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Augmenting freshwater availability in mountain headwater streams:Assessing the sustainability under baseline and future climate change scenarios

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International Soil and Water Conservation Research 2022年第2期10卷 293-307页

作者： Bisrat Ayalew Yifru Il-moon Chung Min-Gyu Kim sun Woo Chang Department of Land Water and Environment ResearchKorea Institute of Civil Engineering and Building TechnologyGoyang10223South Korea Department of Civil and Environmental Engineering University of Science and TechnologyDaejeon34113South Korea

Mountain headwater streams are important freshwater sources,but they are mostly intermittent and highly susceptible to climate *** paper examines the sustainability of augmented freshwater availability in mountain headwater streams for water supply under baseline and future climate change scenarios using an integrated modeling *** climate change data in the 2040s(2030e2059),under Representative Concentration Pathway 4.5 and 8.5 scenarios,were downscaled for the impact *** the region,climate change raises the average precipitation by 5e7%and the temperature by 13e15%in the *** model,integrating Soil and Water Assessment Tool(SWAT2012)and finite-difference Modular Groundwater Flow(MODFLOW)models in a single package,was used to assess the water *** show that extracting a minimum of 16.2 m^(3)/day from the sand storage and 30 m^(3)/day from the aquifer was possible without affecting the groundwater table and water *** average annual catchment recharge was 6%of the precipitation under the baseline *** change is projected to reduce the average water yield and groundwater recharge by 26%and 19%,***,the water supply-demand is significantly small compared to the exploitable rate of water in the *** study was based on limited data,and therefore the findings need to be interpreted with caution,though the model output was validated using satellite *** of a series of sand dams is suggested to maximize the benefit under the potential climate change and water supply-demand increase.

关键词： Headwater stream Sand dam Korea SWATeMODFLOW Water conservation Climate change

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Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

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World Journal of Gastroenterology 2012年第6期18卷 557-562页

作者： Hyung Hun Kim You sun Kim Yun Kyung Kang Jeong Seop moon Department of Internal Medicine Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Department of Pathology Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Hyung Hun Kim Department of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM： To investigate the expressions of leptin and per- oxisome proliferator-activated receptor y （PPARG） in relation to body mass index （BMI）. METHODS： We evaluated leptin and PPARG expres- sion in 30 adenomas over 1 cm in size by immunohisto- chemical staining. In addition, clinicopathologic features including BMI were assessed. RESULTS： PPARG and leptin expression showed a strong positive correlation （P = 0.035）. The average BMI of the leptin-positive group was higher than that of the leptin-negative group （25.4 ＋ 3.4 kg/m2 vs 22.6 ＋ 2.4 kg/m2, P = 0.018）, and leptin expression was sig- nificantly correlated with high BMI （P = 0.024）. Leptinexpression was more frequently observed in intermedi- ate/high grade dysplasia than in low grade dysplasia （P = 0.030）. However, PPARG expression was not cor- related with BMI and grade of dysplasia. CONCLUSION： BMI has influenced on the leptin ex- pression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.

关键词： Leptin Peroxisome proliferator-activated re-ceptor y Obesity Body mass index Colorectal adenoma

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Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment

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Neural Regeneration Research 2012年第21期7卷 1651-1658页

作者： Miyoung Yang Juhwan Kim sung-Ho Kim Joong-sun Kim Taekyun Shin Changjong moon Department of Veterinary Anatomy College of Veterinary Medicine and Animal Medical Institute Chonnam National University Department of Experimental Radiation Research Center Dongnam Institute of Radiological & Medical Sciences (DIRAMS) Department of Veterinary Anatomy College of Veterinary Medicine Jeju National University

Methotrexate, which is used to treat many malignancies and autoimmune diseases, affects brain functions including hippocampal-dependent memory function. However, the precise mechanisms underlying methotrexate-induced hippocampal dysfunction are poorly understood. To evaluate temporal changes in synaptic plasticity-related signals, the expression and activity of N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, extracellular signal-regulated kinase 1/2, cAMP responsive element-binding protein, glutamate receptor 1, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor were examined in the hippocampi of adult C57BL/6 mice after methotrexate （40 mg/kg） intraperitoneal injection. Western blot analysis showed biphasic changes in synaptic plasticity-related signals in adult hippocampi following methotrexate treatment. N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, and glutamate receptor 1 were acutely activated during the early phase （1 day post-injection）, while extracellular signal-regulated kinase 1/2 and cAMP responsive element-binding protein activation showed biphasic increases during the eady （1 day post-injection） and late phases （7-14 days post-injection）. Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression increased significantly during the late phase （7-14 days post-injection）. Therefore, methotrexate treatment affects synaptic plasticity-related signals in the adult mouse hippocampus, suggesting that changes in synaptic plasticity-related signals may be associated with neuronal survival and plasticity-related cellular remodeling.

