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Effect of Doxorubicin on Histomorphology of Liver of Wistar Albino Rats

Journal of Pharmacy and Pharmacology 2016年第4期4卷 174-178页

作者： Deepak Chaudhary Saroj Khatiwada surendra kumar sah Man kumar Tamang Soumya Bhattacharya Chandra Bhushan Jha M.Sc. Human Anatomy Department of Anatomy Nobel Medical College Biratnagar Nepal MSc. Medical Biochemistry Department of Biochemistry Modern Technical College Lalitpur Nepal M Sc. Medical Biochemistry Department of Nutrition and Dietetics Central Campus of Technology Dharan Nepal MD Anatomy Department of Human Anatomy B P Koirala Institute of Health Sciences Dharan Nepal

Doxorubicin is associated with adverse effects on organs like liver. This study was done to find the effects of doxorubicin on liver of wistar albino rats. Sixty healthy wistar albino rats were taken for the study. The rats were randomly divided in to 4 groups （2 experimental groups; group AI and A2, and 2 control groups;group Bland B2 each containing 16 rats）. The experimental groups were given a single dose of doxorubicin i.e. 10 mg/kg body weight intraperitoneally and sacrificed after 7 days and 14 days for each group. Rats under control groups were given a single intraperitoneal dose of 2.5 ml/kg body weight normal saline and sacrificed with their respective experimental groups. A significant difference （p 〈 0.001） and （p = 0.005） in final body weight was observed among group A1 experimental and BI control rats, and among group A2 experimental and B2 control rats. As compared to group B2 control, group A2 experimental rats had significantly （p = 0.043） lower liver weight. Diameter ofhepatocyte （p 〈 0.001 for both groups） and nucleus （p=0.004 for group A1 and control BI, and p 〈 0.001 for group A2 and control B2） was significantly higher in experimental rats as compared to their respective controls. Cross-sections of the liver of both control groups had normal architecture. However, there was progressive destruction of liver architecture across the experimental groups. Doxorubicin causes the disruption of normal architecture of liver in rats. Thus care needs to be taken during doxorubicin chemotherapy to minimize effects on river.

关键词： Doxorubicin Histomorphometry Liver Wistar albino rot.

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Critical Review on Balanites aegyptiaca Delile:Phytoconstituents,Pharmacological Properties and Nanointerventions

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Chinese Journal of Integrative Medicine 2024年第7期30卷 653-663页

作者： surendra kumar Gautam Rakesh kumar Paul Devesh M.Sawant Amita Sarwal Kaisar Raza Department of Pharmacy School of Chemical Sciences and PharmacyCentral University of RajasthanBandarsindriAjmerRajasthan305817India University Institute of Pharmaceutical Sciences Panjab UniversityChandigarh160014India

Balanites aegyptiaca Delile(BA)is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi(Hingot).It belongs to the family Zygophyllaceae,which is specific to be drought areas of Nigeria,Africa,South Asia and India(Rajasthan).In Ayurveda,this traditional medicinal plant is reported for the management of jaundice,syphilis,yellow fever,metabolic disorders,liver,and spleen *** main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of *** per the literature survey,various researchers have focused on the detailed investigation of BA including the phytopharmacological evidence,chemical constituents,nano-formulations,commercialized products,and clinical *** remarkable scaffolds and isolated compounds like diosgenin,yamogenin,balanitin1/2,balanitin 3,bal4/5,bal6/7,rutin-3-glycosides,3,7-diglycosides,(3,12,14,16)–(12-hydroxycholest-5-ene-3,16-diyl-bis)-D-glucopyranoside and balanitoside have been ***,this traditional plant has been scientifically proven by in vitro and in *** on the complete review of this plant,most of the compounds have been isolated from the fruit and kernel ***,based on the literature,a histogram was developed for pharmacological activity in which antidiabetic study was found to be more compared to other pharmacological *** a spinous desert dates,this plant needs to be explored more to bring out newer phytochemicals in the management of various diseases.

