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Small interfering RNA for cancer treatment:overcoming hurdles in delivery

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2075-2109页

作者： Nitin Bharat Charbe Nikhil D.Amnerkar B.Ramesh Murtaza M.Tambuwala Hamid A.Bakshi Alaa A.A.Aljabali Saurabh C.Khadse Rajendran Satheeshkumar Saurabh Satija Meenu Metha Dinesh kumar Chellappan Garima Shrivastava Gaurav Gupta Poonam Negi Kamal Dua Flavia C.Zacconin Departamento de Quimica Orgánica Facultad de Química y de FarmaciaPontificia Universidad Católica de ChileSantiago 7820436Chile Sri Adichunchunagiri College of Pharmacy Sri Adichunchunagiri UniversityBG NagarKarnataka 571418India Adv V.R.Manohar Institute of Diploma in Pharmacy NagpurMaharashtra 441110India School of Pharmacy and Pharmaceutical Science Ulster UniversityColeraineNorthern Ireland BT521SAUK Faculty of Pharmacy Department of Pharmaceutics and Pharmaceutical TechnologyYarmouk UniversityIrbid 21163Jordan Department of Pharmaceutical Chemistry R.C.Patel Institute of Pharmaceutical Education and ResearchDist.DhuleMaharashtra 425405India Discipline of Pharmacy Graduate School of HealthUniversity of Technology SydneyNSW 2007Australia School of Pharmaceutical Sciences Lovely Professional UniversityPhagwara 144411 PunjabIndia Department of Life Sciences School of PharmacyInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia Department of Biochemical Engineering and Biotechnology Indian Institute of TechnologyDelhiNew Delhi 110016India School of Pharmacy Suresh Gyan Vihar UniversityJagatpuraJaipur 302017India School of Pharmaceutical Sciences Shoolini University of Biotechnology and Management SciencesSolan 173229India Priority Research Centre for Healthy Lungs Hunter Medical Research Institute(HMRI)and School of Biomedical Sciences and PharmacyUniversity of NewcastleNSW 2308Australia Institute for Biological and Medical Engineering Schools of EngineeringMedicine and Biological SciencesPontificia Universidad Católica de ChileSantiago 4860Chile

In many ways,cancer cells are different from healthy cells.A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy ***,nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer *** review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer *** also provides the necessary information about siRNA development and its mechanism of ***,this review gives us a clear picture of lipid and polymer-based drug delivery systems,which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.

关键词： Small interfering RNA(siRNA) Nanomedicine Liposomes Micelles Cancer Polymer

Impact of Climate Change on Vegetation Distribution and Net Primary Productivity of Forests of Himalayan River Basins: Brahmaputra, Koshi and Indus

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American Journal of Climate Change 2018年第2期7卷 271-294页

作者： A. Chaitra S. Upgupta L. D. Bhatta J. Mathangi D. S. Anitha K. Sindhu Vidya kumar N. K. Agrawal M. S. R. Murthy F. Qamar Indu K. Murthy J. sharma R. K. Chaturvedi G. Bala N. H. Ravindranath Centre for Sustainable Technologies Indian Institute of Science Bengaluru India International Centre for Integrated Mountain Development (ICIMOD) Kathmandu Nepal Divecha Centre for Climate Change Centre for Atmospheric Sciences Indian Institute of Science Bengaluru India

The impacts of climate change in terms of forest vegetation shifts and Net Primary Productivity (NPP) changes are assessed for Brahmaputra, Koshi and Indus river basins for the mid (2021-2050) and long (2071-2100) terms for RCP4.5 and RCP8.5 scenarios. Two Dynamical Global Vegetation Models (DGVMs), Integrated BIosphere Simulator (IBIS) and (Lund Postdam and Jena (LPJ), have been used for this purpose. The DGVMs are driven by the ensemble mean climate projections from 5 climate models that contributed to the CMIP5 data base. While both DGVMs project vegetation shifts in the forest areas of the basins, there are large differences in vegetation shifts projected by IBIS and LPJ. This may be attributed to differing representation of land surface processes and to differences in the number of vegetation types (Plant Functional Types) defined and simulated in the two models. However, there is some agreement in NPP changes as projected by both IBIS and LPJ, with IBIS mostly projecting a larger increase in NPP for the future scenarios. Despite the uncertainties with respect to climate change projections at river basin level and the differing impact assessments from different DGVMs, it is necessary to assess the “vulnerability” of the forest ecosystems and forest dependent communities to current climate risks and future climate change and to develop and implement resilience or adaptation measures. Assessment of the “vulnerability” and designing of the adaptation strategies could be undertaken for all the forested grids where both IBIS and LPJ project vegetation shifts.

