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Improving antioxidant activities of water-soluble lignin-carbohydrate complex isolated from wheat stalk through prolonging ball-milling pretreatment and homogeneous extraction

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Journal of Bioresources and Bioproducts 2024年第1期9卷 113-125页

作者： Di Xie Zhulan Liu Yunfeng Cao Sheng-I Yang Chen Su mi Li Jiangsu Co-innovation Center for Efficient Processing and Utilization of Forest Products Nanjing Forestry UniversityNanjing 210037China International Innovation Center for Forest Chemicals and Materials Nanjing Forestry UniversityNanjing 210037China Center for Renewable Carbon School of Natural ResourcesUniversity of TennesseeKnoxvilleTN 37996USA Shandong Huatai Paper Co. Ltd.Dongying 257000China School of Natural Resources University of TennesseeKnoxvilleTN 37996USA Key Lab of Biomass Energy and Material Institute of Chemical Industry of Forest ProductsChinese Academy of ForestryJiangsu ProvinceNanjing 210042China

Water-soluble lignin-carbohydrate complex(LCC)rich in polysaccharides exhibits benign in vitro antioxidant activities and distinguishes high biocompatibility from lignin-rich LCC and ***,the antioxidant activity of water-soluble LCCs remains to be improved and its structure-antioxidant relationship is still ***,structurally diversified water-soluble LCCs were isolated under different ball-milling pretreatment durations(4,6,8 h),extraction pathways(ho-mogeneous and heterogeneous),and isolation routines(water extracts and residues after water extraction).Their structures were characterized by wet chemistry,chromatography and *** activities were evaluated by ferric reducing antioxidant power and 1,1-diphenyl-2-picrylhydrazyl radicals scavenging rate(RDPPH).Results show that altering ball-milling duration and isolation procedures cause varied structures and antioxidant activities of the water-soluble ***,prolonging ball-milling duration to 8 hours and homogeneous extrac-tion can enhance their antioxidant activity through releasing more phenolic structures and pro-moting the extraction of high-molecular-weight LCCs via reducing mass-transfer resistance,*** a result,the RDPPH of water-soluble LCCs reaches up to 97.35%,which is associated with the arabinan content with statistical significance(P<0.05).This study provides new insights into the structure-antioxidation relationship of herbaceous LCC as potential antioxidants.

关键词： LCC Homogeneous extraction Ball-milling Structure-antioxidation relationship Wheat straw

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On the Innovation,Design,Construction,and Experiments of OMEGA-Based SSPS Prototype:The sun-Chasing Project

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Engineering 2024年第5期36卷 90-101页

作者： Baoyan Duan Yiqun Zhang Guangda Chen Ze Zhao Jianwei mi Xun Li Lin Yang Xi Li Research Institute on Mechatronics Xidian UniversityXi’an 710071China Research Institute of Antenna Xidian UniversityXi’an 710071China

This study systematically introduces the development of the world’s first full-link and full-system ground demonstration and verification system for the OMEGA space solar power satellite(SSPS).First,the OMEGA 2.0 innovation design was ***,field-coupling theoretical models of sunlight concentration,photoelectric conversion,and transmitting antennas were established,and a systematic optimization design method was ***,a beam waveform optimization methodology considering both a high beam collection efficiency and a circular stepped beam shape was ***,a control strategy was developed to control the condenser pointing toward the sun while maintaining the transmitting antenna toward the ***,a high-efficiency heat radiator design method based on bionics and topology optimization was ***,a method for improving the rectenna array’s reception,rectification,and direct current(DC)power synthesis efficiencies is ***,high-precision measurement technology for high-accuracy beam-pointing control was ***,a smart mechanical structure was designed and ***,the developed SSPS ground demonstration and verification system has the capacity for sun tracking,a high concentration ratio,photoelectric conversion,microwave conversion and emission,microwave reception,and rectification,and thus satisfactory results were obtained.

