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In Vitro Functional Study of Rice Adenosine 5'-Phosphosulfate Kinase

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Rice science 2016年第3期23卷 152-159页

作者： Wang De-zhen chen Guo-guo Lu Lu-jia Jiang Zhao-jun Rao Yu-chun sun Mei-hao College of Chemistry and Life sciences Zhejiang Normal University Jinhua 321004 China

Sulfate can be activated by ATP sulfurylase and adenosine 5'-phosphosulfate kinase(APSK) in vivo. Recent studies suggested that APSK in Arabidopsis thaliana regulated the partition between APS reduction and phosphorylation and its activity can be modulated by cellular redox status. In order to study regulation of APSK in rice(Os APSK), Os APSK1 gene was cloned and its activity was analyzed. Os APSK1 C36 and C69 were found to be the conserved counterparts of C86 and C119, which involved in disulfide formation in At APSK. C36A/C69 A Os APSK1 double mutation was made by site directed mutagenesis. Os APSK1 and its mutant were prokaryotically over-expressed and purified, and then assayed for APS phosphorylation activity. Os APSK1 activity was depressed by oxidized glutathione, while the activity of its mutant was not. Further studies in the case that oxidative stress will fluctuate in vivo 3'-phosphoadenosine-5'-phosphosulfate content, and all APSK isoenzymes have similar regulation patterns are necessary to be performed.

关键词： rice sulfate assimilation adenosine 5'-phosphosulfate kinase cysteine redox environment

Jasmonic acid regulates the biosynthesis of medicinal metabolites via the JAZ9-MYB76 complex in Salvia miltiorrhiza

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Horticulture Research 2023年第3期10卷 110-123页

作者： Shucan Liu Xiankui Gao Min Shi Meihong sun Kunlun Li Yan Cai chengan chen Can Wang Itay Maoz Xinhong Guo Guoyin Kai laboratory of Medicinal Plant Biotechnology School of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhouZhejiang 310053China College of Biology Hunan UniversityChangshaHunan 410082China Institute of Plant Biotechnology School of Life SciencesShanghai Normal UniversityShanghai 200234China Department of Postharvest science AROThe Volcani CenterHaMaccabim Rd 68POB 15159Rishon LeZion7528809Israel

Jasmonic acid(JA)signaling pathway plays an important role in tanshinone and phenolic acid biosynthesis in Salvia ***,the specific regulatory mechanism remains largely *** work showed that a JASMONATE ZIM-domain(JAZ)protein,SmJAZ9,acted as a repressor of tanshinone production in *** this study,we revealed that SmJAZ9 reduced both phenolic acid accumulation and related biosynthetic gene expression,confirming that SmJAZ9 also negatively affected phenolic acid ***,we identified a novel MYB transcription factor,SmMYB76,which interacted with ***76 repressed phenolic acid biosynthesis by directly downregulating SmPAL1,Sm4CL2,and *** investigation demonstrated that JA mediated phenolic acids biosynthesis via SmJAZ9-SmMYB76 *** together,these findings state the molecular mechanism that SmJAZ9-SmMYB76 regulated phenolic acid biosynthesis at the transcriptional and protein levels,which provided new insights into JA signaling pathway regulating plant metabolism.

关键词： complex phenolic insight

维普期刊数据库评论

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大涡模拟燃烧模型对氨气旋流火焰适应性研究

燃烧科学与技术 2022年第3期28卷 261-270页

作者：孙君建张立业孙桂军安振华王金华张猛黄佐华孙晨杨沐村国家电投集团东北电力有限公司沈阳110181 朝阳燕山湖发电有限公司朝阳122099 西安交通大学动力工程多相流国家重点实验室西安710049 国家电投集团科学技术研究院有限公司北京102209

推广无碳燃料是实现“碳达峰、碳中和”的重要举措,氨气具有基础设施完善、安全性高等优势.数值模拟在燃机设计、开发中承担重要作用,燃烧模型对计算对象的适应性非常重要,影响计算精度和效率.本文针对氨气旋流火焰,基于OpenFOAM开展了... 详细信息

推广无碳燃料是实现“碳达峰、碳中和”的重要举措,氨气具有基础设施完善、安全性高等优势.数值模拟在燃机设计、开发中承担重要作用,燃烧模型对计算对象的适应性非常重要,影响计算精度和效率.本文针对氨气旋流火焰,基于OpenFOAM开展了氨气旋流火焰标准化实验及模拟工作,对比了FGM燃烧模型和DTF燃烧模型在氨气旋流火焰燃烧室流场、火焰结构及污染物预测等方面的性能.通过综合分析,给出了模型选用建议,为氨发动机燃烧室和氨燃烧器仿真计算提供参考.

