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Critical Review on Balanites aegyptiaca Delile:Phytoconstituents,Pharmacological Properties and Nanointerventions

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Chinese Journal of Integrative Medicine 2024年第7期30卷 653-663页

作者： surendra kumar Gautam Rakesh kumar Paul Devesh M.Sawant Amita Sarwal Kaisar Raza Department of Pharmacy School of Chemical Sciences and PharmacyCentral University of RajasthanBandarsindriAjmerRajasthan305817India University Institute of Pharmaceutical Sciences Panjab UniversityChandigarh160014India

Balanites aegyptiaca Delile(BA)is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi(Hingot).It belongs to the family Zygophyllaceae,which is specific to be drought areas of Nigeria,Africa,South Asia and India(Rajasthan).In Ayurveda,this traditional medicinal plant is reported for the management of jaundice,syphilis,yellow fever,metabolic disorders,liver,and spleen *** main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of *** per the literature survey,various researchers have focused on the detailed investigation of BA including the phytopharmacological evidence,chemical constituents,nano-formulations,commercialized products,and clinical *** remarkable scaffolds and isolated compounds like diosgenin,yamogenin,balanitin1/2,balanitin 3,bal4/5,bal6/7,rutin-3-glycosides,3,7-diglycosides,(3,12,14,16)–(12-hydroxycholest-5-ene-3,16-diyl-bis)-D-glucopyranoside and balanitoside have been ***,this traditional plant has been scientifically proven by in vitro and in *** on the complete review of this plant,most of the compounds have been isolated from the fruit and kernel ***,based on the literature,a histogram was developed for pharmacological activity in which antidiabetic study was found to be more compared to other pharmacological *** a spinous desert dates,this plant needs to be explored more to bring out newer phytochemicals in the management of various diseases.

关键词： Delile desert date phytochemicals nano-phytopharmaceutical pharmacological activities traditional medicine

Microstructure,Corrosion and Mechanical Properties of Medium-Thick 6061-T6 Alloy/T2 Pure Cu Dissimilar Joints Produced by Double Side Friction Stir Z Shape Lap-Butt Welding

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 385-400页

作者： Jiuxing Tang Guoxin Dai Lei Shi Chuansong Wu Sergey Mironov surendra kumar Patel Song Gao Mingxiao Wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Shandong UniversityJinan 250061China Laboratory of Mechanical Properties of Nanoscale Materials and Superalloys Belgorod State UniversityBelgorod 308015Russia School of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China State Grid Henan Electric Power Research Institute Zhengzhou 450052China

A novel double side friction stir Z shape lap-butt welding(DS-FSZW)process was proposed to achieve excellent mechanical properties of Al/Cu medium-thick dissimilar *** influence of welding parameters on weld microstructure and properties of DS-FSZW joint were systematically *** indicated that defect-free medium-thick Al/Cu DS-FSZW joint could be achieved under an optimal welding ***-FSZW joint was prone to form void defects in the bottom of the second-pass *** recrystallization mechanisms at the top and middle of the weld nugget zone(WNZ)were continuous dynamic recrystallization(CDRX)and geometric dynamic recrystallization(GDRX).While the major recrystallization mechanism at the bottom of the WNZ was ***-FSZW joint of the optimal welding condition with 850 r/min-400 mm/min was produced with a continuous thin and crack-free IMCs layer at the Al/Cu interface,and the maximum tensile strength of this joint is 160.57 MPa,which is equivalent to 65.54%of pure Cu base ***,the corrosion resistance of Al/Cu DS-FSZW joints also achieved its maximum value at the optimal welding parameter of 850 r/min-400 mm/*** demonstrates that the DS-FSZW process can simultaneously produce medium-thick Al/Cu joints with excellent mechanical performance and corrosion resistance.

