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Identifying and Verifying Vulnerabilities through PLC Network Protocol and Memory Structure Analysis

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Computers, Materials & Continua 2020年第10期65卷 53-67页

作者： Joo-Chan Lee Hyun-Pyo Choi jang-Hoon Kim jun-Won Kim Da-Un jung Ji-Ho Shin jung-Taek Seo Department of Information Security Engineering Soonchunhyang UniversityAsan31538Korea

Cyberattacks on the Industrial Control System(ICS)have recently been increasing,made more intelligent by advancing *** such,cybersecurity for such systems is attracting *** a core element of control devices,the Programmable Logic Controller(PLC)in an ICS carries out on-site control over the ICS.A cyberattack on the PLC will cause damages on the overall ICS,with Stuxnet and Duqu as the most representative ***,cybersecurity for PLCs is considered essential,and many researchers carry out a variety of analyses on the vulnerabilities of PLCs as part of preemptive efforts against *** this study,a vulnerability analysis was conducted on the XGB *** vulnerabilities were identified by analyzing the network protocols and memory structure of PLCs and were utilized to launch replay attack,memory modulation attack,and FTP/Web service account theft for the verification of the *** on the results,the attacks were proven to be able to cause the PLC to malfunction and disable it,and the identified vulnerabilities were defined.

关键词： Industrial control system programmable logic controller cybersecurity network protocol vulnerability

Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice

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Neuroscience Bulletin 2022年第4期38卷 373-385页

作者： Seong-Ah Kim jun Ho jang Wheedong Kim Pa Reum Lee Yong Ho Kim Hue Vang Kihwan Lee Seog Bae Oh Department of Neurobiology and Physiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 03080Republic of Korea Department of Brain and Cognitive Sciences College of Natural SciencesSeoul National UniversitySeoul 08826Republic of Korea Gachon Pain Center and Department of Physiology College of MedicineGachon UniversityIncheon 21999Republic of Korea Tooth-Periodontium Complex Medical Research Center School of DentistrySeoul National UniversitySeoul 03080Republic of Korea

Mitochondrial reactive oxygen species(mROS)that are overproduced by mitochondrial dysfunction are linked to pathological conditions including sensory ***,we explored whether mROS overproduction induces itch through transient receptor potential canonical 3(TRPC3),which is sensitive to *** injection of antimycin A(AA),a selective inhibitor of mitochondrial electron transport chain complex III for mROS overproduction,produced robust scratching behavior in naïve mice,which was suppressed by MitoTEMPO,a mitochondria-selective ROS scavenger,and Pyr10,a TRPC3-specific blocker,but not by blockers of TRPA1 or *** activated subsets of trigeminal ganglion neurons and also induced inward currents,which were blocked by MitoTEMPO and ***,dry skin-induced chronic scratching was relieved by MitoTEMPO and Pyr10,and also by resveratrol,an *** together,our results suggest that mROS elicit itch through TRPC3,which may underlie chronic itch,representing a potential therapeutic target for chronic itch.

关键词： Mitochondria Reactive oxygen species TRPC3 Itch Dry skin Trigeminal ganglia

Direct Synthesis of Molybdenum Phosphide Nanorods on Silicon Using Graphene at the Heterointerface for Efficient Photoelectrochemical Water Reduction

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Nano-Micro Letters 2021年第5期13卷 135-150页

作者： Sang Eon jun Seokhoon Choi Shinyoung Choi Tae Hyung Lee Changyeon Kim Jin Wook Yang Woon‑Oh Choe In‑Hyuk Im Cheol‑Joo Kim Ho Won jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea

