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Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul Song Min sung Kim Seungwon Yoo Ja hoon Koo Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

Theoretical Simulation of Surface Evolution Using the Random Deposition and Surface Relaxation for Metal Oxide Film in Atomic Layer Deposition

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Journal of Materials Science & Technology 2010年第4期26卷 371-374页

作者： Ji-hoon ahn Se-Hun Kwon Jin-Hyock Kim Ja-Yong Kim Sang-Won Kang Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology373-1Kusong-dongYusong-guTaejon 305-701Korea Hynix Semiconductor Incorporated San 136-1Ami-riBubal-eubIcheon-siKyongki-do467-701Korea

Atomic layer deposition （ALD） has become an essential deposition method for forming nanometer scale thin films in the microelectronics industry, and its applications have been extended to multi-component thin films, as well as to single metal oxide films. In order to investigate the development of the surface structure of ultra-thin film qualitatively as well as quantitatively, ALD processes are simulated with a molecular scale. For this simulation, the film materials are deposited on a imaginary substrate that consists of small lattice. The deposition behaviors are described by using random deposition （RD） model or random deposition with surface relaxation （RDSR） model as the ALD growth mode, and the proposed model was applied to the deposition of SrO-TiO2 thin films. Through this work, growth characteristics such as surface morphology, deposited film coverage can be predicted.

关键词： Atomic layer deposition Random deposition SrO-TiO2

Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration

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Neural Regeneration Research 2018年第10期13卷 1796-1803页

作者： Jongbae Choi Jun Ho Kim Ji Wook Jang Hyun Jung Kim sung hoon Choi sung Won Kwon R&D Center Genewel Co.Ltd. Department of Surgery CHA Bundang Medical CenterCHA University

The use of autologous nerve grafts remains the gold standard for treating nerve defects, but current nerve repair techniques are limited by donor tissue availability and morbidity associated with tissue loss. Recently, the use of conduits in nerve injury repair, made possible by tissue engineering, has shown therapeutic potential. We manufactured a biodegradable, collagen-based nerve conduit containing decellularized sciatic nerve matrix and compared this with a silicone conduit for peripheral nerve regeneration using a rat model. The collagen-based conduit contains nerve growth factor, brain-derived neurotrophic factor, and laminin, as demonstrated by enzyme-linked immunosorbent assay. Scanning electron microscopy images showed that the collagen-based conduit had an outer wall to prevent scar tissue infiltration and a porous inner structure to allow axonal growth. Rats that were implanted with the collagen-based conduit to bridge a sciatic nerve defect experienced significantly improved motor and sensory nerve functions and greatly enhanced nerve regeneration compared with rats in the sham control group and the silicone conduit group. Our results suggest that the biodegradable collagen-based nerve conduit is more effective for peripheral nerve regeneration than the silicone conduit.

关键词： nerve regeneration biodegradable decellularized collagen nerve conduit growth factor peripheral nerve injury regeneration silicone conduit rat model

Relationship between intraocular pressure and parameters of obesity in ocular hypertension

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 794-800页

作者： Min Won ahn Ji Woong Lee Jong hoon Shin Jong Soo Lee Busan sungmo Eye Hospital Busan 48064Korea Department of Ophthalmology Pusan National University College of Medicine and Medical Research Institute of Pusan National University HospitalBusan 49241Korea Department of Ophthalmology Pusan National University Yangsan HospitalYangsan 50612Korea

AIM:To evaluate the correlation between intraocular pressure(IOP)and various obesity-related health factors in patients with ocular hypertension in ***:A total of 40850 subjects underwent age,sex,body weight,and height assessments and automated multiphasic tests,including non-contact tonometry,automated perimetry,fundus photography,systolic/diastolic blood pressure measurement,and evaluation of obesity-related health parameters such as obesity index,body mass index(BMI),a body shape index(ABSI),and waist-to-height ratio(WtHR).Subjects were divided into ocular hypertension group and normal IOP group according to IOP after matching of age and ***:Of 40850 participants,1515(3.7%)had ocular hypertension,and 1515 with normal IOP were selected as controls using propensity score *** mean IOP of control group was 15.3±2.3 mm Hg,compared with 23.3±1.6 mm Hg in ocular hypertension ***,obesity index,BMI,and WtHR in the ocular hypertension group were significantly higher than in the normal IOP group(P<0.001,P<0.001,P=0.009,P=0.002).IOP of ocular hypertension was positively correlated with obesity index(P=0.027)and BMI(P=0.016),whereas IOP of control was positively correlated with blood pressure(P<0.001,P=0.002),obesity index(P<0.001),BMI(P<0.001),and WHtR(P=0.002).Systolic blood pressure(β=0.022,P<0.001)and body weight(β=0.016,P=0.02)were precursors of IOP in normal subjects,but sex(male;β=-0.231,P=0.008)and obesity index(β=-0.007,P=0.017)were precursors of ocular hypertension according to multiple regression ***:Among various obesity-related health parameters,obesity index is the best indicator for further increase in IOP in ocular hypertension group.

关键词： intraocular pressure ocular hypertension body mass index body shape index waist-to-height ratio

Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

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Cellular & Molecular Immunology 2022年第12期19卷 1373-1391页

作者： Hee Ja Kim Kyungwon Yang Kiyoon Kim Ye‐Ji Lee Sieun Lee sung Yong ahn Young‐Ho ahn Jihee Lee Kang Department of Physiology College of MedicineEwha Womans UniversitySeoul07804Korea Inflammation-Cancer Microenvironment Research Center College of MedicineEwha Womans UniversitySeoul07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul07804Korea

The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and ***-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine ***,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and *** exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation *** secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive *** inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive *** expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 *** receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of *** addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 *** with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic ***,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis.