关键词：氨气旋流火焰大涡模拟模型对比 FGM燃烧模型 DTF燃烧模型

Biomedical polymers: synthesis, properties, and applications

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science China Chemistry 2022年第6期65卷 1010-1075页

作者： Wei-Hai chen Qi-Wen chen Qian chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi chen key laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan UniversityWuhan430072China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China School of Materials science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China key laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Ministry of EducationBeijing Laboratory of Biomedical MaterialsCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029China MOE key laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China state key laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai UniversityTianjin300071China key laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China jinhua Institute of Zhejiang University Jinhua321299China Zhejiang key laboratory of Smart BioMaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China state key laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai200438China CAS key laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nano-scienceNational Center for Nanoscience and Technology(NCNST)Beijing100190China School of Biomedical sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou510006China Institute of Functional Nano and So

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

关键词： biomedical polymer nanomedicine cancer therapy drug delivery bioimaging and biosensing tissue engineering regenerative medicine cytotoxicity biocompatibility

基于突变理论的区域石油安全系统稳定性评估——以重庆市为例

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重庆理工大学学报（社会科学） 2017年第10期30卷 20-28页

作者：胡健陈浈孙金花重庆理工大学管理学院重庆400054

针对近年来频发的区域石油短缺事件,提出基于突变理论的石油安全系统稳定性评估模型。首先,利用因子分析法结合石油自身供需状况、社会经济扰动因素、能源政策调控效应和外部环境突变效应等4个方面的关键要素,构建区域石油安全系统稳定... 详细信息

针对近年来频发的区域石油短缺事件,提出基于突变理论的石油安全系统稳定性评估模型。首先,利用因子分析法结合石油自身供需状况、社会经济扰动因素、能源政策调控效应和外部环境突变效应等4个方面的关键要素,构建区域石油安全系统稳定性评估指标体系。然后,利用信息熵方法确定指标的重要性排序,结合突变理论中的突变级数法,设计区域石油安全系统稳定性评估模型。在此基础上,以重庆市2007—2015年数据为样本,对该地区石油安全系统稳定性进行评估。结果表明:近年来重庆市石油安全系统较不稳定,在2011年和2014年出现两次拐点,这两年的区域安全状态值均低于0.8,特别是在2014年下滑至0.758 1。分析重庆地区石油安全系统发生突变的关键诱因,可以为其他地区防范石油安全突发事件提供决策参考。

关键词：区域石油安全指标体系安全系统稳定性突变级数模型熵

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中国灵长类动物保护的成就与挑战

西北大学学报（自然科学版） 2024年第5期54卷 755-766页

作者：李保国张河李明蒋学龙范朋飞周江郭松涛齐晓光李进华路纪琪夏东坡崔亮伟向左甫周岐海黄志旁黄乘明肖文胡慧建周智鑫陈明勇黎大勇范朋来杨寅潘汝亮西北大学生命科学学院/陕西珍稀濒危动物保育重点实验室陕西西安710069 江西农业大学林学院/保护生物学江西省重点实验室江西南昌330045 中国科学院动物研究所/动物生态学与保护生物学院重点实验室北京100101 中国科学院昆明动物研究所/遗传资源与进化国家重点实验室云南昆明650201 中山大学生命科学学院广州广东510275 贵州师范大学喀斯特研究院贵州贵阳550025 安徽大学黄山生物多样性与短尾猴行为生态学国际联合研究中心安徽合肥230601 郑州大学生物多样性与生态学研究所河南郑州450001 西南林业大学云南省极小种群野生植物综合保护重点实验室云南昆明650224 中南林业科技大学生命科学与技术学院湖南长沙410004 广西师范大学珍稀濒危动植物生态与环境保护教育部重点实验室广西桂林541004 大理大学国际生物多样性中心和灵长类动物保护中心云南大理671003 广东省科学院动物研究所/广东省动物保护与资源利用重点实验室广东广州510663 云南大学生命科学学院云南昆明650500 西华师范大学西南野生动植物资源保护教育部重点实验室四川南充637001 云南大学国际河流与生态安全研究院云南昆明650500 西澳大学人类学学院珀斯WA6009