Transition metal phosphides(TMPs)and transition metal dichalcogenides(TMDs)have been widely investigated as photoelectrochemical(PEC)catalysts for hydrogen evolution reaction(HER).Using high-temperature processes to get crystallized compounds with large-area uniformity,it is still challenging to directly synthesize these catalysts on silicon photocathodes due to chemical incompatibility at the ***,a graphene interlayer is applied between p-Si and MoP nanorods to enable fully engineered interfaces without forming a metallic secondary compound that absorbs a parasitic light and provides an inefficient electron path for hydrogen ***,the graphene facilitates the photogenerated electrons to rapidly transfer by creating Mo-O-C covalent bondings and energetically favorable band *** a bridging role of graphene,numerous active sites and anti-reflectance of MoP nanorods lead to significantly improved PEC-HER performance with a high photocurrent density of 21.8 mA cm−2 at 0 V versus RHE and high ***,low dependence on pH and temperature is observed with MoP nanorods incorporated photocathodes,which is desirable for practical use as a part of PEC *** results indicate that the direct synthesis of TMPs and TMDs enabled by graphene interlayer is a new promising way to fabricate Si-based photocathodes with high-quality interfaces and superior HER performance.

关键词： Photoelectrochemical water splitting Silicon Molybdenum phosphide Hydrogen evolution Graphene

Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson’s disease

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Journal of Traditional Chinese Medicine 2019年第6期39卷 800-808页

作者： Liu Quanfeng Sang Heon Kim Yung-Wei sung Sok Cheon Pak Wonwoong Lee Jongki Hong Jaehwan jang Kyoung Sang Cho Songhee Jeon Byung-Soo Koo Department of Oriental Medicine Dongguk UniversityGyeogju38066Republic of Korea Department of Oriental Neuropsychiatry Graduate School of Oriental MedicineDongguk UniversityGyeonggi-do 10326Republic of Korea College of Pharmacy Kyung Hee UniversitySeoul 02447Republic of Korea School of Biomedical Sciences Charles Sturt UniversityBathurstNew South Wales2795Australia Department of Biological Sciences Konkuk UniversitySeoul 05029Republic of Korea Department of Biomedical Sciences Center for Creative Biomedical Scientists at Chonnam National UniversityGwangju 61469Korea

OBJECTIVE:To examine the role of KSOP1009(a modified formulation of Suhexiang Wan essential oil)in an animal model of Parkinson's disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine(MPTP)***:Cell toxicity,apoptosis,and reactive oxygen species(ROS)levels were analyzed in the human neuroblastoma cell line SH-SY5 *** that,changes in animal behavior and tyrosine hydroxylase(TH)protein levels in the substantia nigra(SN)of MPTP-injected mice were *** different doses of KSOP1009(30,100,and 300 mg/kg,n=8 for each group)were administered daily for 7 d before MPTP injection and 14 d after MPTP injection,totaling 21 ***:MPP+,the active metabolite of MPTP,decreased the viability of SH-SY5 Y cells,whereas KSOP1009 alleviated MPP+-induced ***1009(10 and 50 mg/m L)reduced MPP+-induced ROS generation compared with the control *** with 1 m M MPP+increased the percentage of depolarized/live cells,whereas KSOP1009 intake at a dose of 10 mg/m L decreased the percentage of these *** mean latency to fall in the rotarod test was reduced in mice treated with MPTP compared with the control ***,mice receiving three different doses of KSOP1009 performed better than MPTP-treated ***-treated mice were more hesitant and took longer to traverse the balance beam than the control *** contrast,KSOP1009-treated mice performed significantly better than MPTPtreated ***,the KSOP1009-treated groups had a significantly higher number of TH-positive neurons in the lesioned SN and significantly higher expression of TH in the striatum than the MPTP-treated *** treatment strongly induced jun-N-terminal kinase(JNK)activation,whereas KSOP1009 suppressed MPTP-induced JNK *** addition,KSOP1009 intake reversed the decrease in the phosphorylation levels of c AMP-response element-binding protein in the brain of MPTP-treated ***1009 also restored the decrease in dopaminergic

关键词： Parkinson disease 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mitochondria Reactive oxygen species Suhexiang Wan

