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CMOS direct conversion X-ray detector coupled with fluorinated liquid

Nuclear Science and Techniques 2025年第1期36卷 59-68页

作者： Shi-Hua Liu Chao-Song Gao Xin Zhang Xiang-ming sun Meng Wu zhi-Hui Han Tong Wan Yong-Shuai Ge Key Laboratory of Quark&Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China Guizhou Education University Guiyang 550018China Research Center for Medical Artificial Intelligence Chinese Academy of SciencesShenzhen Institutes of Advanced TechnologyShenzhen 518055China

X-ray detectors show potential applications in medical imaging,materials science,and nuclear *** achieve high detection efficiency and spatial resolution,many conventional semiconductor materials,such as amorphous selenium,cadmium telluride zinc,and perovskites,have been utilized in direct conversion X-ray ***,these semiconductor materials are susceptible to temperature-induced performance degradation,crystallization,delamination,uneven lattice growth,radiation damage,and high dark *** study explores a new approach by coupling an FC40 electronic fluorinated liquid with a specialized high-resolution and high-readout-speed complementary metal-oxide-semiconductor(CMOS)pixel array,specifically the Topmetal II−chip,to fabricate a direct conversion X-ray *** fluorinated liquid FC40(molecular formula:C_(21)F_(48)N_(2))is an electronic medium that is minimally affected by temperature and displays no issues with uniform *** exhibits a low dark current and minimal radiation damage and enables customizable thickness in X-ray *** addresses the limitations inherent in conventional semiconductor-based *** this study,simple X-ray detector imaging tests were conducted,demonstrating the excellent coupling capability between FC40 electronic fluorinated liquid and CMOS chips by the X-ray detector.A spatial resolution of 4.0 lp/mm was measured using a striped line par card,and a relatively clear image of a cockroach was displayed in the digital radiography imaging *** test results indicated the feasibility of fabricating an X-ray detector by combining FC40 electronic fluorinated liquid and CMOS *** to the absence of issues related to chip-material coupling,a high spatial resolution could be achieved by reducing the chip pixel *** method presents a new avenue for studies on novel liquid-based direct conversion X-ray detectors.

关键词： FC40 electronic fluorinated liquid CMOS pixel chip X-ray detector Spatial resolution

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ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice

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中国药理学与毒理学杂志 2018年第9期32卷 713-714页

作者： XIAO Kuo sun zhi-ming JIN Xue-qin MA Wei-ning SONG Yan LAI Shi-rong FAN ming-hua ZHANG Jing-liang YUE Wei-hua HUANG Zhuo State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Department of Neurology Shengjing Hospital affiliated to China Medical UniversityShenyang 110000China Peking University Sixth Hospita(Institute of Mental Health) Beijing 100191China National clinical Research Center for Mental Disorders&Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100191China Key Laboratory for Neuroscience Ministry of EducationBeijing 100191 china

The input-output relationship of neuronal networks depends heavily on the intrinsic properties of their neuronal *** changes in intrinsic properties have been observed in various physiological and pathological processes,such as learning,memory and ***,the cellular and molecular mechanisms underlying acquired changes in intrinsic excitability are still not fully ***,we demonstrate that ERG3 channels are critically involved in the regulation of intrinsic excitability in hippocampal CA1 pyramidal neurons and DG granule ***-down of ERG3 channels significantly increases neuronal intrinsic excitability,which is mainly caused by decreased fast afterhyperpolarization,delayed time to the generation of an action potential and enhanced summation of somatic excitatory post-synaptic ***,the expression level of ERG3 protein is significantly reduced in human and mouse brain tissues with temporal lobe ***,ERG3 channel knock-down in hippocampus significantly enhanced seizure susceptibility,while mice treated with ERG3 channel activator NS1643 were less prone to *** together,our results suggest ERG3 channels play an important role in determining the excitability of hippocampal neurons and dysregulation of these channels may be involved in the generation of ***3 channels may thus be a novel therapeutic target for the prevention of epilepsy.

