检索结果-南通市图书馆

Gefitinib(an EGFR tyrosine kinase inhibitor)plus anlotinib(an multikinase inhibitor)for untreated,EGFR-mutated,advanced non-small cell lung cancer(FL-ALTER):a multicenter phase III trial

引用

Signal Transduction and Targeted Therapy 2024年第9期9卷 4091-4102页

作者： Hua-Qiang Zhou Ya-Xiong Zhang Gang Chen Qi-Tao Yu Hua Zhang Guo-Wu Wu Di Wu Ying-Cheng Lin Jun-Fei Zhu Jian-Hua Chen Xiao-Hua Hu Bin Lan Ze-Qiang Zhou Hai-Feng Lin Zi-Bing Wang Xiao-Lin Lei suo-ming pan Li-ming Chen Jian Zhang Tian-Dong Kong Ji-Cheng Yao Xin Zheng Feng Li Li Zhang Wen-Feng Fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Medical Oncology of Respirotary Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021China Department of Urogenital Oncology the First People’s Hospital of FoshanFoshan 52800China Department of Medical Oncology Meizhou People’s Hospital(Huangtang Hospital)Meizhou 514031China Department of Respiratory and Critical Care Medicine Shenzhen people’s HospitalShenzhen 518020China Department of Medical Oncology of Respirotary Cancer Hospital of Shantou University Medical CollegeShantou 515031China Department of Respiratory and Critical Care Medicine Taizhou Central HospitalTaizhou 318000China Department of Medical Oncology Hunan Provincial Cancer HospitalChangsha 410031China Department of Medical Oncology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Cardiothoracic Surgery Shantou Central HospitalShantou 515031China Department of Oncology the 2nd People’s Hospital of ShenzhenShenzhen 518025China Department of Medical Oncology the Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450003China Department of Oncology Affiliated Hospital of Panzhihua UniversityPanzhihua 617099China Department of Radiotherapy Yuebei People’s HospitalShaoguan 512099China Department of Oncology the First Affiliated Hospital of Shantou University Medicine CollegeShantou 515041China Department of Oncology ZhuJiang Hospital of Southern Medical University(The Second Clinical Medical College)Guangzhou 510280China Department of Respiratory Oncology the Third People’s Hospital of ZhengzhouZhengzhou 450001China Shanghai OrigiMed Co. LtdShanghaiChina

Dual inhibition of vascular endothelial growth factor and epidermal growth factor receptor(EGFR)signaling pathways offers the prospect of improving the effectiveness of EFGR-targeted *** this phase 3 study(***:NCT04028778),315 patients with treatment-naïve,EGFR-mutated,advanced non-small cell lung cancer(NSCLC)were randomized(1:1)to receive anlotinib or placebo plus gefitinib once daily on days 1–14 per a 3-week *** the prespecified final analysis of progression-free survival(PFS),a significant improvement in PFS was observed for the anlotinib arm over the placebo arm(hazards ratio[HR]=0.64,95%CI,0.48–0.80,P=0.003).Particularly,patients with brain metastasis and those harboring EGFR amplification or high tumor mutation load gained significant more benefits in PFS from gefitinib plus *** incidence of grade 3 or higher treatment-emergent adverse events was 49.7%of the patients receiving gefitinib plus anlotinib versus 31.0%of the patients receiving gefitinib plus *** plus gefitinib significantly improves PFS in patients with treatment-naïve,EGFR-mutated,advanced NSCLC,with a manageable safety profile.

关键词： cancer lung treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

引用

Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng Li Chunyan Chen Zhenyang Li Peng Yi Haihan Zou Gao Deng ming Fang Junzhe He Xin Sun Ronghai Yu Jianglan Shui Caofeng pan Xiaofang Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synergistic effect of silicon availability and salinity on metal adsorption in a common estuarine diatom

引用

Journal of Environmental Sciences 2025年第2期148卷 364-374页

作者： Fengyuan Chen Jie Ma Ke pan SZU-HKUST Joint PhD Program in Marine Environmental Science Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Department of Ocean Science The Hong Kong University of Science and TechnologyHong Kong 999077China

