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Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network

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Light(Science & Applications) 2022年第7期11卷 1595-1606页

作者： Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea sung Ryu Gunho Choi Hyun jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park Department of Physics Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea KAIST Institute for Health Science and Technology KAISTDaejeon 34141Republic of Korea Tomocube Inc. Daejeon 34109Republic of Korea Smart Healthcare&Device Research Center Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Emergency Medicine Bundang CHA HospitalSeongnam-siGyeonggi-Do 13496Korea Division of Infectious Diseases Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Laboratory Medicine Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of Physics Massachusetts Institute of TechnologyCambridgeMA 02139USA

The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial *** infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly *** studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to *** main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample ***,we propose a microscopy-based framework that identifies the pathogen from single to few *** framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural *** demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or *** performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical ***,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or *** believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections.

关键词： artificial neural exploit

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Benign gallbladder diseases:Imaging techniques and tips for differentiating with malignant gallbladder diseases

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World Journal of Gastroenterology 2020年第22期26卷 2967-2986页

作者： Mi Hye Yu Young Jun Kim hee Sun Park sung Il jung Department of Radiology Konkuk University Medical CenterKonkuk University School of Medicine120-1 Neungdong-roGwangjin-guSeoul 05030South Korea

Benign gallbladder diseases usually present with intraluminal lesions and localized or diffuse wall *** lesions of the gallbladder include gallstones,cholesterol polyps,adenomas,or sludge and polypoid type of gallbladder cancer must subsequently be *** size,stalk width,and enhancement intensity on contrast-enhanced ultrasound and degree of diffusion restriction may help differentiate cholesterol polyps and adenomas from gallbladder *** gallbladder wall thickening is largely due to segmental or focal gallbladder adenomyomatosis,although infiltrative cancer may present *** of Rokitansky-Aschoff sinuses is pivotal in diagnosing *** layered pattern,degree of enhancement,and integrity of the wall are imaging clues that help discriminate innocuous thickening from gallbladder ***-resolution ultrasound is especially useful for analyzing the layering of gallbladder wall.A diffusely thickened wall is frequently seen in inflammatory processes of the ***,it is important to check for coexistent cancer in instances of acute *** used alone is limited in evaluating complicated cholecystitis and often requires complementary computed *** chronic cholecystitis,preservation of a two-layered wall and weak wall enhancement are diagnostic clues for excluding *** resonance imaging in conjunction with diffusion-weighted imaging helps to differentiate xathogranulomatous cholecystitis from gallbladder cancer by identifying the presence of fat and degree of diffusion *** distinctions require a familiarity with typical imaging features of various gallbladder diseases and an understanding of the roles that assorted imaging modalities play in gallbladder evaluations.

关键词： Cholesterol polyp Gallbladder adenoma Adenomyomatosis Cholecystitis Xathogranulomatous cholecystitis Gallbladder cancer Imaging techniques

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Text-mining analysis using national R&D project data of South Korea to investigate innovation in graphene environment technology

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International Journal of Innovation Studies 2023年第1期7卷 87-99页

作者： Ji Yeon Lee jung Woo Choi Jae-Hak Choi Byeong-hee Lee NTIS Center Korea Institute of Science and Technology InformationDaejeon34141South Korea Department of Science and Technology Management Policy University of Science and TechnologyDaejeon34113South Korea Department of Polymer Science and Engineering Chungnam National UniversityDaejeon34134South Korea

This study investigates the possibilities offered by the development of graphene environment technology that can contribute to new and effective approaches for the transition to an ecologically benign *** analyze the research and development progress in graphene environment technology,graphene environment technology research trends of South Korea for the years 2009e2020 are investigated by acquiring information pertaining to national research and development projects related to graphene environment technology from the National Science and Technology Information *** structured and unstructured data are analyzed using diverse text-mining methods,such as keyword frequency analysis,association rule mining,and topic *** results indicate that graphene research in South Korea is focused primarily on graphene use in batteries and energy-storage devices,such as solar cells,fuel cells,and secondary *** study can help understand the manner by which the South Korean government has been investing in the research and development of graphene environment technology;additionally,it discusses the future applications and prospects of graphene for the next decade.