关键词： ERG3 channels intrinsic property dysregulation epilepsy

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Immune Tolerance Therapy： A New Method for Treatment of Traumatic Brain Injury

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Chinese Medical Journal 2018年第16期131卷 1990-1998页

作者： Ruo-Yang Feng Qian Chen Wei-Jian Yang Xiao-Guang Tong zhi-ming sun Hua Yan Department of Neurosurgery Tianjin Medical University Tianjin 300070 China Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases Tianjin 300350 China Department of Neurosurgery Tianjin Huanhu Hospital Tianjin 300350 China Department of Spine Surgery Tianjin Huanhu Hospital Tianjin 300350 China

Objective： Due to the special anatomical structure and pathophysiological mechanism of the central nervous system （CNS）, there is a big difference between the repair of brain injury and other systems of the body. More and more evidence shows that targetedly reducing the autoimmune response of brain tissue without affecting the immune function in other parts of the body will be the best optimized treatment for brain injury. Data Sources： This review was based on data in articles published in PubMed up to June 5,2017, with the following keywords：＂immune tolerance＂, ＂traumatic brain injury＂, and ＂central nervous system＂. Study Selection： Original articles and critical reviews on immune tolerance and brain damage were selected for this review. References of the retrieved articles were also screened to search for potentially relevant papers. Results： The CNS is isolated from the immune system through the blood-brain barrier. After brain injury, brain antigens are released into the systemic circulation to induce damaging immune responses. Immune tolerance can effectively reduce the brain edema and neurological inflammatory response after brain injury, which is beneficial to the recovery of neurological function. The clinical application prospect and theoretical research value of the treatment of immune tolerance on traumatic brain inj ury （TBi） is worth attention. Conclusions： The establishment of immune tolerance mechanism has a high clinical value in the treatment of TBI. It opens up new opportunities for the treatment of brain damage.

关键词： Central Nervous System Immune Tolerance Traumatic Brain Injury

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Subsection cooling system of hot rolling silicon steel and its industrial application

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Journal of Iron and Steel Research International 2025年第1期32卷 159-170页

作者： Qiu-na Wang Ji-quan sun Li-po Yang Hai-shen Wang Li-jie Dong Jie-ming Li Zhen-yang zhi Yan-wen Bi National Engineering Research Center of Flat Rolling Equipment University of Science and Technology BeijingBeijing100083China Hot Rolling Department of Qian’an Iron and Steel Corporation Shougang Company LimitedTangshan064404HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina

An online subsection cooling method for hot rolling silicon steel was designed to achieve local adjustment of transverse roll ***,it was able to meet the requirements of edge drop of the strip by using the features of online thermal ***,after the new subsection spray beam was installed at the exit of mill,the special local cooling rules were analyzed for altering the thermal crown of roll according to rolling process ***,the dynamic impact of subsection cooling on the local thermal crown could just be obtained according to the measured ***,the heat transfer coefficient was determined by different subsection cooling curves under varied rolling ***,the rolling rhythm and variable conditions were important dynamic factors of transient roll temperature in practical rolling ***,real-time calculation and presetting of the thermal crown were carried out to maximize special requirements of load roll gap on local strip *** this new method,the transient temperature and the thermal crown of roll could be quantitatively controlled *** the practical results showed that the predicted temperature was able to match the measured value by more than 95%.Meanwhile,the adjustable range of thermal crown increased by more than 2.5 ***,the qualification rate of strip edge crown has increased from the original 30%to over 70%.

关键词： Subsection cooling Thermal roll crown Multi-parameter coupling Hot rolling Silicon steel

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Recycling Fe and improving organic pollutant removal via in situ forming magnetic core-shell Fe_(3)O_(4)@CaFe-LDH in Fe(Ⅱ)-catalyzed oxidative wastewater treatment

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Journal of Environmental Sciences 2025年第1期147卷 523-537页

作者： Ting He Jie sun Liangwei Deng Jialin ming Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu 610064China Biogas Institute of Ministry of Agriculture and Rural Affairs Chengdu 610041China Inner Mongolia Key Laboratory of Fine Organic Synthesis Inner Mongolia UniversityHohhot 010021China

