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Celecoxib attenuates 5-fluorouracil-induced apoptosis in HCT-15 and HT-29 human colon cancer cells

World Journal of Gastroenterology 2007年第13期13卷 1947-1952页

作者： Yun Jeong lim Jong chul Rhee Young Mee Bae Wan Joo Chun Department of Internal Medicine Dongguk University International Hospital Dongguk University College of Medicine Goyang Korea Division of Gastroenterology Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Parasitology Seoul National University College of Medicine Seoul Korea Department of Pharmacology Kangwon National University College of Medicine Chuncheon Korea

AIM： To investigate the combined chemotherapeutic effects of celecoxib when used with 5-FU in vitro. METHODS： Two human colon cancer cell lines （HCT-15 and HT-29） were treated with 5-FU and celecoxib, alone and in combination. The effects of each drug were evaluated using the MTT （3-（4, 5-dimethylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide） assay, flow cytometry, and western blotting. RESULTS： 5-FU and celecoxib showed a dosedependent cytotoxic effect. When treated with 10-3 mol/L 5-FU （IC50） and celecoxib with its concentration ranging from 10.8 mol/L to 10.4 mol/L of celecoxib, cells showed reduced cytotoxic effect than 5-FU （10.3 mol/L） alone. Flow cytometry showed that celecoxib attenuated 5-FU induced accumulation of cells at subG1 phase. Western blot analyses for caspase-3 and poly （ADP-ribose） polymerase （PARP） cleavage showed that celecoxib attenuated 5-FU induced apoptosis. Western blot analyses for cell cycle molecules showed that G2/M arrest might be possible cause of 5-FU induced apoptosis and celecoxib attenuated 5-FU induced apoptosis via blocking of cell cycle progression to the G2/M phase, causing an accumulation of cells at the GI/S phase. CONCLUSION： We found that celecoxib attenuated cytotoxic effect of 5-FU. Celecoxib might act via inhibition of cell cycle progression, thus preventing apoptosis induced by 5-FU.

关键词： Antagonism Celecoxib Colorectal neoplasms Fluorouracil

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Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells

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Asian Journal of Andrology 2011年第5期13卷 742-746页

作者： Jung Jun Kim Deok Hyun Han Soo Hyun lim Tae Hun Kim Mee Ree Chae Kyung Jin Chung sung chul Kam Ju-Hong Jeon Jong Kwan Parks sung Won Lee Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seou1135-710 Korea Department of Urology Gachon University Gil Hospital Incheon 405-760 Korea Department of Urology Gyeengsang National University College of Medicine Gyeongsangnam-do 660-702 Korea Department of Physiology and Biophysics Seeul National University College of Medicine Seeul 110-799 Korea Department of Urology Medical School Chonbuk National University and Institute for Medical Sciences Chonbuk National University and Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University Hospital Jeonju-si 561-712 Korea

In this study, we investigated the effects of a combination of Ginkgo biloba extracts （GBE） and phosphodiesterase type 5 （PDE-5） inhibitors on the muscular tone of the corpus cavernosum and potassium channel activity of corporal smooth muscle cells. Strips of corpus cavernosum from male New Zealand white rabbits were mounted in organ baths for isometric tension studies. After contraction with 1 × 10^-5 mol I^-1 norepinephrine, GBE （0.01-1 mg ml^-1） and mirodenafil （0.01-100 nmol I^-1） were added together into the organ bath. In electrophysiological studies, whole-cell currents were recorded by the conventional patch-clamp technique in cultured smooth muscle cells of the human corpus cavernosum. The corpus cavemosum was relaxed in response to GBE in a dose-dependent manner （from 0.64%±8.35% at 0.01 mg ml^-1 to 52.28%±11.42% at 1 mg ml^-1）. After pre-treatment with 0.03 mg ml^-1 of GBE, the relaxant effects of mirodenafil were increased at all concentrations, After tetraethylammonium （TEA）（1 mmol I^-1） administration, the increased effects were inhibited （P〈0.01）. Extracellular administration of GBE increased the whole-cell K^＋ outward currents in a dose-dependent fashion. The increase of the outward current was inhibited by I mmol 1-1 TEA. These results suggest that GBE could increase the relaxant potency of mirodenafil even at a minimally effective dose. The K＋ flow through potassium channels might be one of the mechanisms involved in this synergistic relaxation.

