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Mixed epithelial endocrine neoplasms of the colon and rectum–An evolution over time:A systematic review

World Journal of Gastroenterology 2020年第34期26卷 5181-5206页

作者： Rani Kanthan suresh tharmaradinam Tehmina Asif Shahid Ahmed Selliah C Kanthan Department of Pathology and Laboratory Medicine University of SaskatchewanSaskatoon S7N 0W8SKCanada Division of Oncology Saskatoon Cancer CentreSaskatoon S7N 0W8SKCanada Division of General Surgery University of SaskatchewanSaskatoon S7N 0W8SKCanada

BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare *** can occur anywhere in the gastrointestinal tract and are often diagnosed *** they have been a well-documented entity in the pancreas,where the exocrine-endocrine mixed tumors have been known for a while,recognition and accurate diagnosis of these tumors in the colon and rectum,to date,remains a *** is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and ***,dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case ***,most of these tumors are high grade and of advanced stage,intermediate and low grade lesions of these mixed tumors are also increasingly been *** are no established independent consensus based guidelines for the therapeutic patient management of these unique *** To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape,clinicoradiological features,pathology,treatment,prognosis,the current status of the management of the primary lesions,their recurrences and *** A comprehensive review of the published English literature was conducted using the search engines PubMed,MEDLINE and GOOGLE *** following search terms[“mixed tumors colon”OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors

关键词： Mixed epithelial endocrine neoplasms Mixed adeno-neuroendocrine carcinoma Mixed adeno neuro endocrine tumors Mixed neuroendocrine-non neuroendocrine neoplasms Colorectal

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