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Food Science and Human Wellness 2024年第4期13卷 2060-2067页

作者： yong Fang Tianhang Huang Jian Wu Xieqi Luo Fengjiao Fan Peng Li Jian Ding Xinyang sun College of Food Science and Engineering Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and SafetyNanjing 210023China Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi School of MedicineJiangnan UniversityWuxi 214122China

Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced ***,the crosstalk between mRNA and microRNAs(miRNA)involved in the neuroprotection mechanism remains to be *** this study,RNA-sequencing and miRNA-sequencing were used to independently identify differentially expressed mRNAs and small RNAs profiles in Pb^(2+)-treated primary fetal rat cortical neurons and then the correlated miRNA-mRNA target pairs were *** was found that 34 mRNAs related to oxidative phosphorylation could be reversed by pretreatment of TSeMMM and *** protective effect of TSeMMM and SeMDPGQQ was mediated by upregulation of miR-107-3p,which downregulates the ATPase H+transporting V0 subunit e1(Atp6v0e1)mRNA level.A zebrafish model was applied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative *** results indicated that miR-107-3p was a potential therapeutic target to achieve neuroprotection of Se-containing peptides via stimulation of Atp6v0e1.

关键词： Lead Se-containing peptides Neuroprotection miRNA

Acoustofluidics-enhanced biosensing with simultaneously high sensitivity and speed

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Microsystems & Nanoengineering 2024年第3期10卷 335-346页

作者： Yuang Li Yang Zhao Yang Yang Wenchang Zhang Yun Zhang sheng sun Lingqian Zhang Mingxiao Li Hang Gao Chengjun Huang Institute of Microelectronics of the Chinese Academy of Sciences Beijing 100029P.R.China University of Chinese Academy of Sciences Beijing 101408P.R.China Department of Medicine Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

Simultaneously achieving high sensitivity and detection speed with traditional solid-state biosensors is usually limited since the target molecules must passively diffuse to the sensor surface before they can be *** techniques have been applied to shorten the diffusion time by continuously moving molecules through the biosensing ***,the binding efficiencies of the biomolecules are still limited by the inherent laminar flow inside microscale *** this study,focused traveling surface acoustic waves were directed into an acoustic microfluidic chip,which could continuously enrich the target molecules into a constriction zone for immediate detection of the immune reactions,thus significantly improving the detection sensitivity and *** demonstrate the enhancement of biosensing,we first developed an acoustic microfluidic chip integrated with a focused interdigital transducer;this transducer had the ability to capture more than 91%of passed ***,polystyrene microbeads were pre-captured with human IgG molecules at different concentrations and loaded for detection on the *** representative results,~0.63,2.62,11.78,and 19.75 seconds were needed to accumulate significant numbers of microbeads pre-captured with human IgG molecules at concentrations of 100,10,1,and 0.1 ng/mL(~0.7 pM),respectively;this process was faster than the other methods at the hour level and more sensitive than the other methods at the nanomolar *** results indicated that the proposed method could significantly improve both the sensitivity and speed,revealing the importance of selective enrichment strategies for rapid biosensing of rare molecules.

关键词： fluid continuously simultaneous

Advanced cellulose-based materials toward stabilizing zinc anodes

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Science China Chemistry 2024年第5期67卷 1465-1484页

作者： Zhijiang Li Xiang Chen Rui Zhang Taoyi Shen Jianchao sun Zhongce Hu Lin Li Lanlan Yang Hou-yong Yu College of Textile Science and Engineering(International Institute of Silk) Zhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai 201620China School of Environment and Material Engineering Yantai UniversityYantai 264005China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Rechargeable aqueous zinc metal batteries(RAZMBs) have received extensive attention for large-scale energy storage systems due to the merits of Zn anodes, including moderate volumetric and gravimetric energy density, low redox potential, abundant reserve, low cost and impressive intrinsic safety. However, Zn anodes suffer from a series of adverse reactions(dendrite growth,hydrogen evolution, and surface passivation) resulting in low Coulombic efficiency, large polarization, and unsatisfied cycling performance, which inevitably hinder the wide application of RAZMBs. To address the above issues, cellulose-based materials are widely used for Zn anode protection because of their unique physical and chemical properties and other advantages such as biocompatibility, non-toxicity, degradability and easy extraction. In order to better understand the current progress in cellulosebased materials for the Zn anode protection, we have classified and summarized the relevant literatures. In this review, we summarize and elaborate the causes of poor reversibility for Zn anodes, including dendrite formation, hydrogen evolution, and surface passivation. Subsequently, the effective strategies(anode interfacial engineering, gel electrolyte optimization, and separator modification) of cellulose-based materials toward stabilizing Zn anodes are overviewed. In the end, the existing challenges and prospects of cellulose-based materials in Zn anode protection are summarized to shed light on future work.