Due to its high efficiency,Fe(Ⅱ)-based catalytic oxidation has been one of the most popular types of technology for treating growing organic pollutants.A lot of chemical Fe sludge alongwith various refractory pollutantswas concomitantly produced,whichmay cause secondary environmental problemswithout proper *** here innovatively proposed an effective method of achieving zero Fe sludge,reusing Fe resources(Fe recovery=100%)and advancing organics removal(final TOC removal>70%)simultaneously,based on the in situ formation of magnetic Ca-Fe layered double hydroxide(Fe_(3)O_(4)@CaFe-LDH)***(Ca^(2+)and Fe^(3+))concentration(≥30 mmol/L)and their molar ratio(Ca:Fe≥1.75)were crucial to the success of the *** nano Fe_(3)O_(4)was designed to be involved in the Fe(Ⅱ)-catalytic wastewater treatment process,and was modified by oxidation intermediates/products(especially those with COO-structure),which promoted the co-precipitation of Ca^(2+)(originated from Ca(OH)_(2)added after oxidation process)and byproduced Fe^(3+)cations on its surface to in situ generate core-shell Fe_(3)O_(4)@*** oxidation products were further removed during Fe_(3)O_(4)@CaFe-LDH material formation via intercalation and *** applicable to many kinds of organicwastewater,such as bisphenol A,methyl orange,humics,and biogas *** prepared magnetic and hierarchical CaFe-LDH nanocomposite material showed comparable application performance to the recently reported *** work provides a new strategy for efficiently enhancing the efficiency and economy of Fe(Ⅱ)-catalyzed oxidative wastewater treatment by producing high value-added LDHs materials.

关键词： CaFe layered double hydroxide Fe(Ⅱ)-catalytic oxidation Fe recycling Magnetic nanomaterial in situ formation Fe_(3)O_(4)modification

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Evaluation of diffusion weighted imaging of magnetic resonance imaging in small focal hepatic lesions:a quantitative study in 56 cases

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 406-409页

作者： Xian-Yue Quan, Xi-Jie sun, zhi-Jian Yu and ming Tang Imaging Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China Imaging Center Affiliated Zhujiang Hospital of Southern Medical University Guangzhou 510282 China. quanxianyue@***

Diffusion-weighted imaging (DWI) as a new technique of magnetic resonance imaging (MRI) is used to detect focal hepatic lesions. This study was designed to evaluate the significance of DWI to differentiate focal hepatic lesions less than 3 cm in diameter by the quantitation of apparent diffusion coefficient (ADC) values. METHODS:DWI using 1.5T MRI scanner unit was performed with a spin-echo single-shot echo planar imaging (EPI) in 56 cases of small focal hepatic lesions, including hepatocellular carcinoma (11), hepatic metastatic tumor (15 ), hepatic cavernous hemangioma (14), and hepatic cyst (16).The ADC values of these lesions were calculated respectively. The ratios of the ADC values of lesion/liver in hepatocellular carcinomas and hepatic metastatic tumors were also estimated. RESULTS:The mean ADC values (mm2/s) were (0.93±0.06) ×10-3 in hepatocellular carcinomas, (1.09±0.18)×10-3 in hepatic metastatic tumors,(1.95±0.38)×10-3 in hepatic cavernous hemangiomas, and (3.18±0.33) ×10-3 in hepatic cysts. The ratios of ADC values of lesion/liver were 0.90±0.06 and 1.15±0.14 in hepatocellular carcinoma and hepatic metastatic tumors respectively, which were significantly different (P<0.05). CONCLUSION:The measurement of ADC values and the ratios of ADC values of lesion/liver are helpful in MR diagnosis and differentiation of focal hepatic lesions.

关键词： quantitative study diffusion-weighted imaging apparent diffusion coefficient magnetic resonance imaging b value

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Surface modification of calcium carbonate:A review of theories,methods and applications

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Journal of Central South University 2021年第9期28卷 2589-2611页

作者： LI Chun-quan LIANG Chao CHEN Zhen-ming DI Yong-hao ZHENG Shui-lin WEI Shi sun zhi-ming School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization College of Materials and Chemical EngineeringHezhou UniversityHezhou 542899China

Calcium carbonate,which is widely employed as a filler added into the polymer matrix,has large numbers of applications owing to the excellent properties such as low cost,non-toxicity,high natural reserves and ***,in order to obtain the good filling effect,calcium carbonate needs to be surface modified by organic molecules so as to enhance the dispersion and compatibility within the *** review paper systematically introduces the theory,methods,and applications progress of calcium carbonate with surface ***,the key factors that affect the properties of the composites as well as the current difficulties and challenges are *** current research progress and potential application prospects of calcium carbonate in the fields of plastics,rubber,paper,medicine and environmental protection are discussed as ***,this review can provide valuable reference for the modification and comprehensive utilization of calcium carbonate.

