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Unsupported nanoporous palladium‐catalyzed chemoselective hydrogenation of quinolines:Heterolytic cleavage of H_2 molecule

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Chinese Journal of Catalysis 2018年第11期39卷 1746-1752页

作者： Ye Lu Yoshinori Yamamoto Abdulrahman I.Almansour Natarajan Arumugam Raju suresh kumar Ming Bao State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116023LiaoningChina Department of Chemistry Graduate School of ScienceTohoku UniversitySendai 980‐8578Japan Research Organization of Science and Technology Ritsumeikan UniversityKusatsuShiga 525‐8577Japan Department of Chemistry College of SciencesKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

An efficient and highly chemoselective heterogeneous catalyst system for quinoline hydrogenation was developed using unsupported nanoporous palladium(PdNPore).The PdNPore‐catalyzed chemoselective hydrogenation of quinoline proceeded smoothly under mild reaction conditions(low H2 pressure and temperature)to yield 1,2,3,4‐tetrahydroquinolines(py‐THQs)in satisfactory to excellent *** synthetically useful functional groups,such as halogen,hydroxyl,formyl,ethoxycarbonyl,and aminocarbonyl groups,remained intact during the quinoline *** palladium was leached from PdNPore during the hydrogenation ***,the catalyst was easily recovered and reused without any loss of catalytic *** results of kinetic,deuterium‐hydrogen exchange,and deuterium‐labeling experiments indicated that the present hydrogenation involves heterolytic H2 splitting on the surface of the catalyst.

关键词： Nanoporous materials Palladium Quinoline Chemoselective hydrogenation Heterogeneous catalyst

Supplementation of L-ascorbic acid improves the in vitro development of buffalo(Bubalus bubalis)embryos and alters the expression of apoptosis-related genes

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Asian pacific Journal of Reproduction 2021年第1期10卷 36-42页

作者： Mayank Roshan Diksha Dua Ankur Sharma Manish Tiwari Manoj kumar Singh suresh kumar Singla Prabhat Palta Radhay Sham Manik Manmohan Singh Chauhan Embryo Biotechnology Lab Animal Biotechnology CentreICAR-National Dairy Research InstituteKarnalIndia

Objective:To study the effect of L-ascorbic acid supplementation on the in vitro development of buffalo embryos and evaluate the relative mRNA abundance of some pro-apoptotic,anti-apoptotic,and embryonic development-related ***:In experiment 1,we evaluated the effect of the addition of 0(control),50,and 100μM L-ascorbic acid to the in vitro maturation medium on the developmental competence in terms of blastocyst rate and relative mRNA abundance of some pro-apoptotic(BAX,BID),anti-apoptotic(BCL-XL,MCL1),and embryonic development(GDF9,BMP15)related *** on the results,we chose 50μM as the suitable dose of L-ascorbic acid for the subsequent *** further evaluated the blastocyst rates following the addition of 50μM L-ascorbic acid to the in vitro culture medium(experiment 2),and in vitro maturation and in vitro culture media(experiment 3).In all three experiments,the maturation and culture media devoid of L-ascorbic acid served as the control ***:The blastocyst rate after adding 50μM L-ascorbic acid to the in vitro maturation medium was significantly higher than the control group(P<0.05),whereas 100μM L-ascorbic acid exhibited a negative effect on the blastocyst *** blastocyst rates for embryos cultured in 50μM L-ascorbic acid in the in vitro culture medium alone and both in vitro maturation and in vitro culture media were significantly higher than their corresponding control groups(P<0.05).The relative mRNA abundance of BAX significantly decreased in blastocysts produced after the addition of 50μM L-ascorbic acid as compared with the control group(P<0.05),whereas,for MCL1,it significantly decreased in blastocysts produced after the addition of 100μM L-ascorbic acid(P<0.05).Conclusions:The supplementation of 50μM L-ascorbic acid to in vitro maturation and in vitro culture media supports in vitro embryonic development in buffaloes by improving developmental competence and altering the expression of apoptosis-related genes.