Temporal and spatial differentiation in microhabitat use: Implications for reproductive isolation and ecological niche specification

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Integrative Zoology 2016年第5期11卷 375-387页

作者： Amaël BORZÉE jun Young KIM Marina Andrade Martins DA CUNHA Donggeun Lee Eunchong SIN Sunmin OH Yoonjung YI Yikweon jang Department of Life Sciences and Division of EcoScience Ewha Womans UniversitySeoulKorea Interdisciplinary Program of EcoCreative Ewha Womans UniversitySeoulKorea School of Biological Sciences Seoul National UniversityKorea

Niche differentiation enables ecologically similar species to coexist by lessening competition over food and/or shelters and may be critical for reproductive isolation between closely related species in close ***cause no extra traits need to evolve,spatial and temporal differentiation may readily take place to complement other isolating *** closely related treefrog species occur together in Korea:the endangered Hyla suweonensis and the widespread Hyla *** calls are differentiated,but it is unclear whether call difference is sufficient for reproductive *** tracked individuals of both species to study fine-scale differentiation in microhabitat use in the diel cycle of the breeding season using a harmonic direction *** male movement patterns of both species revealed spatial and temporal differentiation in microhabitat use for calling and resting during the breeding *** of both *** and *** occurred in all 5 microhabitats identified in this study:rice paddy,ground,buried,grass and *** treefrog species showed general similarities in calling from rice paddies and resting in grass and ***,*** moved into rice paddies and produced advertisement calls 3 h earlier than *** differences likely minimize contact between the species and provide an additional isolating *** addition,the activity of *** may be contributing to the decline of this species,as resting in grass would increase dangers from predatory birds and habitat disturbance.

关键词： harmonic direction finding hylid treefrog pre-mating isolation mechanisms spatial isolation temporal isolation

Short-Term Wind Power Prediction Using Fuzzy Clustering and Support Vector Regression

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Journal of Energy and Power Engineering 2012年第10期6卷 1605-1610页

作者： In-Yong Seo Bok-Nam Ha sung-Woo Lee Moon-Jong jang Sang-Ok Kim Seong-jun Kim KEPCO Research Institute Daejeon 305-380 South Korea Gangneung-Wonju National University Gangneung 210-702 South Korea

A sustainable production of electricity is essential for low carbon green growth in South Korea. The generation of wind power as renewable energy has been rapidly growing around the world. Undoubtedly, wind energy is unlimited in potential. However due to its own intermittency and volatility, there are difficulties in the effective harvesting of wind energy and the integration of wind power into the current electric power grid. To cope with this, many works have been done for wind speed and power forecasting. In this paper, an SVR （support vector regression） using FCM （Fuzzy C-Means） is proposed for wind speed forecasting. This paper describes the design of an FCM based SVR to increase the prediction accuracy. Proposed model was compared with ordinary SVR model using balanced and unbalanced test data. Also, multi-step ahead forecasting result was compared. Kernel parameters in SVR are adaptively determined in order to improve forecasting accuracy. An illustrative example is given by using real-world wind farm dataset. According to the experimental results, it is shown that the proposed method provides better forecasts of wind power.

关键词： Support vector regression kernel fuzzy clustering wind power prediction.

Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome

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World Journal of Gastroenterology 2009年第15期15卷 1869-1875页

作者： jun Seok Lee Sang Heum Kim Dae Won jun Jee Hye Han Eun Chul jang Ji Young Park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim Department of Internal Medicine Eulji University School of Medicine Department of Radiology Eulji University School of Medicine Department of Family Medicine Eulji University School of Medicine Department of Occupational and Environmental Medicine College of MedicineSoonchunhyang University Department of Radiology Hanyang University School of Medicine

AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and *** pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on *** a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid *** incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal *** pancreas also showed a strong correlation with metabolic syndrome.