关键词： calcium carbonate surface modification polymer-based composite monolayer coating modification mechanism

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A Preliminary Catalog of Early Aftershocks Following the 7 January 2025 MS6.8 Dingri,Xizang Earthquake

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Journal of Earth Science 2025年

作者： Jiayuan Yao Dongdong Yao Fang Chen ming zhi Li sun Dun Wang Hubei Subsurface Multi-scale Imaging Key Laboratory School of Geophysics and GeomaticsChina University of Geosciences State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences(Wuhan) State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of Geosciences(Wuhan) China Earthquake Networks Center

INTRODUCTION On January 7,2025,at 9:05 AM BJT,a MS6.8 earthquake （CENC epicenter:28.50°N,87.45°E） struck Dingri County,Xizang Province （hereinafter referred to as the Dingri mainshock）.The inferred moment magnitude,based on regional/teleseismic waveform inversion and back-projection,is approximately *** mechanism solutions,aftershock distribution,and field surveys indicate that the Dingri mainshock was a normal-faulting event,with a nearly north-south strike and a westwarddipping fault plane.

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Prediction of intrusive gas pores caused by resin burning in sand core for iron castings

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China Foundry 2025年第1期22卷 23-32页

作者： Ji-wu Wang Xiao-long Wang Yu-cheng sun Yu-hang Huang Xiu-ming Chen Xiong-zhi Wu Na Li Jin-wu Kang Tao Jing Tian-you Huang Hai-liang Yu School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Weichai Power Co. Ltd.Weifang 261061ShandongChina School of Mechanical Engineering Central South UniversityChangsha 41000China School of Materials Science and Engineering Key Laboratory for Advanced Materials Processing TechnologyTsinghua UniversityBeijing 100084China

In the production of castings,intrusive gas pore represents a kind of common defects which can lead to leakage in high gas-tightness requirement castings,such as cylinder blocks and cylinder heads for *** occurs due to the intrusion of gases generated during the resin burning of the sand core into castings during the casting ***,a gas generation and flow constitution model was established,in which the gas generation rate is a function of temperature and time,and the flow of gas is controlled by the gas release,conservation,and Darcy's *** heat transfer and gas flow during casting process was numerically *** dangerous point of cores is firstly identified by a virtual heat transfer method based on the similarity between heat transfer and gas flow in the sand *** gas pores in castings are predicted by the gas pressure,the viscosity and state of the melt for these dangerous *** distinct sand core structures were designed and used for the production of iron castings,and the simulated gas pore results were validated by the obtained castings.

关键词： gas pore numerical simulation iron casting sand core resin

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A cationic radical lanthanide organic tetrahedron with remarkable coordination enhanced radical stability

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Chinese Chemical Letters 2025年第02期36卷 568-573页

作者： Zhengzhong Zhu Shaojun Hu zhi Liu Lipeng Zhou Chongbin Tian Qingfu sun State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of the Chinese Academy of Sciences

Rare–earth supramolecular compounds, such as lanthanide organic polyhedrons（LOPs）, are of particular interest due to their many possible applications in various fields. Here we report the first syntheses of Ln4(L·+)4–type(Ln, lanthanides; L·+, radical ligand) radical–bridged lanthanide organic tetrahedrons by self–assembly of face–capping triphenylamine（TPA）–cored radical ligand with different lanthanide *** coordination enhanced radical stability has been observed, with half–life times(t1/2) for L1·+,La4(L1·+)4, Eu4(L1·+)4, Gd4(L1·+)4, Tb4(L1·+)4and Lu4(L1·+)4estimated to be 53 min, 482 min, 624 min,1248 min, 822 min and 347 min, respectively. The TPA radical in Ln4(L1·+)4containing paramagnetic Ln ions（Ln = EuⅢ, GdⅢand TbⅢ） is observed to be more stable than that in Ln4(L1·+)4（Ln = LaⅢand LuⅢ）constructed by diamagnetic Ln ions. This difference in radical stability is possibly due to the magnetic interactions between paramagnetic LnⅢions and L1·+ligands, as confirmed by electron paramagnetic resonance（EPR） in La4（L）4(L = L1and L1·+) and Tb4（L）4(L = L1and L1·+), and magnetic susceptibility measurements in Tb·4（L）4(L = L1and L1·+). Our study reveals the coordination of radical ligands with lanthanide ions can improve the radical stability, which is crucial for their applications.

关键词： Enhanced stability Lanthanide organic polyhedrons Radical Self–assembly Supramolecular chemistry

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