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Cytomegalovirus colitis induced segmental colonic hypoganglionosis in an immunocompetent patient: A case report

World Journal of Clinical Cases 2021年第20期9卷 5631-5636页

作者： Ban Seok kim Seon-Young Park Dong Hyun kim Nah Ihm kim Jae Hyun Yoon Jae Kyun Ju Chang hwan Park Hyun Soo kim sung Kyu Choi Department of Gastroenterology Chonnam National University HospitalGwangju 501-757South Korea Department of Pathology Chonnam National University HospitalGwangju 501-757South Korea Department of Surgery Chonnam University HospitalGwangju 501-757South Korea

BACKGROUND Cytomegalovirus(CMV)colitis is usually seen in immunocompromised patients with risk factors such as human immunodeficiency virus infection,solid organ transplant,inflammatory bowel disease,or ***,many clinicians usually do not consider the possibility of CMV colitis in immunocompetent *** reported a rare case of segmental colonic hypoganglionosis associated with CMV colitis in an immunocompetent *** SUMMARY A 48-year-old woman with no underlying disease was admitted to our hospital for severe abdominal pain and *** tomography of the abdomen showed diffuse dilatation of the small intestine and the entire *** sigmoidoscopic findings and result of polymerase chain reaction(PCR)for CMV revealed the compatible findings of CMV colitis,the patient was treated with intravenous *** treatment,sigmoidoscopic findings and CMV PCR results *** the patient continued to suffered from *** months after the initial admission,patient visited the emergency department with severe abdominal pain and imaging revealed aggravation of fecal impaction and bowel *** performed subtotal colectomy to control patient’s *** examination of the resected specimen showed significantly reduced number of mature ganglion cells in the sigmoid colon compared to that in the proximal *** Our case demonstrates that CMV colitis can develop even in patients with no other underlying disease,and that CMV colitis can be one of the causes for developing colonic hypoganglionosis.

关键词： Colonic pseudo-obstruction Colitis Cytomegalovirus Ganglia Case report

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URANS simulations for a free-running container ship:Part 2. Added power

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Journal of Hydrodynamics 2021年第3期33卷 448-467页

作者： Dong-hwan kim Yugo Sanada Hamid Sadat-Hosseini Frederick Stern IIHR-Hydroscience and Engineering The University of IowaIowa CityUSA Costal Development and Ocean Energy Research Center Korea Institute of Ocean Science and TechnologyBusanKorea Mechanical Engineering University of North TexasDentonUSA

Part 2 reports the validation,local force and local flow study results for the free-running added power simulations whose conditions are the same as the self-propulsion test except for the increased propeller rotational speed and the presence of *** targeting the same mean Froude number in the wave condition,the propeller requires the increased propeller rotational speed for the operation at the low advance ratio due to the added *** test is performed at five different wavelengths in head waves and four different headings in the oblique *** the validation study,the time series of the validation variables is decomposed with discrete Fourier transform to extract the harmonic *** variables are global parameters,including motions,propeller thrust,and torque coefficients,added power variables,and self-propulsion factors which show reasonable agreement against the experiment results and produces a similar error from the self-propulsion *** local force study shows that the added resistance mostly appears at the bow due to the bow plunging during the short head wave and resonance *** contributions of the gravitational force and the buoyant force are found to increase as the stern motion exceeds the bow motion during the long head wave *** oscillation of the propeller performances shows correlation with the first harmonic amplitude of the propeller ***,pitch,and roll decay tests are performed prior to the main test to assess the natural frequencies of the *** as Part 1,a discretized propeller is used.

