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Measles outbreaks in the Kyeongin area of the Republic of Korea,2013-2014:A single-center experience in a country of measles elimination

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 67-72页

作者： Sun Hyoung Park Dong Hun Lee Jang Yong Jin Young-Lim Shin Meeyong Shin sung Shin Kim Won Suk suh Jae ock Park Yong Hee Hong Department of Pediatrics College of MedicineSoonchunhyang UniversityBucheon HospitalBucheonRepublic of Korea

Objective: To identify the source of infection and determine the clinical features and laboratory finding of measles infection,Methods: In 27 measles patients,except for 3 adult patients,the rest of 24 pediatric measles cases were analyzed with regard to age,sex,immunization status,transmission routes and molecular genotyping of measles virus,Eighteen measles patients who admitted in isolation ward were set apart to investigate clinical findings and its correlation with laboratory characteristics,Retrospective analysis of cases was conducted in this study,Results: Of the 24 pediatric patients,23(95.8%) had not received any measles-containing vaccine(MCV),Sixteen of the patients(66.7%) were aged <12 months,The suspicious index case of a girl aged 34 months was not vaccinated with MCV1 and got measles after a trip to Philippines,and molecular genotype was revealed as B3,Measles outbreaks in the community such as a restaurant were followed by this one imported case,According to analysis of 18 patients admitted in isolation ward,the median level of C-reactive protein(CRP) was 0.38 mg/d L and that of lactate dehydrogenase(LDH) was 1 200 IU/L,All of the 18 patients had LDH levels above the normal range,Age correlated with CRP(ρ = 0.528,P = 0.024) and LDH(ρ = 0.501,P = 0.034),The duration of fever was correlated with the duration of fever before rash(ρ = 0.898,P < 0.01),The duration of hospitalization was correlated with CRP(ρ = 0.586,P = 0.011),The white blood cell counts were correlated with the levels of LDH(ρ = 0.505,P = 0.033),aspartate aminotransferase(ρ = 0.507,P = 0.032),and alanine aminotransferase(ρ = 0.481,P = 0.043),Conclusions: Early weaning of maternally derived measles antibodies therefore vaccination of MCV1 at a young age from 9 months to 12 months should be considered in situations of early exposure,Furthermore there is a call for consideration of scheduling an earlier age for the first dose of MMR vaccine in Europe,It is necessary for Korea to investigat

关键词： Measles Disease outbreaks Pediatrics

Possibility of Solid Hydrometeor Growth Zone Identification Using Radar Spectrum Width

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Advances in Atmospheric Sciences 2023年第2期40卷 317-332页

作者： sung-Ho suh Eun-Ho CHOI Hong-Il KIM Woonseon JUNG Flight Safety Technology Division NARO Space CenterKorea Aerospace Research Institute(KARI)508 Haban-roBongrae-myeonGoheung-gunJeollanam-do 59571Republic of Korea Research Applications Department National Institute of Meteorological Sciences33Seohobuk-roSeoqwipo-siJeju-do 63568Republic of Korea

In this study,the correlation between simulated and measured radar velocity spectrum width(σ_(v))is *** results show that the dendrites growth zones(DGZs)and needles growth zones(NGZs)mostly contain dendrites(DN)and needles(NE),***σ_(v) zones(1.11.2 m s^(-1),a differential reflectivity(ZDR)higher than 0 dB,and a cross-correlation coefficient(ρhv)less than *** contrast,prolate particles with relatively uniform shapes were observed in the NGZ withσ_(v)<0.6 m s^(-1),a ZDR less than 0 dB,andρhv higher than *** simulation results show that the DN exhibited a largerσ_(v) compared to the NE,and this observedσ_(v) was strongly dependent on the wind fluctuations(v’)due to turbulence or wind *** contrast,the NE exhibited a significantly smallσ_(v)~0.55 m s^(-1),which converges irrespective of v’.In addition,a strong correlation between the measuredσ_(v) values at five radar elevation angles(θ=6.2°,9.1°,13.1°,19°,and 80°)and those simulated in this study confirmed the significance of the analysis results.