关键词： calcium-activated potassium channels erectile dysfunction Ginkgo biloba phosphodiesterase inhibitors smooth muscles

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Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: a systematic review and meta-analysis

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Journal of Integrative Medicine 2015年第4期13卷 241-247页

作者： sung Min lim Sook-Hyun Lee Department of Clinical Research on Rehabilitation Korea National Rehabilitation Research Institute

BACKGROUND：Shoulder pain is a common complication of *** venom acupuncture（BVA）is increasingly used in the treatment of post-stroke shoulder ***：To summarize and evaluate evidence on the effectiveness of BVA in relieving shoulder pain after *** STRATEGY：Nine databases,namely MEDLINE,EMBASE,the Cochrane Library,the China National Knowledge Infrastructure（CNKI）,the Japan Science and Technology Information Aggregator,Electronic（J-STAGE）,and four Korean medical databases,namely,the National Assembly Library,the Research Information Service System,the National Discovery for Science Leaders,and OASIS,were searched from their inception through August 2014 without language *** CRITERIA：Randomized controlled trials（RCTs）were included if BVA was used at acupoints as the sole treatment,or as an adjunct to other treatments,for shoulder pain after *** EXTRACTION AND ANALYSIS：Two review authors independently selected trials for inclusion,assessed methodological quality and extracted ***：A total of 138 potentially relevant articles were identifi ed,4 of which were RCTs that met our inclusion *** quality of studies included was generally low,and a preponderance of positive results was *** four trials reported favorable effects of BVA on shoulder pain after *** RCTs assessing the effects of BVA on post-stroke shoulder pain,as opposed to saline injections,were included in the *** was signifi cantly lower for BVA than for saline injections（standardized mean difference on 10-cm visual analog scale：1.46 cm,95%CI=0.30–2.62,P=0.02,n=86）CONCLUSION：This review provided evidence suggesting that BVA is effective in relieving shoulder pain after ***,further studies are needed to confi rm the role of BVA in alleviating post-stroke shoulder *** studies should be conducted with large samples and rigorous study designs.

关键词： bee venoms acupuncture therapy stroke shoulder pain meta-analysis systematic review

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聚酯合成催化技术的研究进展

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高校化学工程学报 2024年第1期38卷 1-13页

作者：王翼嵩王松林姜冰雪李家旭邓维史胜斌 lim Khak Ho 王青月杨轩刘平伟王文俊浙江大学化学工程联合国家重点实验室浙江杭州310058 浙江大学衢州研究院浙江衢州324000 浙江恒逸石化有限公司浙江杭州311209

聚酯工业的进步离不开先进的催化技术。本文对聚酯合成催化体系的研究进展进行了评述。着眼于目前占主导的金属催化剂,对锑、钛、锡、锗、铝等催化剂在活性、副反应等方面所开展的金属复合、配体改性、载体负载等工作进行了总结,介绍了... 详细信息

聚酯工业的进步离不开先进的催化技术。本文对聚酯合成催化体系的研究进展进行了评述。着眼于目前占主导的金属催化剂,对锑、钛、锡、锗、铝等催化剂在活性、副反应等方面所开展的金属复合、配体改性、载体负载等工作进行了总结,介绍了有机物、离子液体、酶等非金属催化体系的研究进展,并对促进聚酯合成的电、光、微波等催化辅助技术进行了评述。催化能力强、副反应少、聚合条件温和催化体系的开发有助于聚酯品质的提升,将先进的表征手段、模型研究以及聚酯构效关系规律探索结合到催化体系的研究中,可加速高效聚酯催化技术的研发。

关键词：聚酯金属催化剂缩聚开环聚合非金属催化剂

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Application of Integrated Database to the Casting Design

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Journal of Materials Science & Technology 2008年第3期24卷 351-355页

作者： In-sung Cho Seung-Mok Yoo Chae-Ho lim Jeong-Kil Choi KITECH 7-47 Songdo-dongYeonsu-gu

Construction of integrated database including casting shapes with their casting design, technical knowledge, and thermophysical properties of the casting alloys were introduced in the present study. Recognition tech- nique for casting design by industrial computer tomography was used for the construction of shape database. Technical knowledge of the casting processes such as ferrous and non-ferrous alloys and their manufacturing process of the castings were accumulated and the search engine for the knowledge was developed. Database of thermophysical properties of the casting alloys were obtained via the experimental study, and the properties were used for the in-house computer simulation of casting process. The databases were linked with intelligent casting expert system developed in center for e-design, KITECH. It is expected that the databases can help non casting experts to devise the casting and its process. Various examples of the application by using the databases were shown in the present study.

