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Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents

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World Journal of Gastroenterology 2015年第11期21卷 3308-3316页

作者： Eun Soo kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok kim Byung Ik Jang Eun Young kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong kook Lee Dong Wook Lee sung kook kim Tae Oh kim Jonghun Lee Hyung Wook kim Sam Ryong Jee Seun Ja Park Hyun Jin kim Division of Gastroenterology Department of Internal MedicineKeimyung University School of Medicine Division of Gastroenterology Department of Internal MedicinePusan National University School of Medicine Division of Gastroenterology Department of Internal MedicineYeungnam University College of Medicine Division of Gastroenterology Department of Internal MedicineCatholic University of Daegu School of Medicine Division of Gastroenterology Department of Internal MedicineKyungpook National University School of Medicine Division of Gastroenterology Department of Internal MedicineDongguk University School of Medicine Division of Gastroenterology Department of Internal MedicineInje University College of Medicine Division of Gastroenterology Department of Internal MedicineDong-A University Medical Center Division of Gastroenterology Department of Internal MedicineKosin University College of Medicine Division of Gastroenterology Department of Internal MedicineGyeongsang National University School of Medicine

AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF ***:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected *** failed to show response or were intolerant to conventional treatments,including steroids or *** measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were ***:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used *** anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of *** patients(8%)had *** cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF ***(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk ***:Anti-TNFs significantly increase the risk of TB infection in Korean patients with *** considerable burden of TB and marked immunosuppression might be attributed to this risk.

关键词： Tuberculosis Anti-TNF Korea Inflammatory bowel dis

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Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis

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World Journal of Gastroenterology 2022年第44期28卷 6294-6309页

作者： Kang Nyeong Lee Oh Young Lee Hoon Jai Chun Jin Il kim sung kook kim Sang Woo Lee Kyung Sik Park kook Lae Lee Suck Chei Choi Jae-Young Jang Gwang Ha kim In-kyung sung Moo In Park Joong Goo Kwon Nayoung kim Jae Jun kim Soo Teik Lee Hyun Soo kim Ki Bae kim Yong Chan Lee Myung-Gyu Choi Joon Seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-Hyun kim Hyunsoo Chung Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Korea University Anam HospitalSeoul 02841South Korea Department of Internal Medicine The Catholic University of KoreaYeouido ST.Mary’s HospitalSeoul 07260South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine Korea University Ansan HospitalAnsan-si 15355South Korea Department of Internal Medicine Keimyung University Dongsan HospitalDaegu 42601South Korea Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Internal Medicine Wonkwang University HospitalIksan 54538South Korea Department of Internal Medicine KyungHee University Medical CenterSeoul 02447South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 47241South Korea Department of Internal Medicine KKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Kosin University Gaspel HospitalBusan 49267South Korea Department of Internal Medicine Daegu Catholic University Medical CenterDaegu 42471South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam-si 13620Gyeonggi-doSouth Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju-si 54907South Korea Department of Internal Medicine Chonnam National University HospitalGwangju 61469South Korea Department of Internal medicine Chungbuk National University School of MedicineCheong Ju 28644South Korea Department of Internal Medicine Severance HospitalSeoul 03722South Korea Department of Internal Medicine The Catholic University of KoreaSeoul ST.Mary’s HospitalSeoul 06591South Korea Digestive Disease Center Soon

BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal ***’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent *** To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight *** primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week *** secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life *** profiles and serum gastrin levels were compared between the *** Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life ***,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the *** Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week *** suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE.

