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Generation of mesenchymal stem-like cells for producing extracellular vesicles

World Journal of Stem Cells 2019年第5期11卷 270-280页

作者： soo kim Tae Min kim Brexogen Research Center Brexogen Inc. Seoul Songpa-gu 05718 South Korea Graduate School of International Agricultural Technology and Institute of Green- Bio Science and Technology Seoul National University Gangwon-do Pyeongchang 25354 South Korea

Mesenchymal stem cells (MSCs) are multipotent progenitor cells with therapeutic potential against autoimmune diseases, inflammation, ischemia, and metabolic disorders. Contrary to the previous conceptions, recent studies have revealed that the tissue repair and immunomodulatory functions of MSCs are largely attributed to their secretome, rather than their potential to differentiate into desired cell types. The composition of MSC secretome encompasses cytokines and growth factors, in addition to the cell-derived structures known as extracellular vesicles (EVs). EVs are membrane-enclosed nanoparticles that are capable of delivering biomolecules, and it is now believed that MSC-derived EVs are the major players that induce biological changes in the target tissues. Based on these EVs’ characteristics, the potential of EVs derived from MSC (MSC-EV) in terms of tissue regeneration and immune modulation has grown during the last decade. However, the use of MSCs for producing sufficient amount of EVs has not been satisfactory due to limitations in the cell growth and large variations among the donor cell types. In this regard, pluripotent stem cells (PSCs)-derived MSC-like cells, which can be robustly induced and expanded in vitro, have emerged as more accessible cell source that can overcome current limitations of using MSCs for EV production. In this review, we have highlighted the methods of generating MSC-like cells from PSCs and their therapeutic outcome in preclinical studies. Finally, we have also discussed future requirements for making this cell-free therapy clinically feasible.

关键词： Mesenchymal stem cells Extracellular vesicles Preclinical studies Exosomes

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Effect of gadolinium incorporation on optical characteristics of YNbO_4:Eu^(3+) phosphors for lamp applications

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Journal of Rare Earths 2012年第3期30卷 205-209页

作者： sung Hwan Choi G. Anoop Dong Wook Suh Kyung Pil kim Hyun Ju Lee Jae soo Yoo Display Materials Laboratory School of Chemical Engineering and Materials Science Chung-Ang University

Eu3＋-doped （Y,Gd）NbO4 phosphor was synthesized by solid-state reaction for possible application in cold cathode fluorescent lamps. A broad absorption band with peak maximum at 272 nm was observed which was due to the charge transfer between Eu3＋ ions and neighboring oxygen anions. A deep red emission at the peak wavelength of 612 nm was observed which could be attributed to the 5D0→7F2 transition in Eu3＋ ions. The highest luminance for Y1-x-yGdyNbO4：Eux3＋ under 254 nm excitation was achieved at Eu3＋ concentration of 18 mol.% （x=0.18） and Gd3＋ concentration of 8.2 mol.% （y=0.082）. The luminance of Y0.738Gd0.082NbO4：Eu3＋0.18 was higher than that of a typical commercial phosphor Y2O3：Eu3＋ and the CIE chromaticity coordinate was （0.6490, 0.3506）, which was deeper than that of Y2O3：Eu3＋. The particle size of the synthesized phosphors was controlled by the NaCl flux and particle size as high as 8 μm with uniform size distribution of particles was obtained.

关键词： YNbO4:Eu oxide phosphors rare earths

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Engaging in sports via the metaverse? An examination through analysis of metaverse research trends in sports

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Data Science and Management 2024年第3期7卷 181-188页

作者： Ahyun kim Sang-soo kim Department of Business Administration Dongyang Mirae UniversitySeoul08221South Korea Department of Business Administration Yong in UniversityGyeonggi-do17092South Korea

