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Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin

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Science China(Life Sciences) 2024年第6期67卷 1226-1241页

作者： Zhengyang Guo Jiaqi Huang xiao Huo Chen Huang xiaotong Yu Yan sun Yanfang Li Tianhui He Hongyan Guo Jianling Yang Lixiang xue Cancer Center of Peking University Third Hospital Beijing 100191China Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third HospitalBeijing 100191China Peking University Third Hospital Cancer Center Department of Radiation OncologyPeking University Third HospitalBeijing 100191China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Ovarian cancer is the most lethal and aggressive gynecological cancer with a high recurrence rate and is often diagnosed *** ovarian cancer,multiple metabolic enzymes of lipid metabolism are abnormally expressed,resulting in metabolism *** a characteristic pathway in polyunsaturated fatty acid(PUFA)metabolism,arachidonic acid(AA)metabolism is disturbed in ovarian ***,we established a 10-gene signature model to evaluate the prognostic risk of PUFA-related *** 10-gene signature has strong robustness and can play a stable predictive role in datasets of various platforms(TCGA,ICGC,and GSE17260).The high association between the risk subgroups and clinical characteristics indicated a good performance of the *** data further indicated that the high expression of LTA4H was positively correlated with poor prognosis in ovarian *** of LTA4H enhanced sensitivity to Cisplatin and modified the characteristics of immune cell infiltration in ovarian ***,our results indicate that CCL5 was involved in the aberrant metabolism of the AA/LTA4H axis,which contributes to the reduction of tumor-infiltrating CD8+T cells and immune escape in ovarian *** findings provide new insights into the prognosis and potential target of LTA4H/CCL5 in treating ovarian cancer.

关键词： ovarian cancer polyunsaturated fatty acids prognostic risk model LTA4H tumor immunity CCL5

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Transplantation of human placental chorionic plate-derived mesenchymal stem cells for repair of neurological damage in neonatal hypoxic-ischemic encephalopathy

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Neural Regeneration Research 2024年第9期19卷 2027-2035页

作者： Lulu xue Ruolan Du Ning Bi Qiuxia xiao Yifei sun Ruize Niu Yaxin Tan Li Chen Jia Liu Tinghua Wang Liulin Xiong Transformation Research Laboratory The Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina State Key Laboratory of Biotherapy Sichuan UniversityChengduSichuan ProvinceChina Institute of Neurological Disease Translational Neuroscience CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Animal Zoology Institute of NeuroscienceKunming Medical UniversityKunmingYunnan ProvinceChina Department of Anesthesiology The Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina Department of Pediatrics the People’s Liberation Army Rocket Force Characteristic Medical CenterBeijingChina

Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy,neurosensory impairments,and cognitive deficits,and there is no effective treatment for complications related to hypoxic-ischemic *** therapeutic potential of human placental chorionic plate-derived mesenchymal stem cells for various diseases has been ***,the potential use of human placental chorionic plate-derived mesenchymal stem cells for the treatment of neonatal hypoxic-ischemic encephalopathy has not yet been *** this study,we injected human placental chorionic plate-derived mesenchymal stem cells into the lateral ventricle of a neonatal hypoxic-ischemic encephalopathy rat model and observed significant improvements in both cognitive and motor *** chip analysis showed that interleukin-3 expression was significantly elevated in neonatal hypoxic-ischemic encephalopathy model *** transplantation of human placental chorionic plate-derived mesenchymal stem cells,interleukin-3 expression was *** further investigate the role of interleukin-3 in neonatal hypoxic-ischemic encephalopathy,we established an in vitro SH-SY5Y cell model of hypoxic-ischemic injury through oxygen-glucose deprivation and silenced interleukin-3 expression using small interfering *** found that the activity and proliferation of SH-SY5Y cells subjected to oxygen-glucose deprivation were further suppressed by interleukin-3 ***,interleukin-3 knockout exacerbated neuronal damage and cognitive and motor function impairment in rat models of hypoxic-ischemic *** findings suggest that transplantation of hpcMSCs ameliorated behavioral impairments in a rat model of hypoxic-ischemic encephalopathy,and this effect was mediated by interleukin-3-dependent neurological function.