关键词： Gastroesophageal reflux Esophagitis Proton pump inhibitors Heartburn Quality of life

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Gastric dysplasia may be an independent risk factor of an advanced colorectal neoplasm

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World Journal of Gastroenterology 2009年第45期15卷 5722-5726页

作者： Rack Cheon Bae Seong Woo Jeon Han Jin Cho Min Kyu Jung Young Oh Kweon sung kook kim Department of Internal Medicine Kyungpook National University Hospital

AIM: To evaluate the relationship between gastric dysplasia and Helicobacter pylori (H pylori) and the occurrence of colorectal adenoma, and to defi ne the necessity for colonoscopy in patients with gastric dysplasia or H pylori ***: From May 2005 to February 2008, 133 patients with established gastric dysplasia by gastroduo-denoscopy (EGD) were additionally investigated by colonoscopy. The authors compared results with those of 213 subjects who underwent both EGD and colonoscopy during the same period at the author’s Health Promotion Center as a control group. H pylori infection was evaluated in both the gastric dysplasia and control ***: The mean age of all 346 study subjects was 54.1 ± 10.5 years, and there were 258 (73%) men and 87 (27%) women. No signif icant difference was found between the H pylori positive and negative subjects in terms of the prevalence of colorectal adenoma and advanced colorectal adenoma (P = 0.261). Patients with gastric dysplasia showed no elevated risk of colorectal adenoma (OR = 0.910, 95% CI: 0.587-1.411, P = 0.738), but had a signif icantly higher risk of having advanced colorectal adenoma (OR = 3.382, 95% CI: 1.700-6.342, P = 0.000).CONCLUSION: The study emphasizes the need for colon surveillance in patients with gastric dysplasia, regardless of H pylori infection.

关键词： Gastric adenoma or dysplasia Helicobacter pylori Colorectal neoplasm

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A comparison of transanal excision and endoscopic resection for early rectal cancer

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World Journal of Gastrointestinal Endoscopy 2009年第1期1卷 56-60页

作者： Soon Hak Lee Seong Woo Jeon Min Kyu Jung sung kook kim Gyu Seog Choi Department of Internal Medicine Kyungpook National University School of Medicine50 Samduk 2GaChung-guDaegu 700-721South Korea Department of Colorectal Surgery Kyungpook National University School of Medicine50 Samduk 2GaChung-guDaegu 700-721South Korea

AIM:To compare the outcomes of endoscopic resection with transanal excision in patients with early rectal ***:Thirty-two patients with early rectal cancer were treated by transanal excision or endoscopic resection between May 1999 and December *** patients were regularly re-examined by means of colonoscopy and abdominal computed tomography after resection of the early rectal ***,length of hospital-stay,disease recurrence and follow up outcomes were ***:Sixteen patients were treated by endoscopic resection and 16 patients were treated by transanal *** significant differences were present in the baseline *** rate of complete resection in the endoscopic resection group was 93.8%,compared to 87.5% in the transanal excision group(P=0.544).The mean length of hospital-stay in the endoscopic resection group was 2.7 ± 1.1 d,compared to 8.9 ± 2.7 d in the transanal excision group(P=0.001).The median follow up was 15.0 mo(range 6-99).During the follow up period,there was no case of recurrent disease in either ***:Endoscopic resection was a safe and effective method for the treatment of early rectal cancers and its outcomes were comparable to those of transanal excision procedures.

关键词： Endoscopic resection Rectal cancer Transanal excision

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Efficacy and safety of ecabet sodium on functional dyspepsia:A prospective,double-blinded,randomized,multi-center controlled trial

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World Journal of Gastroenterology 2006年第17期12卷 2756-2761页

作者： Jun Haeng Lee Jae J kim Ki-Baik Hahm Dong Ho Lee Nayoung kim sung kook kim Jong Jae Park Seok Reyol Choi Jong Hun Lee Soo Teik Lee Eun Hyun Lee Jong Chul Rhee Department of Medicine sungkyunkwan University School of Medicine SeoulKorea Department of Gastroenterology Ajou University School of Medicine SuwonKorea Department of Internal Medicine Seoul National University Bundang Hospital SeoungnamGyeonggi-doKorea Department of Internal Medicine Kyungpook National University College of Medicine DaeguKorea Department of Internal Medicine Korea University Guro Hospital SeoulKorea Department of Internal Medicine Dong-A University BusanKorea Department of Internal Medicine Chonbuk National University College of Medicine ChonjuKorea Department of Preventive Medicine Graduate School of Public Health Ajou UniversitySuwonKorea

