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Neural Regeneration Research 2017年第5期12卷 765-769页

作者： Sun Wook Park sung min son Na Kyung Lee Department of Physical Therapy Faculty of Health Science Eulji University Department of Physical Therapy College of Health Science Cheongju University Department of Physical Therapy College of Rehabilitation Science Daegu University

This study aimed to investigate the effects of exercise-induced muscle fatigue in the unaffected knee joint on postural control and kinematic changes in stroke patients. Forty participants（20 stroke patients, 20 age-matched healthy participants） were recruited. To induce fatigue, maximum voluntary isometric contractions were performed in the unaffected knee joint in a Leg Extension Rehab exercise machine using the pneumatic resistance. We measured static and dynamic balance and lower-limb kinematics during gait. Changes in postural control parameters anteroposterior sway speed and total center of pressure distance differed significantly between the stroke and control groups. In addition, changes in gait kinematic parameters knee and ankle angles of initial contact differed significantly between stroke（paretic and non-paretic） and control groups. Muscle fatigue in the unaffected knee and ankle impaired postural control and debilitates kinematic movement of ipsilateral and contralateral lower limbs, and may place the fatigued stroke patients at greater risk for falls.

关键词： nerve regeneration knee muscle fatigue stroke postural control gait kinemetics neural regeneration

Does hemispheric lateralization influence therapeutic effects of transcranial direct current stimulation?

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Neural Regeneration Research 2016年第1期11卷 126-129页

作者： Yong Hyun Kwon Kyung Woo Kang Na Kyung Lee sung min son Department of Physical Therapy Yeungnam University College Department of Physical Therapy College of Rehabilitation Science Daegu University Department of Physical Therapy College of Health Science Cheongju University

This study investigated the effect of transcranial direct current stimulation（t DCS） polarity depending on lateralized function of task property in normal individuals performing visuomotor and simple repetitive tasks. Thirty healthy participants with no neurological disorders were recruited to participate in this study. Participants were randomly allocated into active or control condition. For the active condition, t DCS intensity was 2 m A with stimulation applied for 15 minutes to the right hemisphere（t DCS condition）. For the sham control, electrodes were placed in the same position, but the stimulator was turned off after 30 seconds（sham condition）. The tapping and tracking task tests were performed before and after for both conditions. Univariate analysis revealed significant difference only in the tracking task. For direct comparison of both tasks within each group, the tracking task had significantly higher Z score than the tapping task in the t DCS group（P 〈 0.05）. Thus, our study indicates that stimulation of the right hemisphere using t DCS can effectively improve visuomotor（tracking） task over simple repetitive（tapping） task.

关键词： nerve regeneration transcranial direct current stimulation visuomotor task tracking task task property hemispheric lateralization neural regeneration

Is effect of transcranial direct current stimulation on visuomotor coordination dependent on task difficulty?

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Neural Regeneration Research 2015年第3期10卷 463-466页

作者： Yong Hyun Kwon Kyung Woo Kang sung min son Na Kyung Lee Department of Physical Therapy Yeungnam University College Department of Physical Therapy College of Rehabilitation ScienceDaegu University Department of Physical Therapy College of Health Science Cheongju University

Transcranial direct current stimulation （tDCS）, an emerging technique for non-invasive brain stimulation, is increasingly used to induce changes in cortical excitability and modulate motor behavior, especially for upper limbs. The purpose of this study was to investigate the effects of tDCS of the primary motor cortex on visuomotor coordination based on three levels of task difficulty in healthy subjects. Thirty-eight healthy participants underwent real tDCS or sham tDCS. Using a single-blind, sham-controlled crossover design, tDCS was applied to the primary motor cortex. For real tDCS conditions, tDCS intensity was 1 mA while stimulation was applied for 15 minutes. For the sham tDCS, electrodes were placed in the same position, but the stimu- lator was turned off after 5 seconds. Visuomotor tracking task, consisting of three levels （levels 1, 2, 3） of difficulty with higher level indicating greater difficulty, was performed before and after tDCS application. At level 2, real tDCS of the primary motor cortex improved the accurate index compared to the sham tDCS. However, at levels 1 and 3, the accurate index was not significantly increased after real tDCS compared to the sham tDCS. These findings suggest that tasks of mod- erate difficulty may improve visuomotor coordination in healthy subjects when tDCS is applied compared with easier or more difficult tasks.

