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永定河门头沟段抗生素污染特征及风险评估

中国环境科学 2024年第6期44卷 3240-3246页

作者：蒋宝凌文翠王亚玲荆降龙杨勇孙成一北京市生态环境保护科学研究院国家城市环境污染控制中心北京100037

采用高效液相色谱-串联三重四极杆质谱对永定河门头沟辖区段(包括官厅水库下游、斋堂水库支流汇入后的干流和城区段)内水体中的抗生素污染特征及风险进行评估.研究结果表明,氟苯尼考、奥索利酸、磺胺甲噁唑在3段流域内均有检出,平均浓... 详细信息

采用高效液相色谱-串联三重四极杆质谱对永定河门头沟辖区段(包括官厅水库下游、斋堂水库支流汇入后的干流和城区段)内水体中的抗生素污染特征及风险进行评估.研究结果表明,氟苯尼考、奥索利酸、磺胺甲噁唑在3段流域内均有检出,平均浓度分别为4.95,2.56,13.96ng/L.磺胺吡啶从支流汇入,检出率为54%,浓度自2.36ng/L上升至4.06ng/L.城区段受生活污水排放等影响,氧氟沙星含量显著增加,浓度达到7.93ng/L.永定河门头沟辖区段内水体整体无健康风险,但在进入城区段后,其生态风险与抗性风险有所上升,可能是由于人类活动水平上升所致,需要进一步关注.

关键词：地表水抗生素生态风险健康风险抗性风险

北京市再生水补水河流中抗生素的赋存特征及生态风险评估

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环境科学 2024年第9期45卷 5244-5253页

作者：武亚林徐井旭刘桂中方瑶瑶蒋宝孙成一孙长虹凌文翠北京市生态环境保护科学研究院国家城市环境污染控制工程技术研究中心北京100037

以北京市再生水补水河流凉水河为研究区域,检测了水体和沉积物中16种抗生素的种类、检出率和浓度(含量)水平,探讨其时空变化和赋存特征.在水体和沉积物中分别检测到9种和13种抗生素,抗生素的浓度(含量)范围分别为ND~116.68 ng·L^(−1)和... 详细信息

以北京市再生水补水河流凉水河为研究区域,检测了水体和沉积物中16种抗生素的种类、检出率和浓度(含量)水平,探讨其时空变化和赋存特征.在水体和沉积物中分别检测到9种和13种抗生素,抗生素的浓度(含量)范围分别为ND~116.68 ng·L^(−1)和ND~235.42 ng·g^(−1).水体中的主要抗生素为氧氟沙星和克拉霉素,沉积物中的主要抗生素为氧氟沙星.凉水河水体和沉积物中的抗生素总浓度(含量)表现为自上游至下游逐渐降低的趋势,其支流浓度(含量)高于干流.支流汇入对凉水河水体抗生素水平有明显影响,但对沉积物则影响不大.枯水期水体和沉积物中的抗生素总浓度(含量)整体高于丰水期.丰水期水体中检出浓度最高的是喹诺酮类抗生素,枯水期则为大环内酯类抗生素;沉积物在两季中检出含量最高的均为喹诺酮类抗生素.生态风险评价结果表明,水体中克拉霉素在枯水期表现为低风险,克拉霉素在两季沉积物中具有低风险,其余抗生素均表现为无风险.联合生态风险及最敏感营养级生态风险表明,所有点位生态风险表现为低风险和无风险,枯水期整体大于丰水期.部分点位在枯水期时接近中风险阈值,需引起重视.

关键词：抗生素再生水城市河流赋存特征生态风险

右美托咪定复合艾司氯胺酮滴鼻用于小儿先天手足畸形矫形手术

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中国处方药 2024年第6期22卷 116-118页

作者：钟凤珍孙承毅卢波东莞市中西医结合医院麻醉科广东东莞532800

目的探讨右美托咪定复合艾司氯胺酮滴鼻用于小儿先天手足畸形矫形手术的应用效果。方法选取东莞市中西医结合医院2022年1月~2023年4月收治的先天手足畸形患儿64例,均择期拟行矫形手术治疗,采用随机数字表法分为试验组(n=32)与对照组(n=... 详细信息

