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Multi-Binary Classifiers Using Optimal Feature Selection for Memory-Saving Intrusion Detection Systems

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Computer Modeling in Engineering & Sciences 2024年第11期141卷 1473-1493页

作者： Ye-Seul Kil Yu-Ran Jeon sun-jin lee Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Republic of Korea Department of Convergence Security Engineering Sungshin Women’s UniversitySeoul02844Republic of Korea

With the rise of remote work and the digital industry,advanced cyberattacks have become more diverse and complex in terms of attack types and characteristics,rendering them difficult to detect with conventional intrusion detection ***-based intrusion detection methods can be used to detect attacks;however,they cannot detect new *** detection and response(EDR)tools are attracting attention as a means of detecting attacks on endpoints in real-time to overcome the limitations of signature-based intrusion detection ***,EDR tools are restricted by the continuous generation of unnecessary logs,resulting in poor detection performance and memory *** learning-based intrusion detection techniques for responding to advanced cyberattacks are memory intensive,using numerous features;they lack optimal feature selection for each attack *** overcome these limitations,this study proposes a memory-efficient intrusion detection approach incorporating multi-binary classifiers using optimal feature *** proposed model detects multiple types of malicious attacks using parallel binary classifiers with optimal features for each attack *** experimental results showed a 2.95%accuracy improvement and an 88.05%memory reduction using only six features compared to a model with 18 ***,compared to a conventional multi-classification model with simple feature selection based on permutation importance,the accuracy improved by 11.67%and the memory usage decreased by 44.87%.The proposed scheme demonstrates that effective intrusion detection is achievable with minimal features,making it suitable for memory-limited mobile and Internet of Things devices.

关键词： Endpoint detection and response feature selection machine learning malware detection

An Effective Threat Detection Framework for Advanced Persistent Cyberattacks

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Computers, Materials & Continua 2023年第5期75卷 4231-4253页

作者： So-Eun Jeon sun-jin lee Eun-Young lee Yeon-Ji lee Jung-Hwa Ryu Jung-Hyun Moon sun-Min Yi Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering Sungshin Women’s UniversitySeoul02844Korea

Recently,with the normalization of non-face-to-face online environments in response to the COVID-19 pandemic,the possibility of cyberattacks through endpoints has *** endpoint devices are managed meticulously to prevent cyberattacks and ensure timely responses to potential security *** particular,because telecommuting,telemedicine,and teleeducation are implemented in uncontrolled environments,attackers typically target vulnerable endpoints to acquire administrator rights or steal authentication information,and reports of endpoint attacks have been increasing *** persistent threats(APTs)using various novel variant malicious codes are a form of a sophisticated ***,conventional commercial antivirus and anti-malware systems that use signature-based attack detectionmethods cannot satisfactorily respond to such *** this paper,we propose a method that expands the detection coverage inAPT attack *** this model,an open-source threat detector and log collector are used synergistically to improve threat detection *** the scope of attack log collection through interworking between highly accessible open-source tools can efficiently increase the detection coverage of tactics and techniques used to deal with APT attacks,as defined by MITRE Adversarial Tactics,Techniques,and Common Knowledge(ATT&CK).We implemented an attack environment using an APT attack scenario emulator called Carbanak and analyzed the detection coverage of Google Rapid Response(GRR),an open-source threat detection tool,and Graylog,an open-source log *** proposed method expanded the detection coverage against MITRE ATT&CK by approximately 11%compared with that conventional methods.

关键词： Advanced persistent threat cybersecurity endpoint security MITRE ATT&CK open-source threat detector threat log collector

Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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Journal of Traditional Chinese Medicine 2023年第4期43卷 686-694页

作者： Dong-Wook Kang Jae-Gyun Choi Hee Ju Song Jaehyuk Kim Miae lee Taehee Kim Suk-Yun Kang Yeonhee Ryu Hwa Seung Yoo jin sun lee jin Bong Park Sang Do lee Hyun-Woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou jin Deng Weihong Nie Shuwei sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min Xu Hai-Ying jin Feng-Li sun Wei-Dong jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen jin Nan Wang Huiqi sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

A mechanical reinforced and antifreezing polyacrylate hydrogel electrolyte for high-performance zinc-ion batteries

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Nano Research 2025年第1期18卷 341-350页

作者： Zili Zhang Ruolin Wang Hongfei Lu Di Zhang Yu Zhao jing Xu Bin sun Zhi-Min Dang Yang jin School of Electrical and Information Engineering Zheng Zhou UniversityZhengzhou 450001China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The operation of aqueous zinc-ion batteries in flexible energy storage field is plagued by the uncontrollable growth of Zn-dendrite and inevitable freeze of water below 0 ℃.Therefore,it is necessary to design a hydrogel electrolyte with good mechanical property and freezing resistance to uniform the Zn-deposition and resist flexibility loss at low *** find that the mechanical property(strength and toughness)of hydrogel electrolyte has a significant impact on the suppression of dendrite growth and the uniform deposition of zinc ***,a polyacrylate hydrogel is prepared in one step by ultraviolet(UV)curing method with Zn(CF_(3)SO_(3))_(2)salt and polyvinyl alcohol(PVA)addition to increase the antifreezing ability and mechanical *** adsorption of water molecules by 2-hydroxyethyl acrylate(HEA)and PVA reduces the freezing point of the hydrogel,which is beneficial for enhancing the electrochemical stability at low *** this basis,the Zn-symmetrical battery with hydrogel electrolyte has a long lifespan of 4710 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2)at room ***,the hydrogel electrolyte exhibits an outstanding stability at low temperature of^(-2)0 ℃,the lifespan of symmetrical battery reaches to 4000 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2).The assembled full cell with NaV3O8·1.5H_(2)O(NVO)cathode and hydrogel electrolyte possesses a high capacity retention ratio of 77%after 10,000 cycles at^(-2)0 ℃.The flexible cell can power light-emitting diode(LED)lamp under bending,warping and cutting without liquid leakage and an electronic watch at the operating temperature of^(-2)0 ℃.

关键词： zinc ion battery hydrogel electrolyte mechanical enhancement freezing resistance

Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety

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Nano Research 2025年第1期18卷 572-585页

作者： Qing Wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li Jiayu Guo Danping Wang Shuo Wang Wenjing Wang Bowen Zhang Minglong Huang Xianbao Shi jin sun Zhonggui He Bingjun sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China

The clinical utility of irinotecan is restricted by individual variability in carboxylesterase *** administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alternative due to its potent anti-tumor ***,the undesirable properties of SN38,such as poor water solubility and nontarget toxicity,present significant hurdles to its clinical *** nanoassemblies based on modular design strategy show promise in overcoming these challenges by enhancing drug delivery and selective *** modular design,the modification module plays a crucial role in improving the self-assembly capability of *** current studies mainly focus on using straight aliphatic chains for prodrug design,branched aliphatic chains emerge as superior alternatives warranting further *** this study,we selected 2-heptylundecanol(BAlc18)as modification module to construct an SN38 *** exquisite design,SN38-SS-BAlc18 NPs integrated prominent properties in selfassembly capability,specific activation and biocompatibility,resolving the challenges of irinotecan and SN38,ultimately demonstrating excellent anti-tumor *** exploration enriched the design theory of prodrug nanoassemblies that can effectively balance safety and colorectal anti-tumor efficacy.

关键词： irinotecan SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu jin jinke Wang Rongqiao Wang Xiuchun Liu Kai Gao jingli sun Yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection