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Efficacy of Heshouwu(Radix Polygoni Multiflori)on gut mircobiota in mice with autoimmune encephalomyelitis

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Journal of Traditional Chinese Medicine 2023年第4期43卷 676-685页

作者： ZHOU Jun WANG Junhua LI Xiaobing WAN Chenyi LI Fangjun LüYanni CHEN Hao sun meiying Department of Chinese Medicine Gaoxin Branch of the First Affiliated Hospital of Nanchang UniversityNanchang 330000China Department of Neurology Gaoxin branch of the First Affiliated Hospital of Nanchang UniversityNanchang 330000China Department of Pharmacy Gaoxin branch of the First Affiliated Hospital of Nanchang UniversityNanchang 330000China

OBJECTIVE:To learn the mechanisms between gut microbiome and the autoimmunity benefits on Traditional Chinese Medicine(TCM)in central nervous system(CNS),we investigated the neuro-protection effects and gut mircobiota changes of Heshouwu(Radix Polygoni Multiflori)on experimental autoimmune encephalomyelitis(EAE),an animal model of multiple sclerosis(MS).METHODS:Mice were randomly divided into four groups:EAE mice(control phosphate-buffered saline group),50 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE mice,100 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE mice,and 200 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE *** spinal cords were stained with hematoxylin and eosin(HE)and luxol fast blue for evaluating inflammatory infiltration and *** percentages of granulocyte macrophage-colony stimulating factor(GM-CSF)+CD4+,interleukin 17(IL-17)+CD4+,Foxp3 CD4+,and interferon-γ(IFN-γ)+CD4+T cells in the inguinal lymph nodes(LNs)and brain were determined by flow cytometry analysis.16S rRNA gene sequencing was employed to analyze the changes in gut ***:We found that Heshouwu(Radix Polygoni Multiflori)alleviated the disease severity and neuropathology of EAE as evaluated by clinical and histopathologyical ***(Radix Polygoni Multiflori)increased the diversity and abundance of the gut microbiota,and decreased Firmicutes/Bacteroidetes ratio(F/B ratio).Heshouwu(Radix Polygoni Multiflori)also decreased the concentrations of IL-10,and IL-21 and increase the levels of GM-CSF,IL-17A,IL-17F and IL-22 in serum of EAE ***,Heshouwu(Radix Polygoni Multiflori)modulated the T cell responses by inhibiting Th17 cells and restoring Treg cells in the small intestine lymphoid tissues and inguinal lymph ***-depleted mice receiving Heshouwu(Radix Polygoni Multiflori)-treated fecal microbiota transplantation had lower disease severity,neuropathology scores and alleviation of T

关键词： gastrointestinal microbiome encephalomyelitis autoimmune experimental Heshouwu(Radix Polygoni Multiflori) T cell response

Simultaneous detection of copper and lead bv means of PVC sensing membrane based ISE

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Simultaneous detection of copper and lead bv means of PVC se...

The Molecular Regulatory Mechanism of the Hydrophobic Protein TaHFB1 from Trichoderma in Promoting Lateral Root Growth and Inducing Disease Resistance in Tomato

第六届全国环境化学大会暨环境科学仪器与分析仪器展览会

作者： Shiyun Guo,Guoxia Zhang,Guoping sun,meiying Xu (Guangdong Institute of Microbiology,Guangzhou 510070)

＜正＞With the industrial development, the growing emissions of wastewater produced from the gold mining and electroplating industries are representing now a worldwide environmental *** kind of industries is responsible for using large amounts of heavy metals in their respective *** these toxic compounds can highly contaminate our planet,including river water, which is the main water source of the biological world,especially as drink-

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The Molecular Regulatory Mechanism of the Hydrophobic Protei...

Adsorption and biotransformation of crystal violet by an offspring of Aeromonas hydrophila DN322

中国植物病理学会2024年学术年会

作者：尹雅萍 WANG Rui LIN Runmao TANG Zhengbin sun meiying YU Xiaoli 刘铜 School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) Hainan University Key Laboratory of Green Prevention and Control of Tropical Diseases and Pests Ministry of Education (School of Tropical Agriculture and Forestry)Hainan University School of Tropical Agriculture and Forestry (School of Agricultural and Rural School of Rural Revitalization)Hainan University School of Life and health Sciences Hainan University Hainan Green Agricultural Biological Agent Innovation Engineering Research Center Hainan University Engineering Center of Agricultural Microbial Preparation Research and Development of Hainan Hainan University

