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Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea

World Journal of Gastrointestinal Oncology 2024年第1期16卷 51-60页

作者： Ga Hee Kim Yeong Chan Lee Tae Jun Kim sung Noh Hong Dong Kyung Chang Young-Ho Kim Dong-hoon Yang Chang Mo Moon Kyunga Kim Hyun Gun Kim Eun-Ran Kim Division of Gastroenterology Department of Internal MedicineAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineEwha Womans UniversitySeoul 07985South Korea Biomedical Statistics Center Samsung Medical CenterSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Korea

BACKGROUND The incidence of colorectal cancer(CRC)and preinvasive CRC(e.g.,early colon cancer and advanced adenoma)is gradually increasing in several *** To evaluate the trend in incidence of CRC and preinvasive CRC according to the increase in the number of colonoscopies performed in *** This retrospective cohort study enrolled Korean patients from 2002 to 2020 to evaluate the incidence of CRC and preinvasive CRC,and assess the numbers of diagnostic colonoscopies and colonoscopic ***-related complications by age group were also *** The incidence of CRC showed a rapid increase,then decreased after 2012 in the 50-75 year-age *** the study period,the rate of incidence of preinvasive CRC increased at a similar level in patients under 50 and 50-75 years of *** 2009,the increase has been rapid,showing a pattern similar to the increase in *** rate of colonoscopic polypectomy in patients aged under 50 was similar to the rate in patients over 75 years of age after *** rate of complications after colonoscopy and related deaths within 3 mo was high for those over 75 years of *** The diagnosis of preinvasive CRC increased with the increase in the number of colonoscopies *** the risk of colonoscopy-related hospitalization and death is high in the elderly,if early lesions at risk of developing CRC are diagnosed and treated under or at the age of 75,colonoscopy-related complications can be reduced for those aged 76 years or over.

关键词： Colorectal cancer Preinvasive colorectal cancer Colorectal polypectomy Colonoscopy

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Real-Time Tunable Gas Sensing Platform Based on SnO_(2) Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

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Nano-Micro Letters 2024年第12期16卷 103-119页

作者： Gi Baek Nam Jung-El Ryu Tae hoon Eom Seung Ju Kim Jun Min Suh Seungmin Lee sungkyun Choi Cheon Woo Moon Seon Ju Park Soo Min Lee Byungsoo Kim sung Hyuk Park Jin Wook Yang Sangjin Min Sohyeon Park sung Hwan Cho Hyuk Jin Kim Sang Eon Jun Tae Hyung Lee Yeong Jae Kim Jae Young Kim Young Joon Hong Jong-In Shim Hyung-Gi Byun Yongjo Park Inkyu Park Sang-Wan Ryu Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Research Laboratory of Electronics Department of Mechanical EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139USA Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Display Materials Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang University ERICAAnsan 15588Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok 25913Republic of Korea Advance Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Physics Chonnam National UniversityGwangju 500-757Republic of Korea

Micro-light-emitting diodes(μLEDs)have gained significant interest as an activation source for gas sensors owing to their advantages,including room temperature operation and low power ***,despite these benefits,challenges still exist such as a limited range of detectable gases and slow *** this study,we present a blueμLED-integrated light-activated gas sensor array based on SnO_(2)nanoparticles(NPs)that exhibit excellent sensitivity,tunable selectivity,and rapid detection with micro-watt level power *** optimal power forμLED is observed at the highest gas response,supported by finite-difference time-domain ***,we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO_(2)*** noble metals induce catalytic interaction with reducing gases,clearly distinguishing NH3,H2,and ***-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated,opening up new avenues for advancements in light-activated electronic nose technologies.

关键词： Micro-LED Gas sensor array Low power consumption Metal decoration Real-time detection

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Quantification of HBsAg:Basic virology for clinical practice

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World Journal of Gastroenterology 2011年第3期17卷 283-289页

作者： Jung Min Lee Sang hoon ahn Department of Internal Medicine Yonsei University College of Medicine Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine Liver Cirrhosis Clinical Research Center

Hepatitis B surface antigen (HBsAg) is produced and secreted through a complex mechanism that is still not fully understood. In clinical fields, HBsAg has long served as a qualitative diagnostic marker for hepatitis B virus infection. Notably, advances have been made in the development of quantitative HBsAg assays, which have allowed viral replication monitoring, and there is an opportunity to make maximal use of quantitative HBsAg to elucidate its role in clinical fields. Yet, it needs to be underscored that a further understanding of HBsAg, not only from clinical point of view but also from a virologic point of view, would enable us to deepen our insights, so that we could more widely expand and apply its utility. It is also important to be familiar with HBsAg variants and their clinical consequences in terms of immune escape mutants, issues resulting from overlap with corresponding mutation in the P gene, and detection problems for the HBsAg variants. In this article, we review current concepts and issues on the quantification of HBsAg titers with respect to their biologic nature, method principles, and clinically relevant topics.