关键词： Zn anode cellulose anode interfacial engineering gel electrolyte optimization separator modification

Molecular solid solution of lanthanide-titanium-oxo clusters with enhanced photocatalytic hydrogen evolution

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Science China Chemistry 2024年第2期67卷 529-535页

作者： Rong Chen Chao-Long Chen Hui Zhang Zi-Han Wang Fu-Li sun Ming-Hao Du Gui-Lin Zhuang Cheng Wang La-sheng Long Lan-sun Zheng Xiang-Jian Kong Collaborative Innovation Centre of Chemistry for Energy Materials State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China College of Chemical Engineering Zhejiang University of TechnologyHangzhou310032China

Molecular solid solutions of metal clusters containing different metal centers with well-defined structures can accurately regulate the HOMO-LUMO gap,but are rarely ***,a series of colorless lanthanide-titanium-oxo clusters Ln_(2)Ti_4(μ_(2)-O)_(2)(μ_(3)-O)_4(Piv)_(10)(THF)_(2)(Ln_(2)Ti_4,Ln = Eu,Gd,Tb,and Ce,HPiv = pivalic acid) were synthesized by the reaction of pivalic acid with Ln(Ac)_(3) and titanium *** light yellow crystal of cluster solid solutions Eu_(2)Ti_(4-x)Cd_(x),containing a mixture of Eu_(2)Ti_4 and Eu_(2)Ti_(3)Cd,was obtained by in situ doping Cd^(2+) and S^(2–).Eu_(2)Ti_(3.92)Cd_(0.08) displays efficient photocatalytic hydrogen evolution activity without a co-catalyst,which is up to 2.6 times that of Eu_(2)Ti_*** time-resolved transient absorption spectroscopy and spin-polarized density functional calculations showed that the enhanced photocatalytic performance of Eu_(2)Ti_(4-x)Cd_(x) can be attributed to the narrower HOMO-LUMO gap and lower LUMO position than that of Eu_(2)Ti_*** studyprovides an in situ doping method to realize the simple preparation of cluster solid solution.

关键词： molecular solid solution lanthanide-titanium-oxo clusters photocatalytic hydrogen evolution

Effect of plateletcrit and methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on folic acid efficacy in stroke prevention

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2694-2701页

作者： Yuncong Shi Zhengzhipeng Zhang Binyan Wang Yu Wang Xiangyi Kong yong sun Aimin Li Yimin Cui Yan Zhang Jianping Li yong Huo Hui Huang Cardiovascular Department The Eighth Affiliated HospitalJoint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic DiseasesSun Yat-sen UniversityShenzhenChina Shenzhen Evergreen Medical Institute ShenzhenChina Shenzhen Tailored Medical Laboratory ShenzhenChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungangChina Institute of Clinical Pharmacology Peking University First HospitalBeijingChina Department of Cardiology Peking University First HospitalBeijingChina

Previous studies have shown that low platelet count combined with high plasma total homocysteine(tHcy)increased stroke risk and can be lowered by 73% with folic ***,the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on stroke risk and folic acid treatment benefit remain to be *** study aimed to investigate if platelet activation parameters and MTHFR genotypes jointly impact folic acid treatment efficacy in first stroke *** were derived from the China Stroke Primary Prevention *** study includes a total of 11,185 adult hypertensive patients with relevant platelet activation parameters and MTHFR genotype *** simultaneously considering both platelet activation parameters(plateletcrit,platelet count,mean platelet volume,platelet distribution width)and MTHFR genotypes,patients with both low plateletcrit(Q1)and the TT genotype had the highest stroke incidence rate(5.6%)in the enalapril *** subgroup significantly benefited from folic acid treatment,with a 66% reduction in first stroke(HR:0.34;95%CI:0.14-0.82;p=0.016).Consistently,the subgroup with low plateletcrit(Q1)and the CC/CT genotype also benefited from folic acid treatment(HR:0.40;95%CI:0.23-0.70;p=0.001).In Chinese hypertensive adults,low plateletcrit can identify those who may greatly benefit from folic acid treatment,in particular,those with the TT genotype,a subpopulation known to have the highest stroke risk.