关键词： spectrum width weather radar aerodynamic properties dendritic growth zone hydrometeor classifications

Efficient detection of pathogen virus in sand dabs,Paralichthys olivaceus using loop-mediated isothermal amplification(LAMP)

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Acta Oceanologica Sinica 2016年第8期35卷 44-50页

作者： HWANG Jinik PARK So Yun suh sung-Suk PARK Mirye LEE Sukchan LEE Taek-Kyun South Sea Environment Research Department Korea Institute of Ocean Science and TechnologyGeoje 53201Republic of Korea Korea University of Science and Technology Daejeon 34113Republic of Korea Department of Genetic Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea

Viral hemorrhagic septicemia virus（VHSV） and marine birnavirus（MABV） are the causative pathogens for some of the most explosive epidemics of emerging viral diseases in many Asian countries, leading to huge economic losses in aquaculture. Rapid molecular detection for surveillance or diagnosis has been a critical component in reducing the prevalence of pathogen infection. The loop-mediated isothermal amplification（LAMP） of DNA is currently one of the most commonly used molecular diagnostic tools, as it is simple, quick, and easy to amplify target DNA under isothermal conditions. In the present study, a novel and highly specific LAMP assay for the sensitive and rapid detection of VHSV and MABV infection in fish was developed. Using a set of synthesized primers matching a specific region of the genome, the efficiency and specificity of the LAMP assay were optimized in terms of the reaction temperature and DNA polymerase concentration, as they are the main determinants of the sensitivity and specificity of the LAMP assay. In particular, we demonstrated that our assay could be applied to efficient detection of VHSV and MABV infection in the wild fish, Paralichthys olivaceus. Our results demonstrate the simplicity and convenience of this method for the detection of viral infection in aquatic organisms.

关键词： viral hemorrhagic septicaemia virus(VHSV) marine birnavirus(MABV) polymerase chain reaction loop-mediated isothermal amplification

Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro

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Journal of Traditional Chinese Medicine 2021年第2期41卷 219-226页

作者： FENG Jinghui Set Byeol Kim Hee Jung Lee Su Min Sim Soon sung Lim Hong Won suh Department of Pharmacology College of MedicineHallym UniversityChuncheon 200-702South Korea Department of Food Sciences and Nutrition College of NaturalHealthand Life SciencesHallym UniversityChuncheon 200-702Republic of

OBJECTIVE:To investigate the possible antinociceptive effects of Salvia(S.)miltiorrhiza Bunge and its single components in monosodium urate(MSU)-induced pain model in mice and lipopolysaccharide(LPS)-induced inflammation model in RAW264.7 ***:Pretreatment of *** Bunge extract(from 1 to 50μg/mL)concentration-dependently attenuated LPS-induced nitric oxide(NO)*** extract of *** Bunge(50 or 100 mg/kg)also caused reversals of decreased threshold for pain in the MSU-treated group as measured by Von-Frey ***,we assessed the antinociceptive and anti-inflammatory properties of the active single components from *** Bunge such as 15,16-dihydrotanshinoneⅠ,tanshinoneⅠ,cryptotanshinone,miltirone,tanshinoneⅡA,and salvianolic acid *** of them showed an anti-inflammatory effect in LPS-induced NO release model and an antinociceptive effect in MSU-treated pain ***:Our results suggest that *** Bunge extract may exert anti-inflammatory effect by reducing LPS-induced NO release and an antinociceptive property in MSU-treated pain ***,tanshinoneⅡA,miltirone,cryptotanshinone,and 15,16-dihydrotanshinoneⅠ,not only appear to be responsible for LPS-induced NO release induced by *** Bunge,but also in the production of *** Bunge extract-induced antinociception in MSU-treated pain ***:Therefore,the analgesic and anti-inflammatory property of *** Bunge indicate it as a therapeutic potential candidate for the treatment of pain and inflammation.

