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Peli： a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance

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Cellular & Molecular Immunology 2012年第2期9卷 113-122页

作者： Wei Jin Mikyoung Chang Shao-cong sun Immunology Program Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Immunology The University of Texas MD Anderson Cancer CenterNew YorkNY 10065USA

E3 ubiquitin ligases play a crucial role in regulating immune receptor signaling and modulating immune homeostasis and activation. One emerging family of such E3s is the Pelle-interacting （Peli） proteins, characterized by the presence of a cryptic forkhead-associated domain involved in substrate binding and an atypical RING domain mediating formation of both lysine （K） 63- and K48-1inked polyubiquitin chains. A well-recognized function of Peli family members is participation in the signal transduction mediated by Toll-like receptors （TLRs） and IL-1 receptor. Recent gene targeting studies have provided important insights into the in vivofunctions of Pelil in the regulation of TLR signaling and inflammation. These studies have also extended the biological functions of Pelil to the regulation of T-cell tolerance. Consistent with its immunoregulatory functions, Peli I responds to different immune stimuli for its gene expression and catalytic activation. In this review, we discuss the recent progress, as well as the historical perspectives in the regulation and biological functions of Peli.

关键词： Peli Pellino ubiquitination NF-kB TLR T-cell tolerance

The PcERF5 promotes anthocyanin biosynthesis in red-fleshed pear(Pyrus communis)through both activating and interacting with PcMYB transcription factors

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农业科学学报:英文版 2023年第9期22卷 2687-2704页

作者： CHANG Yao-jun CHEN Guo-song YANG Guang-yan sun cong-rui WEI Wei-lin Schuyler S.KORBAN WU Jun College of Horticulture State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjing 210095P.R.China Department of Natural Resources and Environmental Sciences University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

As there is a strong interest in red-skinned pears,the molecular mechanism of anthocyanin regulation in red-skinned pears has been widely investigated;however,little is known about the molecular mechanism of anthocyanin regulation in red-fleshed pears due to limited availability of such germplasm,primarily found in European pears(Pyrus communis).In this study,based on transcriptomic analysis in red-fleshed and white-fleshed pears,we identified an ethylene response factor(ERF)from ***,PcERF5,of which expression level in fruit flesh was significantly correlated with anthocyanin *** then verified the function of PcERF5 in regulating anthocyanin accumulation by genetic transformation in both pear skin and apple ***5 regulated anthocyanin biosynthesis by different regulatory *** the one hand,PcERF5 can activate the transcription of flavonoid biosynthetic genes(PcDFR,PcANS and PcUFGT)and two key transcription factors encoding genes PcMYB10 and *** the other hand,PcERF5 interacted with PcMYB10 to form the ERF5-MYB10 protein complex that enhanced the transcriptional activation of PcERF5 on its target *** results suggested that PcERF5 functioned as a transcriptional activator in regulating anthocyanin biosynthesis,which provides new insights into the regulatory mechanism of anthocyanin *** new knowledge will provide guidance for molecular breeding of red-fleshed pear.

关键词： Pyrus communis red-fleshed anthocyanin biosynthesis PcERF5 PcMYB10/PcMYB114

Localization in modified polar representation: hybrid measurements and closed-form solution

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Journal of Systems Engineering and Electronics 2024年第3期35卷 575-588页

作者： cong Xunchao sun Yimao YANG Yanbing ZHANG Lei CHEN Liangyin The 10th Research Institute of China Electronics Technology Group Corporation Chengdu 610036China College of Computer Science and Institute for Industrial Internet Research Sichuan UniversityChengdu 610065China

Classical localization methods use Cartesian or Polar coordinates, which require a priori range information to determine whether to estimate position or to only find bearings. The modified polar representation (MPR) unifies near-field and farfield models, alleviating the thresholding effect. Current localization methods in MPR based on the angle of arrival (AOA) and time difference of arrival (TDOA) measurements resort to semidefinite relaxation (SDR) and Gauss-Newton iteration, which are computationally complex and face the possible diverge problem. This paper formulates a pseudo linear equation between the measurements and the unknown MPR position,which leads to a closed-form solution for the hybrid TDOA-AOA localization problem, namely hybrid constrained optimization(HCO). HCO attains Cramér-Rao bound (CRB)-level accuracy for mild Gaussian noise. Compared with the existing closed-form solutions for the hybrid TDOA-AOA case, HCO provides comparable performance to the hybrid generalized trust region subproblem (HGTRS) solution and is better than the hybrid successive unconstrained minimization (HSUM) solution in large noise region. Its computational complexity is lower than that of HGTRS. Simulations validate the performance of HCO achieves the CRB that the maximum likelihood estimator (MLE) attains if the noise is small, but the MLE deviates from CRB earlier.