AIM： To compare ecabet sodium and cimetidine in relieving symptoms of functional dyspepsia. METHODS： We performed a multi-center, prospective, randomized, double-blinded controlled trial to compare the clinical efficacy of ecabet sodium and cimetidine in patients with functional dyspepsia. Two-hundred and seventy-two patients with dyspeptic symptoms fulfilling the Rome-II criteria were enrolled from 7 centers. In the study group （115 patients）, 1.5 g ecabet sodium was given twice a day. In the control group （121 patients）, 400 mg cimetidine was given twice a day. Symptoms and parameters of quality of life were analyzed at baseline, 3, 14, and 28 d after initiating the treatment. RESULTS： Two-hundred and thirty-six patients completed the clinical trial. After 4 wk of treatment, the rates of improvement in patients with dyspeptic symptoms were not different between two groups （77.4% in the ecabet group and 79.3% in the cimetidine group, respectively, P 〉 0.05）. Likewise, the rates of symptomatic improvement were not different at 3 d and 14 d. The parameters of quality of life did not change significantly during the study period in both groups. There was no clinically significant adverse event in both groups.

关键词： Functional dyspepsia Ecabet sodium Cimetidine

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Bispectral index monitoring as an adjunct to nurse-administered combined sedation during endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2012年第43期18卷 6284-6289页

作者： Se Young Jang Hyun Gu Park Min Kyu Jung Chang Min Cho Soo Young Park Seong Woo Jeon Won Young Tak Young Oh Kweon sung kook kim Young Hoon Jeon Department of Internal Medicine Kyungpook National University School of Medicine Daegu 700-721 South Korea Department of Anesthesiology and Pain Medicine Kyungpook National University School of Dentistry Daegu 700-721 South Korea

AIM:To determine whether bispectral index (BIS) monitoring is useful for propofol administration for deep sedation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Fifty-nine consecutive patients with a variety of reasons for ERCP who underwent the procedure at least twice between 1 July 2010 and 30 November 2010. This was a randomized cross-over study, in which each patient underwent ERCP twice, once with BIS monitoring and once with control monitoring. Whether BIS monitoring was done during the first or second ERCP procedure was random. Patients were intermittently administered a mixed regimen including midazolam, pethidine, and propofol by trained nurses. The nurse used a routine practice to monitor sedation using the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale or the BIS monitoring. The total amount of midazolam and propofol used and serious side effects were compared between the BIS and control groups. RESULTS:The mean total propofol dose administered was 53.1 ± 32.2 mg in the BIS group and 54.9 ± 30.8 mg in the control group (P = 0.673). The individual propofol dose received per minute during the ERCP procedure was 2.90 ± 1.83 mg/min in the BIS group and 3.44 ± 2.04 mg in the control group (P = 0.103). The median value of the MOAA/S score during the maintenance phase of sedation was comparable for the two groups. The mean BIS values throughout the procedure (from insertion to removal of the endoscope) were 76.5 ± 8.7 for all 59 patients in using the BIS monitor. No significant differences in the frequency of < 80% oxygen saturation, hypotension (< 80 mmHg), or bradycardia (< 50 beats/min) were observed between the two study groups. Four cases of poor cooperation occurred, in which the procedure should be stopped to add the propofol dose. After adding the propofol, the procedure could be conducted successfully (one case in the BIS group, three cases in the control group). The endoscopist rated patient sedation as exc

关键词： Conscious sedation Bispectral index monitors Pancreatic neoplasm Endoscopic retrograde cholangiopancreatography

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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑Chang sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong kim Ruqayya Afridi Il-sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Comparison of the impact of endoscopic retrograde cholangiopancreatography between pre-COVID-19 and current COVID-19 outbreaks in South Korea:Retrospective survey

