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Activatable chemiluminescence probe based on four-arm PEGconjugated-pyropheophorbide-a for in vivo autofluorescence-free imaging of peroxynitrite

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Science China Chemistry 2025年

作者： Jianmei Ke Lei Ding Ronggui lian Cheng Zheng Wenjun Li Aixian Zheng Yupeng sun Ming Wu Yongyi Zeng Xiaolong Liu Maochun Hong Xiaolong Zhang The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University Ganjiang Innovation Academy Chinese Academy of Sciences School of Rare Earths University of Science and Technology of China College of Chemistry Fuzhou University State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Peroxynitrite（ONOO-） is a highly reactive nitrogen species that plays pivotal roles in cell signal transduction and physiological or pathological progresses. However, commonly used ONOO-optical imaging probes are still hampered by high background/autofluorescence（fluorescence probe）, short emission wavelength, or poor selectivity in the case of chemiluminescence. Herein,we report a facile method to prepare an activatable chemiluminescence probe（PPA-PEG） with good biocompatibility and functionality for in vivo autofluorescence-free imaging of ONOO-. The PPA-PEG consists of pyropheophorbide-a（PPA）, a typical deep red photosensitizer that acts as both the recognition and signaling element, and 4-arm poly（ethylene glycol）(4-arm PEG), which improves the biosafety and water solubility of probe. These components can self-assemble into nanoparticles（namely PPA-PEG nanoprobe） in aqueous solution. The PPA-PEG nanoprobe showed an ultra-low chemiluminescence signal before interacting with ONOO-, but exhibited good selectivity, high sensitivity and a fast response toward ONOO-. The PPAPEG was successfully applied to image cellular ONOO-changes, as well as the endogenous ONOO-changes in inflammation models and subcutaneous or orthotopic hepatocellular carcinoma（HCC） tumors models in living mice. In vitro and in vivo studies verified the good detection and imaging capabilities of PPA-PEG for peroxynitrite, demonstrating suitable tissue penetration and a high signal-to-background ratio（SBR）. Thus, our nanoprobe can serve as a valuable activatable chemiluminescence imaging tool for studying important peroxynitrite-related chemical and biological applications.

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Effect of Progressive Substitution of Cement and Lime by Powdered Shells Used as a Curing Agent for Dredged Soil in a Port Area

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 88-102页

作者： sun Yang WANG Faxin SU Yaying LI Yiwei HE Feng College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China huai'an Research Institute Hohai UniversityHuai'an 223025China Jiangsu Fangyang Industrial Investment Corp.Ltd. Lianyungang 210098China

This study aimed to address the challenges of solid waste utilization,cost reduction,and carbon reduction in the treatment of deep-dredged soil at Xuwei Port in lianyungang city of *** research in this area was ***,a curing agent made from powdered shells was used to solidify the dredged soil in *** employed laboratory orthogonal tests to investigate the physical and mechanical properties of the powdered shell-based curing *** was collected by conducting experiments to assess the role of powdered shells in the curing process and to determine the optimal ratios of powdered shells to solidified soil for different *** development of strength in solidified soil was studied in both seawater and pure water *** study revealed that the strength of the solidified soil was influenced by the substitution rate of powdered shells and their interaction with *** cement content had a positive effect on *** high-strength solidified soil,the recommended ratio of wet soil:cement:lime:powdered shells were 100:16:4:4,while for low-strength solidified soil,the recommended ratio was 100:5.4:2.4:***,under appropriate conditions,improved short-term strength by promoting the formation of expansive ettringite minerals that contributed to cementation and *** findings suggest that the combination of cement and powdered shells is synergistic,positively affecting the strength of solidified *** recommended ratios provide practical guidance for achieving desired strength levels while considering factors such as cost and carbon *** role of seawater in enhancing short-term strength through crystal formation is noteworthy and can be advantageous for certain *** conclusion,this research demonstrates the potential of using a powdered shell-based curing agent for solidifying dredged soil in an environmentally friendly and cost-effective *** recommended ratios for different str

关键词： carbon reduction and solidification dredged soil abandoned shells orthogonal test chemical additives(lime and cement) unconfined compressive strength(UCS)

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Morphological and functional observations of a novel model of retinal ischemia injury induced by bilateral carotid artery stenosis in mice

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International Journal of Ophthalmology(English edition) 2024年第12期17卷 2192-2202页

作者： lian Shu You-Jia Zhang Xiao-Xiao Chen Xing-huai sun Department of Ophthalmology&Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200032China NHC Key Laboratory of Myopia Chinese Academy of Medical Sciencesand Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China