关键词： DS-FSZW Al/Cu dissimilar joint Corrosion behaviour Intermetallic compounds Microstructure Mechanical properties

Erosion Wear Behaviour of Kenaf/Glass Hybrid Polymer Composites

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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 78-89页

作者： Chandrakanta Mishra Deepak kumar Mohapatra Chitta Ranjan Deo Punyapriya Mishra Kiran kumar Ekka Department of Mechanical Engineering Veer Surendra Sai University of TechnologySambalpur 768018India

The awareness amongst the researchers to develop an environment friendly sustainable material leads to explore new class of plant-based fiber for making composites. Hybridization of such plant-based fiber with inclusion of engineered fiber is one of the promising methods to not only enhanced the mechanical performance but also suppressed the drawbacks that associate with such plant-based fiber to some extent. A usual hand lay-up method was taken-up in this work to fabricate four layered of hybrid kenaf(K)/glass(G)polyester laminates with different stacking order such as KKKK,KGKG,KGGK,GKKG and GGGG. The erosive character of the laminates was examined under three distinct particle velocities(48m/s, 70m/s,82m/s)and four different impact angles(30°, 45°, 60°, 90°). All fabricated laminates exhibited a semiductile character at lower velocities(48m/s and70m/s)as peak wear rate was observed at45° impact angle. However,they showed a semi-brittle character at high velocity(82m/s)as maximum rate of erosion was noticed at60° impact angle. Again,the influence of stacking order of piles on erosion wear was also clearly noticed. Moreover,the semi-brittle/semi-ductile characterization was also evidenced in accordance to the range of erosion efficiencies. The micro-structures of worn surfaces were inspected thoroughly from the images of scanning electron microscope(SEM)to evident the mechanism of erosion.

关键词： hybrid composites erosion wear void micro⁃hardness

Performance Improvement of Kenaf/Glass Polymer Hybrid Composites by Effective Application of Fish Scale Powder as Filler:A Novel Approach

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Journal of Harbin Institute of Technology(New Series) 2024年第3期31卷 80-96页

作者： Chandrakanta Mishra Deepak kumar Mohapatra Chitta Ranjan Deo Chetana Tripathy Kiran kumar Ekka Department of Mechanical Engineering Veer Surendra Sai University of TechnologySambalpur 768018OdishaIndia

Modern technology for developing new items made from renewable resources is becoming more and more popular as a result of rising environmental ***,contemporary polymer composites have included the hybridization of natural fibers with synthetic ones,along with the inclusion of a variety of biowaste filler for developing sustainable *** this work,the kenaf/glass hybrid polyester composites are strengthened by the addition of fish scale(FS),which is taken from the fish􀆳s outermost layer of *** different stacked-order laminates,such as KKKK,KGKG,GKKG,KGGK,and GGGG,are fabricated by using the hand lay-up method with four different weight concentrations of filler content:0%,5%,10%,and 15%.Mechanical possessions such as tensile,flexural,impact strength and micro-hardness have been evaluated through experimentation in accordance with ASTM *** experimental findings revealed that,the tensile strength and micro-hardness value of KGKG laminates with 15wt% of FS filler are found to be maximum of 118.72 MPa and 17.82 HV respectively which are 39.67%and 26.11%greater than that of KGKG laminates without FS ***,the flexural and impact strength of same laminates with 10 wt% FS filler exhibited a maximum value of 142.77 MPa and 62.08 kJ/m^(2).In order to corroborate its applicability for structural and building materials in open environment,the dimensional stability of the composite has been studied through moisture absorption *** influences of FS filler loading on dimensional stability and resistance to moisture absorption capacity of laminates are also *** experimental results reflected that the addition of FS-filler has significantly improved the dimensional stability of the laminates in moist environment by reducing the moisture absorption *** further support the mode of failures,a fractography investigation of fractured surfaces was conducted.

关键词： fish scale fiber polyester hybrid composites mechanical properties

Evaluation of Dielectric Properties of CCTO-BT/Epoxy Composites for Electronic Applications

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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 69-77页

作者： Swagatika Mishra Punyapriya Mishra Punyatoya Mishra Dinesh kumar Mishra Krushna Prasad Shadangi Deepak kumar Mohapatra Department of Mechanical Engineering Veer Surendra Sai University of TechnologyBurlaOdisha 768018India Department of Physics Parala Maharaja Engineering CollegeBerhampurOdisha 761003India Department of Metallurgical and Materials Engineering Veer Surendra Sai University of TechnologyBurlaOdisha768018India Department of Chemical Engineering Veer Surendra Sai University of TechnologyBurlaOdisha 768018India