关键词： behavioral evaluations gene knockout human neuroblastoma cells(SH-SY5Y) human placental chorionic derived mesenchymal stem cells interleukin-3 neonatal hypoxic-ischemic encephalopathy nerve injury oxygen-glucose deprivation protein chip small interfering RNA

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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141,DDHD2,and LHFPL5

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Frontiers of Medicine 2024年第1期18卷 81-97页

作者： Liwei sun xueting Yang Amjad Khan xue Yu Han Zhang Shirui Han Xiaerbati Habulieti Yang sun Rongrong Wang xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory for Complex Severe and Rare DiseasesInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing100005China Chongqing Key Laboratory of Human Embryo Engineering Center for Reproductive MedicineNational Key Clinical Speciality Construction Project(Obstetrics and Gynecology)Chongqing Health Center for Women and ChildrenChongqing400013China Chongqing Clinical Research Center for Reproductive Medicine Women and Children’s Hospital of Chongqing Medical UniversityChongqing400013China Faculty of Biological Sciences Department of ZoologyUniversity of Lakki MarwatKhyber Pakhtunkhwa28420Pakistan Institute for Medical Genetics and Applied Genomics University of TübingenTübingen72076Germany Alexander von Humboldt fellowship Foundation Berlin10117Germany Department of Pediatrics The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Department of Laboratory Medicine State Key Laboratory for Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China

Highly clinical and genetic heterogeneity of neurodevelopmental disorders presents a major challenge in clinical genetics and *** variation analysis is imperative to analyze the disease phenotypes resulting from multilocus genomic ***,a Pakistani family with parental consanguinity was presented,characterized with severe intellectual disability(ID),spastic paraplegia,and *** mapping,integrated single nucleotide polymorphism(SNP)array,whole-exome sequencing,and whole-genome sequencing were performed,and homozygous variants in TMEM141(c.270G>A,***90^(*)),DDHD2(c.411+767_c.1249-327del),and LHFPL5(c.250delC,***84^(*))were identified.A Tmem141^(***90^(*)/***90^(*))mouse model was *** studies showed impairments in learning ability and motor *** slice electrophysiology and Golgi staining demonstrated deficient synaptic plasticity in hippocampal neurons and abnormal dendritic branching in cerebellar Purkinje *** electron microscopy showed abnormal mitochondrial ***,studies on a human in vitro neuronal model(SH-SY5Y cells)with stable shRNA-mediated knockdown of TMEM141 showed deleterious effect on bioenergetic function,possibly explaining the pathogenesis of replicated phenotypes in the cross-species mouse ***,panoramic variation analysis revealed that multilocus genomic variations of TMEM141,DDHD2,and LHFPL5 together caused variable phenotypes in ***,the biallelic loss-of-function variants of TMEM141 were responsible for syndromic ID.

关键词： neurodevelopmental disorder autosomal recessive intellectual disability consanguinity spastic paraplegia hearing loss TMEM141

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Acoustic characterization of hydrate formation and decomposition in clay-bearing sediments

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Petroleum Science 2024年第4期21卷 2830-2838页

作者： Yi-Jian Zhu xiao-Mei Yang Xing Huang Hao Li xiao-Hui Wang Yi-Fei sun Peng xiao Chang-Yu sun Guang-Jin Chen State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and Environment China University of Petroleum

Understanding the acoustic characteristics of hydrates in various sediments is crucial for hydrate resource detection and safe and efficient exploitation, as hydrate occurrence patterns vary greatly in different sediments. In this work, sediments with different bentonite contents, water saturations, and types were prepared to investigate the characteristics of P-wave velocity(reflecting the magnitude of hydrate saturation in the sediment) and amplitude(reflecting the degree of hydrate-sediment cementation) during hydrate formation and depressurization. During hydrate formation, the P-wave velocity and amplitude have similar trends. As clay content increases, the P-wave velocity increase rates quickened. On the other hand, the increased rate of P-wave velocity slows down with the increase of water saturation in the clay-bearing sediments. Comparing various types of sediment shows that the water absorption and swelling of bentonite reduce the pore space, speeding up the cementation of the hydrate with the sediment and increasing P-wave velocity at a faster rate. Correspondence between P-wave velocity and hydrate saturation is strongly related to sediment type, clay content, and water *** rapidly decreasing amplitude in the early stage of hydrate depressurization indicates that hydrate in clay-bearing sediments is weakly cemented to the sediments, which is prone to stratigraphic *** findings of this study offer guidance for hydrate resource assessments in clay-bearing sediments as well as geologic risk estimations during hydrate mining.

