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Comparison of macular changes according to the etiology of optic neuritis:a cross-sectional study

International Journal of Ophthalmology(English edition) 2024年第4期17卷 686-692页

作者： Yeji Moon sung-min kim Jae Ho Jung Department of Ophthalmology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Neurology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul 03080Republic of Korea

AIM:To compare the macular structure including foveal thickness among patients with optic neuritis(ON)according to the etiology and to investigate the possible correlation between structural and visual outcomes METHODS:In this retrospective cross-sectional study,the clinical data of patients with aquaporin-4 immunoglobulin G-related ON(AQP4 group,40 eyes),myelin oligodendrocyte glycoprotein IgG-related ON(MOG group,31 eyes),and multiple sclerosis-related ON(MS group,24 eyes)were *** retinal thickness of the foveal,parafoveal and perifoveal regions were *** acuity(VA),visual field index and mean deviation were measured as visual ***:The AQP4 group showed a significantly thinner fovea(226.4±13.4μm)relative to the MOG(236.8±14.0μm,P=0.015)and MS(238.9±14.3μm,P=0.007)*** thickness in the parafoveal area also was thinner in the AQP4 group,though the difference in perifoveal retinal thickness was not *** thickness was correlated with VA in the AQP4 group(coefficientρ=-0.418,P=0.014),but not in the MOG and MS groups(P=0.218 and P=0.138,respectively).There was no significant correlation between foveal thickness and visual field test in all three ***:The significant thinning in the fovea and parafoveal areas in the AQP4 group compared to the MOG and MS groups are ***,macular changes in AQP4-ON show a significant correlation with *** results provide the possibility that retinal structural damage could reflect functional damage in AQP4-ON,distinct from MOGON and MS-ON.

关键词： foveal thickness optic neuritis aquaporin-4 immunoglobulin myelin oligodendrocyte glycoprotein multiple sclerosis

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Dynamic simulation of universal spacer in Dynesys dynamic stabilization system for human vertebra

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中国有色金属学会会刊：英文版 2009年第B09期19卷 238-242页

作者： sung-min kim In-Chul YANG Seung-Yeol LEE sung-Youn CHO Department of Medical Bio Engineering College of BiosystemDongguk University Research Institute of Biotechnology Dongguk University Department of Advanced Technology Fusion Graduate SchoolKonkuk University Research and Development Center U& I Corporation

The aim of this study is to analyze the simulated behavior of universal spacer in Dynesys dynamic stabilization system inserted in human vertebra. Dynesys, so-called "Dynamic neutralization system for the spine", dynamic stabilization system is a new concept in the surgical treatment of lower back pain recently. Universal spacer used as flexible material is to stabilize the spine and the material property of universal spacer is polycarbonate urethane. Universal spacer may apply different kinematic behaviors at implanted level in vertebra. Spinal range of motion(SROM) of inter-vertebra with installed Dynesys dynamic stabilization system was studied using Adams+LifeMOD as simulation software package. The vertebra model was set up to closely resemble the in-vivo conditions. Inter-vertebra rotations were measured by post processor of Adams and compared with the intact values. SROMs of the flexion, extension, lateral bending, and axial rotation of human virtual models were measured, where three spinal fixation systems such as rigid system, Dynesys system, and fused system were installed. As a result, the value of SROM is decreased in flexion-extension and lateral bending when the spinal fixation system is implanted. The movement of Dynesys system is similar to that of intact model by allowing the movement of lumbar. This means that the Dynesys system is proved to be safe and effective in the treatment of unstable spinal condition.

关键词：稳定系统动态模拟间隔人类脊椎聚碳酸酯聚氨酯运动行为旋转模型

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Electrochemical characteristics of HVOF spray coated layer with WC-27NiCr and WC-10Co4Cr for Al bronze

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中国有色金属学会会刊：英文版 2012年第S3期22卷 753-759页

作者： min-su HAN Seung-jun LEE min-sung kim Seok-ki JANG Seong-jong kim Division of Marine Engineering Mokpo Maritime University

Among the environmentally friendly marine energies,tidal current power plants require low cost because they do not need to construct a large *** power is particularly reliable energy source because the power generation capacity is predictable regardless of weather or *** materials or stainless steel have been used as materials of blades for current power ***,their strength and welding performance generated many problems in field *** alloys with excellent cavitation resistance and corrosion resistance were applied as blade materials to improve the durability of copper *** were coated with WC-27NiCr and WC-10Co4Cr using the high velocity oxy-fuel (HVOF) *** metal spray coating technology has the advantage in terms of the selection of materials for cost effectiveness and environmental effects of corrosion because the properties of the coat layer can be controlled *** with WC-27NiCr and WC-10Co4Cr by HVOF,WC-27NiCr shows better corrosion resistance *** reason for this seems to be that corrosion resistance improves and a stable passive film forms due to the effects of Ni and Cr.