AIM:To investigate the features of retinal ischemic injuries in a novel mouse model with bilateral carotid artery stenosis(BCAS).METHODS:BCAS was induced with microcoil implantation in 6-8-week-old C57BL6 *** blood flow was monitored at 2,7,and 28d *** morphological changes were evaluated by fundus photography and hematoxylin-eosin *** fundus angiography(FFA)was performed to detect retinal vascular changes and *** levels of apoptosis,activation of neurogliosis,and expression of hypoxiainducible factor(HIF)-1αin the retina were assessed by Western blotting and immunofluorescence staining,followed by retinal ganglion cell(RGC)density ***,electrophysiological examinations including photopic negative response(PhNR)was also ***:The mice demonstrated an initial rapid decrease in cerebral blood flow,followed by a 4-week recovery period after *** ratio of retinal artery and vein was decreased under fundus photography and *** with the sham mice,BCAS mice showed thinner retinal thickness on day ***,apoptosis was increased and RGC density was decreased mainly in peripheral retinal *** was mainly located in the inner retinal layers,with a stable increase in HIF-1α*** dark-adapted electroretinogram showed a notable reduction in the a-,b-,and oscillatory potential(OP)wave amplitudes between days 2 and 7;this gradually recovered over the following ***,the b-and OPwave amplitudes were still significantly decreased on PhNR examination on day ***:BCAS can result in relatively mild retinal ischemia injuries in mice,mainly in the inner layer and peripheral *** study provides a novel animal model for investigating retinal ischemic diseases.

关键词： bilateral carotid artery stenosis retinal ischemia mice cerebral hypoperfusion ischemic injury

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A theoretical study of hydrothermal stability of P-modified ZSM-5 zeolites

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Science China Chemistry 2009年第3期52卷 282-287页

作者： YANG Jing sun huai School of Chemistry and Chemical Technology Shanghai Jiao Tong UniversityShanghai 200240China

Density functional theory was employed to study the hydrothermal stability of P-modified ZSM-5 zeolites using cluster models. The calculations of hydrolysis energies indicated that the introduction of phos-phorus increases the hydrothermal stability of ZSM-5 zeolites. The initial paths of dealumination were studied with explicit water molecules. It was found that the framework Al-O coordination bond can be replaced by coodination bonds between water molecules and the aluminium. One to three water molecules can form coordination bonds with framework Al and release energies. The P-modification restrain the dealumination. The calculated 27Al NMR chemical shifts for the obtained structures are consistent with the experimental measurements.

关键词： density functional theory P-ZSM-5 zeolite dealumination NMR

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An image encryption algorithm based on improved baker transformation and chaotic S-box

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Chinese Physics B 2021年第6期30卷 216-225页

作者： Xing-Yuan Wang huai-huai sun Hao Gao School of Information Science and Technology Dalian Maritime UniversityDalian 116026China

The algorithm is an image encryption algorithm based on the improved baker transformation and chaotic substitution box(S-box). It mainly uses the initial values and parameters of a one-dimensional logistic chaotic system as an encryption key. Specifically, in the image scrambling stage, the algorithm primarily uses an improved baker transform method to process the image. In the image diffusion stage, the algorithm first uses the chaotic S-box method to process the encryption key. Secondly, an exclusive OR(XOR) operation is performed on the image and the encryption key to initially diffuse the image. Finally, the image is again diffused using the method of ortho XOR. Simulation analysis shows that the algorithm can achieve good encryption effect, simple and easy implementation, and good security. In the digital image communication transmission, it has good practical value.

关键词： image encryption improved baker transformation chaotic S-box chaotic sequence

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Regulation of graphdiyne-based nanozymes with enhanced oxidaselike activity by cobalt and nitrogen codoping

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Nano Research 2025年第1期18卷 21-29页

作者： Jiali Liu Xiaoli Wang Yongfu lian Xue Wang Xiuxiu Wang Xingfa Gao Baoyun sun Xihong Guo CAS Key Laboratory for Biomedical Effects of Nanomaterial&Nanosafety Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China Laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The development of nanozymes with excellent intrinsic oxidase-like activity and specificity has received increasing ***(GDY)could be a promising choice for designing nanozymes with enhanced oxidase(OXD)-like activity due to its unique structure and ***,Co-N-GDY with high OXD activity but no peroxidase(POD)activity was synthesized by codoping of cobalt(Co)and nitrogen(N)into GDY and compared with other GDY-based nanozymes(including GDY,Co-GDY,and N-GDY).Upon analyzing the doping effect of Co and N on the OXD-like and POD-like activities,we found that the combination of Co and N in GDY played a significant role in enhancing the OXD-like activity,and even reversed the POD-like activity of N-GDY to OXD-like activity of *** electrochemical experiment and the theoretical calculations provided an explanation for the mechanism and showed that the activity was closely linked to the reduction ability of O_(2) or H_(2)O_(2) on the nanozyme substrates,which was determined by the ratedetermining step of the catalytic reaction.