关键词： Added power unsteady Reynolds-averaged Navier-Stokes(URANS) KRISO Container Ship(KCS) CFDShip-IOWA

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Essentials of thoracic outlet syndrome:A narrative review

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World Journal of Clinical Cases 2021年第21期9卷 5804-5811页

作者： Min Cheol Chang Du hwan kim Department of Rehabilitation Medicine College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Physical Medicine and Rehabilitation College of MedicineChung-Ang UniversitySeoul 06973South Korea

Thoracic outlet syndrome(TOS)is a group of diverse disorders involving compression of the nerves and/or blood vessels in the thoracic outlet *** results in pain,numbness,paresthesia,and motor weakness in the affected upper *** reviewed the pathophysiology,clinical evaluation,differential diagnoses,and treatment of *** is usually classified into three types,neurogenic,venous,and arterial,according to the primarily affected *** true neurogenic and disputed TOS are considered neurogenic *** identifying the causative lesions is complex,detailed history taking and thorough clinical investigation are *** and imaging studies are helpful for excluding other possible disorders and confirming the diagnosis of true neurogenic *** existence of a disputed TOS remains *** physicians tend to be skeptical about the existence of disputed TOS,but thoracic surgeons argue that disputed TOS is *** who encounter patients with TOS need to understand its key features to avoid misdiagnosis and provide appropriate treatment.

关键词： Brachial plexus Diagnosis Review Thoracic outlet syndrome Treatment Neuromuscular lesions

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Multivalent network modifier upregulates bioactivity of multispecies biofilm-resistant polyalkenoate cement

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Bioactive Materials 2022年第8期7卷 219-233页

作者： Ji-Yeong kim Woojin Choi Utkarsh Mangal Ji-Young Seo Tae-Yun Kang Joohee Lee Taeho kim Jung-Yul Cha Kee-Joon Lee Kwang-Mahn kim Jin-Man kim Dohyun kim Jae-sung Kwon Jinkee Hong sung-hwan Choi Department of Orthodontics Institute of Craniofacial DeformityYonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea BK21 FOUR Project Yonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department and Research Institute of Dental Biomaterials and Bioengineering Yonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Johns Hopkins University 3400 N.Charles St.Mason HallBaltimoreMD 21218USA Department of Oral Microbiology and Immunology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Conservative Dentistry Oral Science Research CenterYonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Polyalkenoate cement(PAC)is a promising material for regenerative hard tissue *** ionically rich glass component of PAC encourages bioactive interaction *** release of essential ***,PAC bioactivity is restricted owing to(i)structurally inherent cationic network formers and(ii)surface bacterial biofilm *** two factors cause a deficiency in ion release,further complicated by secondary infections and premature therapeutic ***,a multivalent zwitterionic network modifier(mZM)is presented for upregulation of ionic exchange and bioactivity *** introducing a non-zero charged mZM into PACs,an increase in the proportion of non-bridging oxygen *** network modification promotes ion channel formation,causing a multiple-fold increase in ion release and surface deposition of hydroxy-carbonate apatite(ca.74%).Experiments ex vivo and animal models also demonstrate the efficient remineralization ability of the ***,divalent cationic interaction results in bacterial biofilm reduction(ca.68%)while also influencing a shift in the biofilm species composition,which favors commensal ***,PAC modification with mZM offers a promising solution for upregulation of bioactivity,even aiding in customization by targeting site-specific regenerative therapy in future applications.

关键词： Multivalent network modifier Bioactive materials Glass polyalkenoate cement Ion release Remineralization Multispecies biofilm resistance

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Passivation engineering via silica‐encapsulated quantum dots for highly sensitive photodetection

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Carbon Energy 2023年第9期5卷 49-62页

作者： Ji Yun Chun Byung Gi kim Jin Young kim Woongsik Jang Dong hwan Wang School of Integrative Engineering Chung‐Ang UniversitySeoulRepublic of Korea

Organometal halide perovskites are promising semiconducting materials for photodetectors because of their favorable optoelectrical *** nanoscale perovskite materials such as quantum dots(QDs)show novel behavior,they have intrinsic stability *** this study,an effectively silane barrier-capped quantum dot(QD@APDEMS)is thinly applied onto a bulk perovskite photosensitive layer for use in ***@APDEMS is synthesized with a silane ligand with hydrophobic CH_(3)-terminal groups,resulting in excellent dispersibility and durability to enable effective *** introduction of the QD@APDEMS layer results in the formation of a lowdefect perovskite film with enlarged *** is attributed to the grain boundary interconnection effect via interaction between the functional groups of QD@APDEMS and uncoordinated Pb^(2+)in grain *** passivating the grain boundaries,where various trap sites are distributed,hole chargecarrier injection and shunt leakage can be ***,from the energy point of view,the deep highest occupied molecular orbital(HOMO)level of QD@APDEMS can work as a hole charge injection *** charge dynamics(generation,transfer,and recombination properties)and reduced trap density of QD@APDEMS are *** this perovskite film is used in a photodetector,the device performance(especially the detectivity)stands out among existing perovskites evaluated for energy sensing device applications.

关键词： grain boundary passivation perovskite quantum dots photodetectors photosensitive layers trap

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Electrical resistivity evolution in electrodeposited Ru and Ru-Co nanowires

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Journal of Materials Science & Technology 2022年第10期105卷 17-25页

作者： Jun hwan Moon Seunghyun kim Taesoon kim Yoo Sang Jeon Yanghee kim Jae-Pyoung Ahn Young Keun kim Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Institute of Engineering Reserch Korea UniversitySeoul 02481Republic of Korea Advanced Analysis Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Research Resources Division Korea Institute of Science and TechnologySeoul 02792Republic of Korea

Nanoscale ruthenium(Ru)-based materials are promising replacements for existing multilayered Cu interconnects in integrated ***,it is not easy to apply the results of previously reported studies directly to the electrochemical damascene process because the previous studies have mainly focused on thin flms by dry ***,we report the electrical resistivity and microstructure of electrodeposited Ru *** estimate that the resistivity value of a 10 nm diameter Ru nanowire to be71.6μΩcm after analyzing the resistivity values of individual nanowires with various ***,we investigate the electrical properties of Ru_(x)Co_(1-x)nanowires where x is 0.04–0.99 at.%as possible replacements of the current Ta N barrier *** the entire composition range,the resistivity values of alloys are much lower than that of the conventional Ta ***,Ru and Ru-alloy nanowires surrounded by dielectric silica are thermally stable after 450°C heat ***,the nanoscale Ru and Ru-Co alloys possessing low resistivity values can be candidates for the interconnect and barrier materials,respectively.

关键词： Ruthenium(Ru) Ruthenium-cobalt(Ru-Co) Nanowire Electrical resistivity Microstructure Electrodeposition

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Osteotomy Protocol for Implant Insertion of One Day Biotech:One Drill, One Implant

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Open Journal of Stomatology（口腔学期刊） 2024年第5期 255页

作者： Jin hwan kim Jaehyun Song Jaegyun Choi Jose Francisco Ballester Ireh kim Santiago Jose Ballester

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Structural,Sintering and Electrical Properties of Cr-doped La_(0.6)Sr_(0.4)Cr_xFe_(1-x)O_(3-δ)(x=0.10,0.20) Oxides

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Journal of Materials Science & Technology 2012年第7期28卷 654-660页

作者： LinlinZhu Jong Pyo kim Sou hwan Son Jung Hoon Park State Key SLaboratory of Catalysis.Dalian Institute of Chemical Physics Chinese~Academy of Sciences Dalian 116023 China Greenhouse Gas Research Center Climate Change Technology Research Division Korea Institute of Energy ResearchDaejeon 305-343 Korea College of Chemistry and Materials Science Liaoning University of Petroleum and Chemical Technology Fushun113001 China

The perovskite Cr-doped La0.6Sr0.4CrxFe1-xO3-δ （x=0.10, 0.20） oxides were synthesized via the citrate gel method. The perovskite forming of the Lao.6Sr0.4CrxFel-xO3-δ （x=0.10, 0.20） oxides were studied by ther- mogravimetric analysis （TG）, differential scanning calorimetry （DSC）, and X-ray diffraction （XRD）. Structural and chemical stability under H2-containing helium atmospheres of Lao.6Sro.4CrxFel-xO3-δ （x=0.10, 0.20） were investigated by TG and XRD. The sintering microstructures of the perovskite Lao.6Sr0.4Cr2Fel-xO3-δ （x--0.10, 0.20） ceramics were investigated by scanning electron microscopy （SEM）, and the electrical conduc- tivities of both oxide ceramics were also measured up to 900℃. The results demonstrated that the chemical stability of the Co-free ***.4CrxFe1-xO3-δ （x=0.10, 0.20） oxides was significantly improved compared to the Co-containing Lao.6Sr0.4C00.2Fe0.8O3-δ and Ba0.5Sr0.5Co0.8Fe0.2O3-δ oxides. The incorporation of Cr cations in the B-site of the pervoskite oxides resulted in the improved structural and chemical stability of the as-synthesized Lao.6Sr0.4CrxFe1-xO3-δ （x=0.10, 0.20） oxides.

关键词： Perovskite Crystal structure Sintering Electrical conductivity

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Direct interaction of DNMT inhibitors to PrP^C suppresses pathogenic process of prion

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Acta Pharmaceutica Sinica B 2019年第5期9卷 952-959页

作者： Dae-hwan kim Chunyan Ren Chongsuk Ryou Jiaojie Li Institute of Pharmaceutical Science and Technology Hanyang UniversityAnsan15588Republic of Korea School of Undergraduate Studies College of Transdisciplinary StudiesDaegu Gyeongbuk Institute of Science and TechnologyDaegu42988Republic of Korea Boston Children’s Hospital Harvard Medical SchoolBostonMA02115USA Department of Pharmacy Hanyang UniversityAnsan15588Republic of Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea

The conversion of the normal cellular prion protein(PrP^C) to the misfolded pathogenic scrapie prion protein(Pr PSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel anti-prion activity of SGI-1027 and its meta/meta analogue(M/M), previously known only as potent inhibitors of DNA methyltransferases(DNMTs). These compounds effectively decreased the level of Pr PSc in cultured cells with permanent prion infection, without affecting PrP^Cat the transcriptional or translational levels. Furthermore, SGI-1027 prevented effective prion infection of the cells. In a Pr P aggregation assay, both SGI-1027 and M/M blocked the formation of misfolded Pr P aggregates, implying that binding of these compounds hinders the Pr P conversion process. A series of binding and docking analyses demonstrated that both SGI-1027 and M/M directly interacted with the C-terminal globular domain of PrP^C, but only SGI-1027 bound to a specific region of PrP^C with high affinity, which correlates with its potent antiprion efficacy. Therefore, we report SGI-1027 and related compounds as a novel class of potential antiprion agents that preferentially function through direct interaction with PrP^C.

关键词： Prion DNMT Therapeutic compounds PrP^C Epigenetic regulation

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Preparation of MnO2-impregnated carbon-coated Fe3O4 nanocomposites and their application for bovine serum albumin adsorption

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Rare Metals 2020年第10期39卷 1151-1158页

作者： Chol-hwan kim Ze-Fei Zhang Lin-Shan Wang Ting Sun College of Sciences Northeastern UniversityShenyang 110004China

MnO2-impregnated carbon-coated Fe3 O4(Fe3O4/C/MnO2)nanocomposites with a good core-shell structure were prepared by direct oxidation of carbon-coated Fe3 O4(Fe3O4/C)microspheres with KMnO4 in alkaline solution and applied to adsorb bovine serum albumin(BSA).X-ray diffraction(XRD),transmission electron microscope(TEM),Fourier transform infrared spectrometer(FTIR),vibrating sample magnetometer(VSM)and thermogravimetric analyzer(TGA)tests show that Fe3O4/C microspheres were newly functionalized via the oxidation by ***3O4/C/MnO2 nanocomposites exhibit a higher adsorption capacity for BSA than Fe3O4/C microspheres and the maximum adsorption of BSA on them occurs at pH 4.7,which is the isoelectric point of *** isotherm model describes the adsorption of BSA better than Freundlich model and Temkin model,and the kinetics data fit well with the pseudo-second-order model.

关键词： Fe3O4/C/MnO2 nanocomposites Bovine serum albumin Adsorption

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