目的探讨右美托咪定复合艾司氯胺酮滴鼻用于小儿先天手足畸形矫形手术的应用效果。方法选取东莞市中西医结合医院2022年1月~2023年4月收治的先天手足畸形患儿64例,均择期拟行矫形手术治疗,采用随机数字表法分为试验组(n=32)与对照组(n=32)。对照组患儿予以2μg/kg右美托咪定滴鼻,试验组患儿予以2μg/kg右美托咪定+1 mg/kg艾司氯胺酮滴鼻。比较两组患儿的镇静效果、氧化应激指标、血气指标及不良反应发生情况。结果试验组患儿补救镇静率低于对照组,镇静起效时间、苏醒时间、麻醉后监测治疗室停留时间短于对照组,差异有统计学意义(P0.05),但镇静后的Cor、NE、E、心肌肌钙蛋白I(c TnI)水平低于对照组(P<0.05)。试验组患儿不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论右美托咪定复合艾司氯胺酮滴鼻可优化小儿先天手足畸形矫形手术的镇静效果,缩短镇静起效时间,降低患儿应激反应,术后苏醒质量高,不良反应较少,安全性较高。

关键词：小儿先天手足畸形矫形手术右美托咪定艾司氯胺酮滴鼻镇静

Ytterbium modified birnessite MnO_(2) for improving deep oxidation of toluene

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Journal of Rare Earths 2024年第4期42卷 668-675页

作者： Linjiang sun Yan cheng Yujie Liu Can yi Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu611756China

A series of rare earth metals modified birnessite manganese dioxides(RE-Mn)was synthesized by hydrothermal method and their catalytic degradation of toluene was ***-Mn shows the best toluene oxidation activity with the conversion of T50%and T99%at 196 and 226℃,*** physiochemical characterizations identified that the high catalytic performance and excellent stability of Yb-Mn are mainly associated with its higher molar ratios of Mn^(4+)/Mn^(3+),more lattice oxygen(Olatt),and better mobility of surface adsorbed oxygen(O_(ads)).Moreover,it is confirmed that introduction of Yb into birnessite MnO_(2) facilitates the production of acetic acid at lower *** results can aid the design of high-efficiency manganese oxide catalysts for the catalytic combustion of VOCs.

关键词： Manganese oxide Rare earth metal doping Toluene Catalytic combustion

Placebo Response among Different Types of Sham Acupuncture for Low Back Pain:A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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中国结合医学杂志:英文版 2023年第10期29卷 941-950页

作者： XIONG Zhi-yi LIU Xiao-yu MA Pei-hong sun Chong-yang sun cheng-yi LIU Ting-lan LIU Bao-yan LIU Cun-zhi YAN Shi-yan International Acupuncture and Moxibustion Innovation Institute School of Acupuncture-Moxibustion and TuinaBeijing University of Chinese MedicineBeijing100029China School of Acupuncture-Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin301617China China Academy of Chinese Medical Sciences Beijing100007China

Background: Low back pain(LBP) is a prevalent and debilitating condition that poses a significant burden on healthcare systems. Acupuncture has been proposed as a promising intervention for LBP, but the evidence supporting its specific effect is insufficient, and the use of sham acupuncture as a control in clinical trials presents challenges due to variations in sham acupuncture techniques and the magnitude of the placebo ***: To investigate the magnitude of the placebo response of sham acupuncture in trials of acupuncture for nonspecific LBP, and to assess whether different types of sham acupuncture are associated with different responses. Methods: Four databases including PubMed, EMBASE, MEDLINE, and the Cochrane Library were searched through April 15, 2023, and randomized controlled trials(RCTs) were included if they randomized patients with LBP to receive acupuncture or sham acupuncture intervention. The main outcomes included the placebo response in pain intensity, back-specific function and quality of life. Placebo response was defined as the change in these outcome measures from baseline to the end of treatment. Random-effects models were used to synthesize the results, standardized mean differences(SMDs, Hedges’ g) were applied to estimate the effect size. Results: A total of 18 RCTs with 3,321 patients were included. Sham acupuncture showed a noteworthy pooled placebo response in pain intensity in patients with LBP [SMD –1.43, 95% confidence interval(CI) –1.95 to –0.91, I2=89%]. A significant placebo response was also shown in back-specific functional status(SMD –0.49, 95% CI –0.70 to –0.29, I2=73%),but not in quality of life(SMD 0.34, 95% CI –0.20 to 0.88, I2=84%). Trials in which the sham acupuncture penetrated the skin or performed with regular needles had a significantly higher placebo response in pain intensity reduction, but other factors such as the location of sham acupuncture did not have a significant impact on the placebo ***

关键词： low back pain sham acupuncture placebo response meta-analysis randomized controlled trial

Non-synchronous vibration of rotor blade in a six-stage transonic compressor

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Chinese Journal of Aeronautics 2024年第8期37卷 36-48页

作者： Ronghui cheng Zhuo WANG Huawei YU Lin DU yi ZHANG Xiaofeng sun Aeroengine Research Institute Beihang UniversityBeijing 102206China School of Energy and Power Engineering Beihang UniversityBeijing 102206China