气候变化和人类活动的双重影响导致全球灵长类生物多样性急剧下降。中国是北半球灵长类动物种类最多的国家,但在农业社会向现代社会转型的过程中,现代农业的扩张、自然资源的消耗以及土地的过度开发,使中国面临着严重的生态威胁。为此,... 详细信息

气候变化和人类活动的双重影响导致全球灵长类生物多样性急剧下降。中国是北半球灵长类动物种类最多的国家,但在农业社会向现代社会转型的过程中,现代农业的扩张、自然资源的消耗以及土地的过度开发,使中国面临着严重的生态威胁。为此,中国实施了包括栖息地恢复和保护在内的多种生态保护措施,在生物多样性保护方面取得了实质性进展,某些地区的灵长类动物种群数量有所增加。该研究对中国灵长类动物的历史文献和实地调查资料进行了系统分析,对中国灵长类动物的濒危状况进行了评估。尽管大多数灵长类物种的栖息地有所改善,种群数量也有所增长,但许多物种仍然面临着严重的威胁,包括种群数量的减少。例如,缅甸金丝猴、东黑冠长臂猿和海南长臂猿等物种由于分布范围有限和种群数量极少,仍然特别脆弱。科学数据的缺乏以及保护生物学研究的不足,进一步加剧了这些挑战。此外,蜂猴、倭蜂猴、印支灰叶猴、肖氏乌叶猴和戴帽叶猴等物种的详细种群监测数据仍然缺乏,这严重阻碍了针对这些物种保护管理政策的制定。因此,在生物多样性保护方面,迫切需要开展专门的灵长类动物调查,实行跨境保护和区域合作,建立全面系统的数据库平台,对灵长类生物学进行持续深入的研究。此外,加强公众对野生动物保护的认识也至关重要。这些综合、系统的工作将为中国灵长类物种的保护和管理提供科学依据。

关键词：灵长类动物生物多样性栖息地破碎化生境修复保护策略

毛竹赤霉素合成相关酶基因的全基因组鉴定和表达分析

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基因组学与应用生物学 2018年第9期37卷 3966-3977页

作者：杨意宏王思宁徐浩孙化雨赵韩生陈段芬高志民国家林业局竹藤科学与技术重点开放实验室国际竹藤中心北京100102 河北农业大学保定071001

赤霉素（GA）参与调节植物多种生长发育过程,其生物合成在体内受到严格的控制。研究毛竹（Phyllostachys edulis）赤霉素合成通路相关的酶基因,对于揭示其在毛竹生长发育中的作用具有重要价值。对毛竹全基因组进行分析发现,涉及赤霉素... 详细信息

赤霉素（GA）参与调节植物多种生长发育过程,其生物合成在体内受到严格的控制。研究毛竹（Phyllostachys edulis）赤霉素合成通路相关的酶基因,对于揭示其在毛竹生长发育中的作用具有重要价值。对毛竹全基因组进行分析发现,涉及赤霉素生物合成的酶基因有7类共50个,包括4个CPS、3个KS、5个KAO、1个KO、10个GA20ox、20个GA2ox、和7个GA3ox。不同酶基因的各个成员虽是比较保守的,但其基因结构、基本理化性质均存在着一定的差异。亚细胞定位预测表明,PeCPSs和PeKSs定位在叶绿体上,PeKAOs位于内质网上,PeGA20oxs、PeGA2oxs和PeGA3oxs定位于细胞质基质中。进化分析显示,毛竹GA生物合成通路相关酶与来自水稻的相应酶均具有较高的一致性,亲缘关系较近。利用转录组数据分析基因表达的组织特异性,结果表明不同类酶基因以及同一类酶基因的不同成员的表达均存在一定的差异。例如：PeCPS-1、PeCPS-4和PeKO为组成型表达,PeKAO-5主要在笋幼芽中表达,PeGA20ox-10仅在幼芽和根中表达;PeGA2oxs中有9个为组成型表达,7个为特异性表达,而PeGA3oxs中分别有5个和2个。本研究为深入了解毛竹内源GA生物合成奠定了基础,为利用GA生物合成酶基因人为调控植物生长发育提供了参考。