关键词： CAFs Apoptotic lung cancer cells Notch1 WiSP-1 Efferocytosis Migration Invasion Metastasis

Variation in dynamic deformation behavior and resultant yield asymmetry of AZ80 alloy with extrusion temperature

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Journal of Materials Science & Technology 2020年第11期42卷 225-236页

作者： Sang-hoon Kim Sang Won Lee Byoung Gi Moon Ha Sik Kim sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu702701South Korea Implementation Research Division Korea Institute of Materials ScienceChangwon51508South Korea

In this work,variation in the dynamic recrystallization(DRX)and dynamic precipitation behavior of AZ80 alloy during extrusion due to changes in extrusion temperature was investigated,and the resultant microstructure and yield asymmetry were *** the extrusion temperature increases from 250℃to 350℃,the primary DRX mechanism changes from twin-induced DRX to discontinuous DRX,resulting in an increase in the DRX area fraction and un DRXed grain *** addition,as the extrusion temperature rises,Mg17Al12 precipitation during extrusion decreases sharply throughout the extruded *** reduction in the compressive yield strength(CYS)with increasing extrusion temperature is more pronounced than it is for the tensile yield strength(TYS),which ultimately increases the yield asymmetry of the extruded *** higher extrusion temperature has less of an influence on the TYS due to the promotion of certain hardening *** the other hand,the greater reduction in the CYS is attributed to the increased fraction and size of regions in which{1012}twins predominantly form and the lower amount of precipitates,which effectively facilitates{1012}twinning.

关键词： Magnesium alloys Extrusion Recrystallization Precipitation Yield asymmetry

Effectiveness of lorazepam-assisted interviews in an adolescent with dissociative amnesia A case report

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Neural Regeneration Research 2013年第2期8卷 186-190页

作者： Yuna Seo Mi-Hee Shin sung-Gon Kim Ji-hoon Kim Department of Psychiatry Aram Hospital Department of Psychiatry Pusan National University School of Medicine Division of Child-Adolescent Psychiatry Department of Psychiatry Pusan National University School of Medicine

To facilitate gathering information during a psychiatric interview, some psychiatrists advocate augmenting the interview using drugs. Rather than barbiturates, benzodiazepines have been used for drug-assisted interviews. Dissociative amnesia is one of the indications for these interviews. Herein, we present the case of a 15-year-old female who was diagnosed as having dissociative amnesia because of conflicts with her friends. She was administered a Iorazepam-assisted interview to aid recovery of her memories. In this case, a small dose of Iorazepam was sufficient to recover her memories without any adverse effects.

关键词： neural regeneration clinical practice dissociative amnesia dissociative disorder dissociation drug-assisted interview amobarbital, Iorazepam benzodiazepine adolescent memory loss emotional distress distress grant-supported paper neuroregeneration

Extrusion limit diagram of AZ91–0.9Ca–0.6Y–0.5MM alloy and effects of extrusion parameters on its microstructure and mechanical properties

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Journal of Magnesium and Alloys 2022年第12期10卷 3447-3458页

作者： Dong HeeLee Ye Jin Kim Sang-hoon Kim Byoung Gi Moon sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Agency for Defense Development Daejeon 34186Republic of Korea Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

An AZ91–0.9Ca–0.6Y–0.5MM(AZXWMM91100) alloy, which has higher corrosion resistance, ignition resistance, and extrudability than a commercial AZ91 alloy, has been developed recently. In this study, the AZXWMM91100 alloy is extruded at various temperatures(300–400 ℃) and ram speeds(1–14.5 mm/s), and the cracking behaviors, microstructure, and tensile properties of the extruded materials are systematically analyzed. On the basis of the pressure limit and surface and internal cracking limit, the extrusion limit diagram providing a safe extrusion processing zone is established. All of the materials extruded at temperatures and speeds within the safe extrusion processing zone have high surface quality and moderate tensile ductility with an elongation higher than 10%. Moreover, they have a fully recrystallized grain structure and contain undissolved particle stringers arranged parallel to the extrusion direction. The grain size of the extruded material does not show any relationship with the Zener–Hollomon parameter(Z). However, the yield strength(YS) of the extruded material is inversely proportional to the logarithm of the Z value, and their relationship is expressed as YS =-31.2·log(Z) + 536. These findings may broaden the understanding of the AZXWMM91100 alloy with excellent chemical and physical properties and provide valuable information for the development of high-performance extruded Mg products using this alloy.

关键词： Magnesium Extrudability Extrusion limit diagram Microstructure Tensile properties

Comments to young surgeons concerning laparoscopic spleenpreserving D2 lymph node dissection for advanced gastric cancer on the upper body

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Chinese Journal of Cancer Research 2014年第3期26卷 231-233页

作者： Yoon Young Choi Ji Yeong An Woo Jin Hyung sung hoon Noh Department of Surgery Yonsei University Health System Yonsei University College of Medicine

Qualified radical gastrectomy with lymph node dissection is very important to the prognosis of patients with gastric cancer. Now D2 lymph node dissection is standard procedure for gastric cancer surgery, and spleen hilar lymph node dissection is mandatory for gastric cancer in upper body. Because the anatomy of vessels in this area is very complicated, D2 lymph node dissection is technical challenging not only for open gastrectomy but also for laparoscopic one. Adapting a new technique is important to all surgeons, but we surgeons should always consider a patient＇s safety as the most important factor during surgery and that efforts should be based on scientific rationale with oncologic principles. I hope that the recent report by Huang et al. about laparoscopic spleen preserving hilar lymph node dissection would be helpful to young surgeons who will perform laparoscpic total gastrectomy for gastric cancer.

关键词： Gastric cancer lymph node dissection laparoscopy spleen