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World Journal of Clinical Cases 2021年第28期9卷 8404-8412页

作者： kook Hyun kim sung Bum kim Division of Gastroenterology and HepatologyDepartment of Internal Medicine Yeungnam UniversityCollege of MedicineDaegu 42415South Korea

BACKGROUND The coronavirus disease 2019(COVID-19)outbreak has markedly influenced the endoscopic *** retrograde cholangiopancreatography(ERCP)is an essential technique for pancreatobiliary disease but increases the risk of exposure to the virus-containing body fluid;however,the impact of COVID-19 on ERCP is *** To compare the number of endoscopic activities and to analyze the clinical outcomes of ERCPs before and during the COVID-19 outbreak in Daegu,South *** This retrospective cohort study included patients aged≥18 years who underwent ERCP between February 18 and March 28,2020,at a tertiary *** indications and endoscopic details were compared with those from the same period in 2018 and 2019 as control *** Of the 269 ERCP procedures,113(42.0%)cases were performed as emergency *** number of ERCP procedures in 2018 and 2019 decreased by 20.2%and 56.6%,respectively,compared with that in 2020(P<0.01);among the 113 emergency ERCPs,the observed numbers in 2018(n=42)and 2019(n=55)dramatically dropped by 61.9%and 70.9%,respectively,compared with that in 2020(n=16).Of the 16 cases in 2020,stone removal was performed in five,biliary stenting in five,sphincterotomy in five,and nasobiliary drainage in *** case of ERCP-related infection in medical workers or other patients has been *** The COVID-19 outbreak significantly reduced the number of ERCPs;however,there is no difference in the indications and endoscopic interventions before and during the COVID-19 outbreak.

关键词： Coronavirus disease 2019 Coronavirus Endoscopic retrograde cholangi-opancreatography Emergency endoscopic retrograde cholangiopancreatography Endoscopy

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A novel electrospinning method for self-assembled tree-like fibrous scaffolds:Microenvironment-associated regulation of MSC behavior and bone regeneration

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Journal of Materials Science & Technology 2022年第20期115卷 52-70页

作者： Jeong In kim Ju Yeon kim sung-Ho kook Jeong-Chae Lee Cluster for Craniofacial Development and Regeneration Research Institute of Oral Biosciences and School of DentistryJeonbuk National UniversityJeonju 54896Republic of Korea Department of Bionanosystem Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Bioactive Material Sciences Research Center of Bioactive MaterialsJeonbuk National UniversityJeonju 54896Republic of Korea

Numerous studies highlight advantages of electrospun scaffolds in bone tissue engineering,in which cellular behavior is tightly affected by fiber topographical cues of ***,the classic electrospinning setup limits a desired presentation of biomimetic fibrous microenvironments that sense mechanosignaling and regulate stem cell *** aims of this study were to fabricate advanced asspun scaffolds presenting tree-like microfiber/nanonet networks and to evaluate their regulatory potentials on behavior of human mesenchymal stem cells(h MSCs)and bone *** we developed a novel electrospinning setup that allowed the presentation of patterned Trunk microfibers(TMF)and/or branched nanonet fibers(BNn Fs)in biomimetic fibrous *** the cellular mechanisms,anisotropichierarchical topography of TMF controlled behavior of h MSCs through focal adhesion formation and Yesassociated protein(YAP)induction,whereas BNn F disturbed such mechanosensing responses in the *** fiber microenvironment-related expression and nuclear localization of YAP *** correlated with the potentials of as-spun scaffolds to enhance osteogenic differentiation of the h MSCs and alveolar bone defect healing in an animal ***,this study provides an advanced approach of the modified electrospinning setup for presentation of biomimetic fibrillar microenvironments in as-spun scaffolds along with their application in stem cell behavior regulation and regenerative tissue engineering.

关键词： Electrospinning Advanced biomimetic scaffolds Stem cell behavior Mechanosensing Bone tissue engineering

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