关键词： prevention treatment MTHFR

A Deep Deterministic Policy Gradient-Based Method for Enforcing Service Fault-Tolerance in MEC

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Chinese Journal of Electronics 2024年第4期33卷 899-909页

作者： Tingyan LONG Peng CHEN Yunni XIA yong MA Xiaoning sun Jiale ZHAO Yifei LYU College of Computer Science Chongqing University School of Computer and Software Engineering Xihua University School of Computer and Information Engineering Jiangxi Normal University School of Computer and Information Science Chongqing Normal University

Mobile edge computing(MEC) provides edge services to users in a distributed and on-demand *** to the heterogeneity of edge applications, deploying latency and resource-intensive applications on resourceconstrained devices is a key challenge for service providers. This is especially true when underlying edge infrastructures are fault and error-prone. In this paper, we propose a fault tolerance approach named DFGP, for enforcing mobile service fault-tolerance in MEC. It synthesizes a generative optimization network(GON) model for predicting resource failure and a deep deterministic policy gradient(DDPG) model for yielding preemptive migration *** show through extensive simulation experiments that DFGP is more effective in fault detection and guaranteeing quality of service, in terms of fault detection accuracy, migration efficiency, task migration time, task scheduling time,and energy consumption than other existing methods.

关键词： Fault tolerance Multi-access edge computing Processor scheduling Fault detection Image edge detection Fault tolerant systems Quality of service

Boosting oxygen reduction in acidic media through integration of Pt-Co alloy effect and strong interaction with carbon defects

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Nano Research 2024年第9期17卷 7900-7908页

作者： Nannan Ji Haoyun sheng Shilong Liu Yangyuan Zhang Hongfei sun Lingzhi Wei Ziqi Tian Peng Jiang Qianwang Chen Jianwei Su Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityHefei 230601China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Hefei National Laboratory for Physical Science at Microscale Department of Materials Science&EngineeringUniversity of Science and Technology of ChinaHefei 230026China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China

Optimization of Pt atom utilization efficiency is critical for the development of proton-exchange-membrane fuel *** we aim to develop an efficient oxygen reduction reaction(ORR)catalyst with a low Pt content through the concurrent modification of Pt-Co alloy catalysts and carbon *** the present study,ultrafine Pt-Co alloy nanoparticles are successfully synthesized and stabilized by topological carbon defects via adopting the ammonia thermal *** the low Pt loading,the obtained catalyst exhibits an impressive half-wave potential of 0.926 V versus the reversible hydrogen electrode in 0.1 M HClO_(4)***,the durability testing using the timed-current method demonstrates a tiny loss of only 3.6%after 12 *** experimental results and theoretical calculations demonstrate that topological carbon defects significantly enhance the charge transfer processes at the alloy/carbon interface,contributing to the strong electronic metal-support interactions between the Pt-Co alloy nanoparticles and topological carbon *** interactions,along with the alloy effect,play a crucial role in promoting the ORR performance in acidic media.

关键词： electrocatalysis oxygen reduction reaction Pt-Co alloy electronic interaction topological carbon defects

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地层模量分解及在流体识别中的应用

地球物理学报 2016年第11期59卷 4278-4286页

作者：石玉梅曹宏孙夕平李凌高宋建勇孙虎生中国石油勘探开发研究院北京100083

储层流体识别是确定油气水分布,合理布设井位,提高钻井成功率的关键之一.本文基于流体饱和孔隙介质岩石物理模型,对地震反演的地层体积模量进行分解,获得孔隙流体体积模量,并依据油、气、水(尤其是气-油、气-水)模量的显著差异进行识别... 详细信息

储层流体识别是确定油气水分布,合理布设井位,提高钻井成功率的关键之一.本文基于流体饱和孔隙介质岩石物理模型,对地震反演的地层体积模量进行分解,获得孔隙流体体积模量,并依据油、气、水(尤其是气-油、气-水)模量的显著差异进行识别.文中简要分析了Gassmann模型和Kuster-Toksz模型的特征,详细讨论了孔隙形态和饱和度对弹性模量的影响,提出了联合Kuster-Toksz方程和Gassmann方程的体积模量分解方法.该方法通过Kuster-Toksz方程从测井数据中反演地层骨架固体和干骨架的弹性模量,再利用Gassmann方程对地层体积模量进行分解,既考虑了孔隙形态,又充分利用了Gassmann方程的易用性.理论模型结果表明方法是可行的.方法应用于西部地区某气田,流体识别与地层含气性预测结果与钻井基本一致,进一步证实了方法的有效性.

