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Structure,bioavailability and physicochemical properties of icariin-soymilk nanoparticle

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Food Science and Human Wellness 2024年第2期13卷 972-981页

作者： Jinping Wang Lingrong Wen Yueming Jiang Hong Zhu weizheng sun Guangyi Dai Bao Yang Guangdong Provincial Key Laboratory of Applied Botany Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic ImprovementSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China South China National Botanical Garden Guangzhou 510650China College of Food Science and Engineering Jilin Agricultural UniversityChangchun 130118China University of Chinese Academy of Sciences Beijing 100049China School of Food Sciences and Engineering South China University of TechnologyGuangzhou 510640China

Soymilk is a natural ***,the performance of flavonoid-soymilk nano-complex remains *** this work,icariin-soymilk nano-complexes(ISNCs)were successfully fabricated and *** effects of high-pressure homogenization(HPH)treatment on structure and physicochemical properties of soymilk and nano-complexes were *** treatment could significantly improve the surface hydrophobicity and interfacial activity of *** soymilk with HPH treatment could significantly improve the water solubility(20 folds),thermal stability and bioavailability of *** highest encapsulation efficiency(93.28%),loading capacity(39.09μg/mg),ζ-potentia(absolute value,31.20 mV)and bioavailability(72.14%)were observed in HSI-200(200 bar of homogenization pressure).While HSI-500(500 bar of homogenization pressure)showed the smallest particle size(183.73 nm).ISNCs showed a rougher surface and an irregular lamellar structure with large amount of fine particles by using Cryo-SEM,suggesting that icariin was encapsulated in *** data supplied a novel strategy to improve the performance of icariin in functional foods.

关键词： Encapsulation efficiency Flavonoid High pressure homogenization Loading capacity Nano-complex

茶多酚对大豆分离蛋白乳液性质及界面蛋白胆盐置换的影响

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华南理工大学学报（自然科学版） 2024年第4期52卷 26-32页

作者：葛鸽林立郑家宝孙为正北京市食品检验研究院(北京市食品安全监控和风险评估中心) 北京100094 华南理工大学食品科学与工程学院广东广州510640

通过添加不同含量的茶多酚提取物修饰大豆分离蛋白制备水包油乳液,考察大豆分离蛋白乳液的界面张力、蛋白吸附比例、乳液粒径以及Zeta电位等性质变化,探究茶多酚对大豆分离蛋白乳液性质和界面蛋白置换的影响。实验结果表明:添加茶多酚后... 详细信息

通过添加不同含量的茶多酚提取物修饰大豆分离蛋白制备水包油乳液,考察大豆分离蛋白乳液的界面张力、蛋白吸附比例、乳液粒径以及Zeta电位等性质变化,探究茶多酚对大豆分离蛋白乳液性质和界面蛋白置换的影响。实验结果表明:添加茶多酚后,大豆分离蛋白的界面张力升高;大豆分离蛋白溶液(1%,质量分数)按照9∶1(质量比)与大豆油混合后,经过高速剪切和超声制备成水包油乳液,添加茶多酚制备的乳液稳定性提高,与空白对照组相比,当茶多酚添加量为0.04%时,乳液平均粒径从1.702μm显著下降至1.203μm(P<0.05),乳液的蛋白吸附比例从9.22%显著上升至20.68%(P<0.05),Zeta电位绝对值从25.7 mV显著上升至27.1 mV(P<0.05);大豆分离蛋白在油-水界面上具有抗胆盐置换的特性,由茶多酚修饰的大豆分离蛋白更加难以被胆盐置换,这可能是添加茶多酚后大豆分离蛋白具有较强的静电相互作用以及较厚的界面层导致的。肠道中的脂质消化是界面过程,探究脂滴界面上蛋白与胆盐的置换反应对研究脂质代谢和食品精准设计具有指导作用。

关键词：茶多酚大豆分离蛋白乳液胆盐置换电位

Nonlinear Analysis of Axial-load and Stress Distribution for Threaded Connection

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Chinese Journal of Mechanical Engineering 2009年第6期22卷 869-875页

作者： LIAO Ridong sun Yujuan ZHANG weizheng School of Mechanical Engineering Beijing Institute of Technology Beijing 100081 China

Analytical method for the distributions of axial-load and stress is based on elastic assumption, but the threaded connections are often in plastic deformation stage in practice. Meanwhile the strain in the threaded connection is difficult to measure. So it is necessary to study the reliable numerical method. At present neither the convergence analysis of the computational results nor the elastic-plastic analysis in the loading-unloading process are studied. In this paper, von Mises plasticity and kinematic hardening model is used to describe the material response. A new convergence criterion for nonlinear finite element analysis of the loading-unloading process is proposed. An axisymmetric finite element model according to the proposed convergence criterion is developed and used to analyze the distributions of axial-load and stress. It can be conclude that the stress distribution analysis is more dependent on the mesh density than the axial-load distribution analysis. The stress distribution result indicates that with increasing of applied load, the engaged threads close to the nut-bearing surface become plastic firstly. The axial-load distribution result reveals that the load percentage carried by single thread depends on the position of thread and load intensity. When the load is relatively small, the applied load is mainly carried by the engaged threads near the nut-bearing surface, when the load is larger, the differences of percentages for all threads become small. The proposed convergence analyzing procedure is applicable for other nonlinear analyses. The obtained distributions of axial-load and stress can be a reference of engineering application.