Increasing nitrogen and phosphorus discharge and decreasing sediment input have made silicon(Si)a limiting element for diatoms in *** in nutrient structure and salinity fluctuation can greatly affect metal uptake by estuarine ***,the combined effects of Si and salinity on metal accumulation in these diatoms have not been *** this study,we aimed to investigate how salinity and Si availability combine to influence the adsorption of metals by a widely distributed diatom Phaeodactylum *** data indicate that replete Si and low salinity in seawater can enhance cadmium and copper adsorption onto the diatom *** the single-cell level,surface potential was a dominant factor determining metal adsorption,while surface roughness also contributed to the highermetal loading capacity at lower *** a combination of noninvasive micro-test technology,atomic force microscopy,X-ray photoelectron spectroscopy,and Fourier transform infrared spectroscopy,we demonstrate that the diversity and abundance of the functional groups embedded in diatom cell walls vary with salinity and Si *** results in a change in the cell surface potential and transient metal *** study provides novel mechanisms to explain the highly variable metal adsorption capacity of a model estuarine diatom.

关键词： Diatom Metal adsorption Silicon Salinity Functional group Surface potential

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seismic isolation design and resilience improvement of railway station considering the influence of near-fault pulse-like ground motions

引用

Earthquake Engineering and Engineering Vibration 2025年第1期24卷 257-270页

作者： pan Yi Song Jiayu Chen Qi Liu Yongxin School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Key Laboratory of Seismic Engineering of Sichuan Province Chengdu 610031China

To improve the resilience of railway stations,a typical station was selected as the research object,and an isolation design was ***-four groups of near-fault pulse-like ground motions were *** seismic resilience of the no-isolation railway stations(NIRS)and the isolation railway stations(IRS)were compared to provide a numerical result of the improvement in *** results show that in the station isolation design,the station's functional requirements and structural characteristics should be considered and the appropriate placement of isolation bearings is under the waiting *** the action of a rare earthquake,the repair cost,repair time,rate of harm and death of the IRS were decreased by 8.04 million,18.30 days,6.93×10^(-3)and 1.21×10^(-3),respectively,when compared to the *** IRS received a seismic resilience grade of three-stars and the NIRS only one-star,indicating that rational isolation design improves the seismic resilience of ***,for the design of stations close to earthquake faults,it is suggested to utilize appropriate isolation techniques to improve their seismic resilience.

关键词： railway station near-fault pulse-like ground motion isolation design seismic resilience resilience improvement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuromodulation with chemicals: Opportunities and challenges

引用

Fundamental Research 2025年第1期5卷 55-62页

作者： pan, Yifei pan, Cong Mao, Lanqun Yu, Ping Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China College of Chemistry Beijing Normal University Beijing 100875 China

Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This review introduces several chemical modulation techniques, such as microinjection, electrode/nanoparticle-based chemical delivery methods, in situ electrochemical synthesis and chemogenetics. While these techniques show promise in expanding the application of chemical neuromodulation, they currently exhibit different degrees of shortcomings and room for improvement. This review summarizes the opportunities and challenges for chemical neuromodulation methods and provide an outlook for their prospects in the future. © 2024

关键词： Brain chemistry Chemical delivery In vivo Neurochemistry Neuromodulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H_(2)O_(2) synthesis coupled with biomass valorization

引用

Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li Shuang pan Yihuang Chen Qiong Liu College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035ZhejiangChina Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology(China) Institute of AnalysisGuangdong Academy of Sciences(China National Analytical CenterGuangzhou)Guangzhou 510070GuangdongChina

Photocatalytic oxygen reduction for hydrogen peroxide(H_(2)O_(2))synthesis presents a green and costeffective production ***,achieving highly selective H_(2)O_(2)synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H_(2)O_(2)and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride(CNRb).The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h^(-1)for H_(2)O_(2)generation and photooxidation rate of 3.75 mM h^(-1)for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion(SCC)efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H_(2)O_(2)coupled with biomass valorization.

