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Geoscience Frontiers 2021年第3期12卷 428-436页

作者： James C.Hower susan m.rimmer maria mastalerz Nicola J.Wagner University of Kentucky Center for Applied Energy Research 2540 Research Park DriveLexingtonKY 40511USA School of Earth Systems and Sustainability Southern Illinois University CarbondaleCarbondaleIL 62901USA Indiana Geological&Water Survey Indiana UniversityBloomingtonIN 47405USA Department of Geology University of JohannesburgJohannesburgSouth Africa

Previous studies demonstrated that melting,initiated by supercritical fluids in the 375-400℃range,occurred as part of anthracite metamorphism in the Appalachian *** on the known behavior of vitrinite at high temperatures and,to a lesser extent,at high pressures,it was determined that the duration of the heating,melting,and resolidification event was about 1 *** the current study,featureless vitrinite within banded maceral assemblages demonstratesthe intimate association of melted and resolidified vitrinite with anthracite-rank *** analogy with metamorphosed inorganic rocks,such associations represent diadysites and embrechites,i.e.,cross-cutting and layered migmatites,*** though the temperature of formation of the anthracite structures is several hundred℃lower than that seen in metamorphosed inorganic rocks,anthracites are metamorphic rocks and the nomenclature for metamorphic rocks may be appropriate for coal.

关键词： Igneous metamorphic texture Pennsylvania mesozoic basins South Africa

Adenovirus F40/41 Gastroenteritis-Associated Emphysematous Gastritis:A Case Report

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Infectious Diseases & Immunity 2024年第2期4卷 93-95页

作者： maulik K.Lathiya Abigail T.La Nou maria E.Linnaus susan m.Cullinan Emergency Department Mayo Clinic Health SystemEau Claire 54703WIUSA Critical Care medicine Mayo Clinic Health SystemEau Claire 54703WIUSA General Surgery Department Mayo Clinic Health SystemEau Claire 54703WIUSA

Emphysematous gastritis(EG)is a rare form of gastritis characterized by gastric wall *** is associated with a high mortality *** case report describes a patient with a history of atrial fibrillation treated with apixaban,prior stroke,and schizoaffective disorder who showed epigastric tenderness on ***,no peritonitis signs were recorded,and laboratory values revealed high lactate levels and the presence of adenovirus F40/*** computed tomography scan showed extensive portal venous gas in the left hepatic lobe of the liver,as well as pneumatosis involving the entire stomach,indicating *** diagnosis was histologically confirmed and initially managed medically,which proved inefficacious,necessitating surgical intervention in the form of a laparotomy and esophagojejunostomy with Roux-en-Y *** case report suggests a potential association between EG and adenovirus F40/41–induced gastroenteritis,thereby emphasizing the challenging nature of *** underscores the need for comprehensive research to enhance our understanding of its underlying causes and effective treatment strategies.

关键词： Emphysema Gastritis Human adenovirus F40/41 Immunocompromised

Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin Leung Wenjing Chen Anissa N Sari Poojitha Sitaram Pui-Kei Wu susan Tsai Jong-In Park Department of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell *** has not been tested for this *** To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell ***Δψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell *** viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(mitoQ),aΔψm-sensitive *** synergy between erlotinib and mitoQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line *** Erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of *** suggested that these drugs synergistically induced tumor cell *** with in vitro data,erlotinib and mitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib mitochondria-targeted ubiquinone mitochondria Combination therapy

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina Lam Carlos Garcia-Esperon Yash Gawarikar Ronak Patel matthew Lee-Archer Andrew Wong michael Roizman Amanda Gilligan Andrew Lee Kee meng Tan susan Day Christopher Levi Stephen m Davis mark Parsons Bernard Yan melbourne Brain Centre at Royal melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on mRI at 1month in patients commenced on early(mic lesions and more haemorrhages in the early anticoagulant group at 1-month *** A prospective multicentre,observational cohort study was performed at 11 Australian stroke *** and mRI data were collected at baseline and follow-up,with blinded imaging assessment performed by two *** of commencement of anticoagulation was at the discretion of the treating stroke *** We recruited 276 patients of whom 208 met the eligibility *** average age was 74.2 years(SD±10.63),and 79(38%)patients were *** National Institute of Health Stroke Scale score was 5(IQR 1–12).median baseline ischaemic lesion volume was 5mL(IQR 2–17).There were a greater number of new ischaemic lesions on follow-up mRI in patients commenced on anticoagulation≥4days after index event(17%vs 8%,p=0.04),but no difference in haemorrhage rates(22%vs 32%,p=0.10).Baseline ischaemic lesion volume of≤5mL was less likely to have a new haemorrhage at 1month(p=0.02).There was no difference in haemorrhage rates in patients with an initial ischaemic lesion volume of>5mL,regardless of anticoagulation *** Commencing anticoagulationmic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

Current and near-term advances in Earth observation for ecological applications

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Ecological Processes 2021年第1期10卷 1-57页

作者： susan L.Ustin Elizabeth m.middleton John muir Institute of the Environment University of CaliforniaDavisCA 95616USA NASA/Goddard Space Flight Center(Emerita) GreenbeltMD 20771USA.

