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Chinese Chemical Letters 2024年第7期35卷 377-382页

作者： Mengjuan sun Muye Zhou Yifang Xiao Hailei Tang jinhua chen Ruitao Zhang Chunjiayu Li Qi Ya Qian chen Jiasheng Tu Qiyue Wang Chunmeng sun NMPA key laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients China Pharmaceutical UniversityNanjing 210009China state key laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 211198China Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Jiangsu Provincial key laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical UniversityNanjing 210009China School of Pharmaceutical science Nanjing Tech UniversityNanjing 211816China

Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral *** with large sizes have difficulty in deep tumor penetration,while small particles are easily removed from tumor tissues due to the high tumor interstitial fluid *** address these issues,an intelligent core-crosslinked polyion complex micelle(cPCM)with a reversibly sizeswitchable feature was engineered in this *** micelles are consisting of methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PLA),mPEG-PLA-(HE)6CC,and mPEG-PLA-(RG)6CC at an optimal mass ratio of 6:1:1 with an antiangiogenic compound,dabigatran etexilate(DE),*** net charge inside the micelles is switchable when exposed to different pH conditions,thereby leading to revisable size-change of ***-loaded micelles(DE@cPCM)can swell and release drugs at the tumor sites with a mildly acidic pH,while they shrink and protect the cargo from leaking into the blood circulation with a neutral *** indicated that DE@cPCM can inhibit tumor angiogenesis in vitro and in vivo,thereby efficiently restraining tumor growth in a 4T1-bearing mouse ***,the sizeswitchable cPCM is a promising nanoplatform for targeting delivery of anticarcinogens into the matrix of tumor tissues.

关键词： Polyion complex micelle Size-switchable Revisable size-change pH response Antiangiogenic cancer

Influence of rarefaction wave on premixed flame structure and propagation behavior

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Progress in Natural science:Materials International 2007年第3期17卷 328-333页

作者： chen Xianfeng, sun jinhua, LU Shouxiang, CHU Guanquan, YAO Liyin and LIU Yi (state key laboratory of fire science, University of science and Technology of China, Hefei 230026, China) state key laboratory of fire science University of Science and Technology of China Hefei 230026 China

To explore the influence of rarefaction wave on the structure and propagation behavior of the premixed propane/air flame in a rectangle combustion pipe, the techniques of high speed Schlieren photograph method, pressure measurement and so on are used to study the interaction processes between rarefaction wave and flame. Two cases of rarefaction wave-flame interaction were performed in the experiment. The experimental result shows that both the rarefaction waves can cause the flame transition from laminar to turbulent combustion quickly. The cowflow rarefaction wave decreases the flame speed, while the counterflow rarefaction wave leads the flame propagation speed to increasing on the whole, accompanied with sharp vibration.

关键词： gas explosion rarefaction wave flame propagation laminar flame turbulent combustion.

Expert consensus on irrigation and intracanal medication in root canal therapy

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International Journal of Oral science 2024年第1期16卷 26-35页

作者： Xiaoying Zou Xin Zheng Yuhong Liang chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi chen Xi Wei Lihong Qiu Wenxia chen Wenxi He Xin Xu Liuyan Meng chen Zhang Liming chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Center of Stomatology Peking University HospitalBeijingChina state key laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Emergency Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Restorative Dental sciences EndodonticsFaculty of DentistryThe University of Hong KongPok Fu LamHong Kong SARChina state key laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina state key laboratory of Oral&Maxillofacial Reconstruction and R

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.

关键词： treatment irrigation Expert

Simulation study on the effect of pre-evacuation time and exit width on evacuation

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Chinese science Bulletin 2006年第11期51卷 1381-1388页

作者： CHU Guanquan sun jinhua WANG Q ingsong chen sining state key laboratory of fire science University of Science and Technology of China Hefei 230026 China

Occupant pre-evacuation time is often oversimplified into an explicit value in evacuation calculation. In fact, it is not an explicit value but a random variable following some kind of probability distribution. In order to analyze the importance of pre-evacuation time in evacuation calculation, Grid- Flow evacuation model is utilized to study the effect of pre-evacuation time on evacuation under different occupant densities and exit widths in a single room scenario. The evacuation time calculated by using normal pre-evacuation distribution is compared with that calculated by explicit pre-evacuation time. Two faults are presented when pre-evacuation time is considered as an explicit value. The theory of con- gestion and queue is presented to analyze the cal- culation results. Moreover, this paper also presents probability distribution of the total evacuation time when the pre-evacuation time follows normal distri- bution. The results show that the evacuation time is dominated by pre-evacuation time and hardly de- pendent on occupant density when the mean pre- evacuation time is long. For long mean pre-evacua- tion time, low occupant density or wide exit, when pre-evacuation time follows normal distribution, the total evacuation time also follows normal distribution.

