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Characterization of BellaGel SmoothFine<sup>®</sup>Implant Surfaces and Correlation with Capsular Contracture

Journal of Biomaterials and Nanobiotechnology 2019年第4期10卷 196-211页

作者： sun-Young Nam Miji Lee Byung Ho Shin Bassem Elfeky Yang U. Lee Dae Hee moon Daeun Seo Chan Yeong Heo Department of Plastic & Reconstructive Surgery Seoul National University Bundang Hospital Seongnam Republic of Korea HansBiomed Corp. Daejeon Republic of Korea

BellaGel SmoothFine®implant is a novel nanotextured silicone breast implant. The objective of this study was to characterize differences of BellaGel SmoothFine®surfaces with commercial available implant surfaces in terms of texture, topography, and wettability as well as the behavior of capsular contracture. The surface textures of breast implants from two different manufacturers (Hans Biomed and Motiva) were evaluated. The implants utilized in this study were BellaGel Smooth®, BellaGel Textured®, BellaGel SmoothFine®?or Motiva SilkSurface®. The shell textures of these implants were characterized using a scanning electron microscopy, three dimensional confocal laser scanning microscope, and contact angle goniometer. Silicone breast implants were emplaced beneath the panniculus carnosus muscle on the dorsum of Sprague Dawley rats and observed for up to 8 weeks postoperative days. The fibrous capsules around silicone implants were explanted for histological examination. BellaGel SmoothFine®exhibits a relatively flat, with little or no depth in the texturing, 5.96 ± 0.41 μm surface roughness, and a contact angle of 103.14 ± 2.06 BellGel SmoothFine®implant resulted in significant decreases in capsule thickness (P P ®and BellaGel Textured®implant groups. Significant (P ®. Fibrous tissue formation markers (Vimentin and alpha-smooth muscle actin) were significantly reduced in BellaGel SmoothFine®surfaces versus BellaGel Smooth®surfaces (P ®groups (P ®implant is associated with less breast implant derived capsular contracture than other surfaces.

关键词： Silicone Breast Implant Capsular Contracture Topography Roughness iNOS

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SMART COMMUNICATIONS AND NETWORKING FOR FUTURE DEEP-SPACE EXPLORATION

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China Communications 2020年第7期17卷 I0001-I0004页

作者： Qinyu Zhang Zhili sun Tomaso de Cola Kanglian Zhao the EIE School the Institute for Communication Systems(ICS) Department of Electrical and Electronic EngineeringFaculty of Engineering and Physical SciencesUniversity of Surrey the German Aerospace Center(DLR) the Satellite and Space Communications(SSC)technical committee within ComSoc the Space-Internetworking Services(SIS)within the CCSDS standardization body the SatCom working group within the ETP Networld2020 platform School of Electronic Science and Engineering Nanjing University Institute of Space-Terrestrial Intelligent Networks Nanjing University

Since the first space probe flew to the moon in 1959,over 200 deep-space exploration missions have already been carried out on the eight planets,various asteroids and comets in the solar *** of deepspace scientific ex... 详细信息

关键词： SPACE planet NETWORK

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Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease Risk among Chinese Adults

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Biomedical and Environmental Sciences 2023年第1期36卷 1-9页

作者： ZHAO Hui QIU Xia LI Hua Zi CUI Jia Jia sun Yong Ye Department of Nutrition and Food Hygiene School of Public HealthQingdao UniversityQingdao 266071ShandongChina State Key Laboratory of Bioactive Seaweed Substances Qingdao Bright moon Seaweed Group Co.LtdQingdao 266400ShandongChina Department of Medical Imaging Haici Hospital Affiliated to Medical College of Qingdao UniversityQingdao 266071ShandongChina

