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Chinese Journal of Integrative Medicine 2022年第11期28卷 971-974页

作者： ZHANG Tong XU yun sun ling-yun HE Bin HAO Jie ZHANG Da YANG Yu-fei Department of Oncology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China

Objective:To verify the efficacy of Quxie Capsule in patients with metastatic colorectal cancer(m CRC).Methods:It was a block randomized,double-blind,placebo-controlled *** patients with m CRC were randomized into 2 groups at a 1:1 *** patients in the treatment group received conventional therapy including chemotherapy,radiotherapy,targeted therapy and supportive care,and Chinese herbal medicine combined with Quxie Capsule(each capsule of 0.4 g was orally administered at 50 mg/kg,twice daily,day 1–20,in a 30-day course)for 3 *** patients in the control group received conventional therapy and Chinese herbal medicine combined with placebo for 3 *** outcome measures were overall survival(OS)and progression-free survival(PFS).Subgroup analysis was performed according to therapy lines,right or left-sided colon,targeted therapy and RAS gene status to determine the differences in PFS and OS between the two *** were followed up every 3 months until December 31st,***:Median follow-up time was 19.4 *** median OS was 23.9 months in the treatment group[95%confidence interval(CI)15.9-28.5]vs.14.3 months in the control group(95%CI 11.3-21.4,P0.05).In the subgroups of second-line therapy,non-targeted therapy,RAS gene wild type and left-sided colon,the treatment group showed a significant survival benefit compared with the control group(P<0.05 or P<0.01),***:Quxie Capsule can reduce the risk of death and prolong the OS of patients with m CRC.(Registration *** CTR-IOR-16009733).

关键词： Quxie capsule metastatic colorectal cancer randomized controlles trial Chinese medicine

Organizing pneumonia associated with common variable immunodeficiency

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Chinese Medical Journal 2012年第17期125卷 3195-3197页

作者： CAO Meng-shu CAI Hou-rong ZHANG Ying-wei MENG Fan-qing sun ling-yun Department of Respiratory Medicine Affiliated Drum Tower Hospital of Integration of Traditional and Western Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu 210008 China Department of Respiratory Medicine Department of Pathology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Rheumatology and Immunology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China

Common variable immunodeficiency （CVID） is a rare disease characterized by recurrent pulmonary infections, hypogammaglobulinemia, and diminished specific antibody response to immunization. The estimated prevalence rate of CVID ranged from 1/50 000 to 1/200 000.I The common clinical manifestations of CVID are repeated and prolonged respiratory infections.

关键词： organizing pneumonia common variable immunodeficiency surgical lung biopsy

Effect of Jianpi Bushen Sequential Formula on Adjuvant Chemotherapy of Colon Cancer:Study Protocol for a Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2021年第12期27卷 891-895页

作者： ZHANG Tong FEI Yu-tong XU yun sun ling-yun HE Bin YAN Shao-hua TANG Mo YAN yun-zi MAO Jun YANG Yu-fei Department of Oncology Xiyuan Hospital of China Academy of Chinese Medicine SciencesBeijing(100091)China Centre for Evidence-Based Chinese Medicine Beijing University of Traditional Chinese MedicineBeijing(100029)China Integrative Medicine Service Memorial Sloan Kettering Cancer CenterNew York(10041 NY 212)United States

Background The side effects of chemotherapy-induced nausea and vomiting(CINV)and myelosuppression reduce the cancer patients’adherence to *** Chinese patients choose Chinese medicine(CM)during chemotherapy to reduce side effects;however,the evidence is *** efficacy of a CM herbal treatment protocol,Jianpi Bushen Sequential Formula(健脾补肾续贯方,JBSF)will be evaluated on chemotherapy completion rate among patients with colon *** A multi-center double-blind randomized controlled trial(RCT)will be conducted on 400 patients with colon cancer who will receive 8 cycles of adjuvant chemotherapy with oxaliplatin and capecitabine(CAPEOX).Patients will be randomized 1:1 to receive the JBSF or placebo *** primary outcome is the overall chemotherapy completion *** secondary outcomes include individual chemotherapy completion rate,4-cycle completion rate of chemotherapy,time to treatment failure,relative dose intensity and treatment ***-up visits will be scheduled before every and after last *** This study will provide evidence on whether JBSF can improve the chemotherapy completion rate and reduce side effects among patients with colon cancer.(Trial registration:Clinical ***,***03716518)。