关键词： OMEGA-SSPS Full-link and full-system Beam collection efficiency Circular stepped beam shape Smart structure Field coupling theoretical model `Beam pointing control

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Progressive Collapse Resistance of a New Staggered Story Isolated System

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Open Journal of Applied Sciences 2024年第3期14卷 643-659页

作者： Yutong Yang Yuancheng mi Hong Li Zhongfa Guo Dewen Liu Weiwei sun min Lei College of Civil Engineering Southwest Forestry University Kunming China College of Civil Engineering Rattana Bundit University Bangkok Thailand College of Civil Engineering Southwest Jiaotong University Chengdu China

A new staggered isolated system developed from the mid-story isolated system is the new staggered story isolated system. There are not many studies on this structure currently. In this study, an 18-story new staggered story isolated system model is established using SAP2000. The dynamic nonlinear dynamic alternate method is used to analyze the structure against progressive collapse. Results show that the structure has good resistance to progressive collapse, and there is no progressive collapse under each working condition. The progressive collapse does not occur for the case of removing only one vertical structural member of the new staggered of isolated system. The side column has big influence on this isolated structures’ progressive collapse;the removal of vertical structural member of the isolation layer has less impact on the structure than the removal of the bottom vertical structural member. After the removing of the member, the internal force of the structure will be redistributed, and the axial force of the adjacent columns will change obviously, showing a trend of “near large and far small”.

关键词： The New Staggered Story Isolated System Alternative Load Path Method Collapse Resistance

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Functional dissection of parabrachial substrates in processing nociceptive information

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Zoological Research 2024年第3期45卷 633-647页

作者： Jin Ke Wei-Cheng Lu Hai-Yang Jing Shen Qian sun-Wook moon Guang-Fu Cui Wei-Xin Qian Xiao-Jing Che Qian Zhang Shi-Shi Lai Ling Zhang Ying-Jie Zhu Jing-Dun Xie Tian-Wen Huang Shenzhen Key Laboratory of Drug Addiction Shenzhen-Hong Kong Institute of Brain ScienceBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Anesthesiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China University of Science and Technology of China HefeiAnhui 230027China Department of Anesthesiology Shenzhen University General Hospital and Shenzhen University Academy of Clinical Medical SciencesShenzhen UniversityShenzhenGuangdong 518055China School of Medicine Yunnan UniversityKunmingYunnan 650091China

Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of *** lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity ***,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain *** this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such ***,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external ***,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive *** results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.

关键词： Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction Somatosensory

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3176-3241页

作者： Pelin Lu Dongxue Ruan Meiqi Huang mi Tian Kangshun Zhu Ziqi Gan Zecong Xiao Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630PR China Department of minimally Invasive Interventional Radiology and Laboratory of Interventional RadiologyThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260PR China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120PR China Department of Stomatology Chengdu Second People's HospitalChengdu 610021PR China Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510055PR China

The applications of hydrogels have expanded significantly due to their versatile,highly tunable properties and breakthroughs in biomaterial *** this review,we cover the major achievements and the potential of hydrogels in therapeutic applications,focusing primarily on two areas:emerging cell-based therapies and promising non-cell therapeutic *** the context of cell therapy,we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms,provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy,as well as list specific examples of their applications in different disease *** then explore the potential of hydrogels in drug delivery,physical intervention therapies,and other non-cell therapeutic areas(e.g.,bioadhesives,artificial tissues,and biosensors),emphasizing their utility beyond mere delivery ***,we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions,particularly in terms of integration with advanced biomanufacturing *** review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and noncell therapies,tailored to meet the therapeutic requirements of diverse diseases and situations.

关键词： directions overcome breakthrough

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TRPV1:The key bridge in neuroimmune interactions

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Journal of Intensive Medicine 2024年第4期4卷 442-452页

作者： Jianwei Chen Wenqian sun Youjia Zhu Feng Zhao Shuixiang Deng mi Tian Yao Wang Ye Gong Department of Critical Care Medicine Huashan HospitalFudan UniversityShanghai 200040China

The nervous and immune systems are crucial in fighting infections and inflammation and in maintaining immune *** immune and nervous systems are independent,yet tightly integrated and coordinated *** molecules and receptors play key roles in enabling communication between the two *** receptor potential vanilloid subfamily member 1(TRPV1)is a non-selective cation channel,recently shown to be widely expressed in the neuroimmune axis and implicated in neuropathic pain,autoimmune disor-ders,and immune cell ***1 is a key bridge in neuroimmune interactions,allowing for smooth and convenient communication between the two ***,we discuss the coordinated cross-talking between the immune and nervous systems and the functional role and the functioning manner of the TRPV1 *** suggest that TRPV1 provides new insights into the collaborative relationship between the nervous and im-mune systems,highlighting exciting opportunities for advanced therapeutic approaches to treating neurogenic inflammation and immune-mediated diseases.