关键词： hippocampus methotrexate neurotrophic factor synaptic plasticity-related signal neuralregeneration

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System design and validation of Queqiao-2 lunar relay communication satellite

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中国空间科学技术(中英文) 2024年第5期44卷 23-39页

作者： ZHANG Lihua XIONG Liang sun Ji CHEN Luojing XIAO Chuan ZHOU Wenyan WANG Yong LIU Wangwang GUAN Yifeng CHEN Tao YU Xiaochuan XU Jin CHEN Guohui CAO Xiaoping DFH Satellite Co. Ltd. Beijing Institute of Spacecraft System Engineering Beijing Institute of Control Engineering Academy of Space Information Systems

In order to provide relay communication supports for future Chinese lunar exploration program, Queqiao-2 relay communication satellite was ***-2 can perform scientific observations with three kinds of scientific instruments on *** system design of Queqiao-2,including mission orbit and transfer orbit design, configuration and layout design, housekeeping and information flow design, power supply and distribution design, GNC and propulsion system design, communication links design, etc.,was accomplished through comprehensive tradeoff and evaluation on technical maturity, availability, schedule, cost, and so *** a view to reducing development risk, both the platform and relay communication payloads were developed based on significant heritage from previous Queqiao relay satellite and other relevant ***-2 features flexible system architecture to support multiple frequencies, modulations, data rates and software reconfigurations to meet new user *** to a successful launch on March 20,2024,by means of 5 orbit maneuvers, Queqiao-2 was inserted into a highly elliptical frozen mission orbit around the moon with a 24h period on *** on-orbit tests and calibrations, Queqiao-2 has possessed the capacity to provide reliable relay communication services to multiple lunar exploration missions, as well as the capacity to perform scientific *** the support of Queqiao-2,Chang′e-6 achieved its ambitious mission goal to collect and return samples from the moon′s mysterious far *** the meanwhile, Queqiao-2 has also paved the way for the following Chinese lunar exploration missions including Chang′e-7 and Chang′*** design life time of Queqiao-2 is more than 8 *** from flexibility and extensibility of relay communication system design, it is convenient to provide relay communication services for future lunar exploration missions of both China and other *** addition, innovative

关键词： lunar explorations relay communication Queqiao system design test validation

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Ischemic colitis during interferon-ribavirin therapy for chronic hepatitis C:A case report

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World Journal of Gastroenterology 2012年第31期18卷 4233-4236页

作者： Su Jung Baik Tae Hun Kim Kwon Yoo Il Hwan moon Min-sun Cho Department of Gastroenterology Health Promotion CenterYonsei University Gangnam Severance HospitalSeoul 158-050South Korea Department of Internal Medicine Ewha Medical Research InstituteEwha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea Department of Pathology Ewha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea

Ischemic colitis is a rare complication of interferon *** 9 cases in 6 reports have been described *** report describes a case of ischemic colitis during pegylated interferon and ribavirin treatment for chronic hepatitis C,and includes a review of the relevant literature.A 48-year-old woman was treated with pegylated interferon-2a and ribavirin for chronic hepatitis C,genotype *** 19 wk of treatment,the patient complained of severe afebrile abdominal pain with *** signs were stable and serum white blood cell count was within the normal *** computed tomography showed diffuse colonic wall thickening from the splenic flexure to the proximal sigmoid colon,which is the most vulnerable area for the development of ischemic *** revealed an acute mucosal hyperemic change,with edema and ulcerations extending from the proximal descending colon to the sigmoid *** mucosal biopsy revealed acute exudative *** chain reaction and culture for Mycobacterium tuberculosis were negative and the cultures for cytomegalovirus,Salmonella and Shigella species were *** discontinuation of interferon and ribavirin therapy,abdominal pain and hematochezia subsided and,following colonoscopy showed improvement of the mucosal *** colitis cases during interferon therapy in patients with chronic hepatitis C reported so far have all involved the descending *** colitis is a rarely encountered complication of interferon administration in patients with chronic hepatitis C and should be considered when a patient complains of abdominal pain and hematochezia.