关键词： Hepatitis B virus Hepatitis B surface antigen Quantitative assay Virology

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Progress of Materials and Devices for Neuromorphic Vision Sensors

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Nano-Micro Letters 2022年第12期14卷 239-271页

作者： sung Woon Cho Chanho Jo Yong-hoon Kim sung Kyu Park Department of Electrical and Electronics Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Advanced Components and Materials Engineering Sunchon National UniversitySunchŏnJeonnam 57922Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwon 16419Republic of Korea

The latest developments in bio-inspired neuromorphic vision sensors can be summarized in 3 keywords:smaller,faster,and smarter.(1)Smaller:Devices are becoming more compact by integrating previously separated components such as sensors,memory,and processing *** a prime example,the transition from traditional sensory vision computing to in-sensor vision computing has shown clear benefits,such as simpler circuitry,lower power consumption,and less data redundancy.(2)Swifter:Owing to the nature of physics,smaller and more integrated devices can detect,process,and react to input more *** addition,the methods for sensing and processing optical information using various materials(such as oxide semiconductors)are evolving.(3)Smarter:Owing to these two main research directions,we can expect advanced applications such as adaptive vision sensors,collision sensors,and nociceptive *** review mainly focuses on the recent progress,working mechanisms,image pre-processing techniques,and advanced features of two types of neuromorphic vision sensors based on near-sensor and in-sensor vision computing methodologies.

关键词： In-sensor computing Near-sensor computing Neuromorphic vision sensor Optoelectronic synaptic circuit Optoelectronic synapse

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Prediction models of hepatocellular carcinoma development in chronic hepatitis B patients

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World Journal of Gastroenterology 2016年第37期22卷 8314-8321页

作者： Hye Won Lee Sang hoon ahn Department of Internal Medicine Yonsei University College of Medicine Seoul 03722 South Korea Institute of Gastroenterology Yonsei University College of Medicine Seoul 03722 South Korea Liver Cirrhosis Clinical Research Center Seoul 03722 South Korea Brain Korea 21 Project for Medical Science Seoul 03722 South Korea

Chronic hepatitis B virus(HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma(HCC). Applying the same strategies for antiviral therapy and HCC surveillance to all chronic hepatitis B(CHB) patients would be a burden worldwide. To properly manage CHB patients, it is necessary to identify and classify the risk for HCC development in such patients. Several HCC risk scores based on risk factors such as cirrhosis, age, male gender, and high viral load have been used, and have negative predictive values of ≥ 95%. Most of these have been derived from, and internally validated in, treatment-na?ve Asian CHB patients. Herein, we summarized various HCC prediction models, including IPM(Individual Prediction Model), CU-HCC(Chinese University-HCC), GAG-HCC(Guide with Age, Gender, HBV DNA, Core Promoter Mutations and Cirrhosis-HCC), NGM-HCC(NomogramHCC), REACH-B(Risk Estimation for Hepatocellular Carcinoma in Chronic Hepatitis B), and Page-B score. To develop a noninvasive test of liver fibrosis, we also introduced a new scoring system that uses liver stiffness values from transient elastography, including an LSM(Liver Stiffness Measurement)-based model, LSM-HCC, and mR EACH-B(modified REACH-B).

关键词： Chronic hepatitis B Hepatocellular carcinoma Development Prediction models

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Transient elastography in chronic hepatitis B: An Asian perspective

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World Journal of Gastroenterology 2010年第41期16卷 5173-5180页

作者： Seung Up Kim Kwang-Hyub Han Sang hoon ahn Department of Internal Medicine Institute of Gastroenterology Yonsei University College of Medicine Seoul 120-752 South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752 South Korea Brain Korea 21 Project for Medical Science Seoul 120-752 South Kore

Transient elastography (TE) is a new non-invasive tool for assessing liver stiffness, which is correlated with the histologic stage of liver fibrosis. Many studies have reported a good accuracy of TE in predicting signif icant fibrosis and an optimal accuracy in predicting cirrhosis. Furthermore, the potential role of TE in screening the general population has also been proven. TE thus helps physicians to decide treatment strategies, predict prog-nosis, and monitor disease progression in patients with chronic liver disease and to screen the general popula-tion to identify high risk patients with potential liver disease. However, most data on the clinical roles of TE have been gathered in European patients with chronic hepatitis C (CHC), because TE was first developed in France. Accordingly, much data on the usefulness of TE in patients with CHC has accumulated. Recently, however, vigorous efforts have been made to apply TEto patients with chronic hepatitis B (CHB), and TE has also proved to have acceptable accuracy in diagnosing liver fibrosis and cirrhosis in these patients. Thus, we focused on TE in the Asian population with CHB in comparison with the European population with CHC and found that the diagnostic performance and cutoff values were different between the 2 populations possibly as a result of several different confounders between Asian and European populations (the etiology of chronic liver disease, histologic features, major fluctuation in alanine aminotransferase levels, and the prevalence of high body mass index and metabolic syndrome). Therefore, further studies tailored to the Asian population with CHB should be performed before the widespread application of TE in Asian populations with CHB.