关键词： Chinese medicine Jianpi Bushen Sequential Formula Liujun Anwei Formula Qitu Erzhi Formula colon cancer chemotherapy induced nausea and vomiting myelosuppression

Differences in insomnia-related self-reported outcomes among elderly hospitalized patients

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World Journal of Psychiatry 2024年第5期14卷 686-694页

作者： Xia Ding ling-Xia Qi Dong-yun sun Department of Gangzha General Medical Center The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Anesthesiology and Surgery The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Ophthalmic Surgery Room The Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina

Insomnia is among the most common sleep disorders *** in older adults is a social and public health *** affects the physical and mental health of elderly hospitalized patients and can aggravate or induce physical *** subjective feelings and providing reasonable and standardized care for elderly hospitalized patients with insomnia are urgent *** To explore the differences in self-reported outcomes associated with insomnia among elderly hospitalized *** One hundred patients admitted to the geriatric unit of our hospital between June 2021 and December 2021 were included in this ***-reported symptoms were assessed using the Athens Insomnia Scale(AIS),Generalized Anxiety Disorder Scale-7(GAD-7),Geriatric Depression Scale-15(GDS-15),Memorial University of Newfoundland Scale of Happiness(MUNSH),Barthel Index Evaluation(BI),Morse Fall Scale(MFS),Mini-Mental State Examination,and the Short Form 36 Health Survey Questionnaire(SF-36).Correlation coefficients were used to analyze the correlation between sleep quality and self-reported *** of insomnia was analyzed using Logistic regression *** Nineteen patients with AIS≥6 were included in the insomnia group,and the incidence of insomnia was 19%(19/100).The remaining 81 patients were assigned to the non-insomnia *** were significant differences between the two groups in the GDA-7,GDS-15,MUNSH,BI,MFS,and SF-36 items(Pling(P<0.05).Subjective well-being and quality of life were poorer in the insomnia group than in the control *** AIS scores positively correlated with the GAD-7,GDS-15,and MFS scores in elderly hospitalized patients with insomnia(P<0.05).Logistic regression analysis showed that GDS-15≥5 was an independent risk factor for ins

关键词： Elderly hospitalized patients Insomnia Self-reported outcomes Symptoms Subjective feelings Correlation

Safety and efficacy of T-614 in the treatment of patients with active rheumatoid arthritis： a double blind, randomized, placebo-controlled and multicenter trial

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Chinese Medical Journal 2008年第7期121卷 615-619页

作者： Lu Liang-jing TENGJia-lin BAO Chun-de HAN Xing-hai sun ling-yun XU Jiang-hua LI Xing-fu WU Hua-xiang Department of Rheumatology Renji Hospital Shanghai Jiao TongUniversity Shanghai 200001 China Department of Rheumatology Changhai Hospital Second MilitaryUniversity Shanghai 200001 China Department of Rheumatology Gulou Hospital Nanjing UniversityNanjing Jiangsu 210000 China Department of Rlaeumatology Frist Alliliated Hospital AnlluiMedical University Hefei Anhui 230000 China Department of Rheumatology Qilu Hospital of ShandongUniversity Jinan Shandong 250012 China Department of Rheumatology Second Affiliated HospitalZhejiang University Hangzhou Zhejiang 510000 China

Background A novel anti-rheumatic drug, T-614, has been shown to have an anti-inflammatory effect and to improve abnormal immunological findings in rheumatoid arthritis （RA）. To assess the safety and efficacy of T-614 versus placebo in patients with active RA we conducted a 24-week clinical study in 280 Chinese patients. Methods In a multicenter, randomized, double blind, placebo controlled study, 280 patients were randomly assigned to receive placebo （n=95） or T-614 at 50 mg （n=93） or 25 mg （n=92） daily. Active disease was defined by 4 of the following 5 criteria：〉5 tender joints, 〉3 swollen joints, morning stiffness lasting for 〉60 minutes, and Westergren erythrocyte sedimentation rate （ESR）〉28 mm/h, the assessment of pain at the rest by patient as moderate or severe. Clinical and laboratory parameters were analyzed at baseline, 2, 4, 6, 12, 18 and 24 weeks. The primary efficacy variable at week 24 was the American College of Rheumatology （ACR） response rate using the intent-to-treat population. Results The ACR response rate was significantly higher in the T-614 treatment group compared with the placebo group within 8 weeks after the initiation of treatment. After 24 weeks, the 25 mg/d and 50 mg/d dosage groups and the placebo group showed 39.13%, 61.29% and 24.21% in ACR20 and 23.91%, 31.18% and 7.37% in ACR50, respectively. A time-response in ACR response was observed, with clear superiority for the 25 mg/d and 50 mg/d dosage groups compared to placebo （P〈0.0001）, and the 50 mg/d dose compared to the 25 mg/d dose （P〈0.05） when using the ACR response analyses after 24 weeks. ESR and c-reactive protein （CRP） were significantly different in the treatment groups after 24 weeks. The incidence of adverse events （AEs） was not significantly higher with T-614 than with placebo, but upper abdominal discomfort, leucopenia, elevated serum alanine aminotransferase （sALT）, skin rash and/or pruritus were more common in the 50 mg and 25 mg dosage groups. Conclusion T-614, a n