关键词： Fatty pancreas Metabolic syndrome Insulin resistance

Comparison of cytological and histological preparations in the diagnosis of pancreatic malignancies using endoscopic ultrasoundguided fine needle aspiration

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 418-423页

作者： Dong Kee jang Sang Hyub Lee jun Kyu Lee Woo Hyun Paik Kwang Hyun Chung Ban Seok Lee jun Hyuk Son Jae Woo Lee Ji Kon Ryu Yong-Tae Kim Kyoung-Bun Lee Department of Internal Medicine Dongguk University Ilsan Medical CenterGoyang-siGyeonggi-doKorea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Inje University Ilsan Paik HospitalGoyang-siGyeonggi-doKorea Department of Pathology Seoul National University College of MedicineSeoulKorea

BACKGROUND:Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) has become a crucial diagnostic technique for pancreatic *** specimen obtained by EUS-FNA can be prepared for either cytological or histological *** study was to compare diagnostic performance of cytological and histological preparations using EUSFNA in the same lesions when pancreatic malignancies were ***:One hundred and eighteen patients who underwent EUS-FNA for suspected pancreatic malignancies were consecutively *** procedures were conducted by a single echoendoscopist under the same *** adequate preparations were obtained by 22-gauge needles with 20 to-and-fro movements for each *** 4 preparations included 2 cytological and 2 histological *** pathologic reviews of all specimens were conducted independently by a single experienced ***,specificity,and accuracy of the 2 preparations were ***:The enrolled patients consisted of 62 males(52.5%),with the mean age of 64.6±10.5 *** was performed in 23(19.5%) *** hundred and sixteen(98.3%) lesions were classified as malignant,while 2(1.7%) were *** of cytology and histology were 87.9% and 81.9%,respectively,with no significant difference(P=0.190).Accuracy was also not significantly *** preparation was more sensitive when the size of lesion was <3 cm(86.7% vs 68.9%,P=0.033).CONCLUSIONS:Our results suggested that the diagnostic performances of cytological and histological preparations are not significantly different for the diagnosis of pancreatic ***,cytological preparation might be more sensitive for pancreatic lesions <3 cm.

关键词： endoscopic ultrasound-guided fine needle aspiration pancreatic neoplasms cytology pathology histology

Simulation of the extreme waves generated by typhoon Bolaven (1215) in the East China Sea and Yellow Sea

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Acta Oceanologica Sinica 2015年第12期34卷 19-28页

作者： jun Ki Cheon JEONG Weon Mu CHOI Jin Yong PARK Kwang Soon junG Kyung Tae KIM Mee Kyung CHAE jang Won QIAO Fangli Coastal Disaster Research Center Korea Institute of Ocean Science and Technology Coastal & Environmental Engineering Division Korea Institute of Ocean Science and Technology Marine Radionuclide Research Center Korea Institute of Ocean Science and Technology First Institute of Oceanography State Oceanic Administration

Record-breaking high waves occurred during the passage of the typhoon Bolaven（1215）（TYB） in the East China Sea（ECS） and Yellow Sea（YS） although its intensity did not reach the level of a super *** and directional wave measurements were made using a range of in-situ instruments mounted on an ocean tower and *** order to understand how such high waves with long duration occurred,analyses have been made through measurement and numerical *** winds were generated using the TC96 typhoon wind model with the best track data calibrated with the *** then the wind fields were blended with the reanalyzed synoptic-scale wind fields for a wave *** fields were simulated using WAM4.5 with adjustment of C_d for gust of winds and bottom friction for the study *** the accuracy of simulations is considerably enhanced,and the computed results are also in better agreement with measured data than *** is found that the extremely high waves evolved as a result of the superposition of distant large swells and high wind seas generated by strong winds from the front/right quadrant of the typhoon *** the typhoon moved at a speed a little slower than the dominant wave group velocity in a consistent direction for two days,the wave growth was significantly enhanced by strong wind input in an extended fetch and non-linear interaction.

关键词： extreme waves typhoon measurements numerical simulation East China Sea