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Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth Through an Aspartate aminotransferase-independent Pathway

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Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasm...

2021中国畜牧兽医学会兽医寄生虫学分会第16次学术研讨会

作者： Jixu Li yali sun Ying Li Ming Kang Honglin Jia Xuenan Xuan

Toxoplasma gondii is an obligate intracellular protozoan parasite and a successful parasitic pathogen in diverse organisms and host cell ***(HYD) and carboxymethoxylamine(CAR) have been reported as inhibitors of aspartate aminotransferases(AATs),and interferes with the proliferation in Plasmodium ***,AATs are suggested as drug targets against *** genome encodes only one predicted AAT in both *** type I RH and type II PLK ***,effects of HYD and CAR,and their relationship with AAT on *** remain *** this study,we found that HYD and CAR impaired the lytic cycle of *** in vitro,including the inhibition of invasion or reinvasion,intracellular replication and ***,HYD and CAR had the ability for controlling acute toxoplasmosis in *** studies showed that HYD and CAR could inhibit the transamination activity of rTgAAT in ***,our results confirmed that deficiency of AAT in both RH and PLK did not reduce the virulence in mice,although the growth ability of the parasites was affected in *** and CAR could still inhibit the growth of AAT-deficient *** these indicated HYD and CAR inhibiting *** growth and controlling toxoplasmosis can occur on an AATindependent ***,further studies focusing on the elucidation of the mechanism of inhibition is *** study hints at new substrates of HYD and CAR as potential drug targets to inhibit *** growth.

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Study on the Effect of Sarcocystis Cruzi Invasion of Host Cell on the EGFR Signaling Pathway

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Study on the Effect of Sarcocystis Cruzi Invasion of Host Ce...

2021中国畜牧兽医学会兽医寄生虫学分会第16次学术研讨会

作者： Jinfang Yang Caiying Xie yali sun Jixu Li Ying Li Ming,Kang Qinghai University

Objective:Sarcocystis cruzi(***),belong to the Apicomplexan protozoas,is an obligate intracellular pathogenic *** is the most common and pathogenic for *** infection,the cattle can lose weight,miscarry and even die,which seriously affects the development of the *** growth factor receptor(EGFR) signaling pathway is a major signal transduction molecule involved in a variety of cell activities,which can be activated by Microneme protein containing EGF domain(EGF-MIC) of Apicomplexan protozoas to regulate host cell apoptosis and other ***,it is still unclear whether the infection of *** can regulate this pathway and cell ***,the aim of this study is to identify the relationship among host cell,*** and EGFR Signaling ***:Vero cell was regarded as the host cell to culture *** *** that,Vero cell can be collected in a certain time and detected the relative expression of EGFR,PI3 K(phosphatidylinositol-3-kinases)/AKT(serine/threonine protein kinase B) signaling pathway and the apoptosis related molecules,then the effect of specific inhibitors for EGFR signaling pathways on the cell infection by *** were ***:*** infection can activate the EGFR/PI3 K/AKT signaling pathway of host cell,and regulate the expression of apoptosis-related molecules,the expression of anti-apoptotic protein Bcl-2(B-cell lymphoma-2) was up-regulated,pro-apoptotic protein Bax(Bcl-2-associated X protein)was down-regulated and Bad(Bcl-xl/Bcl-2-associatde death pormoter) was *** blocking this pathway with specific inhibitors,the number of *** bradyzoites and the percentage of infected cells are significantly reduced(P<0.05).Summary:the result showed that *** infection can activate the EGFR/PI3 K/AKT signaling pathway of Vero cell,and inhibit the apoptosis of host *** this pathway can inhibit *** infection and multiplication.

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PLK:Δgra9 live attenuated strain induces full protective immunity against acute and chronic toxoplasmosis

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PLK:Δgra9 live attenuated strain induces full protective im...

2021中国畜牧兽医学会兽医寄生虫学分会第16次学术研讨会

作者： Jixu Li Huanping Guo yali sun Ying Li Ming Kang Xuena Xuan

Toxoplasmosis is a zoonotic parasitic disease caused by the obligate intracellular protozoa Toxoplasma gondii,which threatens a range of warm-blooded mammals including *** date,it remains a challenge to find safe and effective drug treatment or vaccine against *** this study,our results found that the development of a mutant strain based on gene disruption of dense granule protein 9(gra9) in type Ⅱ PLK strain decreased parasite replication in vivo,severely attenuated virulence in mice,and significantly reduced the formation of cysts in ***,we developed an immunization scheme to evaluate the protective immunity of the attenuated strain of Δgra9 in type Ⅱ PLK parasite as a live attenuated vaccine against toxoplasmosis in the mouse model.Δgra9 vaccination-induced full immune responses characterized by significantly high levels of pro-inflammatory cytokine interferon gamma(IFN-y) and interleukin-12(IL-12),maintained the high ***-specific IgG level,and mixed high IgG1/IgG2 a *** levels provided the complete protective immunity which is a combination of cellular and humoral immunity in mouse models against further infections of lethal doses of type Ⅰ RH,type ⅡPLK wild-type tachyzoites,or type Ⅱ PLK *** showed that Δgra9 vaccination proved its immunogenicity and potency conferring 100% protection against acute and chronic *** ***,Δgra9 vaccination provided safe and efficient immune protection against challenging parasites,suggesting that PLK:Δgra9 is a potentially promising live attenuated vaccine candidate.

