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Compartmentalized regulation of organelle integrity in neurodegenerative diseases:lessons from the Drosophila motor neuron

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Neural Regeneration Research 2025年第1期20卷 195-196页

作者： Hyun sung Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Medical Research Institute and Department of PharmacologyPusan National University School of MedicineYangsanRepublic of Korea

Neurons are highly polarized,morphologically asymmetric,and functionally compartmentalized cells that contain long axons extending from the cell *** this reason,their maintenance relies on spatiotemporal regulation of organelle distribution between the somatodendritic and axonal *** some organelles,such as mitochondria and smooth endoplasmic reticulum,are widely distributed throughout the neuron,others are segregated to either the somatodendritic or axonal *** example,Golgi outposts and acidified lysosomes are predominantly present in the somatodendritic domain and rarely distributed along the axon,whereas newly formed autophagosomes and synaptic vesicles are mainly distributed in the distal axon(Britt et al.,2016).

关键词： organelle regulation distribution

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli Gu Kijung sung Chengbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Electrodeposition behavior and characteristics of Ni-carbon nanotube composite coatings

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 68-72页

作者： sung-Kyu KIM Tae-sung OH Department of Materials Science and Engineering Hongik University

Ni-CNT (carbon nanotube) composite coatings were processed by electrodeposition and their hardness and corrosion characteristics were investigated with variations of CNT concentration in an electrolyte solution and electrodeposition current density. With increasing the CNT concentration in the electrodeposition bath and the current density, more CNTs are incorporated into Ni matrix. Hardness values of the Ni-CNT coatings are irrelevant to the CNT concentration in the solution, the current density, and current mode, implying poor adhesion of CNTs to Ni matrix. With increasing the CNT content in the coating, the corrosion resistance of the Ni-CNT composite coating becomes inferior due to the porous microstructure.

关键词： composite coating carbon nanotube electrodeposition

UV-assisted flash light welding process to fabricate silver nanowire/graphene on a PET substrate for transparent electrodes

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Nano Research 2018年第4期11卷 2190-2203页

作者： Wan-Ho Chung sung-Hyeon Park sung-Jun Joo Hak-sung Kim Department of Mechanical Engineering Hanyang University 17 Haendang-Dong Seongdong-Gu Seoul 133-791 Republic of Korea Institute of Nano Science and Technology Hanyang University Seou1133-791 Republic of Korea

Graphene oxide and silver nanowires were bar coated onto polyethylene terephthalate （PET） substrates and then welded using an ultraviolet （UV）-assisted flash light irradiation process to achieve both high electrical conductivity and low haze. The irradiation process connected adjacent silver nanowires by welding, while simultaneously reducing the graphene oxide to graphene. This process was performed using a custom W-assisted flash light welding system at room temperature under ambient conditions and was extremely rapid, with processing time of several milliseconds. The effects of varying the weight fractions of the silver nanowires and graphene oxide and of varying the W-assisted flash light welding conditions （light energy and pulse duration） were investigated. The surface morphologies of the welded silver nanowire/graphene films were analyzed using scanning electron microscopy. Optical characterizations, including transmittance and haze measurements, were also conducted using a spectrophotometer. To test their resistance to oxidation, the welded silver nanowire/graphene films were subjected to high temperature in a furnace （100 ℃）, and their sheet resistances were measured every hour. The flash light welding process was found to yield silver nanowire/graphene films with high oxidation resistance, high conductivity （14.35 Ω·sq-1）, high transmittance （93.46%）, and low haze （0.9%）. This material showed uniform temperature distribution when applied as a resistive heating film.

关键词： silver nanowires graphene oxide transparent electrode flash light welding printed electronics

Utilizing Blockchain Technology to Improve WSN Security for Sensor Data Transmission

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Computers, Materials & Continua 2021年第8期68卷 1899-1918页

作者： sung-Jung Hsiao Wen-Tsai sung Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung41170Taiwan

This paper proposes a method for improving the data security of wireless sensor networks based on blockchain *** technology is applied to data transfer to build a highly secure wireless sensor *** this network,the relay stations use microcontrollers and embedded devices,and the microcontrollers,such as Raspberry Pi and Arduino Yun,represents mobile *** proposed system uses microcontrollers to facilitate the connection of various sensor *** adopting blockchain encryption,the security of sensing data can be effectively improved.A blockchain is a concatenated transaction record that is protected by *** section contains the encrypted hash of the previous section,the corresponding timestamp,and transaction *** transaction data denote the sensing data of the wireless sensing *** proposed system uses a hash value representation calculated by the Merkel-tree algorithm,which makes the transfer data of the system difficult to be tamped ***,the proposed system can serve as a private cloud data *** this study,the system visualizes the data uploaded by sensors and create relevant charts based on big data *** the webpage server of the proposed system is built on an embedded operating system,it is easy to model and visualize the corresponding graphics using Python or JavaScript programming ***,this study creates an embedded system mobile database and web server,which can utilize JavaScript program language and *** runtime environment to apply blockchain technology to mobile *** proposed method is verified by the experiment using about 1600 data *** results show that the possibility of data being changed is very small,and the probability of data being changed is almost zero.

关键词： Blockchain embedded system big data analysis python javascript node.js

Improving Speech Enhancement Framework via Deep Learning

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Computers, Materials & Continua 2023年第5期75卷 3817-3832页

Speech plays an extremely important role in social *** individuals suffer from a“speech barrier,”which limits their communication with *** this study,an improved speech recognitionmethod is proposed that addresses the needs of speech-impaired and deaf individuals.A basic improved connectionist temporal classification convolutional neural network(CTC-CNN)architecture acoustic model was constructed by combining a speech database with a deep neural *** sensors were used to convert the collected voice signals into text or corresponding voice signals to improve *** method can be extended to modern artificial intelligence techniques,with multiple applications such as meeting minutes,medical reports,and verbatim records for cars,sales,*** experiments,a modified CTC-CNN was used to train an acoustic model,which showed better performance than the earlier common *** a CTC-CNN baseline acoustic model was constructed and optimized,which reduced the error rate to about 18%and improved the accuracy rate.

关键词： Artificial intelligence speech recognition speech to text CTC-CNN

RFID Positioning and Physiological Signals for Remote Medical Care

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Computer Systems Science & Engineering 2022年第4期41卷 289-304页

作者： Wen-Tsai sung sung-Jung Hsiao Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung411030Taiwan Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan

The safety of patients and the quality of medical care provided to them are vital for their *** study establishes a set of RFID(Radio Fre-quency Identiﬁcation)-based systems of patient care based on physiological sig-nals in the pursuit of a remote medical care *** RFID-based positioning system allows medical staff to continuously observe the patient's health and *** staff can thus respond to medical emergencies in time and appropriately care for the *** the COVID-19 pandemic broke out,the proposed system was used to provide timely information on the location and body temperature of patients who had been screened for the *** results of experiments and comparative analyses show that the proposed system is superior to competing systems in *** use of remote monitoring technology makes user interface easier to provide high-quality medical services to remote areas with sparse populations,and enables better care of the elderly and patients with mobility *** can be found from the experiments of this research that the accuracy of the position sensor and the ability of package delivery are the best among the other related *** presentation of the graphical interface is also the most cordial among human-computer interaction and the operation is simple and clear.

关键词： Remote medical care active RFID positioning physiological signal