关键词： Integrated database Casting design Shape recognition

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基于拉曼光谱技术的聚合物材料制备与组成分布的研究进展

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高校化学工程学报 2024年第3期38卷 341-353页

作者：卫人予陈八斤邓维吴徐冰包界杰张浩然吴彬王小君 lim Khak Ho 王文俊浙江大学工程师学院衢州分院浙江衢州324000 浙江大学衢州研究院浙江衢州324000 浙江传化化学集团浙江杭州311215 化学工程联合国家重点实验室(浙江大学) 浙江杭州310058

聚合物材料制备过程和聚合物中添加剂的含量及分布决定了材料的性能,拉曼光谱技术为相关研究提供了一种有效的表征手段。基于拉曼光谱的基本原理,介绍了表面增强拉曼光谱、拉曼光谱成像、激光显微共聚焦拉曼光谱等多种拉曼光谱衍生技术... 详细信息

聚合物材料制备过程和聚合物中添加剂的含量及分布决定了材料的性能,拉曼光谱技术为相关研究提供了一种有效的表征手段。基于拉曼光谱的基本原理,介绍了表面增强拉曼光谱、拉曼光谱成像、激光显微共聚焦拉曼光谱等多种拉曼光谱衍生技术,总结了相关技术在聚合物加工和聚合反应过程中的应用,评述了聚合物中添加剂分布的检测,涵盖了乳化剂、染料以及其他添加剂的浓度、分布及迁移规律等,并对拉曼光谱衍生技术进行了展望。

关键词：拉曼光谱显微拉曼光谱拉曼光谱成像技术聚合物材料添加剂

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V_(2)O_(3)/VN electrocatalysts with coherent heterogeneous interfaces for selecting low-energy nitrogen reduction pathways

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SusMat 2024年第4期4卷 90-103页

作者： Tae-Yong An Chengkai Xia Minyeong Je Hyunjung Lee Seulgi Ji Min-Cheol Kim Subramani Surendran Mi-Kyung Han Jaehyoung lim Dong-Kyu Lee Joon Young Kim Tae-Hoon Kim Heechae Choi Jung Kyu Kim Uk Sim Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuRepublic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Materials&Chemistry Group Institute of Inorganic ChemistryUniversity of CologneCologneGermany Department of Polymer Engineering Graduate SchoolAlan G.MacDiarmid Energy Research Institute&School of Polymer Science and EngineeringChonnam National UniversityGwangjuRepublic of Korea Research Institute NEEL SciencesJeollanamdoRepublic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangjuRepublic of Korea Department of Chemistry Xi’an Jiaotong-Liverpool UniversitySuzhouChina

Electrochemical nitrogen reduction reaction(NRR)is a sustainable alterna-tive to the Haber-Bosch process for ammonia(NH3)***,the significant uphill energy in the multistep NRR pathway is a bottleneck for favorable serial *** overcome this challenge,we designed a vanadium oxide/nitride(V_(2)O_(3)/VN)hybrid electrocatalyst in which V_(2)O_(3)and VN coex-ist coherently at the heterogeneous *** single-phase V_(2)O_(3)and VN exhibit different surface catalytic kinetics for NRR,the V_(2)O_(3)/VN hybrid elec-trocatalyst can provide alternating reaction pathways,selecting a lower energy pathway for each material in the serial NRR *** a result,the ammo-nia yield of the V_(2)O_(3)/VN hybrid electrocatalyst was 219.6µg h^(-1)cm^(-2),and the Faradaic efficiency was 18.9%,which is much higher than that of single-phase VN,V_(2)O_(3),and VNxOy solid solution catalysts without *** functional theory calculations confirmed that the composition of these hybrid electrocatalysts allows NRR to proceed from a multistep reduction reaction to a low-energy reaction pathway through the migration and adsorption of interme-diate ***,the design of metal oxide/nitride hybrids with coherent heterointerfaces provides a novel strategy for synthesizing highly efficient elec-trochemical catalysts that induce steps favorable for the efficient low-energy progression of NRR.