关键词： tidal power copper alloys HVOF coating corrosion resistance

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Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul Song min sung kim Seungwon Yoo Ja Hoon Koo Dae-Hyeong kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

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Ni Single Atoms and Ni Phosphate Clusters Synergistically Triggered Surface-Functionalized MoS_(2)Nanosheets for High-performance Freshwater and Seawater Electrolysis

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Energy & Environmental Materials 2022年第4期5卷 1340-1349页

作者： min sung kim Duy Thanh Tran Thanh Hai Nguyen Van An Dinh Nam Hoon kim Joong Hee Lee Department of Nano Convergence Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Precision Engineering Graduate School of EngineeringOsaka University2-1Yamada-okaSuita 565-0871Japan Carbon Composite Research Center Department of Polymer-Nanoscience and TechnologyJeonbuk National UniversityJeonju 54896Republic of Korea

Two-dimensional metal dichalcogenides have been evidenced as potential electrocatalysts for hydrogen evolution reaction(HER);however,their application is limited by a poor oxygen evolution reaction(OER)activity due to insufficient number/types of multi-integrated active *** this study,we report a novel bifunctional catalyst developed by simultaneous engineering of single nickel atoms(Ni_(SA)) and nickel phosphate clusters(Ni_(Pi)) to synergistically trigger surface-functionalized MoS_(2) nanosheets(NSs)resulting in high reactivities for both HER and *** Ni_(SA)-Ni_(Pi)/MoS_(2)NSs material exhibits a fairly Pt-like HER behavior with an overpotential of 94.0 mV and a small OER overpotential of 314.0 mV to reach 10 mA cm^(-2) in freshwater containing 1.0 M *** results of the catalyst are well supported by theoretical study,which reveals the significant modulation of electronic structure and enrichment of electroactive site number/types with their reasonably adjusted free adsorption *** evaluating practicability,the Ni_(SA)-Ni_(Pi)/MoS_(2)NSs-based electrolyzer delivers effective operation voltage of 1.62,1.52,and 1.66 V at 10 mA cm^(-2) and superior long-term stability as compared to Pt/C//RuO_(2) system in freshwater,mimic seawater,and natural seawater,*** present study indicates that the catalyst is a promising candidate for the practical production of green hydrogen via water electrolysis.

关键词： bifunctional electrocatalyst freshwater and seawater electrolysis nickel phosphate clusters nickel single atoms surface-functionalized-MoS_(2)nanosheets

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Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control

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Journal of Sport and Health Science 2024年第4期13卷 559-568,F0003页

作者： Kyung-min kim Joo-sung kim Alan R.Needle Department of Sport Science Sungkyunkwan UniversitySuwon-si 16419Republic of Korea Department of Health and Human Performance Texas State UniversitySan MarcosTX 78666USA Department of Public Health&Exercise Science Appalachian State UniversityBooneNC 28608USA Department of Rehabilitation Science Appalachian State UniversityBooneNC 28608USA

Background:Acute lateral ankle sprains(ALAS)are associated with long-term impairments and instability tied to altered neural *** muscle inhibition(AMI)has been observed in this population;however,relationships with injury-related impairments are unclear,potentially due to the resting,prone position in which AMI is typically *** AMI during bipedal stance may provide a better understanding of this ***:AMI was assessed in 38 young adults(19 ALAS within 72 h of injury:10 males,21.4±2.7 years;19 healthy controls:10 males,21.9±2.2 years;mean±SD)using the Hoffmann reflex(H-reflex)during bipedal *** stimulation was administered to identify the _(max)imal H-reflex(H_(max))and _(max)imal motor response(M_(max))from the soleus,fibularis longus,and tibialis anterior *** primary outcome measure was the H_(max)/M_(max) *** outcomes included acute symptoms(pain and swelling),postural control during bipedal stance,and self-reported ***:No significant group-by-limb interactions were observed for any ***,a significant group main effect was observed in the soleus muscle(F(1,35)=6.82,p=0.013),indicating significantly lower H_(max)/M_(max) ratios following ALAS(0.38±0.20)compared to healthy controls(0.53±0.16).Furthermore,lower H_(max)/M_(max) ratios in the soleus significantly correlated with acute symptoms and self-reported function but not with postural ***:This study supports previous evidence of AMI in patients with ALAS,providing insight into neurophysiologic impacts of musculoskeletal *** results suggest that assessing AMI in a standing position following acute injury may provide valuable insight into how AMI develops and guide potential therapeutic options to curb and offset the formation of joint instability.