关键词： Ischemia Hepatitis C Interferon

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Acute amnesia during pregnancy due to bilateral fornix infarction: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4494-4498页

作者： Min Jai Cho Dong-Ick Shin moon-Ku Han Kyu sun Yum Department of Neurosurgery Chungbuk National University HospitalCheongju-si 28644South Korea Department of Neurology Chungbuk National University HospitalCheongju-si 28644South Korea Department of Neurology Seoul National University Bundang HospitalSeongnam-si 463-707South Korea

BACKGROUND Stroke is an important cause of maternal morbidity and mortality during pregnancy and *** amnesia is a rare clinical symptom caused by ischemic stroke during *** present the first documented case of acute amnesia during pregnancy due to bilateral fornix *** SUMMARY A 32-year-old nullipara presented at 35 wk of gestation with acute amnesia and *** magnetic resonance imaging and angiography revealed acute infarction in the bilateral anterior *** was no evidence of causative abnormality after extensive work-up,including for vascular abnormality,cardiac disease,coagulopathy,and pregnancy-related *** patient was diagnosed with cryptogenic *** was administered immediately,and the patient recovered fully without *** Acute isolated amnesia due to stroke is rare during *** diagnosis of stroke and immediate treatment prevent neurologic sequelae.

关键词： Fornix Brain Amnesia Cerebral infarction Pregnancy Stroke Case report

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Stone extraction balloon-guided repeat self-expanding metal stent placement

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World Journal of Gastroenterology 2010年第24期16卷 3087-3090页

作者： Hyung Hun Kim Jeong Seop moon Soo Hyung Ryu Jung Hwan Lee You sun Kim Division of Gastroenterology Department of Internal MedicineSeoul Paik Hospital Inje University College of Medicine

Self-expanding metal stent (SEMS) placement offers safe and effective palliation in patients with upper gastrointestinal obstruction due to a malignancy. Well described complications of SEMS placement include tumor growth, obstruction, and stent migration. SEMS occlusions are treated by SEMS redeployment, argon plasma coagulation application, balloon dilation, and surgical bypass. At our center, we usually place the second SEMS into the first SEMS if there is complete occlusion by the tumor. We discovered an unusual complication during SEMS redeployment. The guide-wire passed through the mesh of the first SEMS and caused the second SEMS to become entangled with the first SEMS. This led to the distortion and malfunction of the second SEMS, which worsened the gastric outlet obstruction. For lowering the risk of entanglement, we studied stone extraction balloon-guided repeat SEMS placement. This is the first report of a SEMS entangled by the mesh of the first SEMS and stone extraction balloon-guided repeat SEMS placement for lowering the risk of this complication.

关键词： Gastric outlet obstruction Self-expanding metal stent

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Atomic Modulation of 3D Conductive Frameworks Boost Performance of MnO2 for Coaxial Fiber‑Shaped Supercapacitors

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Nano-Micro Letters 2021年第1期13卷 44-55页

作者： Xiaona Wang Zhenyu Zhou Zhijian sun Jinho Hah Yagang Yao Kyoung‑Sik moon Jiangtao Di Qingwen Li Ching‑ping Wong Division of Advanced Nanomaterials Key Laboratory of Nanodevices and ApplicationsJoint Key Laboratory of Functional Nanomaterials and DevicesCAS Center for Excellence in NanoscienceSuzhou Institute of Nano‑Tech and Nano‑BionicsChinese Academy of SciencesSuzhou 215123People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Coaxial fiber-shaped supercapacitors are a promising class of energy storage devices requiring high performance for flexible and miniature electronic ***,they are still struggling from inferior energy density,which comes from the limited choices in materials and structure ***,Zn-doped CuO nanowires were designed as 3D framework for aligned distributing high mass loading of MnO2 *** could be introduced into the CuO crystal lattice to tune the covalency character and thus improve charge *** Zn–CuO@MnO2 as positive electrode obtained superior performance without sacrificing its areal and gravimetric capacitances with the increasing of mass loading of MnO2 due to 3D Zn–CuO framework enabling efficient electron transport.A novel category of free-standing asymmetric coaxial fiber-shaped supercapacitor based on Zn0.11CuO@MnO2 core electrode possesses superior specific capacitance and enhanced cell potential *** asymmetric coaxial structure provides superior performance including higher capacity and better stability under deformation because of sufficient contact between the electrodes and *** on these advantages,the as-prepared asymmetric coaxial fiber-shaped supercapacitor exhibits a high specific capacitance of 296.6 mF cm^−2 and energy density of 133.47μWh cm^−*** addition,its capacitance retention reaches 76.57%after bending 10,000 times,which demonstrates as-prepared device’s excellent flexibility and long-term cycling stability.