关键词： Gas hydrate Bentonite Illite P-wave velocity Amplitude

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Learning a Mixture of Conditional Gating Blocks for Visual Question Answering

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Journal of Computer Science & Technology 2024年第4期39卷 912-928页

作者： Qiang sun Yan-Wei Fu Xiang-Yang xue School of Statistics and Information Shanghai University of International Business and EconomicsShanghai 201620China Academy for Engineering and Technology Fudan UniversityShanghai 200433China School of Data Science Fudan UniversityShanghai 200433China School of Computer Science Fudan UniversityShanghai 200433China

As a Turing test in multimedia,visual question answering(VQA)aims to answer the textual question with a given ***,the“dynamic”property of neural networks has been explored as one of the most promising ways of improving the adaptability,interpretability,and capacity of the neural network ***,despite the prevalence of dynamic convolutional neural networks,it is relatively less touched and very nontrivial to exploit dynamics in the transformers of the VQA tasks through all the stages in an end-to-end ***,due to the large computation cost of transformers,researchers are inclined to only apply transformers on the extracted high-level visual features for downstream vision and language *** this end,we introduce a question-guided dynamic layer to the transformer as it can effectively increase the model capacity and require fewer transformer layers for the VQA *** particular,we name the dynamics in the Transformer as Conditional Multi-Head Self-Attention block(cMHSA).Furthermore,our questionguided cMHSA is compatible with conditional ResNeXt block(cResNeXt).Thus a novel model mixture of conditional gating blocks(McG)is proposed for VQA,which keeps the best of the Transformer,convolutional neural network(CNN),and dynamic *** pure conditional gating CNN model and the conditional gating Transformer model can be viewed as special examples of *** quantitatively and qualitatively evaluate McG on the CLEVR and VQA-Abstract *** experiments show that McG has achieved the state-of-the-art performance on these benchmark datasets.

关键词： visual question answering Transformer dynamic network

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论辛弃疾词的曲折含蕴美

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齐鲁学刊 2013年第1期 128-131页

作者：孙雪霄山东大学国际教育学院山东济南250100

辛弃疾是宋代成就最高的词人,其词作不仅抒写了雄浑壮阔的内容,而且具有词这一文体幽深精微的美质。文人和英雄的双重身份,使辛弃疾的情感格外深沉复杂,发而为词,就使其词作盘郁顿挫,具有特别动人的力量;与此相应,在意象上"摧刚为柔"和... 详细信息

辛弃疾是宋代成就最高的词人,其词作不仅抒写了雄浑壮阔的内容,而且具有词这一文体幽深精微的美质。文人和英雄的双重身份,使辛弃疾的情感格外深沉复杂,发而为词,就使其词作盘郁顿挫,具有特别动人的力量;与此相应,在意象上"摧刚为柔"和大小意象的对比,在结构上"以文为词"、"引气入词",在用典上丰赡贴切等艺术特点,也使其词作具有一种独特的曲折含蕴美。

关键词：稼轩词情感意象结构用典曲折含蕴

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Challenges and Suggestions of Ethical Review on Clinical Research Involving Brain-Computer Interfaces

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Chinese Medical Sciences Journal 2024年第2期39卷 131-139页

作者： xue-Qin Wang Hong-Qiang sun Jia-Yue Si Zi-Yan Lin xiao-Mei Zhai Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Chinese Academy of Medical Sciences Research Unit(No.2018RU006)Beijing 100191China Department of Psychology University of CaliforniaDavis 95616USA Department of Psychology University of TorontoToronto M5S 1A1Canada School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Academy for Advanced Interdisciplinary Studies Peking-Tsinghua Centre for Life Sciences and Peking University-International Development Group/McGovern Institute for Brain ResearchPeking UniversityBeijing 100871China