This paper presents an experimental study on the Non-Synchronous Vibration(NSV)in a six-stage transonic *** first part of the paper describes the NSV phenomenon of Rotor 1,which occurs when both Stator 1(S1)and Stator 2(S2)or S1 only are *** measurements and analysis are carried out for the former case through the unsteady wall pressure and the Blade Strain(BS).The spinning mode theory used in the rotor/stator interaction noise is employed to explain the relation between the circumferential wave number of the aerodynamic disturbance and the Nodal Diameter(ND)of the blade *** variations of the vibration amplitudes of different blades and the Inter-Blade Phase Angles(IBPAs)at different moments suggest that the evolution of NSV is a highly nonuniform phenomenon along the circumferential *** addition,the difference between the wall-pressure spectra generated by the NSV and the classic flutter has been *** the second part,the variations of aerodynamic loading due to the adjustment of the staggers of the Inlet Guide Vane(IGV),S1 and S2 have been *** is found that closing S1 only can result in a great fluctuation to the performance of the front stages,which might be detrimental to the flow organization and increase the risk of *** contrast,the effect of closing S2 only on the performance of the first two stages appears to be slighter relatively.

关键词： Transonic compressor Non-synchronous vibration Modal analysis Aerodynamic loading Nodal diameter

Pregnancy Benefit of Acupuncture on in vitro Fertilization:A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2023年第11期29卷 1021-1032页

作者： ZHANG Hao-ran ZHANG cheng MA Pei-hong sun cheng-yi sun Chong-yang LIU Xiao-yu PU Zhen-qing LIN Yu-han LIU Bao-yan LIU Cun-zhi YAN Shi-yan College of Preschool Education Beijing Youth Politics CollegeBeijing(100102)China School of Acupuncture Moxibustion and TuinaBeijing University of Chinese MedicineBeijing(100029)China School of Acupuncture and Moxibustion Tianjin University of Traditional Chinese MedicineTianjin(301617)China China Academy of Chinese Medical Sciences Beijing(100091)China

Background:Currently,more and more infertility couples are opting for combined acupuncture to improve success rate of in vitro fertilization(IVF).However,evidence from acupuncture for improving IVF pregnancy outcomes remains a matter of ***:To quantitatively summarized the evidence of the efficacy of acupuncture among women undergoing IVF by means of systematic review and ***:Four English(PubMed,Web of Science,EMBASE,and Cochrane Register of Controlled Clinical Trials)and Four Chinese databases(Wanfang Databases,Chinese National Knowledge Infrastructure,Chinese Science and Technology Periodical Database,and SinoMed)were searched from database inception until July 2,*** controlled trials(RCTs)that evaluated the acupuncture’s effects for women undergoing IVF were *** subgroup analysis was conducted with respect to the age of participants,different acupuncture types,type of control,acupuncture timing,geographical origin of the study,whether or not repeated IVF failure,and acupuncture *** analyses were predefined to explore the robustness of *** primary outcomes were clinical pregnancy rate(CPR)and live birth rate(LBR),and the secondary outcomes were ongoing pregnancy rate and miscarriage *** effects model with I^(2)statistics were used to quantify *** bias was estimated by funnel plots and Egger’s ***:A total of 58eligible RCTs representing 10,968 women undergoing IVF for pregnant success were *** CPR and LBR showed a significant difference between acupuncture and control groups[69 comparisons,relative risk(RR)1.19,95%confidence intervals(CI)1.12 to 1.25,I^(2)=0],extremely low evidence;23 comparisons,RR 1.11,95%CI 1.02 to 1.21,I^(2)=14.6,low evidence,*** transcutaneous electrical acupoint stimulation showed a positive effect on both CPR(16 comparisons,RR 1.17,95%CI 1.06 to 1.29;I^(2)=0,moderate evidence)and LBR(9 comparisons,R

关键词： acupuncture Acupuncture stimulation

Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

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Petroleum Science 2024年第1期21卷 621-640页

作者： Xue-Qiang Zhang Qing-Lin cheng Wei sun yi Zhao Zhi-Min Li Key Lab of Ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing163318HeilongjiangChina China Petroleum Pipeline Material and Equipment Co. LtdLangfang065000HebeiChina Research Institute of Petroleum Engineering and Technology Sinopec Northwest Oilfield CompanyUrumqi830011XinjiangChina

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex *** is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency *** this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is *** with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation *** comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are *** the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy *** entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their ***,the weak links in energy utilization are identified,and energy conservation and consumption reduction are *** above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

关键词： Crude oil gathering and transportation system GA-BP neural network Energy efficiency evaluation TOPSIS evaluation method Energy saving and consumption reduction

The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di Wu yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly