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Effects of Lizhong Tang on cultured mouse small intestine interstitial cells of Cajal

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World Journal of Gastroenterology 2013年第14期19卷 2249-2255页

作者： Min Woo Hwang Jung Nam Kim Ho Jun Song Bora lim Young Kyu Kwon Byung Joo Kim Department of Sasang Constitutional Medicine College of Korean MedicineKyung-hee University School of Korean Medicine Pusan National University

AIM:To investigate the effects of Lizhong Tang,an herbal product used in traditional Chinese medicine,on mouse small intestine interstitial cells of Cajal(ICCs).METHODS:Enzymatic digestions were used to dissociate ICCs from mouse small intestine *** ICCs were morphologically distinct from other cell types in culture and were identified using phase contrast microscopy after verification with anti c-kit antibody.A whole-cell patch-clamp configuration was used to record potentials(current clamp) from cultured *** of the experiments were performed at 30-32 ℃.RESULTS:ICCs generated pacemaker potentials,and Lizhong Tang produced membrane depolarization in current-clamp *** application of flufenamic acid(a nonselective cation channel blocker) abolished the generation of pacemaker potentials by Lizhong *** with thapsigargin(a Ca 2+-ATPase inhibi-tor in the endoplasmic reticulum) also abolished the generation of pacemaker potentials by Lizhong ***,pacemaker potentials were completely abolished in the presence of an external Ca 2+-free solution,and under this condition,Lizhong Tang induced membrane ***,When GDPβ-S(1 mmol/L) was in the pipette solution,Lizhong Tang still induced membrane *** addition,membrane depolarizations were not inhibited by chelerythrine or calphostin C,which are protein kinase C inhibitors,but were inhibited by U-73122,an active phospholipase C ***:These results suggest that Lizhong Tang might affect gastrointestinal motility by modulating pacemaker activity in interstitial cells of Cajal.

关键词： Interstitial cells of Cajal Lizhong Tang Motility Gastrointestinal tract Whole-cell patch clamp configuration

共面转换液晶显示器中获得对比度高于1:600的新技术

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现代显示 2004年第5期 31-33页

作者： Jae Hyun Kim Joun Ho Lee Ji Chul lim Chang Hoon Lee Moo Hyoung Song Ju Yeon Yoon hee Dong Choi Jeom Jae Kim Chang Ho Oh Sang Deog Yeo 李路海 LG菲利普液晶显示电视开发部乐凯胶片厂

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树... 详细信息

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树脂、电极锥角和摩擦条件等都进行了研究。优化的背光板组合,光滑的电极锥角和摩擦方法的控制是提高对比度的主要控制因素。应用新开发的滤色片树脂,对获得高对比度最为有效。

关键词：高对比度共面转换液晶显示器薄膜晶体管背光 TFT-LCD 滤色片光板偏振片紧凑

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基于辣椒基因组测序探究辣味在种群中的进化

辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo hee-Bum Yang hee-Jin Jeong Won-hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-sung lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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On the need to unify neuroscience and physics

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 271-273页

作者： Maurits van den Noort Sabina lim Peggy Bosch Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701South Korea Brussels Institute for Applied Linguistics Vrije Universiteit Brussel1050 BrusselsBelgium Psychiatric Research Institute LVR-Klinik Bedburg-Hau47511 Bedburg-HauGermany Centre for Cognition Donders Institute for BrainCognition and BehaviourRadboud University Nijmegen6500 GL NijmegenGelderlandThe Netherlands

Neuroscience is a relatively new research field that,so far,has resulted in important progress in understanding the physiology,biochemistry,pharmacology,and structure of the vertebrate brain.^([1])Because of this progress,spectacular technological developments,^([2])*** emission tomography,functional magnetic resonance imaging,transcranial magnetic stimulation(TMS),diffusion tensor imaging,magneto-encephalography,electro-encephalography,etc.,and new treatments based on them,such as high-frequency repetitive TMS(rTMS),^([3])deep brain stimulation.