关键词： localization modified polar representation time difference of arrival(TDOA) angle of arrival(AOA) closed-form solution

Effect of Shenmai Injection on Long-Term Prognosis of Patients with Chronic Heart Failure:A Multicenter,Large Sample Capacity,Long-Term Follow-Up Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2022年第4期28卷 312-318页

作者： GUAN Hui DAI Guo-hua GAO Wu-lin ZHANG Tong sun cong REN Li-li HOU Xiao-ming LIU Zhang The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinan250014China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan250011China

Objective:To explore the effect of Shenmai Injection(SMI)on the long-term prognosis of patients with chronic heart failure(CHF).Methods:The Hospital Information System was used to extract data of CHF patients,and the retrospective cohort study was conducted for *** non-exposed group,standardized Western medicine treatment and Chinese patent medicine or decoction were applied without combination of SMI while in the exposed group,SMI were applied for more than 7 *** indicators are followed with New York Heart Association functional classification(NYHA classification),left ventricular ejection fraction(LVEF),N-terminal brain natriuretic peptide precursor(NT-ProBNP),cardiogenic death and heart failure(HF)*** analysis includes Kaplan-Meier analysis and Cox regression which are used to explore the relationship between SMI and outcome ***:A total of 1,211 eligible CHF patients were involved and finally 1,047 patients were followed up *** treatment,the cases of NYHA classification decline in the exposed and non-exposed groups accounted for 64.30%and 43.45%,respectively;the improvement values of LVEF were 8.89%and 7.91%,respectively;the improvement values of NT-ProBNP were 909 pg/mL and 735 pg/mL,*** exposure on SMI,the rates of cardiogenic death and HF readmission reduced from 15.43%to 10.18%and 38.93%to 32.37%.According to Kaplan-Meier analysis,the log-rank P value of SMI and cardiogenic death was 0.014,while the counterpart of SMI and HF readmission was *** regression analysis indicated that for cardiogenic death,age,cardiomyopathy,diabetes,and NYHA classification were risk factors whileβ-blockers,aldosterone receptor antagonists,Chinese patent medicine/decoction and SMI were protective ***,for HF readmission,age,cardiomyopathy,and NYHA classification were risk factors while SMI was a protective ***:Combination with SMI on the standardized Western medicine tre

关键词： Shenmai Injection chronic heart failure cohort study outcome events long-term prognosis

Control of inflammatory responses by ubiquitin/proteasome pathway

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Control of inflammatory responses by ubiquitin/proteasome pa...

Regulation of IKK/NF-kB Signaling and T-cell Tolerance by Ubiquitination

第十届全国免疫学学术大会

作者： Shao-cong sun Department of Immunology University of Texas MD Anderson Cancer Center

Macrophages and dendritic cells(DCs)are an integral part of the innate immune system and have a crucial role in mediating host defense against infections as well as inflammatory *** and DCs recognize pathogen-asso-

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Regulation of IKK/NF-kB Signaling and T-cell Tolerance by Ub...

第八届全国免疫学学术大会

作者： Shao-cong sun Department of Immunology The University of Texas MD Anderson Cancer Center

NF-k B family of transcription factors plays a pivotal role in mediating immune responses against infections;however,deregulated NF-k B activation is associated with aberrant lymphocyte homeostasis and autoimmune ***,studies from others and us suggest that both the canonical and noncanonical NF-k B signaling pathways are tightly controlled at multiple *** this talk,I will discuss our findings regarding how the canonical NF-k B pathway is regulated by protein ubiquitination in T *** work suggests that ubiquitination not only mediates activation of the NF-k B-activating kinase,IKK,but also prevents accumulation of activated NF-k B in the *** latter function of ubiquitination is crucial for maintaining normal