关键词： TRPV1 Neuroimmune interaction Immune system Nervous system

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan sun Xiu-Na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing Zhang Kai-Wen Liu Na Li Jia-Chen Cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing mi Zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

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An unusual cause of myocardial infarction in an elderly man

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Journal of Geriatric Cardiology 2024年第8期21卷 826-827页

作者： Shing Ching Chiu sun Yue Division of Cardiology Department of Medicine and GeriatricsUnited Christian HospitalHong KongChina

Cardiac involvement in eosinophilic granulomatosis with polyangiitis (EPGA) is increasingly recognized,but it is unusual to be the initial *** report a case of vasculitic myocardial infarction (mi) and cardiogenic shock in an elderly man caused by EPGA.A 73-year-old man presented with acute chest pain radiating to back for two *** has a history of asthma and allergic rhinitis for more than ten years well controlled by inhaled *** electrocardiogram showed sinus rhythm,right bundle-branch block and anterolateral ST-segment *** had elevated troponin T of 548 ng/L (reference:<14 ng/L),creatine kinase of 454 IU/L (reference:39–308 IU/L)。

关键词： infarction involvement elevated

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大数据驱动政府监管的变革之道

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行政论坛 2024年第2期31卷 48-55页

作者：米加宁孙源彭康珺哈尔滨工业大学经济与管理学院黑龙江哈尔滨150001

随着第四次工业革命的兴起,数字空间和物理空间共同构成了我们对现实世界的认识。这一现象让政府监管在面临数字空间新问题的监管缺位和物理空间旧问题的监管不足之双重困境的同时,也为实现协同化、脱域化、精准化和可溯化的新型政府监... 详细信息

随着第四次工业革命的兴起,数字空间和物理空间共同构成了我们对现实世界的认识。这一现象让政府监管在面临数字空间新问题的监管缺位和物理空间旧问题的监管不足之双重困境的同时,也为实现协同化、脱域化、精准化和可溯化的新型政府监管提供了发展契机。基于对大数据驱动政府监管变革的特征和潜在挑战的分析,研究认为,发挥大数据驱动作用,推动我国政府监管转型,应从提高监管人员的适应性、推进关键技术的普及性、提升现有体系的适配性、实现监管责任的明确性等四个方面着手。

关键词：政府监管大数据技术数字经济数字空间物理空间

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FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

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military Medical Research 2024年第4期11卷 521-542页

作者： mi Zhou Yang-Wu-Yue Liu Yu-Hang He Jing-Yu Zhang Hao Guo Hao Wang Jia-Kui Ren Yi-Xun Su Teng Yang Jia-Bo Li Wen-Hui He Peng-Jiao Ma Man-Tian mi Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,multifunctionality,and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly ***:Using the combined single-cell transcriptomics,metabolomics,and proteomics analysis from TBI patients and the TBI mouse model,we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral *** also characterized the underlying mechanisms both invitro and invivo through molecular simulations,signaling detections,gene expression regulation assessments[including dual-luciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cultures or co-cultures of neutrophils and oligodendrocytes,intracellular iron,and lipid hydroperoxide concentration measurements,as well as forkhead box protein O1(FOXO1)conditional knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI,aggravating acute brain inflammatory damage and promoting late TBI-induced *** the acute stage,FOXO1 upregulated cytoplasmic Versican(VCAN)to interact with the apoptosis regulator B-cell lymphoma-2(BCL-2)-associated X protein(BAX),suppressing the mitochondrial translocation of BAX,which mediated the antiapoptotic effect companied with enhancing interleukin-6(IL-6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil ferroptosis,disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein,which contributes to the progression of late depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

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