关键词： Delile desert date phytochemicals nano-phytopharmaceutical pharmacological activities traditional medicine

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A nano-plasmonic HMIM waveguide based concurrent dual-band BPF using circular ring resonator

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Optoelectronics Letters 2024年第3期20卷 152-156页

作者： Miriyala Sridhar surendra kumar Bitra TS N Murthy Koppireddi Padmaraju Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationGunturIndia Astra Microwave Products Ltd. HyderabadIndia Department of Electronics and Communication Engineering JNTU-GV College of EngineeringVizianagaramIndia Department of Electronics and Communication Engineering Jawaharlal Nehru Technological University KakinadaKakinadaIndia

This article analyzes the transmission line characteristics of plasmonic hybrid metal insulator metal(HMIM) wave-guide, circular ring resonator(CRR) based dual-band band-pass filters with two transmission poles in both pass-bands in the optical regime using coupled line feed. The transmission line characteristics of an HMIM waveguide, such as characteristic impedance(Z_(PV)), effective refractive index(n_(eff)) and propagation length(L_(spp)), have been obtained by using full wave simulation.

关键词： waveguide resonator circular

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Microstructure,Corrosion and Mechanical Properties of Medium-Thick 6061-T6 Alloy/T2 Pure Cu Dissimilar Joints Produced by Double Side Friction Stir Z Shape Lap-Butt Welding

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 385-400页

作者： Jiuxing Tang Guoxin Dai Lei Shi Chuansong Wu Sergey Mironov surendra kumar Patel Song Gao Mingxiao Wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Shandong UniversityJinan 250061China Laboratory of Mechanical Properties of Nanoscale Materials and Superalloys Belgorod State UniversityBelgorod 308015Russia School of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China State Grid Henan Electric Power Research Institute Zhengzhou 450052China

A novel double side friction stir Z shape lap-butt welding(DS-FSZW)process was proposed to achieve excellent mechanical properties of Al/Cu medium-thick dissimilar *** influence of welding parameters on weld microstructure and properties of DS-FSZW joint were systematically *** indicated that defect-free medium-thick Al/Cu DS-FSZW joint could be achieved under an optimal welding ***-FSZW joint was prone to form void defects in the bottom of the second-pass *** recrystallization mechanisms at the top and middle of the weld nugget zone(WNZ)were continuous dynamic recrystallization(CDRX)and geometric dynamic recrystallization(GDRX).While the major recrystallization mechanism at the bottom of the WNZ was ***-FSZW joint of the optimal welding condition with 850 r/min-400 mm/min was produced with a continuous thin and crack-free IMCs layer at the Al/Cu interface,and the maximum tensile strength of this joint is 160.57 MPa,which is equivalent to 65.54%of pure Cu base ***,the corrosion resistance of Al/Cu DS-FSZW joints also achieved its maximum value at the optimal welding parameter of 850 r/min-400 mm/*** demonstrates that the DS-FSZW process can simultaneously produce medium-thick Al/Cu joints with excellent mechanical performance and corrosion resistance.

关键词： DS-FSZW Al/Cu dissimilar joint Corrosion behaviour Intermetallic compounds Microstructure Mechanical properties

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A comprehensive review of rectangular duct solar air heaters featuring artificial roughness

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Clean Energy 2024年第5期8卷 186-217页

作者： Ravi Shankar Rajeev kumar Arun kumar Pandey Deep Singh Thakur Department of Mechanical Engineering Rajkiya Engineering College BandaUttar Pradesh 210201India Department of Mechanical Engineering Institute of Engineering&TechnologyLucknowUttar Pradesh 226021India Department of Mechanical Engineering Bundelkhand Institute of Engineering&TechnologyJhansiUttar Pradesh 284128India

Solar air heaters(sahs)are widely used solar thermal systems with applications in diverse ***,its effectiveness is re-strained by low convective heat transfer(HT)coefficients at the absorber plate,leading to inefficient HT,and the elevated temperature of the absorber plate causes significant heat losses,reducing thermal *** study addresses these challenges by introducing ribs or roughness on the absorber plate creating turbulence in the airflow,resulting in significant *** research inves-tigates various rib configurations,the influence of rib parameters,performance methods,and arrangements to evaluate their HT and friction *** these rib configurations,a comparative analysis is done on various factors such as the Nusselt number ratio,thermal enhancement factor,friction factor ratio,and thermal efficiency to optimize distinct roughness parameters and rib ar-rangement *** study also provides valuable recommendations from existing literature,offering insights into the effective design,prospects,and implementation of sah systems.