There is an unprecedented array of new satellite technologies with capabilities for advancing our understanding of ecological processes and the changing composition of the Earth’s biosphere at scales from local plots to the whole *** identified 48 instruments and 13 platforms with multiple instruments that are of broad interest to the environmental sciences that either collected data in the 2000s,were recently launched,or are planned for launch in this *** have restricted our review to instruments that primarily observe terrestrial landscapes or coastal margins and are available under free and open data *** focused on imagers that passively measure wavelengths in the reflected solar and emitted thermal *** suite of instruments we describe measure land surface characteristics,including land cover,but provide a more detailed monitoring of ecosystems,plant communities,and even some species then possible from historic *** newer instruments have potential to greatly improve our understanding of ecosystem functional relationships among plant traits like leaf mass area(LmA),total nitrogen content,and leaf area index(LAI).They provide new information on physiological processes related to photosynthesis,transpiration and respiration,and stress detection,including capabilities to measure key plant and soil biophysical *** include canopy and soil temperature and emissivity,chlorophyll fluorescence,and biogeochemical contents like photosynthetic pigments(e.g.,chlorophylls,carotenoids,and phycobiliproteins from cyanobacteria),water,cellulose,lignin,and nitrogen in foliar *** data will enable us to quantify and characterize various soil properties such as iron content,several types of soil clays,organic matter,and other *** of these satellites are in low Earth orbit(LEO),but we include a few in geostationary orbit(GEO)because of their potential to measure plant physiological traits over diurnal periods,impro

关键词： Terrestrial ecosystems Earth Observing Satellites Ecosystem processes Physiological functions multispectral Hyperspectral Thermal LiDAR Radar imagers Biochemistry Soil properties Species mapping Change detection 3D canopy structure Topography

Biased activity of soluble guanylyl cyclase:the Janus face of thymoquinone

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Acta Pharmaceutica Sinica B 2017年第4期7卷 401-408页

作者： Charlotte Detremmerie Paul m.Vanhoutte susan Leung Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

The natural compound thymoquinone, extracted from Nigella sativa(black cumin), is widely used in humans for its anti-oxidative properties. Thymoquinone is known for its acute endotheliumindependent vasodilator effects in isolated rat aortae and pulmonary arteries, depending in part on activation of adenosine triphosphate-sensitive potassium channels and inhibition of voltage-dependent calcium channels. The compound also improves endothelial dysfunction in mesenteric arteries of ageing rodents and in aortae of rabbits treated with pyrogallol, by inhibiting oxidative stress. Serendipitously,thymoquinone was found to augment contractions in isolated arteries with endothelium of both rats and pigs. The endothelium-dependent augmentation it causes counterintuitively depends on biased activation of soluble guanylyl cyclase(sGC) producing inosine 3',5'-cyclic monophosphate(cyclic ImP) rather than guanosine 3',5'-cyclic monophosphate. This phenomenon shows a striking mechanistic similarity to the hypoxic augmentation previously observed in porcine coronary arteries. The cyclic ImP preferentially produced under thymoquinone exposure causes an increased contractility of arterial smooth muscle by interfering with calcium homeostasis. This brief review summarizes the vascular pharmacology of thymoquinone, focussing in particular on how the compound causes endothelium-dependent contractions by biasing the activity of sGC.

关键词： Thymoquinone Endothelium-dependentcontraction Nitric oxide Soluble guanylyl cyclase Cyclic ImP NADPH:quinone oxidoreductase

Social learning in nest-building birds watching live-streaming video demonstrators

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Integrative Zoology 2019年第2期14卷 204-213页

作者： Lauren m.GUILLETTE susan D.HEALY School of Biology University of St AndrewsSt AndrewsFifeUK

Determining the role that social learning plays in construction behaviors,such as nest building or tool manufacture,could be improved if more experimental control could be gained over the exact public information that is provided by the demonstrator,to the observing *** video playback allows the experimenter to choose what information is provided but will only be useful in determining the role of social learning if observers attend to,and learn from,videos in a manner that is similar to live *** goal of the current experiment was to test whether live-streamed video presentations of nest building by zebra finches Taeniopygia guttata would lead observers to copy the material choice demonstrated to ***,males that had not previously built a nest were given an initial preference test between materials of 2 *** observers then watched live-stream footage of a familiar demonstrator building a nest with material of the color that the observer did not *** this experience,observers were given the chance to build a nest with materials of the 2 *** two-thirds of the observer males preferred material of the demonstrated color after viewing the demonstrator build a nest with material of that color more than they had previously,their preference for the demonstrated material was not as strong as that of observers that had viewed live demonstrator builders in a previous *** results suggest researchers should proceed with caution before using video demonstration in tests of social learning.