In sports, virtual spaces are sometimes utilized to enhance performance or user experience. In this study, we conducted a frequency analysis, semantic network analysis, and topic modeling using 134 abstracts obtained through keyword searches focusing on “sport(s)” in combination with “metaverse”, “augmented reality”, “virtual reality”, “lifelogging”, and “mixed reality”. First, the top 20 words were extracted through frequency analysis, and then each type of extracted word was retained to select seven words. The analysis revealed the emergence of key themes such as “user(s)”, “game(s)”, “technolog(y/ies)”, “experience(d)”, “physical”, “training”, and “video”, with variations in intensity depending on the type of metaverse. Second, the relationships between the words were reconfirmed using semantic networks based on the seven selected words. Finally, topic modeling analysis was conducted to uncover themes specific to each type of metaverse. We also found that “performance/scoring” was a prominent word across all types of metaverses. This suggests that in addition to providing enjoyment through sports, there is a high possibility that all users (both general users and athletes) utilize the metaverse to achieve positive outcomes and success. The importance of “performance/scoring” in sports may seem obvious;however, it also provides significant insights for practitioners when combined with metaverse-related keywords. Ultimately, this study has managerial implications for enhancing the performance of specialized users in the sports industry.

关键词： Sport Metaverse Frequency analysis Topic modeling Semantic network analysis

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Factors associated with strabismus after cataract extraction and primary intraocular lens implantation in congenital cataracts

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 522-527页

作者： soo Jung Lee Wan-soo kim Department of Ophthalmology Haeundae Paik Hospital

AIM:To evaluate factors associated with the development of strabismus after cataract extraction and primary intraocular lens ***:The medical records of 122 patients,aged1.5mo to 9y,who had undergone cataract extraction with primary intraocular lens implantation between January1993 and August 2011 were *** patients(17 eyes)with strabismus before cataract surgery were *** were divided into those with congenital bilateral cataracts(64 patients,128 eyes)and those with unilateral cataracts(44 patients,44 eyes).The associations between the development of strabismus and age at cataract surgery,pre-and post-cataract extraction corrected distance visual acuity(CDVA),interocular CDVA difference,nystagmus,surgical method,and secondary cataract were ***:Factors significantly associated with the development of strabismus included age at cataract surgery(≤1y),preoperative mean CDVA≤20/100,presence of nystagmus in the bilateral cataract group and postoperative interocular CDVA difference>20/70 in the unilateral *** CDVA≤20/100 and preservation of posterior capsule,and presence of secondary cataract were significant factors in both ***:Children with congenital cataracts should be monitored carefully after cataract surgery for the development of strabismus,especially when they underwent surgery at age≤1y,and they have nystagmus,large postoperative interocular CDVA difference,poor preoperative and postoperative CDVA,preservation of the posterior capsule,or secondary cataract.

关键词： strabismus congenital cataract nystagmus

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Factors influencing stereoacuity levels after surgery to correct unilateral developmental cataracts in children

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 331-336页

作者： soo Jung Lee Wan-soo kim Department of Ophthalmology Haeundae Paik Hospital

·AIM: To evaluate factors influencing stereoacuity after surgery to correct unilateral developmental pediatric cataracts. ·METHODS: We retrospectively surveyed 110 patients who had undergone removal of unilateral acquired developmental cataracts and primary posterior chamber intraocular lens implantation between February 1992 and December 2009. In all patients, stereoacuity was assessed using the Titmus test at the last follow -up period of minimum 2 years after surgery. Patients were divided into two groups according to the extent of stereoacuity : group 1 ( = 42 ) had stereoacuity values ≤ 100sec/arc and group 2 ( =68) values >100sec/arc. The values of ten parameters associated with stereoacuity were measured in each group: Cataract types, preoperative best corrected visual acuity (BCVA) of the affected eyes, preoperative inter -ocular difference of BCVA, age at cataract surgery, operative method, secondary cataract, postoperative strabismus, postoperative BCVA of the affected eyes, postoperative inter-ocular difference of BCVA, and anisometropia. ·RESULTS: The extent of stereoacuity was significantly associated with both operative method and secondary cataract ( =0.000 and =0.016, respectively). All patients in whom the posterior capsule was preserved, had poor stereoacuity >100sec/arc. Significant correlations with the extent of stereoacuity were found with postoperative strabismus ( =0.048),postoperative BCVA of the affected eyes ( =0.002), anisometropia ( =0.034). ·CONCLUSION: Postoperative stereoacuity was better in patients who underwent either optic capture or anterior vitrectomy after posterior continuous curvilinear capsulorhexis, and who didn’t develop secondary cataracts or strabismus postoperatively. Furthermore, postoperative BCVA of the affected eyes, and anisometropia influenced the stereoacuity of the patients surgically treated for unilateral developmental pediatric cataracts. ·