Trichoderma *** a beneficial fungus known for its role in enhancing root growth and improving plant resistance to diseases,thereby sustaining plant *** the interactions between Trichoderma and plants have been the subject of several studies,the specific molecular mechanisms by which it promotes lateral root development and triggers plant disease resistance still need to be fully *** the interaction between Trichoderma harzianum and tomato,significant up-regulation of the expressed gene TaHFB1(with an up-regulation of 155-fold compared to the control) was observed,which promotes tomato lateral root growth and induces disease *** expression of the TaHFB 1 protein and its application to plant roots confirmed its functions in promoting growth and inducing disease *** function validation was performed to determine its role in promoting growth and inducing disease ***-MS/MS technology was used to screen for plant receptors interacting with the hydrophobicprotein TaHFB1,and yeast two-hybrid,pull-down,and co-immunoprecipitation assays were employed to confirm the target proteins involved in plant *** co-expression techniques were used to study the molecular mechanisms and signal transduction pathways of protein-receptor *** research aims to thoroughly comprehend the regulatory mechanism of TaHFBl and provide a theoretical foundation for the development of new plant growth stimulants or immune inducers.

关键词： Trichoderma harzianum plant disease resistance lateral root development plant receptors hydrophobic protein

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Adsorption and biotransformation of crystal violet by an off...

第六届全国环境化学大会暨环境科学仪器与分析仪器展览会

作者： Pan Tao,Ren Suizhou,Guo Jun,Xu meiying,sun Guoping (Guangdong Institute of Microbiology,Guangzhou 510070)

＜正＞Crystal violet,a triphenylmethane dye,is extensively used in the textile industry,pharmaceutical, food and cosmetic manufacture. As a recalcitrant molecule,crystal violet has microbial and mammalian cells *** of physical and chemical methods have been used to remove it,but these methods are costly and sometimes produce much sludge. Biological treatment of these dyes would be a better alternative,which is environmentally friendly and cost-effective compared with conventional *** et al discovered the color removal of crystal violet by

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超声在诊断输尿管结石中的临床价值探讨

影像研究与医学应用 2019年第17期3卷 20-22页

作者：孙美英江苏省东台市中医院B超室

目的:探讨输尿管结石诊断中B超诊断的临床价值。方法:选取2016年5月-2018年8月收治的输尿管结石患者40例作为探讨对象,分为基础组(黑白B超)和探讨组(彩色多普勒超声),各20例。对比组间检查准确率及检出率。结果:探讨组的检查出19例(95%)... 详细信息

目的:探讨输尿管结石诊断中B超诊断的临床价值。方法:选取2016年5月-2018年8月收治的输尿管结石患者40例作为探讨对象,分为基础组(黑白B超)和探讨组(彩色多普勒超声),各20例。对比组间检查准确率及检出率。结果:探讨组的检查出19例(95%),基础组检查出14例(70%),数据对比差异P<0.05;探讨组检出输尿管上段结石10例、中段结石5例,下段结石3例,基础组检出输尿管结石上段7例,中段结石6例,下段结石4例(P<0.05)。结论:超声在诊断输尿管结石中诊断检出率高,但相对比诊断准确率,黑白超声联合彩色多普勒超声更为精准。

关键词：输尿管结石黑白B超彩色多普勒超声诊断临床价值

鼻后神经切断术治疗对复发性鼻窦炎伴息肉患者的影响

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临床研究 2024年第6期32卷 65-68页

作者：孙梅英郑州民生耳鼻喉医院鼻咽喉科河南郑州450000

目的分析鼻后神经切断术治疗对复发性鼻窦炎伴息肉患者的影响。方法将2020年6月至2023年12月收治的76例复发性鼻窦炎伴息肉患者纳入为研究对象,依据随机单双数抽签法分组,38例单数者入对照组,实施功能性鼻内镜手术治疗;38例双数者入研究... 详细信息

目的分析鼻后神经切断术治疗对复发性鼻窦炎伴息肉患者的影响。方法将2020年6月至2023年12月收治的76例复发性鼻窦炎伴息肉患者纳入为研究对象,依据随机单双数抽签法分组,38例单数者入对照组,实施功能性鼻内镜手术治疗;38例双数者入研究组,实施功能性鼻内镜手术+鼻后神经切断术治疗。对比两组一年内疾病复发率、治疗前后鼻腔鼻窦结局测试-20(SNOT-20)评分、Lund-Kennedy鼻内镜评分及血清炎性因子C反应蛋白(CRP)水平。结果研究组术后1年内疾病复发率(2.63%)低于对照组(31.58%),差异具有统计学意义(P0.05),治疗后两组SNOT-20评分低于治疗前,且研究组SNOT-20评分低于对照组,差异具有统计学意义(P0.05),治疗后两组Lund-Kennedy鼻内镜评分低于治疗前,且研究组Lund-Kennedy鼻内镜评分低于对照组,差异具有统计学意义(P0.05),治疗后两组CRP水平低于治疗前,且研究组低于对照组,差异具有统计学意义(P<0.05)。结论复发性鼻窦炎伴息肉患者采取鼻后神经切断术治疗可降低疾病复发率、减少疾病相关症状、降低炎性因子,值得应用。