关键词： Asia Chronic hepatitis B Fibroscan Hepatitis B virus Liver stiffness measurement Transient elas-tography

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Post-Translational Regulation of FLOWERING LOCUS T Protein in Arabidopsis

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Molecular Plant 2016年第2期9卷 308-311页

作者： Soo-Jin Kim sung Myun Hong Seong Jeon Yoo Suhyun Moon Hye Seung Jung Ji hoon ahn Creative Research Initiatives Department of Life Sciences Korea University Seoul 136-701 Korea

Dear Editor,Here, we report the developmental regulation of proteolytic cleavage of the FLOWERING LOCUS T （FT） protein. FT, a mem- ber of the phosphatidylethanolamine-binding protein （PEBP） family, functions as a florigen or a component of florigen. PEBP binds phosphoethanolamine, and its ligand-binding domain is evolutionarily conserved from bacteria to plants and animals （Schoentgen and Jolles, 1995; Bradley et al., 1996）. PEBPs regulate important signaling pathways to control growth and differentiation （Chautard et al., 2004）. Some animal PEBP homologs undergo post-translational regulation. For example,

关键词： cleavage functions phosphoethanolamine

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Immunotherapy for pancreatic cancer

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World Journal of Clinical Cases 2021年第13期9卷 2969-2982页

作者： Jai hoon Yoon Ye-Ji Jung sung-hoon Moon Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Hallym UniversityAnyang 14068South Korea Department of Internal Medicine University of Hallym College of MedicineHallym University Sacred Heart HospitalAnyang 14068South Korea

Pancreatic cancer, a highly lethal cancer, has the lowest 5-year survival rate forseveral reasons, including its tendency for the late diagnosis, a lack of serologicmarkers for screening, aggressive local invasion, its early metastaticdissemination, and its resistance to chemotherapy/radiotherapy. Pancreaticcancer evades immunologic elimination by a variety of mechanisms, includinginduction of an immunosuppressive microenvironment. Cancer-associatedfibroblasts interact with inhibitory immune cells, such as tumor-associatedmacrophages and regulatory T cells, to form an inflammatory shell-like desmoplasticstroma around tumor cells. Immunotherapy has the potential to mobilizethe immune system to eliminate cancer cells. Nevertheless, althoughimmunotherapy has shown brilliant results across a wide range of malignancies,only anti-programmed cell death 1 antibodies have been approved for use inpatients with pancreatic cancer who test positive for microsatellite instability ormismatch repair deficiency. Some patients treated with immunotherapy whoshow progression based on conventional response criteria may prove to have adurable response later. Continuation of immune-based treatment beyond diseaseprogression can be chosen if the patient is clinically stable. Immunotherapeuticapproaches for pancreatic cancer treatment deserve further exploration, given theplethora of combination trials with other immunotherapeutic agents, targetedtherapy, stroma-modulating agents, chemotherapy, and multi-way combinationtherapies.

关键词： Pancreatic adenocarcinoma Pancreatic cancer Immunotherapy Immune checkpoint inhibitor

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Effect of carbon on microstructure of CrAlC_xN_(1-x) coatings by hybrid coating system

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 78-82页

作者： sung-Kyu ahn Se-Hun KWON Kwang-Ho KIM National Core Research Center for Hybrid Materials Solution Pusan National University School of Materials Science and Engineering Pusan National University

A systematic investigation of the microstructure of CrA1CxN1-x coatings as a function of carbon contents was conducted. Quaternary CrA1CxN1-x coatings were deposited on Si wafers by a hybrid coating system combining an arc-ion plating technique and a DC reactive magnetron sputtering technique using Cr and AI targets in the Ar/N2/CH4 gaseous mixture. The effect of carbon content on microstructure of CrA1C^N~ x coatings was investigated with instrumental analyses of X-ray diffraction, X-ray photoelectron, and high-resolution transmission electron microscopy. The results show that the carbon content of CrA1CxN1-x coatings linearly increases with increasing CH4/（CH4/N2） gas flow rate ratio. The surface roughness of the CrA1CxN1-x coating layer decreases with the increase of carbon content.

关键词： CrA1C,N1-x, coating nanocomposite microstructure hybrid coating system

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Light Intensity and Floral Transition： Chloroplast Says ＂Time to Flower!＂

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Molecular Plant 2016年第12期9卷 1551-1553页

作者： Hendry Susila Suhyun Jin Ji hoon ahn Creative Research Initiatives Department of Life Sciences Korea University Seoul 02841 South Korea

Flowering represents a pivotal developmental transition from the vegetative stage to the reproductive stage. The timing of flower- ing must be carefully controlled under ever-changing environ- mental conditions to ensure successful reproduction. Extensive genetic and molecular biological analyses in the model species Arabidopsis thaliana have identified important regulators of flowering time and revealed a complex network of highly inter- connected pathways that are regulated by seasonal cues （e.g., light and temperature） and internal factors （e.g., age and nutrient availability）（Bouche et al., 2016）.

关键词： Prediction Classification Plant

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