关键词： anisometropia developmental cataract secondary cataract stereoacuity stereopsis strabismus unilateral pediatric cataract visual acuity

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Looping by RNA: Dynamic control of the chromatin loop by long non-coding RNAs in plants

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Molecular Plant 2021年第9期14卷 1430-1432页

作者： Junghyun kim Sibum sung Department of Molecular Biosciences The University of Texas at AustinAustinTX 78712USA

In eukaryotes,the three-dimensional(3D)structure of the genome plays a critical role in the transcriptional *** though the 3D structure of the genome is mainly determined by DNA and protein components,increasing evidenee has demonstrated that RNA also occupies a large portion of chromatin and in flue nces genomic architecture(Ramirez-Colmenero et al.,2020;Wierzbicki et al.,2021).Long non-coding RNA(IncRNA)is a class of non-coding RNAs longer than 200 nucleotides but that lacks protein-coding *** are key regulators of gene expression through their capacity to harbor regulatory proteins and to establish molecular interactions.

关键词： potential harbor

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Microstructure investigation and multicolor upconversion in Yb3+/Ln3+(Ln=Er/Tm/Ho) ions doped α-Sialon

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Progress in Natural Science:Materials International 2019年第5期29卷 549-555页

作者： Sang Hoon Jeong Yuwaraj K.Kshetri Seung Ho kim sung Hun Cho soo W.Lee Department of Environment and Bio-Chemical Engineering Sun Moon University Research Center for Eco Multi-Functional Nano Materials Sun Moon University The Institute of Scientific and Industrial Research (ISIR) Osaka University

Yb3+/Ln3+(Ln=Er/Tm/Ho)-α-sialon ceramics were fabricated by hot press sintering *** microstructure and luminescent properties were studied by XRD,EDS,HRTEM and photoluminescence *** results showed that the sintered ceramics consisted ofα-Sialon with a trace amount ofβ-Sialon *** frequency upconversion and downconversion properties of Yb3+/Ln3+(Ln=Er/Tm/Ho)-α-Sialon ceramics were investigated under 980 nm low-power *** different concentrations of Yb3+/Ln3+(Ln=Er/Tm/Ho)produced multicolor emissions characteristics of each Ln3+ion as a result of the energy transfer from Yb3+to Er3+,Tm3+and Ho3+*** EDS spectra measurements and mappings showed that the Ln3+ions were well incorporated in theα-Sialon *** evolution of the emission decay behavior has been investigated to understand the energy transfer mechanism.

关键词： α-Sialon Hot press sintering Upconversion Energy transfer

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Accurate Multi-Site Daily-Ahead Multi-Step PM_(2.5)Concentrations Forecasting Using Space-Shared CNN-LSTM

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Computers, Materials & Continua 2022年第3期70卷 5143-5160页

作者： Xiaorui Shao Chang soo kim Department of Information Systems Pukyong National UniversityBusan608737Korea

Accurate multi-step PM_(2.5)(particulate matter with diameters≤2.5 um)concentration prediction is critical for humankinds’health and air populationmanagement because it could provide strong evidence for ***,it is very challenging due to its randomness and *** paper proposed a novel method based on convolutional neural network(CNN)and long-short-term memory(LSTM)with a space-shared mechanism,named space-shared CNN-LSTM(SCNN-LSTM)for multi-site dailyahead multi-step PM_(2.5)forecasting with self-historical *** proposed SCNN-LSTM contains multi-channel inputs,each channel corresponding to one-site historical PM_(2.5)concentration *** which,CNN and LSTM are used to extract each site’s rich hidden feature representations in a stack ***,CNN is to extract the hidden short-time gap PM_(2.5)concentration patterns;LSTM is to mine the hidden features with long-time *** channel extracted features aremerged as the comprehensive features for future multi-step PM_(2.5)concentration ***,the space-shared mechanism is implemented by multi-loss functions to achieve space information ***,the final features are the fusion of short-time gap,long-time dependency,and space information,which enables forecasting more *** validate the proposed method’s effectiveness,the authors designed,trained,and compared it with various leading methods in terms of RMSE,MAE,MAPE,and R^(2)on four real-word PM_(2.5)data sets in Seoul,South *** massive experiments proved that the proposed method could accurately forecast multi-site multi-step PM_(2.5)concentration only using self-historical PM_(2.5)concentration time series and running ***,the proposed method obtained averaged RMSE of 8.05,MAE of 5.04,MAPE of 23.96%,and R^(2)of 0.7 for four-site daily ahead 10-hourPM_(2.5)concentration forecasting.

