低高度ENA辐射事件的抵近观测与反演

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中国科学：地球科学 2019年第5期49卷 838-847页

作者：路立 susan mckenna-lawlor Jan BALAZ 中国科学院国家空间科学中心空间环境探测研究室北京100190 Space Technology Ireland Ltd.Maynooth Co. Space Technology Ireland Ltd.Maynooth Co. Institute of Experimental Physics

2004年11月12日的系列地磁亚暴期间, TC-2卫星上的中性原子成像仪(NUADU)在飞临近地点附近的南、北极上空观测到低高度能量中性原子(ENA)辐射.通过对高时空分辨探测数据的反演,我们首次给出亚暴期间环电流能量离子沉降和注入过程的全球... 详细信息

2004年11月12日的系列地磁亚暴期间, TC-2卫星上的中性原子成像仪(NUADU)在飞临近地点附近的南、北极上空观测到低高度能量中性原子(ENA)辐射.通过对高时空分辨探测数据的反演,我们首次给出亚暴期间环电流能量离子沉降和注入过程的全球视场展示,展示的时间分辨率高达1min.探测结果表明,观测到的ENA辐射主要来自低高度、高纬极区.由于沉降能量离子沿磁力线运动,在该区域通过电荷交换产生ENA的几率更大.因此,利用低轨道卫星探测高时间和高空间分辨率的ENA成像数据是监测地磁活动期间环电流离子动力学过程演化的最佳方法.

关键词：低高度ENA辐射 ENA图像反演投掷角分布离子注入离子沉降

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卫星姿态对磁层中性原子成像探测的影响

科技创新导报 2014年第24期11卷 76-78页

作者：路立 susan mckenna-lawlor Jan Balaz 史建魁杨垂柏罗静中国科学院空间科学与应用研究中心北京100190 Space Technology Ireland National University of Ireland Institute of Experimental Physics KosiceSlovakia

适于磁层中性原子威像探测的一般是运行在磁层高度的极轨自旋稳定卫星。利用设置在不同仰角方向的探测器通过卫星自旋进行方位角扫描以实现二维中性原子成像探测。这样以来,卫星自旋轴的取向就是我们选择中性原子二维图像的仰角和方位... 详细信息

适于磁层中性原子威像探测的一般是运行在磁层高度的极轨自旋稳定卫星。利用设置在不同仰角方向的探测器通过卫星自旋进行方位角扫描以实现二维中性原子成像探测。这样以来,卫星自旋轴的取向就是我们选择中性原子二维图像的仰角和方位角分布的依据。为了提高角分辨,我们总是希望把垂直于自旋轴方向的探测器时准主要成像位置。考虑卫星在极区的最佳遥测位置,我们选择卫星自旋轴垂直于轨道面将最有利于中性原子的成像探测。对于三轴稳定卫星,我们可以利用多组硅条探测器设计二维中性原子成像仪。

关键词：能量中性原子自旋稳定三轴稳定

用NUADU/TC-2成像探测数据反演磁层离子和逃逸层蒸发粒子分布

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用NUADU/TC-2成像探测数据反演磁层离子和逃逸层蒸发粒子分布

NAIS-H/MIT:中性原子成像探测的物理设计与仿真

中国地球物理学会第22届年会

作者：路立 susan mckenna-lawlor 刘振兴沈超曹晋滨中国科学院空间科学与应用研究中心 Space Technology Ireland National University of Ireland MaynoothCo.KildareIreland 中国科学院空间科学与应用研究中心中国科学院空间科学与应用研究中心中国科学院空间科学与应用研究中心

＜正＞中性原子成像数据反演是正在发展中的空间探测数据模拟技术。探测到的中性原子图象数据中包含了视线方向参与电荷交换的所有粒子携带的大量物理信息难以直接判读。从中性原子成像探测数据中提取特定区域里的等离子体物理信息正在...