关键词： Graphene technology Environmental transition National R&D project information Text mining Trend analysis

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Incidence and Related Risk Factors of Junctional Ectopic Tachycardia in Infants after Cardiac Surgery for Congenital Heart Disease

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Congenital Heart Disease 2022年第5期17卷 569-578页

作者： Jae hee Seol Se Yong jung Jae Young Choi Han Ki Park Young Hwan Park Nam Kyun Kim Department of Pediatrics Congenital Heart Disease CenterDivision of Pediatric CardiologySeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics Yonsei University Wonju College of MedicineWonjuKorea Department of Thoracic and Cardiovascular Surgery Division of Cardiovascular SurgeryCongenital Heart Disease CenterSeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics and Biomedical Engineering School of MedicineEmory UniversityAtlantaUSA

Objective:Junctional ectopic tachycardia is common after cardiac surgery for congenital heart ***,its incidence and related risk factors in infants after cardiac surgery are not well *** objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and ***:We enrolled a total of 271 patients aged<1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December *** criteria were immediate postoperative mortality,other arrhythmias detected in the perioperative period,and ***:The overall incidence of junctional ectopic tachycardia was 12.9%.The logistic regression analysis revealed that longer cardiopulmonary bypass time,surgery involving atrioventricular node stretching,and the presence of early repolarization on preoperative electrocardiography increased the risk of junctional ectopic *** with junctional ectopic tachycardia had longer intubation time and intensive care unit ***:Junctional ectopic tachycardia is a common arrhythmia after cardiac surgery for congenital heart disease in ***,infants developing junctional ectopic tachycardia after cardiac surgery have specific preoperative electrocardiography *** risk factors for junctional ectopic tachycardia were associated not only with surgical procedural factors but also with preoperative electrocardiographic parameters.

关键词： Junctional ectopic tachycardia congenital heart disease early re-polarization

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Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro

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Journal of Traditional Chinese Medicine 2021年第2期41卷 219-226页

作者： FENG Jinghui Set Byeol Kim hee jung Lee Su Min Sim Soon sung Lim Hong Won Suh Department of Pharmacology College of MedicineHallym UniversityChuncheon 200-702South Korea Department of Food Sciences and Nutrition College of NaturalHealthand Life SciencesHallym UniversityChuncheon 200-702Republic of

OBJECTIVE:To investigate the possible antinociceptive effects of Salvia(S.)miltiorrhiza Bunge and its single components in monosodium urate(MSU)-induced pain model in mice and lipopolysaccharide(LPS)-induced inflammation model in RAW264.7 ***:Pretreatment of *** Bunge extract(from 1 to 50μg/mL)concentration-dependently attenuated LPS-induced nitric oxide(NO)*** extract of *** Bunge(50 or 100 mg/kg)also caused reversals of decreased threshold for pain in the MSU-treated group as measured by Von-Frey ***,we assessed the antinociceptive and anti-inflammatory properties of the active single components from *** Bunge such as 15,16-dihydrotanshinoneⅠ,tanshinoneⅠ,cryptotanshinone,miltirone,tanshinoneⅡA,and salvianolic acid *** of them showed an anti-inflammatory effect in LPS-induced NO release model and an antinociceptive effect in MSU-treated pain ***:Our results suggest that *** Bunge extract may exert anti-inflammatory effect by reducing LPS-induced NO release and an antinociceptive property in MSU-treated pain ***,tanshinoneⅡA,miltirone,cryptotanshinone,and 15,16-dihydrotanshinoneⅠ,not only appear to be responsible for LPS-induced NO release induced by *** Bunge,but also in the production of *** Bunge extract-induced antinociception in MSU-treated pain ***:Therefore,the analgesic and anti-inflammatory property of *** Bunge indicate it as a therapeutic potential candidate for the treatment of pain and inflammation.

关键词： Salvia miltiorrhiza lipopolysaccharides nitric oxide inflammation analgesics

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Factors Affecting the Genetic Diagnostic Rate in Congenital Heart Disease

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Congenital Heart Disease 2022年第6期17卷 653-673页

作者： Jun sung Park Go Hun Seo Yunha Choi Soojin Hwang Minji Kang Hyo-Sang Do Young-Hwue Kim Jeong Jin Yu Ellen Ai-Rhan Kim Euiseok jung Byong Sop Lee Jae Suk Baek Beom hee Lee Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea 3 Billion Inc.SeoulKorea Genome Research Center for Birth Defects and Genetic Diseases Asan Institute for Life SciencesAsan Medical CenterSeoulKorea Division of Cardiology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Division of Neonatology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Medical Genetics Center Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoulKorea

Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally,multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This studyinvestigated the diagnostic yield of whole-exome sequencing (WES) in patients with sporadic syndromic CHDand the phenotypic factors affecting the genetic diagnostic rate. Methods: Sixty-four patients with sporadic syndromicCHD aged 0.05), betweenthe groups with and without a diagnostic variant. However, patients with ≥3 extracardiac phenotypes had a significantlyhigher likelihood of having a diagnostic variant than those with ≤2 (38.3% vs. 5.9%, odds ratio = 9.93,95% confidence interval = 1.21–81.44, P = 0.013). Conclusions: The number of extracardiac phenotypes is importantin predicting the possibility of genetic diagnosis. Physicians will be able to select patients with a high probabilityof genetic diagnosis and provide appropriate genetic counseling based on the results of this study.