关键词： Acute injuries Balance Hoffmann reflex Neural excitability Patient-reported outcomes

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Controlling the contact levels of details for fast and precise haptic collision detection

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Frontiers of Information Technology & Electronic Engineering 2017年第8期18卷 1117-1130页

作者： A Ram CHOI sung min kim Mee Young sung Department of Computer Science and Engineering lncheon National University lncheon Korea

For accurate and stable haptic rendering, collision detection for interactive haptic applications has to be done by filling in or covering target objects as tightly as possible with bounding volumes （spheres, axis-aligned bounding boxes, oriented bounding boxes, or polytopes）. In this paper, we propose a method for creating bounding spheres with respect to the contact levels of details （CLOD）, which can fit objects while maintaining the balance between high speed and precision of collision detection. Our method is composed mainly of two parts： bounding sphere formation and two-level collision detection. To specify further, bounding sphere formation can be divided into two steps： creating spheres and clustering spheres. Two-level collision detection has two stages as well： fast detection of spheres and precise detection in spheres. First, bounding spheres are created for initial fast probing to detect collisions of spheres. Once a collision is probed, a more precise detection is executed by examining the distance between a haptie pointer and each mesh inside the colliding boundaries. To achieve this refmed level of detection, a special data structure of a bounding volume needs to be defined to include all mesh information in the sphere. After performing a number of experiments to examine the usefulness and performance of our method, we have concluded that our algorithm is fast and precise enough for haptic simulations. The high speed detection is achieved through the clustering of spheres, while detection precision is realized by voxel-based direct collision detection. Our method retains its originality through the CLOD by distance-based clustering.

关键词： Collision detection Haptic rendering Bounding sphere Clustering Contact levels of details (CLOD)

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Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease:pathologic roles and therapeutic implications

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Translational Neurodegeneration 2021年第4期10卷 643-665页

作者： Hyeon soo kim Sujin kim Soo Jung Shin Yong Ho Park Yunkwon Nam Chae won kim Kang won Lee sung-min kim In Duk Jung Hyun Duk Yang Yeong-min Park minho Moon Department of Biochemistry College of MedicineKonyang UniversityDaejeon 35365Republic of Korea Research Institute for Dementia Science Konyang UniversityDaejeon 35365Republic of Korea Dandi Bioscience Inc 6th Floor of Real Company Building66Achasan-roSungdong-guSeoulRepublic of Korea Harvard Neurology Clinic 294 Gwanggyojungang-roSuji-guYongin 16943Republic of Korea Department of Immunology School of MedicineKonkuk University268ChungwondaeroChungju-siChungcheongbuk-doRepublic of Korea

Alzheimer's disease(AD)is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive *** in the development of therapeutics targeting amyloid-β(Aβ)and tau;principal proteins inducing pathology in AD,suggest a paradigm shift towards the development of new therapeutic *** gram-negative bacteria and lipopolysaccharides(LPS)are attractive new targets for AD ***,an altered distribution of gram-negative bacteria and their LPS has been reported in AD ***,gram-negative bacteria and their LPS have been shown to affect a variety of AD-related pathologies,such as Aβ homeostasis,tau pathology,neuroinflammation,and ***,therapeutic approaches targeting gram-negative bacteria or gram-negative bacterial molecules have significantly alleviated AD-related pathology and cognitive *** multiple evidence showing that the gram-negative bacteria and their LPS play a crucial role in AD pathogenesis,the pathogenic mechanisms of gram-negative bacteria and their LPS have not been ***,we summarize the roles and pathomechanisms of gram-negative bacteria and LPS in ***,we discuss the possibility of using gram-negative bacteria and gram-negative bacterial molecules as novel therapeutic targets and new pathological characteristics for AD.