关键词：毛竹赤霉素生物合成分子特征基因表达模式

Nb-Ti-Co氢分离合金的显微组织和耐腐蚀性能

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材料导报 2021年第18期35卷 18109-18115页

作者：狄翀博王金华闫二虎王星粤陈运灿贾丽敏徐芬孙立贤桂林电子科技大学广西信息材料重点实验室桂林541004 河北科技大学材料科学与工程学院石家庄150001

目前,传统商业用氢分离合金Pd膜资源稀缺且价格昂贵,亟待开发新型氢分离合金膜,Nb-Ti-Co合金可以很好地满足上述要求。不过,上述合金膜过滤的混合气体中常常混有少量的酸性气体,如CO_(2)、H_(2)S和HCl等,对合金膜造成不同程度的腐蚀。... 详细信息

目前,传统商业用氢分离合金Pd膜资源稀缺且价格昂贵,亟待开发新型氢分离合金膜,Nb-Ti-Co合金可以很好地满足上述要求。不过,上述合金膜过滤的混合气体中常常混有少量的酸性气体,如CO_(2)、H_(2)S和HCl等,对合金膜造成不同程度的腐蚀。到目前为止,关于氢分离合金膜耐腐蚀性能的研究鲜有报道,合金组织和耐腐蚀性能之间的关系尚未建立。基于此,本工作针对Nb-Ti-Co氢分离合金的显微组织和耐腐蚀性能开展了一系列研究,首先利用扫描电镜(SEM)和X射线衍射(XRD)等设备研究了合金显微组织结构,得出其与合金成分之间的本征关系;其次,通过一系列电化学实验测量了上述合金膜的耐腐蚀性能,阐明了其随合金成分和组织(或相结构)变化的变化规律;最后,利用X射线电子能谱(XPS)等设备分析了合金腐蚀后表面元素的价态变化,提出了Nb-Ti-Co合金的耐腐蚀机理。结果表明:除Nb_(30)Ti_(35)Co_(35)合金之外,其他合金均由初生α-Nb相和共晶相(α-Nb+TiCo)构成,并且,前者体积分数随着Nb含量和Ti/Co比率的增加而增加,后者随之降低;伴随上述变化,腐蚀电流(I_corr)逐渐增加,相反,腐蚀电压(E_(corr))逐渐减小,上述二者与初生Nb相体积分数之间的关系分别为:E_(corr)=-0.25259-1.30818×10^(-4)e^(V_(bcc-Nb)/-11.01588)和I_corr=2.10147+3.51536×10^(-5)e^(V_(bcc-Nb)/-3.94597)。另外,腐蚀后Nb、Ti和Co元素易于在合金表面富集并生成Nb_(2)O_5、TiO_(2)和CoO氧化层,并伴随着氧化还原、析氢和复分解反应,促进腐蚀的进一步发生,上述反应过程首次揭示了高Nb含量合金耐腐蚀性能相对较弱的根本原因。

关键词： Nb-Ti-Co氢分离合金显微组织耐腐蚀性能

Constraining self-interacting dark matter with the full dataset of PandaX-II

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science China(Physics,Mechanics & Astronomy) 2021年第11期64卷 2-7页

作者： Jijun Yang Abdusalam Abdukerim Wei chen Xun chen Yunhua chen chen cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityMOE Key Laboratory for Particle Astrophysics and CosmologyShanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institude Chengdu 610213China Yalong River Hydropower Development Company Ltd.Chengdu 610051China School of Physics Sun Yat-sen UniversityGaungzhou 510275China Tsung-Dao Lee Institute Shanghai 200240China School of Physics Nankai UniversityTianjin 300071China key laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 100191China International Research Center for Nuclei and Particles in the Cosmos&Beijing key laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China Shandong Institute of Advanced Technology Jinan 250103China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China state key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China key laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityJinan 250100China Research Center for Particle science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Department of Physics and Astronomy University of CaliforniaRiversideCalifornia 92507USA Center of High Energy Physics Peking UniversityBeijing 100871China

Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of *** SIDM models predict the existence of a light force carrier that mediates strong dark matter *** the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection *** report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 *** significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling *** further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator.

关键词： dark matter direct detection self-interacting dark matter