关键词：火灾预疏散时间正态分布出口宽度居住密度模拟研究

Microstructure of premixed propane/air flame in the transition from laminar to turbulent combustion

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Chinese science Bulletin 2007年第5期52卷 685-691页

作者： chen XianFeng sun jinhua LIU Yi LIU XuanYa chen sining LU ShouXiang state key laboratory of fire science University of Science and Technology of China Hefei 230026 China

In order to explore the flame structure and propagation behavior of premixed propane/air in the transi-tion from laminar to turbulent combustion, the high speed camera and Schlieren images methods were used to record the photograph of flame propagation process in a semi-vented pipe. Meanwhile, the super-thin thermocouple and ionization current probe methods were applied to detect the temperature distribution and reaction intensity of combustion reaction. The characteristics of propane/air flame propagation and microstructure were analyzed in detail by the experimental results coupled with chemical reaction thermodynamics. In the test, the particular tulip flame behavior and the formation process in the laminar-turbulent transition were disclosed clearly. From the Schlieren images and iron current results, one conclusion can be drawn that the small-scale turbulent combustion also appeared in laminar flame, which made little influence on the flame shape, but increased the flame thickness obviously.

关键词：丙烷/空气预混火焰火焰结构层流焰紊流燃烧过渡可燃气体爆炸

Thermal stability of LiPF_6/EC+DMC+EMC electrolyte for lithium ion batteries

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Rare Metals 2006年第z1期25卷 94-99页

作者： WANG Qingsong sun jinhua chen Chunhua state key laboratory of fire science University of Science and Technology of China Hefei 230026 China State Key Laboratory of Fire Science University of Science and Technology of China Hefei 230026 China Department of Materials Science & Engineering University of Science and Technology of China Hefei 230026 China

The thermal stability of lithium-ion battery electrolyte could substantially affect the safety of lithium-ion battery. In order to disclose the thermal stability of 1.0 mol·L-1 LiPF6/ethylene carbonate (EC)+dimethyl carbonate (DMC)+ethylmethyl carbonate (EMC) electrolyte, a micro calorimeter C80 micro calorimeter was used in this paper. The electrolyte samples were heated in argon atmosphere, and the heat flow and pressure performances were detected. It is found that LiPF6 influences the thermal behavior remarkably, with more heat generation and lower onset temperature. LiPF6/EC shows an exothermic peak at 212 ℃ with a heat of reaction -355.4 J·g-1. DMC based LiPF6 solution shows two endothermic peak temperatures at 68.5 and 187 ℃ in argon filled vessel at elevated temperature. EMC based LiPF6 solution shows two endothermic peak temperatures at 191 and 258 ℃ in argon filled vessel. 1.0 mol·L-1 LiPF6/EC+DMC+ EMC electrolyte shows an endothermic and exothermic process one after the other at elevated temperature. By comparing with the thermal behavior of single solvent based LiPF6 solution, it can be speculated that LiPF6 may react with EC, DMC and EMC separately in 1.0 mol·L-1 LiPF6/EC+DMC+EMC electrolyte, but the exothermic peak is lower than that of 1.0 mol·L-1 LiPF6/EC solution. Furthermore, The 1.0 mol·L-1 LiPF6/EC+DMC+EMC electrolyte decomposition reaction order was calculated based on the pressure data, its value is n=1.83, and the pressure rate constants kp=6.49×10-2 kPa·-0.83·min-1.