关键词： Salvia miltiorrhiza lipopolysaccharides nitric oxide inflammation analgesics

Phenol content,antioxidant and tyrosinase inhibitory activity of mangrove plants in Micronesia

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 531-535页

作者： sung-Suk suh Jinik Hwang Mirye Park Heung-Sik Park Taek-Kyun Lee South Sea Environment Research Department.Korea Institute of Ocean Science and Technology Korea South Pacific Ocean Research Center Korea Institute of Ocean Science and Technology

Objective:To find out and compare the in vitro antioxidant and tyrosinase inhibitory activities of two species of mangrove ***:Mangrove samples were harvested at the shoreline on the island of Weno,Chuuk State in *** phenol content,antioxidant activity(based on DPPH-free radical scavenging)and tyrosinase inhibitory activity in different tissues(leaves,barks and roots)of Rhizophora stylosa(***)and Sonneratia alba(***),collected from the island of ***:Total phenol content ranged from 4.87 to 11.96 mg per g of freeze dried *** highest antioxidant activity was observed in *** bark(85.5%).The highest tyrosinase inhibitory activity was found in *** ***,total phenol content and antioxidant activity were higher in methanol extracts than in aqueous ***:Taken together,the results of this study proved that mangroves can be excellent sources of antioxidant compounds.

关键词： Rhizophora stylosa Sonneratia alba Phebolics Antioxidant activity Tyrosinase inhibitory activity

Growth and Magnetic Properties of Sol-Gel Derived Co-Doped ZnO Thin Film

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Journal of Rare Earths 2006年第Z1期24卷 59-63页

作者： Young sung Kim Ki Chul Kim Won Pil Tae Dae Ho Yoon Tae Seok Park Su Jeong suh Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Cambridge-ETRI Joint R&D Centre Electronics and Telecommunications Research Institute Daejeon 305-350 Korea Ulsan Industry Promotion Techno Park Ulsan 683-804 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea

Zn1-xCoxO films were grown on glass by sol-gel spin coating process. A homogeneous and stable Zn1-xCoxO sol was prepared by dissolving zinc acetate dihydrate, cobalt acetate tetrahydrate and aluminium chloride hexahydrate as solutes in solution of isopropanol and monoethanolamine. The films were postheated and vacuum annealed, and investigated for c-axis preferred orientation and electromagnetic properties. Zn1-xCoxO films with different Co concentrations were oriented well along the c-axis, especially the Zn1-xCoxO film with 10% Co(atom fraction) was highly c-axis oriented. The transmittance spectra show that Zn1-xCoxO films occur d-d transition and sp-d exchange interaction between Co2+ ions. The electrical resistivity of the films at 10% Co had the lowest value because the crystallite size became largest and the crystallinity of the c-axis was improved. X-ray photoelectron spectroscopy and alternating gradient magnetometer analyses indicated that no Co metal cluster was formed, and the ferromagnetism at room temperature appeared. The characteristics of the electrical resistivity and room temperature ferromagnetism of sol-gel derived Zn1-xCoxO films suggest a potential application of dilute magnetic semiconductor devices.

关键词： sol-gel Zn1-xCoxO thin film dilute magnetic semiconductor (DMS)

Effect of gadolinium incorporation on optical characteristics of YNbO_4:Eu^(3+) phosphors for lamp applications

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Journal of Rare Earths 2012年第3期30卷 205-209页

作者： sung Hwan Choi G. Anoop Dong Wook suh Kyung Pil Kim Hyun Ju Lee Jae Soo Yoo Display Materials Laboratory School of Chemical Engineering and Materials Science Chung-Ang University