关键词： nanozymes oxidase-like activity graphdiyne heteroatom doping regulation

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Numerical investigation on the geodynamical mechanism of the first major shock of 2006 Pingtung M_w7.0 earthquake

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Science China Earth Sciences 2011年第5期54卷 631-639页

作者： sun YuJun ZHANG huai SHI YaoLin Laboratory of Computational Geodynamics Graduate University of Chinese Academy of Sciences Beijing 100049 China

A strong Mw7.0 earthquake struck Pingtung offshore of Talwan on December 26, 2006. It consisted of two major events with an 8-minute interval. The first major shock occurred at 12：26 UTC. Focal mechanism results from Harvard, USGS, and BATS all indicated that the first major shock was a normal fault earthquake and the second one was dominated by strike-slip offsets. The location of the epicenter varied greatly in depth in different analyses. The latest results showed that the focal depth of the first shock was most probably around 40-44 km, placing the epicenter in the lithospheric mantle. However, this is not a location where earthquakes usually occur. To explore the geodynamical mechanism of this event, we carded out 2D finite element method （FEM） numerical experiments. Our primary results indicate that the geodynamical background, as well as the formation of Pingtung earthquake, is a consequence of the collision between Luzon arc and Chinese continental margin. Although Taiwan Island is in the shadow of NW-SE trending compressive collision zone, the existence of ductile lower crust leads to the decoupling between upper crust and lithospheric mantle. As lithospheric mantle subducts to the depth of around 250 km, the upper part of the bending subduction slab puts itself in an extensional state. The extensional stress from bending induced the occurrence of this normal fault earthquake at the critical point.

关键词： Pingtung earthquake geodynamical mechanism FEM simulation hierarchical rheology geodynamics

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The Mediating Effect of Body Dissatisfaction in Association between Obesity and Dietary Behavior Changes for Weight Loss in Chinese Children

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Biomedical and Environmental Sciences 2019年第9期32卷 639-646页

作者： GAO huai Quan WANG Bang Xuan sun Li Li LI Ting WU Lu FU lian Guo MA Jun Department of Child and Adolescent Health School of Public HealthBengbu Medical CollegeBengbu 233030AnhuiChina Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective The aim of this study was to analyze the mediating effect of body dissatisfaction in correlation between obesity and dietary behavior changes for weight loss(DBCWL).Methods A total of 680 primary and middle school students were included in this study. Their body height, weight, and waistline were effectively measured, and they were also evaluated to assess their body dissatisfaction, perception of dietary behaviors, and DBCWL. The correlation among these factors was analyzed using mediating effect *** The prevalence of overweight/obesity and abdominal obesity was significantly higher in males than in females(P < 0.05). Overweight/obesity, abdominal obesity, and body dissatisfaction significantly increased the risk for DBCWL(OR = 2.57, 2.77, and 1.95, respectively). Overweight/obesity and abdominal obesity significantly increased the risk for body dissatisfaction(OR = 6.00 and 4.70,respectively). Significant mediating effects of body dissatisfaction were observed in correlation between overweight/obesity and DBCWL and between abdominal obesity and DBCWL(OR = 2.20 and 1.92,respectively;P < 0.05), and the proportions of mediating effects among the total effects were 48.89% and 46.60%, *** Body dissatisfaction might play an important mediating effect in association between DBCWL and obesity, which indicates that guiding children to correctly recognize their body might be more conducive than promoting obese children toward weight loss through dietary behavior changes.

关键词： Children and adolescents Obesity Body dissatisfaction Dietary behavior changes for weight loss

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Prediction of adsorption of small molecules in porous materials based on ab initio force field method

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Science China Chemistry 2008年第8期51卷 760-767页

作者： LIU lianChi FU Jia sun huai School of Chemistry and Chemical Technology Shanghai Jiao Tong University Shanghai 200240 China

Computational prediction of adsorption of small molecules in porous materials has great impact on the basic and applied research in chemical engineering and material sciences. In this work,we report an approach based on grand canonical ensemble Monte Carlo(GCMC) simulations and ab initio force fields. We calculated the adsorption curves of ammonia in ZSM-5 zeolite and hydrogen in MOF-5(a metal-organic-framework material). The predictions agree well with experimental data. Because the predictions are based on the first principle force fields,this approach can be used for the adsorption prediction of new molecules or materials without experimental data as guidance.

关键词： Porous materials adsorption ab initio force field Grand Canonical ensemble Monte Carlo

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Effects of fabricated error on transmission performance of double layer frequency selective surface configuration

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光学精密工程 2005年第5期13卷 599-603页

作者： HE Bin sun lian-chun Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130033China

Based on the experimental results, in which the fabricated error of the double layer frequency selective surface (FSS) leads to the transmission loss and the resonant frequency leaves away the design resonant frequency, the inter-layer separation distance (ISD) and the unit cell aligning error (UAE) were used as main variables to study the transmission performance attenuation of the double layer FSS configuration. The numerical analysis model for ISD and UAE was established and also was used to simulate the ring unit cell FSS transmission performance by the finite element and periodic moment methods. The double layer ring aperture FSS configuration designed was used as the numerical model. As a result of the numerical analysis, it is shown that both ISD and UAE produce insertion transmission loss (ITL) and insertion phase distortion (IPD) directly. Furthermore, ISD results in more loss of the amplitude of the transmitted signal for the FSS than UAE. It is significant for the designer of the multiplayer FSS to assign the fabricated error of the FSS dielectric layers. The UAE introduces the insertion phase variation badly.

关键词： FSS 平衡性 ISD 结构设计 UAE 光学机械

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