关键词： Climate Change Forests Himalayan River Basins Impacts NPP Change Forest Type Shift

“A Prospective Randomized Case-Control Study To Evaluate Mini Right Thoracotomy versus Conventional Sternotomy For Mitral Valve Repair In Rheumatic Heart Disease.”

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World Journal of Cardiovascular Surgery 2016年第11期6卷 139-152页

作者： Ashok kumar Chahal Preeti Gehlaut Sanjay Johar Ashish Asija Divya Arora Naveen Malhotra Kuldeep Singh Lallar Shamsher Singh Lohchab Department of Cardiac Surgery Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India Department of Anaesthesiology Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India Department of Cardiac Surgery Max Hospital Delhi India Department of Cardiology Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India

Purpose: Right mini thoracotomy has been evaluated in many studies for mitral valve repair mainly in degenerative valvular disease but not in rheumatic heart disease. Mitral valve repair is more challenging in rheumatic etiology due to complexity of lesions. This prospective randomized case control study was designed to evaluate repair through mini right thoracotomy and to compare the clinical and echocardiographic outcomes with sternotomy in rheumatic patients. Methods: 25 patients of rheumatic heart disease underwent mitral valve repair through mini right thoracotomy (group I). Various clinical and functional parameters were compared with 25 patients of mitral valve repair through sternotomy (group II). On follow up the results were compared in both groups for clinical and echocardiographic parameters. Results: The various pre-operative demographic parameters were comparable in two groups. Equal rate of mitral valve repair (group I-21/25, 84% and group II-21/25, 84%) was achieved in both groups. The various intra-operative and post-operative clinical parameters were better in group I .There were equivalent functional and valve related outcomes in both groups in term of NYHA class (1.28 ± 0.613 vs 1.08 ± 0.276, P = 0.144), post-operative mitral valve area (2.43 ± 0.891 vs 2.82 ± 0.662, P = 0.090), incidence of more than mild mitral regurgitation (0) and mean pressure gradient across mitral valve (4.98 ± 3.33 vs 4.23 ± 1.5, P = 0.309). Conclusion: Mitral valve repair through mini right thoracotomy approach in rheumatic etiology is feasible and safe with equivalent rate of successful repair as compared to median sternotomy. It is associated with lesser morbidity, cosmetic advantage and lesser resource utilization.

关键词： “Rheumatic Heart Disease Minimally Invasive Mitral Valve Repair Right antero-lateral thoracotomy.” Mitral valve repair

The Corpse Is a Silent Witness Who Never Lies—A Case Report

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Forensic Medicine and Anatomy Research 2014年第3期2卷 43-47页

作者： Vijay Pal Pawan Mittal Jitender K. Jakhar Yogesh kumar Vashist A. D. Aggarwal Bhavesh Bohra Department of Forensic Medicine Government Medical College Patiala India Department of Forensic Medicine Jhalawar Medical College Jhalawar India Department of Forensic Medicine Pt. B. D. Sharma PGIMS Rohtak Pt. Bhagwat Dayal Sharma University of Health Sciences Rohtak India Department of Forensic Medicine Pt. B. D. Sharma PGIMS Rohtak Pt. Bhagwat Dayal Sharma University of Health Sciences Rohtak India Pt. Bhagwat Dayal Sharma University of Health Sciences Rohtak India