关键词： arthritis, rheumatoid T-614 randomized controlled trial

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基于专利图片的产品外观设计专利分析技术

计算机集成制造系统 2008年第2期14卷 234-240页

作者：孙凌云孙守迁浙江大学计算机学院现代工业设计研究所浙江杭州310027

为挖掘外观设计专利图片中蕴涵的丰富信息,将基于内容的图像检索技术和数据挖掘技术应用于外观设计专利分析过程中,提出了基于专利图片的产品外观设计专利分析技术。借助基于内容的图像检索技术提取外观设计专利图片的颜色、纹理和形状... 详细信息

为挖掘外观设计专利图片中蕴涵的丰富信息,将基于内容的图像检索技术和数据挖掘技术应用于外观设计专利分析过程中,提出了基于专利图片的产品外观设计专利分析技术。借助基于内容的图像检索技术提取外观设计专利图片的颜色、纹理和形状特征,通过相关反馈确定权重,据此计算外观设计专利的相似性并完成专利聚类。利用聚类结果生成带有专利发展轨迹和专利区域状态等信息的专利地图。以此为基础开发完成了外观设计专利分析软件,分析产品外观设计专利的发展趋势,从而辅助设计师和企业进行决策分析和产品定位。

关键词：外观设计专利产品设计专利分析专利图片

A double-blind, double-dummy, randomized controlled, multicenter trial of ^(99)Tc-methylene diphosphonate in patients with moderate to severe rheumatoid arthritis

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Chinese Medical Journal 2021年第12期134卷 1457-1464页

作者： Qiong Fu Ping Feng ling-yun sun Xiao-Xia Zuo Dong-Bao Zhao Dong-Yi He Hua-Xiang Wu Wei Zhang Wei Zhang Fang Du Chun-De Bao Department of Rheumatology Renji Hospital of Shanghai Jiaotong University School of MedicineShanghai 200000China National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs Institute of Clinical TrialsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsu 210008China Department of Rheumatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Rheumatology and Immunology Changhai HospitalShanghai 200433China Department of Rheumatology Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western MedicineShanghai 200052China Department of Rheumatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China Department of Quality Control Cheng Fei HospitalChengduSichuan 610091China

Background:Clinical observational studies revealed that ^(99)Tc-methylene diphosphonate(^(99)Tc-MDP)could reduce joint pain and swollenness in rheumatoid arthritis(RA)*** multicenter,randomized,double-blind,double-dummy study aimed to evaluate the effects of ^(99)Tc-MDP plus methotrexate(MTX)*** alone or ^(99)Tc-MDP alone on disease activity and structural damage in MTX-naïve Chinese patients with moderate to severe ***:Eligible patients with moderate to severely active RA were randomized to receive ^(99)Tc-MDP plus MTX(n=59)***(n=59)alone or ^(99)Tc-MDP(n=59)alone for 48 weeks from six study sites across four provinces in *** primary outcomes were the American College of Rheumatology 20%improvement(ACR20)response rates at week 24 and changes in modified total Sharp score at week ***:At week 24,the proportion of participants achieving ACR20 was significantly higher in the MTX+^(99)Tc-MDP combination group(69.5%)than that in the MTX group(50.8%)or ^(99)Tc-MDP group(47.5%)(P=0.03 for MTX+^(99)Tc-MDP ***,and MTX+^(99)Tc-MDP vs.^(99)Tc-MDP,respectively).The participants in the MTX+^(99)Tc-MDP group and the ^(99)Tc-MDP group had significantly less important radiographic progression than the participants in the MTX group over the 48 weeks(MTX+^(99)Tc-MDP ***:P=0.03,^(99)Tc-MDP ***:P=0.03,respectively).There was no significant difference in terms of adverse events(AEs)among the *** serious AEs were ***:This study demonstrated that the combination of ^(99)Tc-MDP with MTX inhibited structural damage and improved disease activity in RA patients compared with MTX and ^(99)Tc-MDP monotherapies,without increasing the rate of *** clinical studies of ^(99)Tc-MDP therapy in patients with RA are *** Registration:***,ChiCTR-IPR-14005684;http://***/***?proj=10088.