Objective The aim of this case-control study was to explore the association between serum uric acid to high density lipoprotein cholesterol ratio(UHR) and the risk of nonalcoholic fatty liver disease(NAFLD) in Chinese *** A total of 636 patients with NAFLD and 754 controls were enrolled from the Affiliated Hospital of Qingdao University, China, between January and December 2016. All patients completed a comprehensive questionnaire survey and underwent abdominal ultrasound examination and a blood test. NAFLD was diagnosed using ultrasonography after other etiologies were excluded. Logistic regression and restricted cubic spline model were conducted to evaluate the relationship of UHR with NAFLD *** The multivariable adjusted odds ratio(95% confidence interval, CI) for NAFLD in the highest versus lowest quartile of UHR was 3.888(2.324–6.504). In analyses stratified by sex and age, we observed significant and positive associations between UHR and the risk of NAFLD in each subgroup. In analyses stratified by body mass index(BMI), a significant and positive association was found only in individuals with a BMI of ≥ 24 kg/m2. Our dose-response analysis indicated a linear positive correlation between UHR and the risk of *** UHR is positively associated with the risk of NAFLD and may serve as an innovative and noninvasive marker for identifying individuals at risk of NAFLD.

关键词： Serum uric acid HDL-cholesterol The UHR index Inflammation Nonalcoholic fatty liver disease

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Macrophage PD-L1 strikes back: PD-1/PD-L1 interaction drives macrophages toward regulatory subsets

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Advances in Bioscience and Biotechnology 2013年第8期4卷 19-29页

作者： Yun-Jung Lee Young-Hye moon Kyeong Eun Hyung Jong-sun Yoo Mi Ji Lee Ik Hee Lee Byung sung Go Kwang Woo Hwang Laboratory of Host Defense Modulation College of Pharmacy Chung-Ang University Seoul Korea

Activated macrophages have been simply de?ned as cells that secrete in?ammatory mediators and kill intracellular pathogens until few years ago. Recent studies have proposed a new classification system to separate activated macrophages based on their functional phenotypes: host defense, wound healing, and immune regulation. Regulatory macrophages can arise following innate or adaptive immune responses and hinder macrophage-mediated host defense and inflammatory functions by inhibiting the production of pro-inflammatory mediators. In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host defense activity, which consists of the production of pro-inflammatory cytokine IL-6 and the exhibition of increased IL-10, SPHK1 and LIGHT gene levels in early phases of LPS stimulation. This differentiation seems to occur through excessive activation of TLR4 downstream MAPK signaling pathways. Regulatory macrophages induced from PD-1/PD-L1 interaction decrease inflammatory mediators and produce anti-inflammatory cytokines, so this macrophage subset has been under considerable attention as a possible immune regulation mechanism. Understanding and modulating regulatory macrophages may lead to new approches to treat or prevent auto-immune diseases such as type I diabetes, rheumatic syndrome and hypersensitivity-related diseases, which are concerned with the overproduction of inflammatory cytokines in macroages.

关键词： Regulatory Macrophage PD-1 PD-L1

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A Lunar-based Soft X-ray Imager(LSXI)for the Earth's magnetosphere

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Science China Earth Sciences 2021年第7期64卷 1026-1035页

作者： Yihong GUO Chi WANG Fei WEI Tianran sun Xizheng YU Songwu PENG Graziella BRANDUARDI-RAYMONT Steven SEMBAY National Space Science Center Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Mullard Space Science Laboratory University College LondonSurrey RH56NTUK Department of Physics and Astronomy University of LeicesterLeicester LEI 7RHUK

We propose to use the moon as a platform to obtain a global view of Earth's magnetosphere by a Lunar-based Soft X-ray Imager(LSXI).LSXI is a wide field-of-view Soft X-ray telescope,which can obtain X-ray images of Earth's magnetosphere based on the solar wind charge exchange(SWCX)X-ray *** perspective is crucial to understand the overall interaction of the solar wind with *** is capable of continuously monitoring the evolution of geospace conditions under the impact of the solar wind by simultaneous observation of the bow shock,magnetosheath,magnetopause and cusps for the first *** proposal is answering the call for the Chinese Lunar Exploration Program Phase IV.