关键词： solar air heater artificial roughness low heat transfer heating solar energy

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Erosion Wear Behaviour of Kenaf/Glass Hybrid Polymer Composites

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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 78-89页

作者： Chandrakanta Mishra Deepak kumar Mohapatra Chitta Ranjan Deo Punyapriya Mishra Kiran kumar Ekka Department of Mechanical Engineering Veer Surendra Sai University of TechnologySambalpur 768018India

The awareness amongst the researchers to develop an environment friendly sustainable material leads to explore new class of plant-based fiber for making composites. Hybridization of such plant-based fiber with inclusion of engineered fiber is one of the promising methods to not only enhanced the mechanical performance but also suppressed the drawbacks that associate with such plant-based fiber to some extent. A usual hand lay-up method was taken-up in this work to fabricate four layered of hybrid kenaf(K)/glass(G)polyester laminates with different stacking order such as KKKK,KGKG,KGGK,GKKG and GGGG. The erosive character of the laminates was examined under three distinct particle velocities(48m/s, 70m/s,82m/s)and four different impact angles(30°, 45°, 60°, 90°). All fabricated laminates exhibited a semiductile character at lower velocities(48m/s and70m/s)as peak wear rate was observed at45° impact angle. However,they showed a semi-brittle character at high velocity(82m/s)as maximum rate of erosion was noticed at60° impact angle. Again,the influence of stacking order of piles on erosion wear was also clearly noticed. Moreover,the semi-brittle/semi-ductile characterization was also evidenced in accordance to the range of erosion efficiencies. The micro-structures of worn surfaces were inspected thoroughly from the images of scanning electron microscope(SEM)to evident the mechanism of erosion.

关键词： hybrid composites erosion wear void micro⁃hardness

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Performance Improvement of Kenaf/Glass Polymer Hybrid Composites by Effective Application of Fish Scale Powder as Filler:A Novel Approach

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Journal of Harbin Institute of Technology(New Series) 2024年第3期31卷 80-96页

作者： Chandrakanta Mishra Deepak kumar Mohapatra Chitta Ranjan Deo Chetana Tripathy Kiran kumar Ekka Department of Mechanical Engineering Veer Surendra Sai University of TechnologySambalpur 768018OdishaIndia

Modern technology for developing new items made from renewable resources is becoming more and more popular as a result of rising environmental ***,contemporary polymer composites have included the hybridization of natural fibers with synthetic ones,along with the inclusion of a variety of biowaste filler for developing sustainable *** this work,the kenaf/glass hybrid polyester composites are strengthened by the addition of fish scale(FS),which is taken from the fish􀆳s outermost layer of *** different stacked-order laminates,such as KKKK,KGKG,GKKG,KGGK,and GGGG,are fabricated by using the hand lay-up method with four different weight concentrations of filler content:0%,5%,10%,and 15%.Mechanical possessions such as tensile,flexural,impact strength and micro-hardness have been evaluated through experimentation in accordance with ASTM *** experimental findings revealed that,the tensile strength and micro-hardness value of KGKG laminates with 15wt% of FS filler are found to be maximum of 118.72 MPa and 17.82 HV respectively which are 39.67%and 26.11%greater than that of KGKG laminates without FS ***,the flexural and impact strength of same laminates with 10 wt% FS filler exhibited a maximum value of 142.77 MPa and 62.08 kJ/m^(2).In order to corroborate its applicability for structural and building materials in open environment,the dimensional stability of the composite has been studied through moisture absorption *** influences of FS filler loading on dimensional stability and resistance to moisture absorption capacity of laminates are also *** experimental results reflected that the addition of FS-filler has significantly improved the dimensional stability of the laminates in moist environment by reducing the moisture absorption *** further support the mode of failures,a fractography investigation of fractured surfaces was conducted.