关键词： construction behavior copying nest social learning video playback zebra finch

Initial impacts of rain gardens＇ application on water quality and quantity in combined sewer： field-scale experiment

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Frontiers of Environmental Science & Engineering 2017年第4期11卷 127-138页

作者： Isam Alyaseri Jianpeng Zhou susan m. morgan Andrew Bartlett Department of Civil Engineering Al-Muthanna University Alsamawah Al-Muthanna 72001 Iraq Department of Civil Engineering Southern Illinois University Edwardsville Edwardsville IL 62026 USA Graduate School Southern Illinois University Edwardsville Edwardsville IL 62026 USA Agricultural Statistics Laboratory University of Arkansas Fayetteville AR 72701 USA

Green infrastructures such as rain gardens can benetit onsite reduction ot stormwater runott, leading to reduced combined sewer overflows. A pilot project was conducted to evaluate the impact of rain gardens on the water quality and volume reduction of storm runoff from urban streets in a combined sewer area. The study took place in a six-block area on South Grand Boulevard in St. Louis, missouri. The impact was assessed through a comparison between the pre-construction （2011/2012） and the post-construction （2014） phases. Shortly after the rain gardens were installed, the levels of total suspended solids, chloride, total nitrogen, total phosphorous, zinc, and copper increased. The level of mercury was lower than the detection level in both phases. E. coli was the only parameter that showed statistically significant decrease following the installation of rain gardens. The likely reason for initial increase in monitored water quality parameters is that the post-construction sampling began after the rain gardens were constructed but before planting, resulted from soil erosion and wash-out from the mulch. However, the levels of most of water quality parameters decreased in the following time period during the post-construction phase. The study found 76% volume reduction of stormwater runoff following the installation of rain gardens at one of studied sites. Statistical analysis is essential on collected data because of the encountered high variability of measured flows resulted from low flow conditions in studied sewers.

关键词： Rain gardens Bioretention Combined sewer Stormwater quality and quantity

Recent advances and future directions in preclinical research of argininevasopressin(AVP) receptor blocker conivaptan in the context of stroke

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Neural Regeneration Research 2016年第3期11卷 392-393页

作者： Emil Zeynalov susan m.Jones Swedish medical Center Neurotrauma Research Department Englewood

Stroke is a major cause of mortality and permanent *** onset of stroke is followed by life-threatening pathophysiological responses including brain edema,elevation of intracranial pressure,disruption of blood-brain barrier（BBB）,brain infarct and permanent tissue *** edema develops due to accumulation of water in intracellular and extracellular compartments of the brain,

关键词： edema permanent disability intracranial elevation blocker infarct disruption advances mortality

Constipation-predominant irritable bowel syndrome: A review of current and emerging drug therapies

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World Journal of Gastroenterology 2014年第27期20卷 8898-8909页

作者： Khaled A Jadallah susan m Kullab David S Sanders Department of Internalmedicine King Abdullah University Hospital Faculty of medicine Jordan University of Science and Technology Department of Gastroenterology and Liver Unit Royal Hallamshire Hospital Sheffield South Yorkshire S102JF United Kingdom

Irritable bowel syndrome(IBS) is a highly prevalent medical condition that adversely affects patient quality of life and constitutes a significant economic burden on healthcare resources. A large proportion of patients suffer from the constipation subtype of IBS(IBS-C), most commonly afflicting older individuals and those with a lower socioeconomic status. Conventional pharmacologic and nonpharmacologic treatment options have limited efficacies and/or significant adverse events, which lead to increased long-term health care expenditures. Failure to effectively treat IBS-C patients over the past decades has largely been due to a poor understanding of disease pathophysiology, lack of a global view of the patient, and an inappropriate selection of patients and treatment endpoints in clinical trials. In recent years, however, more effective and safer drugs have been developed for the treatment of IBS-C. The advancement in the area of pharmacologic treatment is based on new knowledge of the pathophysiologic basis of IBS-C and the development of drugs with increased selectivity within pharmacologic classes with recognized efficacies. This narrative review covers the spectrum of available drugs and their mechanisms of action, as well as the efficacy and safety profiles of each as determined in relevant clinical trials that have investigated treatment options for IBS-C and chronic constipation. A brief summary of laxative-based treatment options is presented, followed by up-to-date assessments for three classes of drugs: prokinetics, prosecretory agents, and bile acid modulators.

关键词： Constipation Irritable bowel syndrome Drug therapy Serotonergic agents Prokinetics 5-hydroxytryptamine type 4 agonists Secretagogues Prosecretory agents Bile acid modulators