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多彩液晶微胶囊的制备及性能研究

液晶与显示 2019年第7期34卷 682-689页

作者：孙聪东北石油大学秦皇岛校区石化系

采用手性剂掺杂向列相混合液晶制备出具备类似胆甾相液晶温变显色性能的液晶混合物.通过控制向列相液晶中手性剂的添加量,调节混合液晶的颜色,制备出系列室温下呈颜色转变的液晶混合物.在此基础上,探究3种不同添加剂对混合液晶显色性能... 详细信息

采用手性剂掺杂向列相混合液晶制备出具备类似胆甾相液晶温变显色性能的液晶混合物.通过控制向列相液晶中手性剂的添加量,调节混合液晶的颜色,制备出系列室温下呈颜色转变的液晶混合物.在此基础上,探究3种不同添加剂对混合液晶显色性能的影响,确定具备最佳温变显色性能的液晶混合物配方.以上述液晶混合物为芯材、异佛尔酮二异氰酸酯(IPDI)为壁材,采用界面聚合法在不同反应条件下制备出一系列液晶微胶囊,并确定最佳反应条件.结果表明:最佳反应条件下,制备的液晶微胶囊粒径范围在50~105μm之间,平均粒径在68.06μm左右,囊芯材料含量约占35%.液晶微胶囊呈规则球形,粒径比较均匀,具有良好的温变显色性能,且热稳定性较高,热分解温度达330℃以上.

关键词：向列相液晶手性剂掺杂微胶囊界面聚合

Survival and maintenance of regulatory T cells require the kinase TAK1

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Cellular & Molecular Immunology 2015年第5期12卷 572-579页

作者： Jae-Hoon Chang Hongbo Hu Shao-cong sun Department of Immunology The University of Texas MD Anderson Cancer Center 7455 Fannin Street Box 902 Houston TX 77030 USA Center for Inflammation and Cancer The University of Texas MD Anderson Cancer Center 7455 Fannin Street Box 902 Houston TX 77030 USA The University of Texas Graduate School of Biomedical Sciences at Houston Houston TX 77030 USA College of Pharmacy Yeungnam University Gyeongsan 712- 749 Republic of Korea

Regulatory T （Treg） cells play a central role in regulating peripheral immune tolerance and preventing autoimmunity. Despite the extensive studies on the development of Treg cells, the molecular mechanisms that maintain the population of committed Treg cells remain poorly understood. We show here that Treg-conditional ablation of the kinase TAK1 reduced the number of Treg cells in the peripheral lymphoid organs, causing abnormal activation of conventional T cells and autoimmune symptoms. Using an inducible gene knockout approach, we further demonstrate that TAK1 is crucial for the survival of Treg cells. Expression of a constitutively active IKB kinase partially restored the level of Treg cells in the TAKITreg-KO mice. These results suggest a crucial role for TAK1 for maintaining the survival of committed Treg cells under physiololzical conditions.

关键词： regulatory T cells autoimmunity TAK1 IKK Foxp3

Silurian ostracods from the Nyalam region,southern Tibet,China and their implications on palaeoenvironment and palaeobiogeography

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Journal of Palaeogeography 2022年第1期11卷 85-96页

作者： Jun-Jun Song Wen Guo Jia-Yuan Huang Yi-Chun Zhang Zhong-Yang Chen Yu-cong sun Juan Ma Wen-Kun Qie State Key Laboratory of Paleobiology and Stratigraphy Nanjing Institute of Geology and Paleontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Biogeology and Environmental Geology School of Earth SciencesChina University of Geosciences(Wuhan)Wuhan 430074Hubei ProvinceChina

The overall occurrence,stratigraphical distribution,palaeoenvironmental and palaeobiogeographical significances of the ostracod faunas from the Silurian Pulu Formation in the Yalai West Ⅱ section,Nyalam region,southern Tibet,China,are documented for the first ***-two species belonging to 19 genera are identified and figured *** ostracod fauna in the Pulu Formation indicates an age of the late *** ostracods belong to a podocope-rich association,which suggests an offshore environment for the Yalai West II *** ostracods of the Pulu Formation have strong affinities with the South China taxa and also share some similarities with those from *** implies that ostracods could probably benefit from sea-level changes to facilitate faunal exchanges between peri-Gondwana and *** isolation and global sea-level changes are proposed as the primary factors controlling the palaeobiogeographical distribution of ostracods during the Silurian.

关键词： Ostracods Silurian Pulu Formation Tethyan Himalaya terrane South Tibet Paleobiogeography