关键词： Alzheimer's disease Gram-negative bacteria Lipopolysaccharide Exotoxin Amyloid beta Tau

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Identification and comparison of the local physicochemical structures of transition metal-based layered double hydroxides for high performance electrochemical oxygen evolution reactions

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Journal of Energy Chemistry 2023年第12期87卷 89-97,I0004页

作者： min sung kim Bipin Lamichhane Ju-Hyeon Lee Jin-Gyu Bae Jeong Yeon Heo Hyeon Jeong Lee Shyam Kattel Ji Hoon Lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea KNU Advanced Material Research Institute Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Department of Physics Florida A&M UniversityTallahasseeFlorida 32307United States

Layered double hydroxides(LDHs) have attracted considerable attention as a cost effective alternative to the precious iridium-and ruthenium-based electrocatalysts for an oxygen evolution reaction(OER),a bottleneck of water electrolysis for sustainable hydrogen *** their excellent OER performance,the structural and electronic properties of LDHs,particularly during the OER process,remain to be poorly *** this study,a series of LDH catalysts is investigated through in situ X-ray absorption fine structure analyses and density functional theory(DFT) *** experimental results reveal that the LDH catalyst with equal amounts of Ni and Fe(NF-LDH) exhibits the highest OER activity and catalytic life span when compared with its counterparts having equal amounts of Ni and Co(NC-LDH)and Ni only(Ni-LDH).The NF-LDH shows a markedly enhanced OER kinetics compared to the NC-LDH and the Ni-LDH,as proven by the lower overpotentials of 180,240,and 310 mV,respectively,and the Tafel slopes of 35.1,43.4,and 62.7 mV dec^(-1),*** DFT calculations demonstrate that the lowest overpotential of the NF-LDH is associated with the active sites located at the edge planes of NF-LDH in contrast to those located at the basal planes of Ni-LDH and *** current study pinpoints the active sites on various LDHs and presents strategies for optimizing the OER performance of the LDH catalysts.

关键词： Layered double hydroxides Oxygen evolution reaction In situ X-ray analyses Density functional theory Catalytic active sites

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Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis

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Molecular Plant 2021年第11期14卷 1951-1960页

作者： Arabidopsis Sera Choi Maxim Prokchorchik Hyeonjung Lee Ravi Gupta Yoonyoung Lee Eui-Hwan Chung Buhyeon Cho min-sung kim Sun Tae kim Kee Hoon Sohn Department of Life Sciences Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Plant Bioscience Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Department of Botany School of Chemical and Life SciencesJamia HamdardHamdard NagarNew Delhi 110062India Division of Biotechnology Korea UniversitySeoul 02841Republic of Korea The Institute of Crop Science and Resource Conservation(INRES) University of BonnNussallee 953115 BonnGermany

Plant pathogenic bacteria deliver effectors into plant cells to suppress immunity and promote pathogen survival;however, these effectors can be recognised by plant disease resistance (R) proteins to activate innate immunity. The bacterial acetyltransferase effectors HopZ5 and AvrBsT trigger immunity in Arabidopsis thaliana genotypes lacking SUPPRESSOR OF AVRBST-ELICITED RESISTANCE 1 (SOBER1). Using an Arabidopsis accession, Tscha-1, that naturally lacks functional SOBER1 but is unable to recognise HopZ5, we demonstrate that RESISTANCE TO P. SYRINGAE PV MACULICOLA 1 (RPM1) and RPM1-INTERACTING PROTEIN 4 (RIN4) are indispensable for HopZ5- or AvrBsT-triggered immunity. Remarkably, T166 of RIN4, the phosphorylation of which is induced by AvrB and AvrRpm1, was directly acetylated by HopZ5 and AvrBsT. Furthermore, we demonstrate that the acetylation of RIN4 T166 is required and sufficient for HopZ5- or AvrBsT-triggered RPM1-dependent defence activation. Finally, we show that SOBER1 interferes with HopZ5- or AvrBsT-triggered immunity by deacetylating RIN4 T166. We have thus elucidated detailed molecular mechanisms underlying the activation and suppression of plant innate immunity triggered by two bacterial acetyltransferases, HopZ5 and AvrBsT from different bacterial pathogens.

关键词： Acetyltransferase effectors Effector-triggered immunity Immunity suppressors NLR Plant deacetylase Plant immunity

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