关键词： neural regeneration transcranial direct current stimulation visuomotor coordination task difficulty primary motor area motor learning neural regeneration

A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-378页

作者： Ji Yeong An sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo min Kim minah Cho Keun Won Ryu Hong Man Yoon Young Kyu Park In Gyu Kwon sung Hoon Noh Kyung Hee Lee In Cho Myoung Won son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Yonsei University College of Medicine Gastric Cancer Center Yonsei Cancer CenterYonsei University Health System Center for Gastric Cancer National Cancer Center Department of Surgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Hematology-Oncology Yeungnam University Medical Center Department of Surgery Soonchunhyang University College of Medicine Department of Surgery Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Department of Surgery Chung-Ang University Hospital Chung-Ang University College of Medicine

Objective: Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier(SPC) test, a new clinical-grade prognostic assay, in stage Ⅱ-Ⅲ gastric cancer ***: A prospective multicenter study was conducted, involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals. The SPC test was employed to stratify patients into risk groups, and its feasibility and performance were evaluated. The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment. Furthermore, 3-year disease-free survivals of risk groups were ***: The SPC test met the primary endpoint criteria. The 99.5% of SPC tests were timely delivered to hospitals before the postoperative treatment started. In a clinical setting, the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d. Furthermore, 3-year disease-free survivals were significantly different between risk groups classified with SPC ***: This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies. It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test adjuvant chemotherapy advanced gastric cancer feasibility gastrectomy

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae son Soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

Paenarthrobacter nitroguajacolicus can promote cucumber growth and control cucumber corynespora leaf spot

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Frontiers of Agricultural Science and Engineering 2024年第3期11卷 485-498页

作者： min LI Yahui HUANG Xiaomin DONG Xu ZHANG Qing MA College of Horticulture South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Crop Stress Biology for Arid Areas/College of Plant Protection Northwest A&F UniversityYangling 712100China College of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhou 510642China

Currently,the disease control in cucumber mainly depends on agrochemicals,which is not an environmentally benign *** bacteria not only resist plant pathogens but also promote plant growth,which is ecofriendly and sustainable option.A biocontrol bacterial strain BJ-5 was screened using Corynespora cassiicola as the target pathogen,and BJ-5 was determined to be Paenarthrobacter nitroguajacolicus by morphological and molecular *** effect of BJ-5 on *** was studied,including the spore germination,cell membrane permeability and infected ***-5 inhibited the germination of *** spores in vitro and led to atrophy and deformation of the *** budding ***-5 caused the relative extracellular conductivity of *** mycelia to increase compared with the ***,BJ-5 reduced the severity of cucumber corynespora leaf spot of cucumber infected with *** inhibition efficacy of BJ-5 suspension as a foliar spray against cucumber corynespora leaf spot reached 63%inhibition,which is higher than a 5000-fold dilution of Luna-son SC *** addition,BJ-5 was tested on the emergence of cucumber seedlings,recording the biomass and photosynthesis of cucumber during the growth ***-5 at 1.5×10^(5)CFU·mL^(−1)promoted the germination of cucumber seeds and increased biomass and photosynthesis at the adult plant ***,the secondary metabolites of BJ-5 were ***-5 could produce chitinases,siderophore,cellulase,amylase and protease in the respective ***,adaptation assay of BJ-5 showed good salt tolerance and good adaptability in alkaline conditions,and that BJ-5 retains inhibition of fungi activity at higher *** is the first report of the biocontrol by *** with antagonism to *** and promote cucumber *** study indicates that *** may serve as potential biocontrol agents against cucumber corynespora leaf spot fungu

关键词： Adaptability antagonistic bacterium disease resistance growth promotion secondary metabolite

Boosting electrocatalytic activity with the formation of abundant heterointerfaces and N, S dual-doped carbon nanotube for rechargeable Zn-air battery

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Journal of Energy Chemistry 2023年第9期84卷 140-152页

作者： Rin Na Kyeongseok min Hyejin Kim Yujin son Sang Eun Shim sung-Hyeon Baeck Department of Chemistry and Chemical Engineering Education and Research Center for Smart Energy Materials and ProcessInha UniversityIncheon 22212Republic of Korea

Herein,a facile synthetic strategy is proposed to fabricate high-performance electrocatalysts for rechargeable Zn-air batteries(ZABs).Heterostructured NiCo/NiCo_(2)S_(4) nanoparticles encapsulated in N-,S-co-doped CNT(NiCo/NiCo_(2)S_(4)@NSCNT) are synthesized via co-precipitation,thermal carbonization,and partial sulfidation *** strongly coupled NiCo/NiCo_(2)S_(4) heterostructure can improve the redox property and charge transfer ***,the CNTs with abundant foreign dopants provide high electrical conductivity and abundant defect sites for both the oxygen evolution reaction(OER) and oxygen reduction reaction(ORR).The prepared NiCo/NiCo_(2)S_(4)@NSCNT electrocatalyst exhibits a low overpotential of 349 mV at a current density of 10 mA cm-2 and a half-wave potential of 0.865 V for the OER and ORR,***,the ZAB assembled using as-prepared NiCo/NiCo_(2)S_(4)@NSCNT can provide superior specific capacity(756.16 mA h g_(Zn)^(-1)],peak power density(155.82 mW cm^(-2)),and long-term cyclability compared to those of the precious metal-based electrocatalyst(Pt/C+RuO_(2)).