＜正＞中性原子成像数据反演是正在发展中的空间探测数据模拟技术。探测到的中性原子图象数据中包含了视线方向参与电荷交换的所有粒子携带的大量物理信息难以直接判读。从中性原子成像探测数据中提取特定区域里的等离子体物理信息正在成为针对该类仪器的一项专门的反演技术。以往的反演侧重于对磁赤道面环电流区能量离子通量分布不均匀性的模拟恢复,忽略了地冕逃逸层蒸发的能

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NAIS-H/MIT:中性原子成像探测的物理设计与仿真

Ferroptosis mediators vary in metabolic syndrome,type-2 diabetes,and hypercholesterolemia:A meta-analysis report

中国空间科学学会空间探测专业委员会第二十六届全国空间探测学术研讨会

作者：路立 susan mckenna-lawlor Jan Balaz 史建魁王月罗静 Karel Kudela 中国科学院空间科学与应用研究中心 Space Technology Ireland National University of IrelandIreland Institute of Experimental Physics KosiceSlovakia

本文初步论述了MIT卫星计划中的高能中性原子成像仪(NAIS-H)探测方案的原理设计和模拟仿真。在继承双星中性原子成像仪设计理念的基础上,我们依据MIT卫星计划的总体科学目标和磁层卫星的轨道环境,以及相应的自旋姿态,初步给出中性原子... 详细信息

本文初步论述了MIT卫星计划中的高能中性原子成像仪(NAIS-H)探测方案的原理设计和模拟仿真。在继承双星中性原子成像仪设计理念的基础上,我们依据MIT卫星计划的总体科学目标和磁层卫星的轨道环境,以及相应的自旋姿态,初步给出中性原子成像仪的技术架构,并针对地磁偶极场的环电流模型进行了模拟仿真。仿真结果表明拟研制的NAIS-H以其高时空分辨能力适用于监测和反演磁暴期间磁层等离子体的全球动力学过程。

关键词：能量中性原子自旋姿态环电流

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Genes & Diseases 2024年第3期11卷 109-112页

作者： Indra Kundu Ashlesha Pande Tannishtha Das susan Idicula-Thomas Biomedical Informatics Centre Indian Council of Medical Research-National Institute for Research in Reproductive and Child HealthMumbaiMaharashtra 400012India Department of Biotechnology St.Xavier's CollegeKolkataWest Bengal 700016India

Metabolic syndrome(MetS)is a complex disorder characterized by the coexistence of phenotypes such as obesity,hypertension,hyperglycemia,high triglyceride level,and low level of high-density lipoprotein *** majorly dri... 详细信息

关键词： obesity cholesterol diabetes

Impact of the carbon market on investment benefits of power-grid enterprises in China: a system dynamics analysis

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Global Energy Interconnection 2024年第4期7卷 402-414页

作者： Wanning Mao Liang Hu Wenjuan Niu Xiaorong Sun Lili Hao Abimbola susan Ajagun School of Public Administration Hohai University211100NanjingP.R.China Business School Hohai UniversityNanjing 211100P.R.China School of Electrical and Power Engineering Hohai UniversityNanjing211100P.R.China College of Electrical Engineering&Control Science Nanjing Tech UniversityNanjing 211816P.R.China School of Electrical Engineering and Technology Federal University of TechnologyMinnaNigeria

The power grid,as the hub connecting the power supply and consumption sides,plays an important role in achieving carbon neutrality in *** emerging carbon markets,assessing the investment benefits of power-grid enterprises is ***,studying the impact of the carbon market on the investment and operation of powergrid enterprises is key to ensuring their efficient ***,few studies have examined the interaction between the carbon and electricity markets using system dynamics models,highlighting a research gap in this *** study investigates the impact of the carbon market on the investment of power-grid enterprises using a novel evaluation system based on a system dynamics model that considers carbon-emissions from an established carbon-emission accounting ***,an index system for benefit evaluation was constructed from six aspects:financing ability,economic benefit,reliability,social responsibility,user satisfaction,and carbon-emissions.A system dynamics model was then developed to reflect the causal feedback relationship between the impact of the carbon market on the investment and operation of power-grid *** simulation results of a provincial power-grid enterprise analyze comprehensive investment evaluation benefits over a 10-year period and the impact of carbon emissions on the investment and operation of power-grid *** study provides guidelines for the benign development of power-grid enterprises within the context of the carbon market.