关键词： threaded connection finite element method (FEM) axial-load distribution stress distribution convergence criterion

Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway

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Journal of Traditional Chinese Medicine 2014年第1期34卷 23-29页

作者： Jinhuan Wang Feng sun weizheng sun Yanli Yong Haitao Shi Sijia Liu Limei Liu Department of Hematology First Affiliated HospitalHeilongjiang University of Chinese Medicine Department of Traditional Chinese Medicine Longnan Hospital of Daqing City Department of Encephalopathy Chinese Medicine Hospital of Harbin Renal Department of Internal Medicine Heilongjiang Provincial Academy of Traditional Chinese Medicine

OBJECTIVE:To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia(NSAA)and investigate its effect on the mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)***:Sixty NSAA patients were divided equally into two *** in the experimental group were treated with Busuishengxue granules,and the control group with Zaizaoshengxue *** treatment course was 6 months and cu-rative efficacy was compared between the two groups as well as with 10 healthy *** cytometry(FCM)was used to detect the intracellular concentration of Ca2+([Ca2+]i).Western blotting was employed to detect the expression of enzymes in the MAPK/ERK ***:The efficacy of Busuishengxue granules was significantly better than that of Zaizaoshengxue tablets(P<0.05).Before treatment,expression of JNK,phospho-ERK 1/2 and p-JNK was higher,and[Ca2+]i higher,than that of the control group(P<0.05).After treatment with Busuishengxue granules,expression of all enzymes related to signal transduction pathways in the blood cells of NSSA patients were altered to different ***:Busuishengxue granules had a better effect with regard to improving symptom scores,increasing the number of blood leukocytes,and increasing hemoglobin levels than Zaizaoshengxue tablets,and they differed slightly in terms of increasing the number of platelets.

关键词： Anemia aplastic MAP kinase signaling system Busuishengxue granule Zaizaoshengxue tablet

Accumulation in Dasuopu ice core in Qinghai-Tibet Plateau and solar activity

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Chinese Science Bulletin 2000年第11期45卷 1038-1042页

作者： Keqin Duan Ninglian Wang Yuefang Li weizheng sun Lanzhou Inst Glaciol & Geocryol Ice Core & Cold Reg Res Lab Lanzhou 730000 Peoples R China

The time series of accumulation in recent 300 years correlated well with solar activity in Dasuopu ice core. Results of spectrum analysis on the accumulation time series of the Dasuopu ice core shows that there are some periods that coincide with the periods of solar activity. By comparing the long-time change trend of the accumulation in the Dasuopu ice core with various kinds of indexes of solar activity intensity, a negative correlation is found between the trend and solar activity.

关键词： Dasuopu ice core accumulation solar activity.

China Leaps to Lead in Global FPSO

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China Oil & Gas 2005年第3期12卷 38-39页

作者： sun weizheng CNOOC Bohai Company

Floating production, storage and offloading unit （FPSO）, a single engineering unit with the largest investment in offshore petroleum industry, carries on board various facilities including oil production, storage and export, as well as living and power. It is used to process and storage crude oil, which will be shipped regularly by tankers to various places. Along with the intensification of offshore exploration and development in China, China National Offshore Oil Corporation （CNOOC） has been working hard to expand its FPSO industry scope. Now, 14 FPSO units have been put into operation in 16 oilfields, of which 13 FPSO units operate in China＇s offshore and 1 in Java offshore in Indonesia. China＇s FPSO technology has reached international advanced level and China has become the largest manufacturer and user of FPSO in the world, with both the number and gross tonnage of FPSO units ranking the top of the world.