关键词： stimulation rTMS treatment

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国际白菜基因组测序项目中的参考遗传图

国际白菜基因组测序项目中的参考遗传图

ACUPUNCTURE ON GB34 ACTIVATES THE PRECENTRAL GYRUS AND PREFRONTAL CORTEX IN PARKINSON'S DISEASE

第十二届国际油菜大会

作者： Su Ryun Choi Graham R.Teakle Prikshit Plaha Jeong hee Kim Charlotte J.Allender Elena Beynon Zhong Yun Piao Tae Ho Han Graham J.King Guy C.Barker Paul Hand Derek J.Lydiate Jacqui Batley Dave Edwards Thomas C.Osborn Dal Hoe Koo Jae Wook Bang Beom-Seok Park Yong Pyo lim Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Saskatoon Research Centre Agriculture and Agri-Food Canada107 Science PlaceSaskatoonSKS7N3V3Canada Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Department of Applied Plant Science Chonnam National UniversityGwangju 500-757Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Saskatoon Research Centre Agriculture and Agri-Food Canada107 Science PlaceSaskatoonSKS7N3V3Canada Plant Biotechnology Centre Primary Industries Research VictoriaLa Trobe UniversityBundooraVictoria 3086Australia Plant Biotechnology Centre Primary Industries Research VictoriaLa Trobe UniversityBundooraVictoria 3086Australia Seminis Vegetable Seeds Inc. 37437 State Highway 16woodlandCA 95695USA Department of Biology Chungnam National UniversityDaejeon 305-764Korea Department of Biology Chungnam National UniversityDaejeon 305-764Korea Brassica Genomics Team National Institute of Agricultural BiotechnologySuwon 441-707Korea Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea

我们目前正在构建的大白菜遗传连锁图是国际白菜基因组测序项目作为骨架图,将用来序列重叠群的锚定工作。图谱是基于以遗传差异大的两个中国大白菜品种---“Chiifu”和”Kenshin”杂交得到的F1经花药培养而得到78个DH系构建的。目前,图...

我们目前正在构建的大白菜遗传连锁图是国际白菜基因组测序项目作为骨架图,将用来序列重叠群的锚定工作。图谱是基于以遗传差异大的两个中国大白菜品种---“Chiifu”和”Kenshin”杂交得到的F1经花药培养而得到78个DH系构建的。目前,图谱上一共定位了556个标记,其中包括278个AFLP、235个SSR、25个RAPD和18个ESTP、STS、CAPS标记。对本遗传图谱和甘蓝型油菜遗传图谱中的通用SSR标记进行了位置和方向比较,从而把确定的10个连锁群分别记为R1-R10,并与甘蓝型油菜的N1-N10相对应。同时,通过定位的235个通用SSR标记,我们还可以对来自白菜的A基因组和来自甘蓝型油菜的A基因组进行比较分析。通过与拟南芥基因组序列进行比较,选出了500个BAC克隆,作为部分最小跨度克隆。对这些BAC的测序工作已完成,并成为设计和发展SSR引物的一个重要序列来源。用这些BAC序列发展而来的SSR标记已被定位到了参考遗传图上——CKDH图谱。这些做为锚定用的SSR标记,将在遗传图和物理图的整合中起重要作用,同时也为随后BAC-BY-BAC的测序策略中构建重叠群提供种子BAC。这样一个参考图谱的成功构建将对国际社会中改良白菜以及其它芸薹属作物起重要作用。

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Journal of Integrative Medicine 2014年第3期 261-261页

作者： Min-gyu Lee Sujung Yeo Hyejin Jung Younghong Kim Dong-hoon Shin Sabina lim Kyung hee University

Background: Acupuncture is increasingly used as an additional treatment for patients with Parkinson's disease(PD).Methods: In this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy *** was conducted on a specific acupoint,the right Yanglingquan(GB34), which is a frequently used acupoint for motor function treatment in the oriental medical ***: Acupuncture stimulation on this acupoint activated the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with *** with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially in the left ***: The neuroimaging results of our study suggest that in future acupuncture research, the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of PD and that GB34 seems to be a suitable ***, acupuncture evoked more different brain activations in patients with PD than that in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture's efficacy.

关键词： PD GB ACUPUNCTURE ON GB34 ACTIVATES THE PRECENTRAL GYRUS AND PREFRONTAL CORTEX IN PARKINSON’S DISEASE

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花拉阁,新加坡

城市建筑 2010年第10期 118-121页

作者： Edward Calver Bianca Cheung Dominiki Dadatsi Loreto Flores Helen Lee hee Seung Lee Jeonghoon Lee Feng Lin Jee Seon lim Ludovico Lombardi Clara Martins Kutbuddin Nadiadi Hoda Nobakhti Annarita Papeschi Line Rahbek Hala Sheikh Zhong Tian evil Yazici Effie Kuan Sandra Riess Eleni Pavlidou Federico Dunkelberg Evan Erlebacher Gorka Blas Bozana Komljenovic Sophie Le Bienvenu Kelly Lee Jose M.Monfa Selahattin Tuysuz TaKang Hsu Emily Chang Judith Wahle Zaha Hadid Architects Zaha Hadid with Patrik Schumacher GROSSMAX Edinburgh Engineering Acviron/Singapore

建筑基址花拉阁基址地处新加坡住宅区的关键地段,毗邻荷兰路(Holland Road)及未来规划中的MRT车站,与交通干道花拉路(Farrer Rd.)直接连通,基址周边无高层建筑。如此优越的地理及交通条件使该项目广受全城民众的关注。

关键词：基址规划长远计划新加坡直接连通花拉交通干道高层建筑