关键词： Heart defects congenital whole-exome sequencing genetic testing phenotype

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Assessment of pathogens and risk factors associated with bloodstream infection in the year after pediatric liver transplantation

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World Journal of Gastroenterology 2022年第11期28卷 1159-1171页

作者： Yeong Eun Kim Ho jung Choi Hye-Jin Lee Hyun Ju Oh Mi Kyoung Ahn Seak hee Oh jung-Man Namgoong Dae Yeon Kim Won Kyoung Jhang Seong Jong Park Dong-Hwan jung Deok Bog Moon Gi-Won Song Gil-Chun Park Tae-Yong Ha Chul-Soo Ahn Ki-Hun Kim Shin Hwang sung Gyu Lee Kyung Mo Kim Department of Pediatrics Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Pediatric Surgery Department of SurgeryAsan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Bloodstream infection(BSI)is one of the most significantly adverse events that can occur after liver transplantation(LT)in *** To analyze the profile of BSI according to the postoperative periods and assess the risk factors after pediatric *** Clinical data,collected from medical charts of children(n=378)who underwent primary LT,were retrospectively *** primary outcome considered was BSI in the first year after *** and multivariate analyses were performed to identify risk factors for BSI and respective odds ratios(ORs).RESULTS Of the examined patients,106(28%)experienced 162 episodes of pathogen-confirmed BSI during the first year after *** were 1.53±0.95 episodes per children(mean±SD)among BSIcomplicated patients with a median onset of 0.4 mo *** most common pathogenic organisms identified were Coagulase-negative staphylococci,followed by Enterococcus *** Streptococcus *** half(53%)of the BSIs were of unknown *** analysis demonstrated that young age(≤1.3 year;OR=2.1,P=0.011),growth failure(OR=2.1,P=0.045),liver support system(OR=4.2,P=0.008),and hospital stay of>44 d(OR=2.3,P=0.002)were independently associated with BSI in the year after *** BSI was frequently observed in patients after pediatric LT,affecting survival *** profile of BSI may inform clinical treatment and management in high-risk children after LT.

关键词： Bloodstream infection Liver transplantation Children Pathogens

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Rice pollen-specific OsRALF17 and OsRALF19 are essential for pollen tube growth

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植物学报:英文版 2023年第9期65卷 2218-2236页

作者： Eui‐jung Kim Ji‐Hyun Kim Woo‐Jong Hong Eun Young Kim Myung‐hee Kim Su Kyoung Lee Cheol Woo Min Sun Tae Kim Soon Ki Park Ki‐Hong jung Yu‐Jin Kim Graduate School of Green Bio‐Science&Crop Biotech Institute Kyung Hee UniversityYongin 17104Republic of Korea Department of Life Science and Environmental Biochemistry Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Department of Smart Farm Science Kyung Hee UniversityYongin 17104Republic of Korea School of Applied Biosciences Kyungpook National UniversityDaegu 41566Republic of Korea Genomics Division Department of Agricultural Bio‐ResourcesNational Institute of Agricultural SciencesRural Development AdministrationJeonju 54874Republic of Korea Department of Plant Bioscience Pusan National UniversityMiryang 50463Republic of Korea Research Center for Plant Plasticity Seoul National UniversitySeoul 08826Republic of Korea

Pollen tube growth is essential for successful double fertilization, which is critical for grain yield in crop plants. Rapid alkalinization factors(RALFs) function as ligands for signal transduction during fertilization. However, functional studies on RALF in monocot plants are ***, we functionally characterized two pollen-specific RALFs in rice(Oryza sativa) using multiple clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-induced loss-of-function mutants,peptide treatment, expression analyses, and tag reporter lines. Among the 41 RALF members in rice, OsRALF17 was specifically expressed at the highest level in pollen and pollen *** applied OsRALF17 or OsRALF19peptide inhibited pollen tube germination and elongation at high concentrations but enhanced tube elongation at low concentrations, indicating growth regulation. Double mutants of OsRALF17 and OsRALF19(ralf17/19) exhibited almost full male sterility with defects in pollen hydration, germination, and tube elongation,which was partially recovered by exogenous treatment with OsRALF17 peptide. This study revealed that two partially functionally redundant OsRALF17 and OsRALF19 bind to Oryza sativa male-gene transfer defective 2(OsMTD2) and transmit reactive oxygen species signals for pollen tube germination and integrity maintenance in rice. Transcriptomic analysis confirmed their common downstream genes, in osmtd2 and ralf17/19. This study provides new insights into the role of RALF, expanding our knowledge of the biological role of RALF in regulating rice fertilization.