关键词：中国海洋石油总公司石油工业石油市场海上石油发展战略

Compound Zhebei granules combined with chemotherapy for the treatment of refractory acute leukemia: a randomized clinical trial

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Journal of Traditional Chinese Medicine 2016年第5期36卷 606-612页

作者： Hou Li Yang Shulian Yang Wenhua Zhou Yuhong Liu Feng Yang Hongyong sun weizheng Li Dongyun Xu Yamei Chen Xinyi Department of Oncology and Hematology Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Department of Hematology Langfang Chinese Medicine Hospital Affiliated to Hebei Medical University Department of Hematology First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Department of Hematology Chinese Medicine Hospital of Zhejiang Province Department of Hematology Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences Department of Hematology First Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Hematology First Affiliated Hospital of Heilongjiang University of Chinese Medicine

OBJECTIVE: To observe the effect of compound Zhebei granules(CZBG) with chemotherapy in the treatment of refractory acute ***: In this multicenter, double-blind, placebo-controlled clinical trial, we used a central(online) randomization system to assign 235 patients to two treatment groups. A total of 118 patients received chemotherapy combined with CZBG(4 g,twice daily) and 117 patients received chemotherapy plus placebo. The clinical efficacy was evaluated at the end of one chemotherapeutic ***: In the full analysis set, in which deaths due to disease progression were regarded as inefficacy, the rates of complete remission(CR) and partial remission(CR + PR) were 32.35% and 50.00%,respectively, for the chemotherapy combined with CZBG group, and 23.08% and 35.58%, respectively,for the chemotherapy plus placebo group. There was a statistically significant difference between the two groups according to a ysis set(PPχ2test(P < 0.05). In the per protocol analS), the CR(33.67%),CR+PR(52.04%) response rates for the chemotherapy plus CZBG group were significantly different from the response rates of the control group(CR:24.24% and CR+PR: 37.37%), respectively(P < 0.05).CONCLUSION: CZBG plus chemotherapy can improve the clinical remission rate of refractory acute leukemia after one just one therapeutic cycle.

关键词： Refractory acute leukemia Zhebei granules Chemotherapy remission rate Randomized clinical trial

The protective effects of peptides from Chinese baijiu on AAPH-induced oxidative stress in HepG2 cells via Nrf2 signaling pathway

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Food Science and Human Wellness 2022年第6期11卷 1527-1538页

作者： Jiaying Huo Yuezhang Ming Huifeng Li Anjun Li Jiwen Zhao Mingquan Huang weizheng sun Jihong Wu Jinglin Zhang Key Laboratory of Brewing Molecular Engineering of China Light Industry Beijing Technology and Business UniversityBeijing 100048China School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China Inner Mongolia Taibusiqi Grassland King Wine Co. Ltd.Inner Mongolia 027000China Anhui Gujing Distillery Co. Ltd.Anhui 236000China Shandong Bandaojing Co. Ltd.Shandong 256300China

Antioxidant peptides have been widely ***,only a few reports have been published examining the antioxidant peptides derived from Chinese *** this study,6 novel peptides derived from Chinese baijiu were identified successfully using high-performance liquid chromatography-quadrupoletime-of-flight mass spectrometry(HPLC-QTOF-MS)with a concentration of 0.835–24.540μg/*** underlying molecular mechanisms were investigated,and their cytoprotective effects were examined against 2,2’-azobis(2-methylpropanimidamidine)dihydrochloride(AAPH)-induced oxidative stress in Hep G2 *** results showed that these peptides exerted protective effects by suppressing reactive oxygen species(ROS)generation,preventing malondialdehyde(MDA)formation,and upregulating cellular antioxidant enzyme activities(SOD,CAT,and GSH-Px)in a dose-dependent *** experiments proved that these peptides exerted antioxidant effects via Nrf2/ARE-mediated signaling pathway by promoting Nrf2 nuclear translocation,inhibiting ubiquitination,and enhancing transcription capacity of Nrf2 in Hep G2 *** findings provide the molecular basis for the effects of antioxidant peptides derived from Chinese baijiu,which is important for a deeper understanding of the relationship between human health and moderate drinking.

关键词： Chinese baijiu High-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry Antioxidant peptides HepG2 cells Nrf2 signaling pathway

罗普司亭治疗再生障碍性贫血的机制与临床应用研究进展

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疑难病杂志 2024年第4期23卷 504-508页

作者：李洋洋高明洁田飞孙伟正(综述) 王金环(审校) 黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院血液病科

再生障碍性贫血(AA)是一种严重的造血系统疾病,临床上以全血细胞减少和骨髓造血功能受损为特征。罗普司亭作为一种Janus激酶抑制剂,近年来引起了广泛的关注。文章从多个角度对罗普司亭治疗AA的机制与临床应用展开了全面而深入的讨论,包... 详细信息

再生障碍性贫血(AA)是一种严重的造血系统疾病,临床上以全血细胞减少和骨髓造血功能受损为特征。罗普司亭作为一种Janus激酶抑制剂,近年来引起了广泛的关注。文章从多个角度对罗普司亭治疗AA的机制与临床应用展开了全面而深入的讨论,包括该药物在治疗过程中的作用机制、免疫调节作用以及潜在的不良反应和安全性考量。并展望个体化治疗策略的发展和新型治疗靶点的探索,为该领域的进一步研究提供有益的思路。

关键词：再生障碍性贫血罗普司亭 Janus激酶抑制剂治疗研究进展