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Research Progress of Cardiac Myosin Binding Protein C in Dilated Cardiomyopathy and Other Cardiac Conditions

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World Journal of Cardiovascular Diseases 2018年第9期8卷 452-461页

作者： yali sun Muhammad Nabeel Dookhun Huayiyang Zou Xiaoqian Cao Yi Zhang Xin-Zheng Lu Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Cardiology Sir Run Run Hospital of Nanjing Medical University Nanjing China

Since its discovery, myosin-binding protein C (cMyBP-C) has become a protein of interest clinically. With emergence of new methodologies and technologies, the structure and functions of cMyBP-C from different aspects can be studied, enabling us to better understand its involvement in certain cardiac conditions. Studying its kinetics of release and clearance from the circulation and by comparing to other conventional biomarkers, it has been reported that cMyBP-C is eligible to be a novel biomarker for several cardiac conditions. Moreover, studying the genetics and their involvement in pathogenic mechanisms has opened the ideas for potential therapeutic strategies. More and more researches are constantly being done to better understand the role of cMyBP-C in dilated cardiomyopathy (DCM). The importance of cMyBP-C to the heart is still actively being investigated. Its presence is however crucial for sarcomere organization and proper regulation of cardiac contraction during systole and complete relaxation during diastole. Genetic mutation in cMyBP-C has been linked to cardiac conditions including hypertrophic and dilated cardiomyopathies. Around 350 types of mutations have already been documented leading to various cardiac conditions and abnormalities. Analyzing human heart samples has enabled us to better understand the importance of cMyBP-C and how its mutations lead to inherited cardiomyopathies. It is therefore necessary to have an update about the research progress of cMyBP-C in relation to DCM and other cardiac conditions.

关键词： Dilated Cardiomyopathy Cardiac Myosin Binding Protein C Contraction Diastole Systole

Linkage Disequilibrium Based Association Mapping of Cotton(*** L.) Germplasm with Fuzzless Trait

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Linkage Disequilibrium Based Association Mapping of Cotton(*...

第十二届全国植物基因组学大会

作者： yali sun,Xiongming Du~* Cotton Research Institute,Chinese Academy of Agricultural Sciences,Anyang,Henan 455000,China

The cotton fuzzless mutant germplasm can be used for cotton breeding due to the ease and cleanliness of ***,historic domestication of upland cotton leads to the limited polymorphism and genetic ***,it underlies a need for charactering,evaluating,and utilizing the natural polymorphisms existing in cotton germplasm *** we reported genetic diversity,population characteristics and association mapping of the agronomic traits using 52 microsatellite marker pairs in 220 ***

关键词： upland cotton genectic diversity SSR association mapping

内蒙古乌努格吐山斑岩铜钼矿床辉钼矿铼锇等时线年龄及其成矿地球动力学背景

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岩石学报 2007年第11期23卷 2881-2888页

作者：李诺孙亚莉李晶李文博北京大学造山带与地壳演化教育部重点实验室北京100871 中国科学院广州地球化学研究所同位素年代学和地球化学重点实验室广州510640 中国科学院广州地球化学研究所成矿动力学重点实验室广州510640

内蒙古乌努格吐山斑岩铜钼矿床是我国东北地区大型铜钼矿床之一,其矿石中5件辉钼矿Re/Os同位素模式年龄介于(166.1±2.0)～(176.4±2.8)Ma之间,^(187)Re^(187)Os等时线年龄为178±10Ma(1σ误差,MSWD=3.3),代表流体成矿年龄。斑岩流体成... 详细信息

内蒙古乌努格吐山斑岩铜钼矿床是我国东北地区大型铜钼矿床之一,其矿石中5件辉钼矿Re/Os同位素模式年龄介于(166.1±2.0)～(176.4±2.8)Ma之间,^(187)Re^(187)Os等时线年龄为178±10Ma(1σ误差,MSWD=3.3),代表流体成矿年龄。斑岩流体成矿系统发育在183±6Ma左右。在区域构造演化框架中,乌努格吐山斑岩铜钼矿床形成于陆陆碰撞过程的减压增温体制,而非与B型俯冲有关的岩浆弧环境。