关键词：鼻后神经切断术复发性鼻窦炎息肉炎性因子

低温等离子射频消融术对小儿扁桃体肥大合并鼾症的疗效研究

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临床研究 2024年第8期32卷 27-30页

作者：孙梅英郑州民生耳鼻喉医院鼻咽喉科河南郑州450000

目的探究低温等离子射频消融术(LPRFA)对小儿扁桃体肥大合并鼾症的治疗效果。方法选取郑州民生耳鼻喉医院2021年8月至2024年1月收治的72例扁桃体肥大合并鼾症患儿的临床资料进行回顾性分析,并根据不同的治疗方案分为对照组(行传统扁桃... 详细信息

目的探究低温等离子射频消融术(LPRFA)对小儿扁桃体肥大合并鼾症的治疗效果。方法选取郑州民生耳鼻喉医院2021年8月至2024年1月收治的72例扁桃体肥大合并鼾症患儿的临床资料进行回顾性分析,并根据不同的治疗方案分为对照组(行传统扁桃体切除术)与研究组(行LPRFA),各36例,比较两组治疗效果。结果研究组治疗有效率(97.22%)高于对照组(77.78%),差异有统计学意义(P0.05);术后,研究组睡眠质量评分低于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率(5.56%)低于对照组(22.22%),差异有统计学意义(P<0.05)。结论对扁桃体肥大合并鼾症患儿予以LPRFA治疗,可显著提升临床疗效,改善手术指标,缓解机体疼痛,调节睡眠质量,降低并发症发生率,值得应用。

关键词：射频消融术扁桃体肥大鼾症睡眠质量

西南地区土地利用变化对生态系统服务价值的影响

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环境工程技术学报 2022年第1期12卷 207-214页

作者：张钰莹孙美莹杨荣金张乐中国环境科学研究院北京师范大学全球变化与地球系统科学研究院

选择西南地区2000年、2010年、2020年3期土地利用遥感影像数据,利用土地利用动态度分析土地利用变化情况,并依据当量因子法对生态系统服务价值(ecosystem service value,ESV)开展评估。结果表明:西南地区土地利用以林地、耕地和草地为主... 详细信息

选择西南地区2000年、2010年、2020年3期土地利用遥感影像数据,利用土地利用动态度分析土地利用变化情况,并依据当量因子法对生态系统服务价值(ecosystem service value,ESV)开展评估。结果表明:西南地区土地利用以林地、耕地和草地为主,分别约占总面积的48%、28%、20%。人工表面、草地、林地和耕地面积变化显著,20年间的净变化量分别为11971.18、−8738.63、−5344.95、−2244.40 km^(2)。土地利用动态度呈上升趋势,尤其是2010年后土地利用变化程度加剧,其中人工表面动态度正向变化幅度最大。2000—2020年总ESV呈下降趋势,共减少195.55亿元,其中四川省、云南省下降较为明显。各类ESV变化趋势与土地利用类型变化趋势相似,林地、草地和耕地面积的减少是导致ESV亏损的主要因素。在未来发展中,应加大对林地、草地的保护力度,加强基本农田保护和高标准农田建设,提高土地集约节约利用水平,合理规划城乡建设用地,缓解经济增长对土地资源和生态系统的压力。

关键词：土地利用时空变化生态系统服务价值(ESV) 西南地区

河北省南水北调中线受水区水资源统一调配方案研究

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南水北调与水利科技 2018年第5期16卷 66-76页

作者：马素英孙梅英白振江张爽河北省水利科学研究院石家庄050051 南水北调中线干线工程建设管理局河北分局石家庄050035

针对南水北调中线受水区外调水及当地地表水来水过程的不均匀性及来水频率的不确定性、供用水系统的复杂性(多水源、多工程、多用户)等特点,以河北省南水北调受水区为研究对象,以多目标群决策理论和大系统分解协调理论为指导,以优化与... 详细信息

针对南水北调中线受水区外调水及当地地表水来水过程的不均匀性及来水频率的不确定性、供用水系统的复杂性(多水源、多工程、多用户)等特点,以河北省南水北调受水区为研究对象,以多目标群决策理论和大系统分解协调理论为指导,以优化与模拟为主要技术,构建了基于MIKE BASIN的1+7受水区水资源优化调配模型,制定了基于不同年份、不同保证率、不同节水水平、不同用水户需求条件的受水区水资源优化调配方案。在2020年供受水区来水频率组合(引江水P=50%、当地地表水P=50%)条件下,对基本节水及高效节水的优化调配方案优化效果进行了分析,以期在充分利用水资源、满足需水要求的情况下,寻求多水源与多用户之间最优的配水方案,实现区域综合效益最大化,促进区域经济可持续发展。

关键词：南水北调受水区水资源优化调配多水源多用户多目标