关键词： Buffalo Blastocyst In vitro embryo production L-ascorbic acid Oocyte

Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第7期8卷 526-532页

作者： MALLIKARJUNA B.P. suresh kumar G.V. SASTRY B.S. NAGARAJ MANOHARA K.P. Department of Medicinal Chemistry St. Johns Pharmacy College Bangalore-560040 Karnataka India Department of Pharmaceutical Sciences Andhra University Visakhapatnam-530002 Andhra Pradesh India Pharmacy Department M.S. University Baroda-390002 Gujarat India Department of Pharmacognosy Dr. H.L.T. College of Pharmacy Bangalore-571502 Karnataka India

In the present research, a series of 5,6-bis aryl 1,2,4-triazines 5a^5f were synthesized by condensation of various benzils 4a^4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 5a, 5b and 5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopic data.

关键词： 5,6-Bis aryl 1,2,4-triazines Synthesis Anticonvulsant activity

Recent Technology Advancements in Smart City Management:A Review

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Computers, Materials & Continua 2024年第12期81卷 3617-3663页

作者： Chiranjeevi Karri JoséJ.M.Machado Joao Manuel R.S.Tavares Deepak kumar Jain suresh Dannana Santosh kumar Gottapu Amir H.Gandomi Department of Mechanical Engineering Faculty of EngineeringUniversity of PortoPorto4200-465Portugal Department of Electronics and Communication Engineering Andhra University College of EngineeringAndhra UniversityVisakhaptnam530003Andhra PradeshIndia Laboratory of lntelligent Control and Optimization for Industrial Equipment of Ministry of Education School of Artificial IntelligenceDalian University of TechnologyDalian116024China Department of Electronics and Communication Engineering GMR Institute of TechnologyRajamVizianagaram532127Andhra PradeshIndia Department of Civil Engineering Gayatri Vidya Parishad College of Engineering(GVPCE)Visakhapatnam530048Andhra PradeshIndia Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia University Research and Innovation Center(EKIK) óbuda UniversityBudapest1034Hungary

The rapid population growth,insecure lifestyle,wastage of natural resources,indiscipline behavior of human beings,urgency in the medical field,security of patient information,agricultural-related problems,and automation requirements in industries are the reasons for invention of *** cities aim to address these challenges through the integration of technology,data,and innovative *** a smart city involves integrating advanced technologies and data-driven solutions to enhance urban living,improve resource efficiency,and create sustainable *** review presents five of the most critical technologies for smart and/or safe cities,addressing pertinent topics such as intelligent traffic management systems,information and communications technology,blockchain technology,re-identification,and the Internet of *** challenges,observations,and remarks of each technology in solving problems are discussed,and the dependency effects on the technologies’performance are also *** deep learning models for various applications are *** models performance,their dependency on dataset size,type,hyper-parameters,and the non-availability of labels or ground truth are discussed.

关键词： Smart cities intelligent traffic management systems internet of things deep learning blockchain technology

Optimal Confidential Mechanisms in Smart City Healthcare

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Computers, Materials & Continua 2022年第3期70卷 4883-4896页

作者： R.Gopi P.Muthusamy P.suresh C.G.Gabriel Santhosh kumar Irina V.Pustokhina Denis A.Pustokhin K.Shankar Department of Computing Science and Engineering Dhanalakshmi Srinivasan Engineering CollegePerambalur621212India School of Computing Science and Engineering Galgotias UniversityNCRDelhi203201India Department of Computer Science and Engineering KPR Institute of Engineering and TechnologyCoimbatore641407India Department of Electrical and Electronics Engineering K.Ramakrishnan College of EngineeringTiruchirappalli621112India Department of Entrepreneurship and Logistics Plekhanov Russian University of EconomicsMoscow117997Russia Department of Logistics State University of ManagementMoscow109542Russia Department of Computer Applications Alagappa UniversityKaraikudi630001India