In the current study,the calcium copper titanate(CCTO)/epoxy,barium titanate(BT)/epoxy and CCTO-BT/epoxy composite samples with variable volume fractions of CCTO and BT are fabricated using hand lay-up and compression moulding process. The composite samples are characterized for the frequency dependence on dielectric properties,conductivity,impedance spectroscopy and electrical modulus.X-ray diffraction(XRD)representation of CCTO-BT/epoxy composite samples confirmed the presence of both CCTO and BT ceramic samples separately. The dielectric characteristics of hybrid CCTO-BT/epoxy composite samples with CCTO∶BT ratio of 40∶60, 60∶40,and 50∶50 was found relatively better than those of single ceramic filler reinforced epoxy composites. AC conductivity analysis shows improvement in the results of hybrid filler-filled CCTO-BT/epoxy composites in comparison with single filler-filled epoxy composite.50∶50 CCTO-BT/epoxy composite shows the best AC conductivity value of~ 2.2 ×10^(-5) ohm^(-1)·m^(-1) at a higher frequency of 1MHz. The impedance analysis confirms the higher insulating properties for hybrid 40∶60 and 60∶40 CCTO-BT/epoxy composites with respect to the single and other hybrid ceramic epoxy composites. The analysis suggests the hybrid CCTO-BT/epoxy composites to be adopted as a potential dielectric material for energy storage devices and other electronic applications.

关键词： ceramic filler dielectric characterization hybrid Composite AC conductivity impedance analysis

Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease

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World Journal of Diabetes 2024年第7期15卷 1603-1614页

作者： Dharmsheel Shrivastav Satyam kumar Kumbhakar Shivangi Srivastava Desh Deepak Singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002RajasthanIndia Department of Biotechnology Govt Veer Surendra Say P.G.CollegeGariaband 493889ChhattisgarhIndia Department of Life Science Chhatrapati Shahu ji Maharaj UniversityKanpur 208024Uttar PradeshIndia

BACKGROUND Type 2 diabetes(T2D)is a metabolic disease of impaired glucose utilization and a major cause of cardiovascular disease(CVD).The pathogenesis of both diseases shares common risk factors and mechanisms,and both are significant contributors to global morbidity and *** of natural products for T2D mellitus(T2DM)and CVD can be seen as a potential preventive and effective therapeutic *** To critically evaluate the therapeutic potential of natural products in T2D and coronary artery disease(CAD).METHODS By using specific keywords,we strategically searched the PubMed *** controlled trials(RCTs)were searched as the primary focus that examined the effect of natural products on glycemic control,oxidative stress,and antioxidant *** focused on outcomes such as low blood glucose levels,adjustment on markers of oxidative stress and *** screening fulllength papers,we included 9 RCTs in our review that met our inclusion *** In the literature search on the database,we found that various natural products like plant secondary metabolites play a diverse role in the management of *** ginseng,sesame oil and cocoa flavanols proved effective in lowering blood glucose levels and controlling blood pressure,which are key factors in managing T2DM and *** diabetic patients Melissa officinalis effectively reduce inflammation and shows diabetes *** fish oil and flaxseed oil reduced insulin levels and inflammatory markers,suggesting benefits for both *** lipid profile and endothelial function were enhanced by Nigella sativa oil and Terminalia chebula,which is significant for the management of cardiovascular risk factors in *** Bilberry extract also showed promise for improving glycemic control in patients with *** The high level of antioxidant,anti-inflammatory,and anti-angiogenic properties found in natural products makes them promising therapeutic opt

关键词： Type 2 diabetes mellitus Cardiovascular disease Natural products Antioxidants Oxidative stress Therapeutic impact Global burden

miR-106b as an emerging therapeutic target in cancer

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Genes & Diseases 2022年第4期9卷 889-899页

作者： surendra kumar Sagar Department of Zoology Swami Shraddhanand CollegeUniversity of DelhiDelhi 110036India