There are two very common sayings about corpse (dead body). The first common saying is that “the corpse is a silent witness who never lies” and the other common saying is that “the dead body is extremely eloquent and honestly informative, if one exercises patience in listening to it.” Both these sayings were proved in one of our cases. In the present case, decomposed body of an unidentified female individual aged about 25 - 26 years was recovered from the bank of western Yamuna canal in Haryana. The police made the efforts for establishing the identity of the deceased but could not succeed. The body was forwarded to the district hospital for autopsy along with the inquest report. However, the body being in advanced stage of decomposition so it was referred from the district hospital to the department of Forensic Medicine, PGIMS, Rohtak (Haryana) for the examination and the expert opinion regarding the cause of death. The findings observed on examination of the body helped to deduce the cause, time and manner of death whereas certain important objective features of identification were also observed and ultimately proper identity of the deceased could be established beyond the reasonable doubt by DNA profile of the samples preserved at autopsy. The autopsy findings, DNA profile and the results of examination of other materials (exhibits) taken from the body not only revealed the truth from the silent witness—the corpse, but also provided objective and scientific evidence to establish the corpus delicti in this case.

关键词： Corpus Delicti Rape Throttling Murder Putrefaction DNA Profile

Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search

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Science China(Physics,Mechanics & Astronomy) 2019年第3期62卷 58-65页

作者： Hao Jiang LiTao Yang Qian Yue KeJun Kang JianPing Cheng YuanJing Li Henry Tsz-King Wong M.A?artio?lu HaiPeng An JianPing Chang JingHan Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He Jin Wei Hu QingDong Hu HanXiong Huang LiPing Jia HauBin Li Hong Li Jian Min Li Jin Li Xia Li XueQian Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu YuanYuan Liu ZhongZhi Liu Hao Ma JingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda Vivek sharma ManBin Shen Lakhwinder Singh Monoj kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang JiMin Wang Li Wang Qing Wang Yi Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue XiongHui Zeng Ming Zeng Zhi Zeng FengShou Zhang YunHua Zhang MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu ZhongHua Zhu Key Laboratory of Particle and Radiation Imaging (Ministry of Education)and Department of Engineering Physics Tsinghua University College of Nuclear Science and Technology Beijing Normal University Institute of Physics Academia Sinica Department of Physics Dokuz Eylül University Department of Physics Tsinghua University NUCTECH Company Ya Long River Hydropower Development Company College of Physical Science and Technology Sichuan University Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University Department of Physics Beijing Normal University

The CDEX-10 experiment searches for light weakly interacting massive particles, a form of dark matter, at the China Jinping Underground Laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1 B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype detector, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1 B spectrum. Both sets of results showed good consistency in the 0-12 ke Vee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper.

关键词： WIMP pPCGe liquid nitrogen bulk/surface event discrimination extremely fast events

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沙棘饮料的化学成分和最优口感的研究

国际沙棘研究与开发 2008年第1期6卷 40-44页

作者：杨唐英温秀凤 Shipra Saklani H. R. sharma Virendra Singh 北京林业大学水土保持学院北京100083 水利部沙棘开发管理中心北京100038 College of Home Science Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya PalampurIndia 176 062 CSKHPKV山地农业推广中心 BajauraKullu 175 125India

沙棘(Hippophae rhamnoids L.),属于胡颓子属,在印度喜马偕尔邦地区称作"Chharma and Surch",沙棘能够在这种非常恶劣的气候条件下自然生长。本文介绍了制作沙棘饮料的一系列程序和如何储存饮料120d而不使其变质的方法。沙棘果实采自印... 详细信息

沙棘(Hippophae rhamnoids L.),属于胡颓子属,在印度喜马偕尔邦地区称作"Chharma and Surch",沙棘能够在这种非常恶劣的气候条件下自然生长。本文介绍了制作沙棘饮料的一系列程序和如何储存饮料120d而不使其变质的方法。沙棘果实采自印度喜马偕尔邦河谷。用碎浆机提取沙棘汁,制作沙棘饮料要准备好合适比例的沙棘汁和制作饮料所需的糖。随着果浆比例的升高,维生素C的含量明显增加(P≤0.05),随着贮藏时间的延长,维生素C的含量明显降低。而随着糖和果浆的增加以及储存期的延长,还原性糖呈上升趋势。当饮料中果浆和糖的比例分别为10%和13%、12.5%和13%、15%和15%时,饮料最为宜口,给于较高的评价。在喜马偕尔邦,人们一直认为沙棘具有商业价值,但是其价值在此前一直没有得到足够的重视。