关键词：铼锇等时线年龄大陆碰撞鸟努格吐山斑岩铜钼矿床内蒙古

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基于RHRS系统的景区落石风险评估与决策

工程地质学报 2020年第4期28卷 822-831页

作者：崔志强孙亚丽衢州学院建筑工程学院衢州324000

近年国内山地景区落石掉块现象常有发生,游客的生命安全受到严重威胁,因此对落石风险研究具有科学价值和重要社会效益。通过引入RHRS风险评估系统,针对两座样本景区,对可能导致落石灾害的各项影响因子(包括斜坡高度、地质特征、落石体积... 详细信息

近年国内山地景区落石掉块现象常有发生,游客的生命安全受到严重威胁,因此对落石风险研究具有科学价值和重要社会效益。通过引入RHRS风险评估系统,针对两座样本景区,对可能导致落石灾害的各项影响因子(包括斜坡高度、地质特征、落石体积/块体大小、降雨量和历史落石频率等)进行较为深入的分析,根据原始评分公式进行风险评分,以综合分值来反映落石风险程度并结合风险允许标准划分高、中、低风险区域进行决策,将抽象的定性评价转为具体的定量评价,得到衢州药王山与江郎山两座样本景区的自然落石风险评分分别为142、117.2。采用FN曲线与ALARP原则相结合的方法来确定风险允许标准,计算我国可接受风险平均值为1.62×10-5/a,得到我们国家地质灾害可接受的风险水平FN曲线的上下限依次为10×10-4/a和10×10-5/a,为景区落石风险评估与决策提供借鉴。

关键词： RHRS 落石风险影响因子 ALARP区 FN曲线

A fluid-guided printing strategy for patterning high refractive index photonic microarrays

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Science Bulletin 2021年第3期66卷 250-256,M0004页

作者： Meng Su yali sun Bingda Chen Zeying Zhang Xu Yang Sisi Chen Qi Pan Dmitry Zuev Pavel Belov Yanlin Song Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijing 100190China Department of Physics and Engineering ITMO UniversitySaint Petersburg 197101Russia University of Chinese Academy of Sciences Beijing 100049China

High refractive index(HRI,n>1.8)photonic structures offer strong light confinement and refractive efficiencies,cover the entire visible spectrum and can be tuned by designing geometric arrayed ***,its practical applications are still hindered by the applicability and material limitation of lithography-based micro/nano fabrication ***,we demonstrate a fluid-guided printing process for preparing HRI selenium *** microstructured flexible template is replicated from the diced silicon wafer without any lithography-based *** heated above the glass transition temperature,the flow characteristics of selenium endows the structure downsizing and orientation patterning between the target substrate and the *** 10 times narrowing selenium microarrays(1.9μm width)are patterned from the non-lithography template(18μm width).HRI selenium microarrays offer high refractive efficiencies and strong optical confinement abilities,which achieve angledependent structurally coloration and ***,the color difference can be recognized under the one degree distinction of the angle between incident and refracted *** printing platform will facilitate HRI optical metasurfaces in a variety of applications,ranging from photonic sensor,polarization modulation to light manipulation.

关键词： Printing High refractive index Microarray Photonic Miniature

东秦岭寨凹钼矿床辉钼矿Re-Os同位素年龄及熊耳期成矿事件

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岩石学报 2009年第11期25卷 2739-2746页

作者：邓小华姚军明李晶孙亚莉北京大学造山带与地壳演化重点实验室北京100871 中国科学院广州地球化学研究所成矿动力学重点实验室广州510640

河南寨凹钼矿床位于东秦岭钼矿带,是近年来新发现的脉状钼矿床。9件辉钼矿样品Re-Os模式年龄介于1603.1±10.8～2031.9±10.2Ma,其中7件样品给出了精确的等时线年龄为1762±31Ma(1σ误差,MSWD=3.6),模式年龄的加权平均值为1753±26Ma(1... 详细信息

河南寨凹钼矿床位于东秦岭钼矿带,是近年来新发现的脉状钼矿床。9件辉钼矿样品Re-Os模式年龄介于1603.1±10.8～2031.9±10.2Ma,其中7件样品给出了精确的等时线年龄为1762±31Ma(1σ误差,MSWD=3.6),模式年龄的加权平均值为1753±26Ma(1σ误差,MSWD=3.2),表明寨凹钼矿形成于古元古代或熊耳期,代表着～1.76Ga左右的钼成矿事件。根据区域地质演化,认为寨凹钼矿形成于与熊耳群弧火山岩建造相当的活动大陆边缘岩浆弧背景。寨凹矿床的发现表明,熊耳期成矿事件虽遭受后期多次增生和碰撞造山作用的改造和破坏,但仍可在秦岭造山带最北部保留。

关键词：熊耳期成矿事件辉钼矿Re-Os同位素年龄寨凹钼矿东秦岭造山带