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Characterization of mouse clonal mesenchymal stem cell lines established by subfractionation culturing method

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World Journal of Stem Cells 2011年第8期3卷 70-82页

作者： Myung-Shin Jeon Tac-Ghee Yi Hyun-Ja Lim sun-Hwa moon moon-Hee Lee Joon-Soon Kang Chul-Soo Kim Dae-Hyun Lee sun U Song Clinical Research Center School of Medicine Inha University 7-2063-GaShinheung-DongChung-GuInchon 400-711South Korea

AIM:To characterize single-cell-derived mouse clonal mesenchymal stem cells (mcMSCs) established with bone marrow samples from three different mouse strains. METHODS:We established mcMSC lines using subfractionation culturing method from bone marrow samples obtained from long *** lines were characterized by measuring cell growth, cell surface epitopes, differentiation potential, lineage-specific gene expression and T-cell suppression capability. Nonclonal MSCs isolated by the conventional gradient centrifugation method were used as controls. RESULTS:All mcMSC lines showed typical nonclonal MSC-like spindle shape morphology. Lines differed inoptimal growth density *** surface epitope prof iles of these mcMSC lines were similar to those of nonclonal MSCs. However, some lines exhibited different expression levels in a few epitopes, such as CD44 and CD105. Differentiation assays showed that 90% of the mcMSC lines were capable of differentiating into adipogenic and/or chondrogenic lineages, but only 20% showed osteogenic lineage differentiation. T-cell suppression analysis showed that 75% of the lines exhibited T-cell suppression capability. CONCLUSION:mcMSC lines have similar cell morphology and cell growth rate but exhibit variations in their cell surface epitopes, differentiation potential, lineage-specifi c gene expression and T-cell suppression capability.

关键词： Clonal stem cells Bone marrow stem cells Multilineage differentiation Clonal stromal cell isolation T-cell suppression

Toothpick impaction with sigmoid colon pseudodiverticulum formation successfully treated with colonoscopy

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World Journal of Gastroenterology 2008年第6期14卷 948-950页

作者： Youn Son Chung Yong Woo Chung sun You moon Su Mi Yoon Min-Jeong Kim Kyoung Oh Kim Cheol Hee Park Taeho Hahn Kyo-Sang Yoo Sang Hoon Park Jong Hyeok Kim Choong Kee Park Department of Gastroenterology Hallym University College of Medicine Anyang Korea Department of Radiology Hallym University College of Medicine Anyang Korea

Foreign bodies in the colon are encountered with increasing frequency, but only sporadic reports concerning their management have appeared in the literature. While most ingested foreign bodies usually pass through the gastrointestinal tract uneventfully, sharp foreign bodies such as toothpicks infrequently cause intestinal perforation and may even result in death. We report our experience with a patient with a sigmoid colon pseudodiverticulum formation, a complication of accidental ingestion of a toothpick that was diagnosed and successfully managed colonoscopically.

关键词： Toothpick Colon Colonoscopy Pseudodiverticulum

Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans

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World Journal of Gastroenterology 2014年第26期20卷 8592-8598页

作者： Yong-Dae Kim Dong-Hyuk Yim Sang-Yong Eom sun in moon Hyo-Yung Yun Young-Jin Song Sei-Jin Youn Taisun Hyun Joo-Seung Park Byung Sik Kim Jong-Young Lee Hee Kwan Won Heon Kim Department of Preventive Medicine College of MedicineChungbuk National University Department of Surgery College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Food and Nutrition Chungbuk National University Department of Surgery College of MedicineEulji University Department of Surgery Asan Medical CenterCollege of MedicineUlsan University Center for Genome Science National Institute of Health Department of Internal Medicine Division of Endocrinology and MetabolismSchool of MedicineKonyang University

AIM: To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer.