关键词： Atomic economy Radical pathway regulation Photocatalytic H_(2)O_(2)synthesis Rubidium atom coordination Biomass valorization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Airborne fungal communities are more susceptible to anthropogenic activities than bacteria

引用

Journal of Environmental Sciences 2025年第3期149卷 564-573页

作者： Yuanyuan pan Zhiwei Zuo Xueyun Huang Renguo Zhu School of Water Resources&Environmental Engineering East China University of TechnologyNanchang 330013China Jiangxi Province Key Laboratory of the Causes and Control of Atmospheric Pollution East China University of TechnologyNanchang 330013China

Airborne microorganisms(AM)have significant environmental and health *** studies have been conducted to investigate the factors influencing the composition and diversity of ***,the knowledge of AM with anthropogenic activities has not reach a *** this study,we took advantage of the dramatic decline of outdoor anthropogenic activities resulting from COVID-19 lockdown to reveal their *** collected airborne particulate matter before and during the lockdown period in two *** results showed that it was fungal diversity and communities but not bacteria obviously different between pre-lockdownand lockdown samples,suggesting that airborne fungiwere more susceptible to anthropogenic activities than ***,after the implementation of lockdown,the co-occurrence networks of both bacterial and fungal community became more complex,whichmight be due to the variation of microbial ***,Mantel test and correlation analysis showed that air pollutants also partly contributed to microbial *** fungal community was more affected by air pollutants than bacterial ***,some human pathogens like Nigrospora and Arthrinium were negatively correlated with air ***,our study highlighted the more impacts of anthropogenic activities on airborne fungal community than bacterial community and advanced the understanding of associations between anthropogenic activities and AM.

关键词： COVID-19 lockdown Anthropogenic activities Airborne microorganisms Response Air pollutants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of axon guidance molecules in the pathogenesis of epilepsy

引用

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent progress in flexible sensors based on 2D materials

引用

Journal of Semiconductors 2025年第1期46卷 130-142页

作者： Xiang Li Guancheng Wu Caofeng pan Rongrong Bao School of Physics Beihang UniversityBeijing 100191China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

With the rapid development of the internet of things(IoT)and wearable electronics,the role of flexible sensors is becoming increasingly irreplaceable,due to their ability to process and convert information ***-dimensional(2D)materials have been widely welcomed by researchers as sensitive layers,which broadens the range and application of flexible sensors due to the advantages of their large specific surface area,tunable energy bands,controllable thickness at the atomic level,stable mechanical properties,and excellent optoelectronic *** review focuses on five different types of 2D materials for monitoring pressure,humidity,sound,gas,and so on,to realize the recognition and conversion of human body and environmental ***,the main problems and possible solutions of flexible sensors based on 2D materials as sensitive layers are summarized.

关键词： 2D materials flexible sensors layered structure solution method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine learning based damage state identification:A novel perspective on fragility analysis for nuclear power plants considering structural uncertainties

引用

Earthquake Engineering and Engineering Vibration 2025年第1期24卷 201-222页

作者： Zheng Zhi Wang Yong pan Xiaolan Ji Duofa College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Lab of Structures Dynamic Behavior and Control(Harbin Institute of Technology) Ministry of EducationHarbin 150090China Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin 150090China

Seismic fragility analysis(SFA)is known as an effective probabilistic-based approach used to evaluate seismic *** are various sources of uncertainties associated with this approach.A nuclear power plant(NPP)system is an extremely important infrastructure and contains many structural uncertainties due to construction issues or structural deterioration during *** of structural uncertainties effects is a costly and time-consuming endeavor.A novel approach to SFA for the NPP considering structural uncertainties based on the damage state is proposed and *** results suggest that considering the structural uncertainties is essential in assessing the fragility of the NPP structure,and the impact of structural uncertainties tends to increase with the state of ***,machine learning(ML)is found to be superior in high-precision damage state identification of the NPP for reducing the time of nonlinear time-history analysis(NLTHA)and could be applied in the damage state-based ***,the impact of various sources of uncertainties is investigated through sensitivity *** Sobol and Shapley additive explanations(SHAP)method can be complementary to each other and able to solve the problem of quantifying seismic and structural uncertainties simultaneously and the interaction effect of each parameter.

关键词： seismic fragility analysis damage state structural uncertainties machine learning sensitivity analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：