MicroRNAs (miRNAs) comprise short non-coding RNAs that function in regulating the expression of tumor suppressors or oncogenes and modulate oncogenic signaling pathways in cancer. miRNAs expression alters significantly in several tumor tissues and cancer cell lines. For example, miR-106b functions as an oncogene and increases in multiple cancers. The miR-106b directly targets genes involved in tumorigenesis, proliferation, invasion, migration, and metastases. This review has focused on the miR-106b function and its downstream target in different cancers and provide perspective into how miR-106 regulates cancer cell proliferation, migration, invasion, and metastases by regulating the tumor suppressor genes. Since miRNAs-based therapies are currently being developed to enhance cancer therapy outcomes, miR-106b could be an attractive and prospective candidate in different cancer types for detection, diagnosis, and prognosis assessment in the tumor.

关键词： Apoptosis Cancer Metastases miRNA Oncogene Tumor suppressor

Wavelet Synchro-squeezing Transform and Dynamic Threshold Supported Symmetrical Power Swing Technique for Modern Transmission Network

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Chinese Journal of Electrical Engineering 2024年第2期10卷 30-43页

作者： Monalisa Biswal kumar Raja Andanapalli Papia Ray Department of Electrical Engineering National Institute of Technology RaipurChhattisgarh 492010India Department of Electrical Engineering Veer Surendra Sai University of TechnologyBurla Sambalpur 768018India

Distance relays are prone to symmetrical power swing *** mitigate this issue,a dynamic threshold-supported algorithm is proposed.A single logic is not supposed to be secure for all ***,a supervisory algorithm,as proposed in this study,can aid in the improvement of the immunity of the relay during swing cases and be sensitive to symmetrical *** the developed stages,a three-phase power signal was used and processed in two different steps:(i)extraction of the effective intrinsic mode function(IMF)selected from the Kurtosis analysis using the wavelet synchro-squeezing transform,and(ii)estimation of the average Euclidean distance index using the absolute values of the decomposed IMF’*** adaptive threshold facilitated resistance to swing *** the onset of a symmetrical fault,the proposed algorithm efficiently discriminated among events using a dynamic *** IEEE 39-bus test system and Indian Eastern Power Grid networks were modelled using PSCAD software,and cases were generated to test the efficacy of the *** impact of the proposed method on a large-scale wind farm was also evaluated.A comparative analysis with other existing methods revealed the security and dependability of the proposed method.

关键词： Distance relays symmetrical power swing wind farm wavelet synchro-squeezing transform(WSST) Euclidean distance

Erosive Wear Study of PPLSF/Glass Fiber Reinforced Hybrid Laminates

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Journal of Harbin Institute of Technology(New Series) 2024年第2期31卷 68-79页

作者： Chetana Tripathy Deepak kumar Mohapatra Chitta Ranjan Deo Punyapriya Mishra Department of Mechanical Engineering Veer Surendra Sai University of Technology(VSSUT)Sambalpur 768018India

This work is focused to examine the erosive performance of hybrid Palmyra palm leaf stalk fiber(PPLSF)/glass polyester laminate against solid particle bombardment.A hand lay-up method was adopted for the fabricating four piles of five distinct laminates with different stacking order glass and PPLSF *** them,one group of pure PPLSF and pure E-glass laminates were *** hybrid laminates were exposed to high speed stream of solid sand particle at three distinct impact velocities(48,70 and 82 m/s)and four different angles of impingement(30°,45°,60°and 90°).The effect of particle velocity,angle of impingement and stacking order on both wear rate and efficiency were *** experimental assessment reveals a significant improvement in erosive wear resistance properties due to hybridization of PPLSF with ***,the laminates with PPLSF layer as skin and glass as core layer exhibited better erosive wear resistance properties than other types of ***,a maximum value of erosion at lower velocity(48 m/s)is also noticed at 45°impingement ***,at high velocity of impact 70 m/s and 82 m/s,the maximum rate of erosion has been shifted from 45°impact angle to 60°impact *** alternation of this semi-ductile character to semi-brittle character is evidenced by analyzing the experimental *** to justify the mode of erosion,the eroded surface samples were inspected by scanning electron microscope(SEM).

关键词： hybrid composites erosion wear void micro-hardness SEM