关键词： Coaxial fiber-shaped supercapacitors 3D framework Zn-CuO nanowires Zn-CuO@MnO2 core-shell structure

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Three-dimensional magnetic reconnection in complex multiple X-point configurations in an ancient solar-lunar terrestrial system

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Chinese Physics B 2024年第3期33卷 488-495页

作者：何向磊毛傲华孙萌萌邹继同王晓钢 School of Physics Harbin Institute of TechnologyHarbin 150001China Laboratory for Space Environment and Materials Science Harbin Institute of TechnologyHarbin 150001China

Magnetic reconnection processes in three-dimensional(3D)complex field configurations have been investigated in different magneto-plasma systems in space,laboratory,and astrophysical ***-dimensional(2D)features of magnetic reconnection have been well developed and applied successfully to systems with symmetrical property,such as toroidal fusion plasmas and laboratory experiments with an axial *** in asymmetric systems,the 3D features are inevitably different from those in the 2D *** reconnection structures in multiple celestial body systems,particularly star-planet-moon systems,bring fresh insights to the understanding of the 3D geometry of ***,we take magnetic reconnection in an ancient solar-lunar terrestrial magneto-plasma system as an example by using its crucial parameters approximately estimated already and also some specific applications in pathways for energy and matter transports among Earth,ancient moon,and the interplanetary magnetic field(IMF).Then,magnetic reconnection of the ancient lunar-terrestrial magnetospheres with the IMF is investigated numerically in this *** a 3D simulation for the Earth-moon-IMF system,topological features of complex magnetic reconnection configurations and dynamical characteristics of magnetic reconnection processes are *** is found that a coupled lunar-terrestrial magnetosphere is formed,and under various IMF orientations,multiple X-points emerge at distinct locations,showing three typical magnetic reconnection structures in such a geometry,i.e.,the X-line,the triple current sheets,and the A-B null *** results can conduce to further understanding of reconnection physics in 3D for plasmas in complex magnetic configurations,and also a possible mechanism for energy and matters transport in evolutions of similar astrophysical systems.

关键词： magnetic reconnection multiple X-points complex magneto-plasma system

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An Effective Threat Detection Framework for Advanced Persistent Cyberattacks

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Computers, Materials & Continua 2023年第5期75卷 4231-4253页

作者： So-Eun Jeon sun-Jin Lee Eun-Young Lee Yeon-Ji Lee Jung-Hwa Ryu Jung-Hyun moon sun-Min Yi Il-Gu Lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering Sungshin Women’s UniversitySeoul02844Korea

Recently,with the normalization of non-face-to-face online environments in response to the COVID-19 pandemic,the possibility of cyberattacks through endpoints has *** endpoint devices are managed meticulously to prevent cyberattacks and ensure timely responses to potential security *** particular,because telecommuting,telemedicine,and teleeducation are implemented in uncontrolled environments,attackers typically target vulnerable endpoints to acquire administrator rights or steal authentication information,and reports of endpoint attacks have been increasing *** persistent threats(APTs)using various novel variant malicious codes are a form of a sophisticated ***,conventional commercial antivirus and anti-malware systems that use signature-based attack detectionmethods cannot satisfactorily respond to such *** this paper,we propose a method that expands the detection coverage inAPT attack *** this model,an open-source threat detector and log collector are used synergistically to improve threat detection *** the scope of attack log collection through interworking between highly accessible open-source tools can efficiently increase the detection coverage of tactics and techniques used to deal with APT attacks,as defined by MITRE Adversarial Tactics,Techniques,and Common Knowledge(ATT&CK).We implemented an attack environment using an APT attack scenario emulator called Carbanak and analyzed the detection coverage of Google Rapid Response(GRR),an open-source threat detection tool,and Graylog,an open-source log *** proposed method expanded the detection coverage against MITRE ATT&CK by approximately 11%compared with that conventional methods.

关键词： Advanced persistent threat cybersecurity endpoint security MITRE ATT&CK open-source threat detector threat log collector

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