关键词：沙棘化学成分感官 RTS饮料

Limits on light WIMPs with a 1 kg-scale germanium detector at 160 eVee physics threshold at the China Jinping Underground Laboratory

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Chinese Physics C 2018年第2期42卷 12-21页

作者：杨丽桃李浩斌岳骞康克军程建平李元景王子敬 M.Agartioglu 安海鹏常建平陈景瀚陈云华邓智杜强宫辉何力胡津纬胡庆东黄瀚雄贾历平江灏李红李荐民李金李霞李学潜李玉兰林枫凯林兴德刘书魁刘仲智马豪马菁露潘辉任杰阮锡超 B.Sevda Vivek sharma 申满斌 Lakhwinder Singh Manoj kumar Singh 唐昌建唐维优田阳王继敏王力王青王轶吴世勇吴玉成幸浩洋徐音薛涛杨松伟易难喻纯旭于海军岳剑峰曾雄辉曾鸣曾志张云华赵明刚赵伟周济芳周祖英朱敬军朱忠华 Key Laboratory of Particle and Radiation Imaging (Ministry of Education) and Department of Engineering Physics Tsinghua University Department of Physics Tsinghua University Institute of Physics Academia Sinica Key Laboratory of Particle and Radiation Imaging vand Department of Engineering Physics Tsinghua University NUCTECH Company YaLong River Hydropower Development Company College of Physical Science and Technology Sichuan University Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University Key Laboratory of Particle and Radiation Imaging and Department of Engineering Physics Tsinghua University

We report results of a search for light weakly interacting massive particle（WIMP） dark matter from the CDEX-1 experiment at the China Jinping Underground Laboratory（CJPL）. Constraints on WIMP-nucleon spin-independent（SI） and spin-dependent（SD） couplings are derived with a physics threshold of 160 eVee, from an exposure of 737.1 kg-days. The SI and SD limits extend the lower reach of light WIMPs to 2 GeV and improve over our earlier bounds at WIMP mass less than 6 GeV.

关键词： dark matter WIMPs CDEX pPCGe

MODIFICATION OF THE CLASTOGENICITY OF HEAVY METALS THROUGH INTERACTION WITH Ca AS SHOWN BY MOUSE BONE MARROW TEST

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癌变．畸变．突变 1991年第S1期3卷 20-20页

作者： Asis kumar Chosh Debisree Sarkar and Archana sharma Genetic Toxicology UnitCentre of Advanced Study in Cell and Chromosome ResearchDepartment of BotanyUniv.of Calcutta35 Ballygunge Circular RoadCalcutta-700 019India

Interaction between an essential element calcium andtwo heavy metals (Cr and Hg) was observed in micebone marrow cells in *** chloride andcalcium chloride (1:1 ratio) were administered orallyto laboratory bred Swiss a... 详细信息

关键词： Swiss preparations exposure somal

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肝外门静脉梗阻病人肝脏与脾僵硬度的研究

国际医学放射学杂志 2012年第4期 390-390页

作者： P. sharma S.R. Mishra M. kumar B.C. sharma S.K. Sarin 唐光健 Department of Hepatology Institute of Liver and Biliary SciencesVasant Kunj New Delhi 110070 India

摘要目的评价肝外门静脉梗阻(EHPVO)病人肝脏僵硬度(LS)与脾的僵硬度(SS)。材料与方法研究由学院科研委员会批准,获取知情同意通知。测量65例连续EHPVO病人的LS与SS。病人进行了内镜检查、肝脏活检、肝功能检验、腹部超声检查、详细病... 详细信息

摘要目的评价肝外门静脉梗阻(EHPVO)病人肝脏僵硬度(LS)与脾的僵硬度(SS)。材料与方法研究由学院科研委员会批准,获取知情同意通知。测量65例连续EHPVO病人的LS与SS。病人进行了内镜检查、肝脏活检、肝功能检验、腹部超声检查、详细病史询问与体格检查。50例年龄匹配的健康对

关键词：病人 LS 僵硬度肝脏