Smart City Healthcare(SHC2)system is applied in monitoring the patient at home while it is also expected to react to their needs in a timely *** system also concedes the freedom of a *** is a part of this system and it helps in providing care to the *** healthcare devices are trustworthy since it almost certainly recognizes the potential intensifications at very early stage and alerts the patients and medical experts to such an extent that they are provided with immediate *** methodologies exhibit few shortcomings in terms of computational complexity,cost and data ***,the current research article examines SHC2 security through LightWeight Cipher(LWC)with Optimal S-Box model in PRESENT *** procedure aims at changing the sub bytes in which a single function is connected with several bytes’information to upgrade the security level through Swam *** key contribution of this research article is the development of a secure healthcare model for smart city using SHC2 security via LWC and Optimal S-Box *** study used a nonlinear layer and single 4-bit S box for round configuration after verifying SHC2 information,constrained by Mutual Authentication(MA).The security challenges,in healthcare information systems,emphasize the need for a methodology that immovably concretes the *** methodology should act practically,be an effective healthcare framework that depends on solidarity and adapts to the developing *** service providers integrated the IoT applications and medical services to offer individuals,a seamless technology-supported healthcare *** proposed SHC^(2) was implemented to demonstrate its security levels in terms of time and access *** model was tested under different parameters such as encryption time,decryption time,access time and response time inminimum ***,the level of the model and throughput were analyzed by maximum value i.e.,50Mbp

关键词： Smart city healthcare security block cipher LWC

A prospective randomized, placebo-controlled trial comparing mifepristone and vaginal misoprostol to vaginal misoprostol alone for elective termination of early pregnancy

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Open Journal of Obstetrics and Gynecology 2012年第1期2卷 81-84页

作者： Roopa Malik Viral kumar Vijayata Sangwan Smiti nanda Post Graduate Institute of Medical Science Rohtak India

A prospective randomized, placebo-controlled trial comparing mifepristone and vaginal misoprostol to vaginal misoprostol alone for elective termination of early pregnancy. Author: Dr Roopa Malik, Assistant Professor, Obstetrics and gynaecology department Pt BDS PGIMS Rohtak BACKGROUND: Vaginal misoprostol has been shown to be an effective single agent for medical agent for medical abortion. This randomized, placebo controlled trial compared a regimen of mefipristone and misoprostol with misoprostol alone for termination of early pregnancy. METHODS: 200 women with gestation <56 days were randomized by a random number table to receive either 200 mg mifepristone orally or placebo followed 48 h later by 800 ug vaginal misoprostol. Abortion success was defined as complete abortion without the use of surgical aspiration. RESULTS: Successful medical abortions occurred in 96 out of 100 subjects (96%) after mifepristone followed by vaginal misoprostol. In all, 79 out of 100 subjects (79%) successfully aborted after placebo and vaginal misoprostol. The higher success rate of complete abortion with mifepristone and misoprostol regimen was statistically significant compared with the placebo and misoprostol regimen (p < 0.05). CONCLUSION: A regimen of mifepristone and misoprostol was significantly more effective for termination of pregnancies <56 days than misoprostol alone. The misoprostol alone regimen for termination of early pregnancy is not a very good method for medical abortion but 79% efficacy obtained with vaginal misoprostol alone may clinically acceptable when mifepristone is not available.

关键词： Abortion Medical Abortion Mifepristone Misoprostol Pregnancy

Fitting Generalized Additive Logistic Regression Model with GAM Procedure

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Journal of Mathematics and System Science 2013年第9期3卷 442-453页

作者： suresh kumar Sharma Rashmi Aggarwal Kanchan Jain Department of Statistics Panjab University Chandigarh India

In dealing with nonparametric regression the GAM procedure is the most versatile of several new procedures. The terminology behind this procedure is more flexible than traditional parametric modeling tools. It relaxes the usual assumptions of parametric model and enables us to uncover structure to establish the relationship between independent variables and dependent variable in exponential family that may not be obvious otherwise. In this paper, we discussed two methods of fitting generalized additive logistic regression model, one based on Newton Raphson method and another based on iterative weighted least square method for first and second order Taylor series expansion. The use of the GAM procedure with the specified set of weights, using local scoring algorithm, was applied to real life data sets. The cubic spline smoother is applied to the independent variables. Based on nonparametric regression and smoothing techniques, this procedure provides powerful tools for data analysis.