Eu3＋-doped （Y,Gd）NbO4 phosphor was synthesized by solid-state reaction for possible application in cold cathode fluorescent lamps. A broad absorption band with peak maximum at 272 nm was observed which was due to the charge transfer between Eu3＋ ions and neighboring oxygen anions. A deep red emission at the peak wavelength of 612 nm was observed which could be attributed to the 5D0→7F2 transition in Eu3＋ ions. The highest luminance for Y1-x-yGdyNbO4：Eux3＋ under 254 nm excitation was achieved at Eu3＋ concentration of 18 mol.% （x=0.18） and Gd3＋ concentration of 8.2 mol.% （y=0.082）. The luminance of Y0.738Gd0.082NbO4：Eu3＋0.18 was higher than that of a typical commercial phosphor Y2O3：Eu3＋ and the CIE chromaticity coordinate was （0.6490, 0.3506）, which was deeper than that of Y2O3：Eu3＋. The particle size of the synthesized phosphors was controlled by the NaCl flux and particle size as high as 8 μm with uniform size distribution of particles was obtained.

关键词： YNbO4:Eu oxide phosphors rare earths

Neuroprotective effects of tamsulosin on intracerebral hemorrhage

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Neural Regeneration Research 2011年第32期6卷 2505-2510页

作者： Hong-Jin suh sung-Min So Young-Gil Na Il-Gyu Ko sung-Eun Kim Yun-Hee sung Mal-Soon Shin Chang-Ju Kim Young-Sam Cho Khae-Hawn Kim Department of Urology Incheon St. Mary's Hospital the Catholic University of Korea School of Medicine Department of Urology Chungnam National University School of Medicine Department of Physiology Kyung Hee University School of Medicine Department of Urology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Urology Gachon University Gil Hospital Gachon University of Medicine and Science

The alpha1 adrenoreceptor antagonist tamsulosin is primarily used to treat benign prostatic hypertrophy. In this study, we intragastrically administered rats with 0.01,0.1 and 1 mg/kg tamsulosin to investigate the effects of tamsulosin on memory function, and hippocampal cell apoptosis and proliferation following intracerebral hemorrhage. Step-down avoidance task results showed that tamsulosin treatment markedly alleviated intracerebral hemorrhage- induced short-term memory impairment. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling results showed that tamsulosin treatment markedly suppressed intracerebral hemorrhage-induced caspase-3 expression in the hippocampal CA1 region and cell proliferation in the hippocampal dentate gyrus. Tamsulosin treatment at a dose of 0.01 mg/kg exhibited the most potent inhibitory effects on cell apoptosis and proliferation. These findings suggest that tamsulosin treatment facilitates the recovery of rat memory function by inhibiting hippocampal cell apoptosis and proliferation followincl intracerebral hemorrhaQe.

关键词： tamsulosin, intracerebral hemorrhage short-term memory apoptosis cellproliferation hippocampus neural regeneration

Gastric ischemia after epinephrine injection in a patient with liver cirrhosis

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World Journal of Gastroenterology 2013年第3期19卷 411-414页

作者： Su Young Kim Seung-Hee Han Kyung Han Kim Sang ock Kim Sang-Young Han sung-Wook Lee Yang Hyun Baek Department of Internal Medicine Dong-A University College of MedicineBusan 602-715South Korea

Endoscopic epinephrine injection is relatively easy,quick and ***,it has a low rate of com-plications,and it is widely used for the management of nonvariceal upper gastrointestinal *** have been several case reports of gastric ischemia after en-doscopic injection *** intra-arterial in-jection may result in either spasm or thrombosis,leading to subsequent tissue ischemia or necrosis,although the stomach has a rich vascular supply and the vascular reserve of the intramural *** addition to endoscopic injection therapy,smoking,hypertension and atherosclerosis are risk factors of gastric ischemia. We report a case of gastric ischemia after submucosal epinephrine injection in a 51-year-old woman with hy-pertension and liver cirrhosis.

关键词： Hematemesis Epinephrine Gastric ischemia Liver cirrhosis Hypertension