关键词： fish scale fiber polyester hybrid composites mechanical properties

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Reoperation for early postoperative complications after gastric cancer surgery in a Chinese hospital

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World Journal of Gastroenterology 2010年第1期16卷 98-103页

作者： Birendra kumar sah Department of General Surgery Ruijin HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai Institute of Digestive Surgery

AIM:To investigate the occurrence of postoperative complications of gastric cancer surgery,and analyze the potential causes of reoperation for early postoperative complications. METHODS:A total of 1639 patients who underwent radical or palliative gastrectomies for gastric cancer were included in the *** study endpoint was the analysis of postoperative complications in inpatients. RESULTS:About 31%of patients had early postoperative complications,and complications of infection occurred most ***-abdominal hemorrhage and anastomotic leak were the main causes of reoperation,which accounted for about 2.2%.Mortality was 11.1%in the reoperation group,but was only 0.8%in other *** duration of postoperative stay in hospital was significantly longer and the total expenditure was markedly higher in the patients who underwent reoperation(P<0.001).There was no significant association of any available factors in this study with the high rate of ***:Reoperation significantly increases the mortality rate and raises the burden of the surgical *** prospective studies are required to explore the potential risk factors.

关键词： Reoperation Gastric cancer Surgery Postoperative complications

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Evaluation of Dielectric Properties of CCTO-BT/Epoxy Composites for Electronic Applications

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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 69-77页

作者： Swagatika Mishra Punyapriya Mishra Punyatoya Mishra Dinesh kumar Mishra Krushna Prasad Shadangi Deepak kumar Mohapatra Department of Mechanical Engineering Veer Surendra Sai University of TechnologyBurlaOdisha 768018India Department of Physics Parala Maharaja Engineering CollegeBerhampurOdisha 761003India Department of Metallurgical and Materials Engineering Veer Surendra Sai University of TechnologyBurlaOdisha768018India Department of Chemical Engineering Veer Surendra Sai University of TechnologyBurlaOdisha 768018India

In the current study,the calcium copper titanate(CCTO)/epoxy,barium titanate(BT)/epoxy and CCTO-BT/epoxy composite samples with variable volume fractions of CCTO and BT are fabricated using hand lay-up and compression moulding process. The composite samples are characterized for the frequency dependence on dielectric properties,conductivity,impedance spectroscopy and electrical modulus.X-ray diffraction(XRD)representation of CCTO-BT/epoxy composite samples confirmed the presence of both CCTO and BT ceramic samples separately. The dielectric characteristics of hybrid CCTO-BT/epoxy composite samples with CCTO∶BT ratio of 40∶60, 60∶40,and 50∶50 was found relatively better than those of single ceramic filler reinforced epoxy composites. AC conductivity analysis shows improvement in the results of hybrid filler-filled CCTO-BT/epoxy composites in comparison with single filler-filled epoxy composite.50∶50 CCTO-BT/epoxy composite shows the best AC conductivity value of~ 2.2 ×10^(-5) ohm^(-1)·m^(-1) at a higher frequency of 1MHz. The impedance analysis confirms the higher insulating properties for hybrid 40∶60 and 60∶40 CCTO-BT/epoxy composites with respect to the single and other hybrid ceramic epoxy composites. The analysis suggests the hybrid CCTO-BT/epoxy composites to be adopted as a potential dielectric material for energy storage devices and other electronic applications.

关键词： ceramic filler dielectric characterization hybrid Composite AC conductivity impedance analysis

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Does testosterone prevent early postoperative complications after gastrointestinal surgery?

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World Journal of Gastroenterology 2009年第44期15卷 5604-5609页

作者： Birendra kumar sah Department of General Surgery&Shanghai Institute of Digestive Surgery Rui Jin HospitalShanghai Jiao Tong UniversitySchool of Medicine

AIM:To investigate the role of sex hormones in the early postoperative complications of gastrointestinal diseases. METHODS:A total of 65 patients who underwent operations for gastric and colorectal diseases(mainly malignant diseases)were included in the study. Peripheral venous blood samples were collected at different times for analysis of estradiol,testosterone and *** only study endpoint was analysis of postoperative complications. RESULTS:Patients of both sexes were uniform but postoperative complication rate was significantly higher in female patients(P=0.027).There was no significant association of estradiol and progesterone with postoperative *** levels in complicated patients were significantly lower than in uncomplicated patients(P<0.05).Area under the receiver operating characteristic curve showed that a lower value of testosterone was a predictor for higher complication rate(P<0.05),and a lower value oftestosterone at later times after surgery was a better predictor of complications. CONCLUSION:Patients with low testosterone level were prone to higher postoperative complications,which was evident in both ***,further studies are necessary to support this result.

关键词： Stomach neoplasms Testosterone Sex differences Postoperative complications

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