关键词： Bifunctional electrocatalyst NiCo alloy Bimetallic sulfide Heterojunction Zinc–air battery

Genetic Algorithm to Optimize the Design of Main Combustor and Gas Generator in Liquid Rocket Engines

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Journal of Thermal Science 2014年第3期23卷 259-268页

作者： min son Sangho Ko Jaye Koo Graduate Student Korea Aerospace University School of Aerospace and Mechanical Engineering Korea Aerospace University

A genetic algorithm was used to develop optimal design methods for the regenerative cooled combustor and fuel-rich gas generator of a liquid rocket engine. For the combustor design, a chemical equilibrium analysis was applied, and the profile was calculated using Rao's method. One-dimensional heat transfer was assumed along the profile, and cooling channels were designed. For the gas-generator design, non-equilibrium properties were derived from a counterflow analysis, and a vaporization model for the fuel droplet was adopted to calculate residence time. Finally, a genetic algorithm was adopted to optimize the designs. The combustor and gas generator were optimally designed for 30-tonf, 75-tonf, and 150-tonf engines. The optimized combustors demonstrated superior design characteristics when compared with previous non-optimized results. Wall temperatures at the nozzle throat were optimized to satisfy the requirement of 800 K, and specific impulses were maximized. In addition, the target turbine power and a burned-gas temperature of 1000 K were obtained from the optimized gas-generator design.

关键词： Liquid Rocket Engine Main Combustor Gas Generator Optimization Genetic Algorithm

Activation of less affected corticospinal tract and poor motor outcome in hemiplegic pediatric patients:a diffusion tensor tractography imaging study

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Neural Regeneration Research 2015年第12期10卷 2054-2059页

作者： Jin Hyun Kim Su min son Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

The less affected hemisphere is important in motor recovery in mature ***,in terms of motor outcome in immature brains,no study has been reported on the less affected corticospinal tract in hemiplegic pediatric ***,we examined the relationship between the condition of the less affected corticospinal tract and motor function in hemiplegic pediatric *** patients with hemiplegia due to perinatal or prenatal injury（13.7±3.0 months）and 40 age-matched typically developing controls were *** patients were divided into two age-matched groups,the high functioning group（20 patients）and the low functioning group（20 patients）using functional level of hemiplegia *** tensor tractography images showed that compared with the control group,the patient group of the less affected corticospinal tract showed significantly increased fiber number and significantly decreased fractional anisotropy *** increased fiber number and significantly decreased fractional anisotropy value in the low functioning group were observed than in the high functioning *** findings suggest that activation of the less affected hemisphere presenting as increased fiber number and decreased fractional anisotropy value is related to poor motor function in pediatric hemiplegic patients.

关键词： nerve regeneration unaffected hemisphere hemiplegia corticospinal tract diffusiontensor imaging motor function neural regeneration

Effects of Supercritical Environment on Hydrocarbon-fuel Injection

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Journal of Thermal Science 2017年第2期26卷 183-191页

作者： Bongchul Shin Dohun Kim min son Jaye Koo Graduate School Korea Aerospace UniversityGoyangRepublic of Korea School of Aerospace and Mechanical Engineering Korea Aerospace UniversityGoyangRepublic of Korea

In this study, the effects of environment conditions on decane were investigated. Decane was injected in subcritical and supercritical ambient conditions. The visualization chamber was pressurized to 1.68 MPa by using nitrogen gas at a temperature of 653 K for subcritical ambient conditions. For supercritical ambient conditions, the visualization chamber was pressurized to 2.52 MPa by using helium at a temperature of 653 K. The decane injection in the pressurized chamber was visualized via a shadowgraph technique and gradient images were obtained by a post processing method. A large variation in density gradient was observed at jet interface in the case of subcritical injection in subcritical ambient conditions. Conversely, for supercritical injection in supercritical ambient conditions, a small density gradient was observed at the jet interface. In a manner similar to that observed in other cases, supercritical injection in subcritical ambient conditions differed from supercritical ambient conditions such as sphere shape liquid. Additionally, there were changes in the interface, and the supercritical injection core width was thicker than that in the subcritical injection. Furthermore, in cases with the same injection conditions, the change in the supercritical ambient normalized core width was smaller than the change in the subcritical ambient normalized core width owing to high specific heat at the supercritical injection and small phase change at the interface. Therefore, the interface was affected by the changing ambient condition. Given that the effect of changing the thermodynamic properties of propellants could be essential for a variable thrust rocket engine, the effects of the ambient conditions were investigated experimentally.

关键词： Decane Jet Subcritical Supercritical Visualization