关键词： CRISPR-Cas9 CrRLK1L monocot Oryza sativa pollen tube growth rapid alkalinization factor(RALF)

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UV light driven high-performance room temperature surface acoustic wave NH_(3) gas sensor using sulfur-doped g-C_(3)N_(4) quantum dots

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Nano Research 2023年第5期16卷 7682-7695页

作者： Kedhareswara Sairam Pasupuleti Sourabh S.Chougule Devthade Vidyasagar Na-hyun Bak Namgee jung Young-Heon Kim Jong-hee Lee Song-Gang Kim Moon-Deock Kim Department of Physics Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Materials Science and Engineering Kyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea Graduate School of Analytical Science and Technology Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Digital Agricultural Promotion Agricultural Cooperative UniversityGoyang-siGyeonggi-do 10292Republic of Korea Department of Smart Information Technology Joonbu University305 Donghen-roGoyangKyunggi-do 10279Republic of Korea Institute of Quantum Systems(IQS) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea

Nanomaterials integrated surface acoustic wave(SAW)gas sensing technology has emerged as a promising candidate for realtime toxic gas sensing applications for environmental and human health ***,the development of novel chemical interface based on two-dimensional(2D)sensing materials for SAW sensors for the rapid and sensitive detection of NH_(3)gas at room temperature(RT)still remains ***,we report a highly selective RT NH_(3)gas sensor based on sulfur-doped graphitic carbon nitride quantum dots(S@g-C_(3)N_(4)QD)coated langasite(LGS)SAW sensor with enhanced sensitivity and recovery rate under ultraviolet(UV)***,the sensitivity of the S@g-C_(3)N_(4)QD/LGS SAW sensor to NH_(3)(500 ppb)at RT is dramatically enhanced by~4.5-fold with a low detection limit(~85 ppb),high selectivity,excellent reproducibility,fast response/recovery time(70 s/79 s)under UV activation(365 nm)as compared to dark ***,the proposed sensor exhibited augmented NH_(3)detection capability across the broad range of relative humidity(20%–80%).Such remarkable gas sensing performances of the as-prepared sensor to NH_(3)are attributed to the high surface area,enhanced functional groups,sulfur defects,UV photogenerated charge carriers,facile charge transfer in the S@g-C_(3)N_(4)QD sensing layer,which further helps to improve the gas molecules adsorption that causes the increase in conductivity,resulting in larger frequency *** gas sensing mechanism of S@g-C_(3)N_(4)QD/LGS SAW sensor is ascribed to the enhanced electroacoustic effect,which is supported by the correlation of resistive type and COMSOL Multiphysics simulation *** envisage that the present work paves a promising strategy to develop the next generation 2D g-C_(3)N_(4)based high responsive RT SAW gas sensors.

关键词： two-dimensional graphitic carbon nitride(2D g-C_(3)N_(4)) sulfur doping quantum dots surface acoustic wave(SAW)sensor NH_(3)gas electroacoustic effect

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Rice tissue-specific promoters and conditiondependent promoters for effective translational application

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Journal of Integrative Plant Biology 2015年第11期57卷 913-924页

作者： hee-Jeong Jeong Ki-Hong jung Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Graduate School of Biotechnology Kyung Hee University

Rice （Oryza sativa） is one of the most important staple food crops for more than half of the world＇s population. The demand is increasing for food security because of population growth and environmental challenges triggered by climate changes. This scenario has led to more interest in developing crops with greater productivity and sustainability. The process of genetic transformation, a major tool for crop improvement, utilizes promoters as one of its key elements. Those promoters are generally divided into three types： constitutive, spatiotemporal, and condition-dependent. Tran- scriptional control of a constitutive promoter often leads to reduced plant growth, due to a negative effect of accumu- lated molecules during cellular functions or energy consump- tion. To maximize the effect of a transgene on transgenic plants, it is better to use condition-dependent or tissue- specific promoters. However, until now, those types have not been as widely applied in crop biotechnology. In this review, we introduce and discuss four groups of tissue-specific promoters （5o promoters in total） and six groups of condition-dependent promoters （27 promoters）. These pro- moters can be utilized to fine-tune desirable agronomic traits and develop crops with tolerance to various stresses, enhanced nutritional value, and advanced productivity.

关键词： Condition-dependent promoters crop biotechnologyapplication genetic transformation rice tissue-specific promoters

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