关键词： AMP-activated protein kinase Gastric cancer PRKAA1 Single nucleotide polymorphism Case-control study

Successful Treatment of Kounis Syndrome Type I Presenting as Cardiac Arrest with ST Elevation

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Chinese Medical Journal 2016年第5期129卷 626-627页

作者： Kie Young Oh Yong Nam In Chi Hwan Kwack Jung Soo Park Jin Hong Min Min Gyu Kang sun moon Kim Department of Emergency Medicine Chungbuk National University Cheongju Korea Department of Internal Medicine Chungb-uk National UniversityCheongju Korea

To the Editor： Kounis syndrome describes a group of symptoms that manifest as unstable vasospastic or nonvasospastic angina or as acute myocardial infarction. It is triggered by the release of inflammatory mediators ... 详细信息

关键词： ANGINA

CO/SI/CO MULTILAYER STRUCTURES FOR OHMIC CONTACT ON N-TYPE 4H-SIC SUBSTRATES

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CO/SI/CO MULTILAYER STRUCTURES FOR OHMIC CONTACT ON N-TYPE 4...

Integrated On-line Instrumentation System of Magnetic Properties Measurement

第8届国际材联电子材料国际研讨会

作者： Nam-Ihn Cho Kyung-Hwa Jung Yong Choi Dept. of Electronic Engineering sun moon University Asan 336-708 Korea Dept. of Metallurgical Engineering sun moon University Asan 336-708 Korea

＜正＞ Silicon carbide （SiC）, a wide bandgap semiconductor material, has recently gained interest for the future electronic devices in the areas of power, sensor, and microwave applications [1-3]. In the production of the electronic devices, one of the main problems is a formation of reproducible ohmic contacts, which have a low contact resistivity. Lowing the Schottky barrier height between the contact metal and substrate or increasing doping level of the substrate may reduce the contact resistivity. For the ohmic contact, nickel （Ni） electrodes

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Journal of Materials Science & Technology 2000年第2期16卷 248-249页

作者： D.G.Park, Y.Y.Song. H.Song and J.H.Hong (Korea Atomic Energy Research Institute, Yusong P.O.Box 105, Taejon, 305-600 Korea) C.G.Kim (Department of Physics, sun moon Univ., Asan-si, Chungnam, 336840 Korea) Korea Atomic Energy Research Institute Yusong P.O.Box 105 Taejon 305-600 South Korea Department of Physics Sun Moon Univ. Asan-si Chungnam 336-840 South Korea

A portable microcomputer-controlled inspection system has been developed for detection of magnetic properties of soft magnetic materials. It incorporates custom designed software for control of the magnetic field during operation such as demagnetization, field sweeping, and for data logging and analysis. Results are recorded using a 12-bit analog to digital converter and are then stored on disk. The magnetic hysteresis loop and Barkhausen noise data can be converted into important magnetic parameters: coecivity, remanence, and hysteresis loss, Barkhausen amplitude, and Barkhausen noise energy. This system incorporated with the magnetostriction, and magnetoacoustic emission, is then related with the nondestructive detection of material degradation.

关键词： line Integrated On-line Instrumentation System of Magnetic Properties Measurement

Changes in microorganisms and metabolites during long-term fermentation of commercially manufactured anchovy sauce

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Food Science and Human Wellness 2024年

作者： Daehyeon Kim Seong-Eun Park Eun-Ju Kim Seung-Ho Seo Kwang-moon Cho sun Jae Kwon Hong-Seok Son Department of Biotechnology， College of Life Sciences and Biotechnology， Korea University Sonlab Inc. 3. AccuGene Inc.

This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce. Samples of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 years. The complex bacterial community was simplified to two genera， Tetragenococcus and Halanaerobium， after approximately 0.55 years of fermentation. Although genera， such as Saccharomyces， Cladosporium， Candida， and Aspergillus， were relatively dominant， no clear pattern was identified in fungal community analysis. The longitudinal metabolite profile demonstrated that approximately half (55.8%) of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid fermentation. Despite the static microbial community， the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy sauce. This study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo moon Chonsaeng Kim Mi-Hwa Kim Yoon-sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis

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World Journal of Gastroenterology 2013年第40期19卷 6842-6848页

作者： Jeong Ah Hwang sun moon Kim Hyun Jung Song Yu Mi Lee Kyung Min moon Chang Gi moon Hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung Division of Gastroenterology and Hepatology Department of Internal MedicineKonyang University College of MedicineDaejeon 302-718South Korea Department of Diagnostic Radiology Konyang University College of MedicineDaejeon 302-718South Korea

AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic ***:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ***:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan.

关键词： Acute abdomen Differential diagnosis Appendix epiploica Colonic diverticulitis Multidetector computed tomography