关键词： Carbon market Power-grid enterprises Investment benefit evaluation System dynamics analysis

Rodent management in Aotearoa New Zealand: approaches and challenges to landscape-scale control

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Integrative Zoology 2024年第1期19卷 8-26页

作者： John G.INNES Grant NORBURY Araceli SAMANIEGO susan WALKER Deborah J.WILSON Manaaki Whenua-Landcare Research HamiltonNew Zealand Manaaki Whenua-Landcare Research AlexandraNew Zealand Manaaki Whenua-Landcare Research AucklandNew Zealand Manaaki Whenua-Landcare Research DunedinNew Zealand

Aotearoa—New Zealand has only four rodent species,all *** order of arrival,they are Pacific rat Rattus exulans,brown rat ***,house mouse Mus musculus,and black rat *** management in New Zealand aims mainly to conserve indigenous biodiversity rather than to protect crops or manage diseases,as is usual *** describe four major“regimes”and one major vision for rodent control in New Zealand to meet ecological restoration *** challenges for island eradications are for large islands that are remote or populated by *** 1080 is the only large-scale(tens of thousands of hectares)option for black rat control,but its application requires adjustment to counter subsequent rapid black rat ***“ecosanctuaries”(mean 720 ha)use ground-based traps and poisons to target mainly black rats and face constant *** with mammal-resistant fences(up to 3500 ha)limit reinvasion and target more pest species and have enabled the return of previously extirpated taxa to the main *** Free 2050 aims to eradicate the rat species(but not mice)plus some other introduced mammals from New Zealand by *** vision is not attainable with current tools,but research and experimental management is exploring techniques and *** large scale(to 100000 ha)at which black rats are now targeted for control to extremely low abundance seems to be unique to New Zealand.

关键词： black rat brown rat eradication house mouse rodent control

Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast:A case report

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World Journal of Clinical Cases 2024年第2期12卷 412-417页

作者： Allison Akers susan Read John Feldman Casey Gooden Diana P English Department of Obstetrics and Gynecology University of South FloridaTampaFL 33606United States Department of Gynecologic Oncology Sky Ridge Medical CenterLone TreeCO 80124United States Department of Radiology University of South FloridaTampaFL 33606United States Department of Pathology University of South FloridaTampaFL 33606United States

BACKGROUND Cervical cancer is a rare primary tumor resulting in metastases to the breast with few cases reported in *** metastases are associated with poor *** following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized *** SUMMARY A 44-year-old G7P5025 with no significant past medical or surgical history presented with heavy vaginal to an outside emergency department where an exam and a pelvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving upper two thirds of vagina,parametria and lymph node *** biopsies confirmed high grade adenocarcinoma with mucinous features.A positron emission tomography/computed tomography(PET/CT)did not show evidence of metastatic *** received concurrent cisplatin with external beam radiation *** up PET/CT scan three months later showed no suspicious fluorodeoxyglucose uptake in the cervix and no evidence of metastatic *** was lost to follow up for six *** was re-imaged on re-presentation and found to have widely metastatic disease including breast *** biopsy confirmed programmed death-ligand 1 positive metastatic cervical *** patient received six cycles of carboplatin and paclitaxel with *** imaging demonstrated *** continued on pembrolizumab with disease *** Metastatic cervical cancer to the breast is uncommon with nonspecific clinical findings that can make diagnosis *** history and immunohistochemical evaluation of breast lesion,and comparison to primary tumor can support diagnosis of metastatic cervical cancer to the ***,the prognosis is poor,but immunotherapy can be considered in select patients and may result in good disease response.

关键词： Cervical adenocarcinoma Breast metastases Immunotherapy Pembrolizumab Carboplatin Paclitaxel Case report

XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation

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Genes & Diseases 2024年第5期11卷 350-359页

作者： Yun Zhang susan Lin Jing Yao Wantong Cai Huaqiu Chen Ailikemu Aierken Zhe Wang Weihong Song National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China Townsend Family Laboratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and the Affiliated Kangning HospitalWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325001China

As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been implicated in the pathogenesis of *** examine the role of ER stress in T2DM,we cloned the hIAPP promoter and analyzed its promoter activity in human *** found that ER stress significantly enhanced hIAPP promoter activity and expression in human b-cells via triggering X-box binding protein 1(XBP1)*** identified a binding site of XBP1 in the hIAPP *** of this binding site by substitution or deletion mutagenesis significantly diminished the effects of ER stress on hIAPP promoter *** of XBP splicing by MKC3946 treatment inhibited ER stress-induced hIAPP up-regulation and improved human b-cell survival and *** study uncovers a link between ER stress and IAPP at the transcriptional level and may provide novel insights into the role of ER stress in IAPP cytotoxicity and the pathogenesis of T2DM.

关键词： b-cell function Endoplasmic reticulum stress Islet amyloid polypeptide Type 2 diabetes mellitus XBP1