关键词： Logistic model iterative generalized additive model weighted least squares cubic splines.

Effect of Reduction in Peak Expiratory Flow Rate on Blood Pressure of Sand Stone Mine Workers

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Journal of Geoscience and Environment Protection 2016年第4期4卷 14-19页

作者： Banna Ram Panwar Anil Vyas suresh kumar Singh Rajasthan State Pollution Control Board Jaipur India Department of Chemical Engineering Jai Narain Vyas University Jodhpur India Department of Civil Engineering Jai Narain Vyas University Jodhpur India

Peak Expiratory Flow Rate (PEFR) measures the airflow through the bronchi and thus the degree of obstruction in the airways. Exposure to high concentration of respirable suspended particulate matter (RSPM) decreases the PEFR and the decrease depends upon the exposure concentration of particles and exposure duration. The decrease in PEFR is found to be responsible for increase in blood pressure (BP). Relationship between increase in BP and reduction in PEFR is not exactly linear but it can be considered as liner. It is noticed that if PEFR is reduced to about 50% to 60% in that case sudden increase in BP is recorded and behaviour of BP rise has complex pattern. It is also an established fact that if PEFR is reduced more than 50%, this is treated as severe respiratory problem. There are many factors (i.e. smoking habits, medical treatment, physiology, etc.) which may govern the increase of BP in this condition. Estimated relationship is found as: ISBP = 0.213 + 0.263 IPEF, IDBP = 0.102 + 0.176 IPEF.

关键词： PEFR BP SBP DBP RSPM

Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen

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Asian Journal of Andrology 2019年第6期21卷 565-569页

作者： Ashok Agarwal Manesh kumar Panner Selvam Mohamed Arafa Hiroshi Okada Sheryl Homa Aideen Killeen Basak Balaban Ramadan Saleh Abdullah Armagan Shubhadeep Roychoudhury suresh Sikka American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA Hamad Medical Hospital Doha 3050Qatar Dokkyo Medical University Koshigaya 343-0845Japan University of Kent Can terbury CT27N乙UK 叮he Doctor's Laboratory London WC1H 9 AXUK American Hospital of Istanbul Nisantasi 34365IstanbulTurkey Sohag University Sohag 82524Egypt Bezmialem Vakif University Fatih 34093IstanbulTurkey Assam University Silchar 788011India Tulane University New OrleansLA 70118USA.

According to the World Health Organization(WHO),oxidative stress(OS)is a significant contributor to male *** can be measured by a number of assays,all of which are either costly or time sensitive and/or require large semen volume andcomplex *** less expensive alternative is to quantify the oxidation-reduction potential(ORP)with the *** this international multi-center study,we assessed whether ORP levels measured by the MiOXSYS could distinguish semensamples that fall within the 2010 WHO normal reference values from those that do *** samples were collected from 2092patients in 9 countries;ORP was normalized to sperm concentration(mV/10^6 sperm/ml).Only those samples with a concentration>1×10^6 sperm ml1 were in *** results showed that 199 samples fell within the WHO no rmal refere nee range while theremaining 1893 samples did not meet one or more of the *** was negatively correlated with all semen parameters(P <0.01)except *** area under the curve for ORP was *** ORP cut-off value(1.34 mV/10^6 sperm/ml)was able todifferentiate specimens with abnormal semen parameters with 98.1%sensitivity,40.6%specificity,94.7%positive predictivevalue(PPV)and 66.6%negative predictive value(NPV).When used as an adjunct to traditional semen analysis,ORP levels mayhelp identify altered functional status of spermatozoa caused by OS in cases of idiopathic male infertility and in male partners ofcouples sufferi ng recurre nt pregna ncy loss,and thereby directi ng these men to relevant medical therapies and lifestyle modificati ons.

关键词： male infertility oxidation-reduction potential semen analysis spermatozoa