关键词： Rheumatoid arthritis Methotrexate ^(99)Tc-MDP Efficacy Safety

Prediction of suitable water content in granulation of sintering mixture based on Litster's model

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Journal of Iron and Steel Research International 2024年第3期31卷 552-560页

作者： Fang-lei Dai Xiao-hui Fan Xiao-xian Huang Xu-ling Chen Min Gan Zhi-yun Ji Zeng-qing sun School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Suitable water content plays a decisive role in the granulation of sintering ***,a method was proposed to predict the suitable water content for effective granulation on the basis of Litster's granulation *** granulation effectiveness of a sintering mixture was predicted by the model,with the allowance error of±10%.The effects of the water absorption properties,particle size composition and content of adhesive particles on the suitable water content were *** results showed that the allowable error of prediction was within±0.5%compared to the experimentally determined suitable water *** an increase in adhesive powder content of mixtures with higher water absorption,the suitable water content increased to achieve similar granulation ***,as the amount of concentrates increased,the suitable water content first increased and then remained *** influence of the water absorption characteristics of the adhesive particles on the suitable water content was less than that of their particle size composition in the mixture.

关键词： Adhesive particle Sintering mixture Granulation effectiveness Suitable water content

Exploration on Integrative Traditional Chinese and Western Medicine Strategy for Treating Patients of Lung Cancer over 80 Years Old

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World Journal of Integrated Traditional and Western Medicine 2020年第2期6卷 39-45页

作者： sun ling-yun XU yun YANG Yu-fei Oncology Department Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China

Lung cancer incidence and mortality are much higher among elderly patients over 80 years'***,surgery,chemo and radiotherapy,target therapy all are refined in treating this *** article summarized 3 types of over 80 years'old elderly cancer patient in real world,which include:*** non-small cell lung cancer that cannot be tolerated by targeted therapy;*** lung malignancies for which a clear pathological diagnosis cannot be obtained;*** lung cancer with distance metastasis at first *** current paper summarized real cases from YANG Yu-fei at Xiyuan Hospital and her traditional Chinese medicine treatment methods and experiences to guide further clinical practice were discussed and shared.

关键词： Elderly lung cancer integration of traditional Chinese and Western medicine Real world Explore ideas

Probabilistic seismic inversion based on physics-guided deep mixture density network

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Petroleum Science 2024年第3期21卷 1611-1631页

作者： Qian-Hao sun Zhao-yun Zong Xin Li National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina Laoshan Laboratory Qingdao266580ShandongChina CNOOC Research Institute Ltd. Beijing100028China

Deterministic inversion based on deep learning has been widely utilized in model parameters *** by logging data,seismic data,wavelet and modeling operator,deterministic inversion based on deep learning can establish nonlinear relationships between seismic data and model ***,seismic data lacks low-frequency and contains noise,which increases the non-uniqueness of the *** conventional inversion method based on deep learning can only establish the deterministic relationship between seismic data and parameters,and cannot quantify the uncertainty of *** order to quickly quantify the uncertainty,a physics-guided deep mixture density network(PG-DMDN)is established by combining the mixture density network(MDN)with the deep neural network(DNN).Compared with Bayesian neural network(BNN)and network dropout,PG-DMDN has lower computing cost and shorter training time.A low-frequency model is introduced in the training process of the network to help the network learn the nonlinear relationship between narrowband seismic data and low-frequency *** addition,the block constraints are added to the PG-DMDN framework to improve the horizontal continuity of the inversion *** illustrate the benefits of proposed method,the PG-DMDN is compared with existing semi-supervised inversion *** synthetic data examples of Marmousi II model are utilized to quantify the influence of forward modeling part,low-frequency model,noise and the pseudo-wells number on inversion results,and prove the feasibility and stability of the proposed *** addition,the robustness and generality of the proposed method are verified by the field seismic data.

关键词： Deep learning Probabilistic inversion Physics-guided Deep mixture density network