关键词： lithium ion battery electrolyte thermal stability C80 micro calorimeter

Expert consensus on difficulty assessment of endodontic therapy

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International Journal of Oral science 2024年第1期16卷 15-25页

作者： Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei chen Jiyao Li Ling Ye Lei cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi chen Lihong Qiu Wenxia chen Xi Wei Zhengwei Huang jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou state key laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghuaSchool of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina The state key laboratory Breeding Base of Basic science of Stomatology(Hubei-MOST)&key laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry&Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina Department of Endodontics Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina state key laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Preventive Dentistry West China Hospital of StomatologySichuan UniversityChengduChina state key laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric dentistry West China Hospital of Stomatology

Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.

关键词： anatomy difficulty treatment

Persistence of charge density wave against variation of band structures in V_(x)Ti_(1−x)Se_(2)(x=0–0.1)

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Nano Research 2024年第3期17卷 2129-2135页

作者： Zhanfeng Liu Tongrui Li Wen Zhu Hongwei Shou Mukhtar Lawan Adam Qilong Cui Yuliang Li Sheng Wang Yunbo Wu Hongen Zhu Yi Liu Shuangming chen Xiaojun Wu Shengtao Cui Li Song Zhe sun National Synchrotron Radiation laboratory CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230029China CAS key laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China state key laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China School of Chemistry and Materials sciences CAS Key Laboratory of Materials for Energy Conversionand CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230026China School Zhejiang Institute of Photonelectronics Jinhua 321004China

Charge density wave(CDW)is a phenomenon that occurs in materials,accompanied by changes in their intrinsic electronic *** study of CDW and its modulation in materials holds tremendous significance in materials research,as it provides a unique approach to controlling the electronic properties of ***_(2) is a typical layered material with a CDW phase at low *** V substitution for Ti in TiSe_(2),we tuned the carrier concentration in V_(x)Ti_(1-x)Se_(2) to study how its electronic structures ***-resolved photoemission spectroscopy(ARPES)shows that the band-folding effect is sustained with the doping level up to 10%,indicating the persistence of the CDW phase,even though the band structure is strikingly different from that of the parent compound TiSe_(2).Though CDW can induce the band fold effect with a driving force from the perspective of electronic systems,our studies suggest that this behavior could be maintained by lattice distortion of the CDW phase,even if band structures deviate from the electron-driven CDW *** work provides a constraint for understanding the CDW mechanism in TiSe_(2),and highlights the role of lattice distortion in the band-folding effect.

关键词： charge density wave band structure lattice distortion

Transition-metal redox evolution and its effect on thermal stability of LiNixCoyMnzO_(2) based on synchrotron soft X-ray absorption spectroscopy

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Journal of Energy Chemistry 2021年第8期30卷 446-454,I0010页

作者： chen Liang Wenhua Zhang Zesen Wei Zhaoyu Wang Qingsong Wang jinhua sun state key laboratory of fire science University of Science and Technology of ChinaHefei 230026China National Synchrontron Radiation laboratory University of Science and Technology of ChinaHefei 230026China

Based on the synchrotron soft X-ray absorption spectroscopy experiments,the fundamental electronic structures of layered Li NixCoyMnzO_(2)(NCM)are investigated systematically and the data of transitionmetal(TM)L-and O K-edges spectra are *** of Ni ions under different oxidation states is evaluated according to linear combination *** is found that the ratio of Ni^(4+)expands with the increase of Ni since it dominates in charge compensation during charging,and that the existence of Ni^(3+)is nearly negligible in delithiated *** valence state of Co also strongly depends on Ni content,the perceptible position shift of Co L_(3)-edge absorption peak towards higher energy in Ni-rich material agrees well with the small voltage plateau at around 4.2 *** stability of Mn is verified as no obvious spectral change with the Mn L-edge is ***,as Ni content rises,the O 2p holes near the Femi level increases with higher oxidation state of Ni,indicating the enhanced hybridization of O 2p-TM 3 *** NCMs with higher Ni content are prior to lose electron existing in highly hybridized Ni3 dO 2 p bands upon heating,which accounts for the pronounced O_(2)release in phase transitions and the deterioration in thermal *** detailed observation of the electronic structure evolution is one of the key ingredients to improving the electrochemical and thermal performance of NCM.

关键词： Lithium ion battery safety Cathode material Soft X-ray absorption spectroscopy Thermal stability