Brain-computer interface(BCI)technology is rapidly advancing in medical research and *** an emerging biomedical engineering technology,it has garnered significant attention in the clinical research of brain disease diagnosis and treatment,neurological rehabilitation,and mental ***,BCI also raises several challenges and ethical concerns in clinical *** this article,the authors investigate and discuss three aspects of BCI in medicine and healthcare:the state of international ethical governance,multidimensional ethical challenges pertaining to BCI in clinical research,and suggestive concerns for ethical *** the great potential of frontier BCI research and development in the field of medical care,the ethical challenges induced by itself and the complexities of clinical research and brain function have put forward new special fields for ethics in *** ensure"responsible innovation"in BCI research in healthcare and medicine,the creation of an ethical global governance framework and system,along with special guidelines for cutting-edge BCI research in medicine,is suggested.

关键词： brain-computer interface clinical research bioethics ethical governance ethical review

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二十世纪顾炎武诗文研究评述

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山东社会科学 2010年第5期 142-146页

作者：孙雪霄山东大学文学与新闻传播学院山东济南250100

迄今为止,学界对顾炎武的研究呈现重学术而轻文学的局面。之所以会出现这种局面,究其根源在于顾炎武本身就是一位对清代学术诸领域有着奠基性重大意义且并不以文人自居的研究对象。然而,事实上,顾炎武的文学创作,特别是其诗歌创作,成就... 详细信息

迄今为止,学界对顾炎武的研究呈现重学术而轻文学的局面。之所以会出现这种局面,究其根源在于顾炎武本身就是一位对清代学术诸领域有着奠基性重大意义且并不以文人自居的研究对象。然而,事实上,顾炎武的文学创作,特别是其诗歌创作,成就很高且影响深远。因此,诗文研究,应是顾炎武整体研究中不可或缺的一个方面,应当摆到与其学术思想研究并重的位置上。现从诗文集整理情况、生平事迹研究、诗文创作研究、诗文思想研究四个方面,对二十世纪学术界对顾炎武的诗文研究状况做一评述。

关键词：二十世纪顾炎武诗文研究评述

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以赋为词:柳永的市井之“俗”

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河北学刊 2011年第1期31卷 255-257页

作者：孙雪霄山东大学文学与新闻传播学院山东济南250100

"以赋为词"作为柳永作词的一个重要手法,与"俗"有着极为密切的关系。一方面,柳永长期混迹于市井民间,其受市井俗文学的影响具有客观基础和主观条件;另一方面,受市井俗文学影响的"以赋为词",又使得柳永一部分词作因词境的直露浅切、结构... 详细信息

"以赋为词"作为柳永作词的一个重要手法,与"俗"有着极为密切的关系。一方面,柳永长期混迹于市井民间,其受市井俗文学的影响具有客观基础和主观条件;另一方面,受市井俗文学影响的"以赋为词",又使得柳永一部分词作因词境的直露浅切、结构的平铺陈列而具有"俗"的特点。"以赋为词"正是沟通市井俗文学与柳永俗词的一个中介。

关键词：以赋为词市井俗文学俗词

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Metasurface array for single-shot spectroscopic ellipsometry

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Light(Science & Applications) 2024年第5期13卷 835-842页

作者： Shun Wen Xinyuan xue Shuai Wang Yibo Ni Liqun sun Yuanmu Yang Department of Precision Instrument State Key Laboratory of Precision Measurement Technology and InstrumentsTsinghua UniversityBeijing 100084China

Spectroscopic ellipsometry is a potent method that is widely adopted for the measurement of thin film thickness and refractive *** conventional ellipsometers utilize mechanically rotating polarizers and grating-based spectrometers for spectropolarimetric ***,we demonstrated a compact metasurface array-based spectroscopic ellipsometry system that allows single-shot spectropolarimetric detection and accurate determination of thin film properties without any mechanical *** silicon-based metasurface array with a highly anisotropic and diverse spectral response is combined with iterative optimization to reconstruct the full Stokes polarization spectrum of the light reflected by the thin film with high ***,the film thickness and refractive index can be determined by fitting the measurement results to a proper material model with high *** approach opens up a new pathway towards a compact and robust spectroscopic ellipsometry system for the high throughput measurement of thin film properties.

关键词： properties. spectroscopic film

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