关键词：油气地层岩石物理模量分解流体识别

Reinforcing oxygen electrocatalytic activity via selective dualphase heterointerface engineering for rechargeable Zn-air batteries

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Rare Metals 2024年第4期43卷 1524-1536页

作者： Chao Cheng Chuang Zhi Zhong-Ti sun yong-Qiang Ming Ting-Ting Xiang Qing-Chao Zhu Zi-Rui Wu Bing Li Yi Li Cheng Jin yong Cao Juan Yang School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013China Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming650093China

Dual-phase heterointerface electrocatalysts(DPHE)constructed by oxygen reduction reaction(ORR)-and oxygen evolution reaction(OER)-active elements exhibit excellent bifunctional activity and long-term durability due to the abundant interface exposure and synergistic catalytic ***,low-dimensional N-doped graphene nanoribbons(N-GNRs)coupling with ultrathin CoO nanocomposites(N-GNRs/CoO)were controllably fabricated through a facile two-step approach using synthesized Co(OH)_2 nanosheet as CoO *** functional theory(DFT)calculations and experimental characterizations prove that the formation of interface between N-GNRs and CoO can induce local charge redistribution,contributing to the improvement of catalytic activity and *** optimal N-GNRs/CoO DPHE possesses hierarchically porous architectures and presents outstanding bifunctional activities with a small potential gap of 0.729 V between the potential at 10 mA·cm^(-2)for OER and the halfwave potential for ORR,which outperforms Pt/C+IrO_(2)and the majority of noble-metal-free bifunctional ***-and solid-state rechargeable Zn-air batteries assembled with N-GNRs/CoO as the cathode also display high peak power density and fantastic cycle stability,superior to that of benchmark Pt/C+IrO_(2)*** is anticipated to offer significant benefits toward high activity,stability and mechanical flexibility bifunctional oxygen electrocatalysts for rechargeable Zn-air batteries.

关键词： Interface engineering Graphene nanoribbons CoO Bifunctional electrocatalyst Zn-air batteries

Efficacy of laparoscopic low anterior resection for colorectal cancer patients with 3D-vascular reconstruction for left coronary artery preservation

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1548-1557页

作者： Ye Wang Zhi-sheng Liu Zong-Bao Wang Shawn Liu Feng-Bo sun Department of General Surgery Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033Shandong ProvinceChina Department of Gastrointestinal Surgery National University Hospital of SingaporeSingapore 119228Singapore

BACKGROUND Laparoscopic low anterior resection(LLAR)has become a mainstream surgical method for the treatment of colorectal cancer,which has shown many advantages in the aspects of surgical trauma and postoperative ***,the effect of surgery on patients'left coronary artery and its vascular reconstruction have not been deeply *** the development of medical imaging technology,3D vascular reconstruction has become an effective means to evaluate the curative effect of *** To investigate the clinical value of preoperative 3D vascular reconstruction in LLAR of rectal cancer with the left colic artery(LCA)*** A retrospective cohort study was performed to analyze the clinical data of 146 patients who underwent LLAR for rectal cancer with LCA preservation from January to December 2023 in our *** patients underwent LLAR of rectal cancer with the LCA preserved,and the intraoperative and postoperative data were *** patients were divided into a reconstruction group(72 patients)and a nonreconstruction group(74 patients)according to whether 3D vascular reconstruction was performed before *** clinical features,operation conditions,complications,pathological results and postoperative recovery of the two groups were collected and *** A total of 146 patients with rectal cancer were included in the study,including 72 patients in the reconstruction group and 74 patients in the nonreconstruction *** were 47 males and 25 females in the reconstruction group,aged(59.75±6.2)years,with a body mass index(BMI)(24.1±2.2)kg/m^(2),and 51 males and 23 females in the nonreconstruction group,aged(58.77±6.1)years,with a BMI(23.6±2.7)kg/m^(2).There was no significant difference in the baseline data between the two groups(P>0.05).In the submesenteric artery reconstruction group,35 patients were type Ⅰ,25 patients were type Ⅱ,11 patients were type Ⅲ,and 1 patient was type Ⅳ.There were 37 type Ⅰ patients,24

关键词： Laparoscopic low anterior resection 3D vascular reconstruction Coronary artery Colorectal cancer Retrospective cohort study