关键词： coherent heterogeneous interfaces green ammonia synthesis hybrid electrocatalyst low-energy progression nitrogen reduction reaction(NRR) vanadium oxide/nitride(V_(2)O_(3)/VN)

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Bilateral snapping triceps syndrome:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8228-8234页

作者： chul-Hyun Cho Kyung-Hwan lim Du-Han Kim Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea Orthopedic Surgery Allright HospitalDaegu 42038South Korea

BACKGROUND Snapping triceps syndrome(STS)is a rare disease,while occurrence of bilateral STS is extremely *** is usually accompanied by dislocation of the ulnar nerve and double snapping is a clinically important ***,to the best of our knowledge,there has been no report of bilateral STS in young active *** SUMMARY A 23-year-old male presented with a complaint of discomfort and snapping on the medial side of both elbows while performing *** physical examination,two distinct snaps that were both palpable and audible were detected on additional clinical *** ultrasonography showed that the ulnar nerve and the medial head of the triceps were dislocated anteriorly over the medial epicondyle of the elbow during flexion ***,he was diagnosed as dislocation of the ulnar nerve and *** anterior subcutaneous transposition of the ulnar nerve combined with partial resection of the snapping portion of the triceps was *** patient’s pain and snapping symptoms were resolved immediately after *** months later,the patient was completely asymptomatic and returned to normal *** STS should be included in the differential diagnosis for active young patients who present with painful snapping on the medial side of the elbow joint,particularly when dislocation of the ulnar nerve is *** sonography is used to assist in accurate diagnosis and differentiation between isolated dislocation of the ulnar nerve and STS.

关键词： Triceps Triceps snapping syndrome Ulnar nerve Elbow Dynamic sonography Case report

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Code generation and recognition using a modified ejection system in die-casting process

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China Foundry 2020年第5期17卷 364-371页

作者： Jaekyung Song Jeongsu Lee Young chul Lee Byoung Jun Lee Chaeho lim Industrial Materials and Smart Manufacturing Engineering Korea University of Science and TechnologyDaejeon CityRepublic of Korea Digital Manufacturing Process Group Korea Institute of Industrial TechnologyGyeonggi-doRepublic of Korea

A code-generation and recognition technology that uses a modified ejection system in the diecasting process is *** achieve the highest level of quality management,the first requirement in the manufacturing process is to establish a product management system according to the specific product ***,a method to individually identify each product,such as a barcode or QR code,is required during the production *** manufactured in the die-casting process always have ejector pin(EP)***,an ejection system was modified to generate a unique code using EP *** ejection system has two features:an EP with a modified head to show the direction of rotation,and a function to dependently rotate EPs(five or six EPs)with a constant *** EPs are numbered according to the rotation ***,the EP marks can be viewed as a five-or six-digit code.A program was also developed to individually identify the products by automatically detecting and reading the EPs using deep learning-based object detection and classification technology.

关键词： code recognition die-casting ejection system object detection product management smart manufacturing

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Viral-host molecular interactions and metabolic modulation:Strategies to inhibit flaviviruses pathogenesis

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World Journal of Virology 2024年第4期13卷 41-50页

作者： Zeeshan Ahmad Khan Mukesh Kumar Yadav Dong-Woo lim Hojun Kim Jing-Hua Wang AbuZar Ansari Biohealth Products Research Center(BPRC) Research Center for Agedlife Redesign(RCAR)Department of Physical TherapyINJE UniversityGimhae 5084South Korea Department of Microbiology Central University of PunjabBathinda 151401India Department of Diagnostics College of Korean MedicineDongguk UniversityGoyang 10326South Korea Division of Rehabilitation Medicine of Korean Medicine Department of Oriental Rehabilitation MedicineDongguk UniversityIlsan HospitalGoyang 10326South Korea Institute of Oriental Medicine Dongguk UniversityGoyang 10326South Korea Department of Obstetrics and Gynecology Ewha Womans UniversitySeoul 07985South Korea

Flaviviruses,which include globally impactful pathogens,such as West Nile virus,yellow fever virus,Zika virus,Japanese encephalitis virus,and dengue virus,contribute significantly to human *** the ongoing emergence and resurgence of flavivirus-mediated pathogenesis,the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral *** the intricate processes of fusion,transcription,replication,and maturation,the complex interplay of viral and host metabolic interactions affects *** interactions involve metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,each playing a pivotal role in the replication and maturation of *** viral-host metabolic molecular interactions hijack and modulate the molecular mechanisms of host metabolism.A comprehensive understanding of these intricate metabolic pathways offers valuable insights,potentially unveiling novel targets for therapeutic interventions against flaviviral *** review emphasizes promising avenues for the development of therapeutic agents that target specific metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,which interact with flavivirus replication and are closely linked to the modulation of host *** clinical limitations of current drugs have prompted the development of new inhibitory strategies for flaviviruses based on an understanding of the molecular interactions between the virus and the host.

关键词： Flavivirus Nonstructural proteins Virus-host interaction Metabolism Inhibitors Vaccines

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