关键词： PM_(2.5)forecasting CNN-LSTM air quality management multi-site multi-step forecasting

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Patient-reported ejaculatory function and satisfaction in men with lower urinary tract symptoms/benign prostatic hyperplasia

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Asian Journal of Andrology 2018年第1期20卷 69-74页

作者： Min Chul Cho Jung Kwon kim Sang Hoon Song sung Yong Cho Sang Wook Lee soo Woong kim Jae-Seung Paick Department of Urology Seoul National University Boramae Medical Center Seou107061 Korea Department of Urology Seoul National University College of Medicine Seoul 03080 Korea Department of Urology Asan Medical Center Seou105505 Korea Department of Urology Kangwon National University College of Medicine Chuncheon 24289 Korea

This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms （LUTS）/benign prostatic hyperplasia （BPH） and to identify associations between specific categories of ejaculatory dysfunctions （EjDs） and LUTS. A total of 1574 treatment-naive men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5-item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time. Patients who had sexual intercourse over the past 4 weeks were classified as sexually active group. A total of 783 patients were categorized as sexually active group. Decreased ejaculatory volume and force were reported by 53.4% and 55.7% of 783 sexually active men, respectively, There was a strong correlation between ejaculatory volume and force. Ejaculatory pain/discomfort, premature ejaculation （PE）, and delayed ejaculation （DE） were reported in 41,0%, 16.3%, and 41.4% of the patients, respectively. Over 40.0% of men without decreased ejaculation volume/force were satisfied with ejaculatory function, whereas approximately 6.0% of men with decreased volume/force were satisfied with ejaculatory function. About 30.0% of men with decreased volume/force had orgasmic dysfunction, while approximately 10.0% of men without decreased volume/force did. Decreased ejaculatory volume or force was associated with LUTS severity after adjusting for other influential factors including testosterone level, erectile function, and prostate size on ultrasonography, but PE or DE or ejaculatory pain/discomfort was not. In conclusion, a considerable portion of men with LUTS/BPH appear to have a variety of EjDs. Ejaculatory volume/force and satisfaction/orgasm do not always appear to be concordant. Ejaculatory volume or force is independently associated with LUTS severity, whereas PE or DE or ejaculatory pain/discomfort is not.

关键词： dysfunction ejaculation lower urinary tract symptoms (LUTS) satisfaction

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Game Outlier Behavior Detection System Based on Dynamic Time Warp Algorithm

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 219-237页

作者： Shinjin Kang soo Kyun kim School of Games Hongik UniversitySejong30016Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

This paper proposes a methodology for using multi-modal data in gameplay to detect outlier *** proposedmethodology collects,synchronizes,and quantifies time-series data fromwebcams,mouses,and *** expressions are varied on a one-dimensional pleasure axis,and changes in expression in the mouth and eye areas are detected ***,the keyboard and mouse input frequencies are tracked to determine the interaction intensity of ***,we apply a dynamic time warp algorithm to detect outlier *** detected outlier behavior graph patterns were the play patterns that the game designer did not intend or play patterns that differed greatly from those of other *** outlier patterns can provide game designers with feedback on the actual play experiences of users of the *** results can be applied to the game industry as game user experience analysis,enabling a quantitative evaluation of the excitement of a game.

关键词： Facial expression recognition webcam behavior analysis affective computing

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