关键词： Soft X-ray imager Lunar Magnetosphere Micro-pore optics

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基于星星双中继的国际月球科研站的全时无缝通信

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空间科学学报 2024年第3期44卷 592-605页

作者：王振河孙宝升刘永桦张利民李澎上官勇王坚李超史江博姚增利北京遥测技术研究所北京100094 北京跟踪与通信技术研究所北京100094 北京航空航天大学电子信息工程学院北京100191

2021年中国提出与相关国家、国际组织和国际合作伙伴共同开展国际月球科研站建设的建议,引起多方广泛关注,国际月球科研站工程建设按计划顺利推进.国际月球科研站建设完成后,与中国地面控制中心间保持全时无缝通信将是重要需求.中国地... 详细信息

2021年中国提出与相关国家、国际组织和国际合作伙伴共同开展国际月球科研站建设的建议,引起多方广泛关注,国际月球科研站工程建设按计划顺利推进.国际月球科研站建设完成后,与中国地面控制中心间保持全时无缝通信将是重要需求.中国地面深空测控网设立的国外站,长期来看可能存在一定风险,例如降低中国地面深空测控网的可用性,影响国际月球科研站与地面控制中心间的全时通信.为此,根据中国对月探测现状,借鉴天链中继卫星系统的设计、建设、应用、发展实际,提出一个“鹊桥–天链”星星双中继通信设想.从几何可见性角度进行多种条件的覆盖仿真分析,并从传输体制、链路设计、系统组成、捕获跟踪、工作流程、整体定位等多方面进行研究分析,初步完成了基于星星双中继的国际月球科研站全时无缝通信研究.在地面控制中心统一控制下,通过地面深空测控网、星星双中继的综合利用,国际月球科研站与地面控制中心间的全时无缝通信将具备完全实现的技术基础.此外,该设想也可为地月空间、行星际探测的其他航天器通信提供借鉴,并可进一步促进中国地基测控网、天基测控网和深空测控网的融合发展.

关键词：国际月球科研站深空测控天链中继卫星月球中继卫星星间链路

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Spectrum of final pathological diagnosis of gastric adenoma after endoscopic resection

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World Journal of Gastroenterology 2011年第47期17卷 5177-5183页

作者： Kwan Woo Nam Kyu Sang Song Heon Young Lee Byung Seok Lee Jae Kyu Seong Seok Hyun Kim Hee Seok moon Eaum Seok Lee Hyun Yong Jeong Gastroenterology Center Sun Hospital Pathologic Department Chung-Nam National University Hospital Gastroenterology Unit of Internal Medicine Department Chung-Nam National University Hospital

AIM: To investigate how many discrepancies occur in patients before and after endoscopic treatment of referred adenoma and the reason for these results. METHODS: We retrospectively reviewed data from 554 cases of 534 patients who were referred from primary care centres for adenoma treatment and treated for endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) at Chungnam National University Hospital, from July 2006 to June 2009. Reendoscopy was examined in 142 cases and biopsywas performed in 108 cases prior to treatment. Three endoscopists (1, 2 and 3) performed all EMRs or ESDs and three pathologists (1, 2 and 3) diagnosed most of the cases. Transfer notes, medical records and endoscopic pictures of these cases were retrospectively reviewed and analyzed. RESULTS: Adenocarcinoma was 72 (13.0%) cases in total 554 cases after endoscopic treatment of referred adenoma. When the grade of dysplasia was high (55.0%), biopsy number was more than three (22.7%), size was no smaller than 2.0 cm (23.2%), morphologic type was depressed (35.8%) or yamada type Ⅳ (100%), and color was red (30.9%) or mixed-or-undetermined (25.0%), it had much more malignancy rate than the others (P < 0.05). All 18 cases diagnosed as adenocarcinoma in the re-endoscopic forceps biopsy were performed by endoscopist 1. There were different malignancy rates according to the pathologist (P = 0.027). CONCLUSION: High grade dysplasia is the most important factor for predicting malignancy as a final pathologic diagnosis before treating the referred gastric adenoma. This discrepancy can occur mainly through inappropriately selecting a biopsy site where cancer cells do not exist, but it also depends on the pathologist to some extent.

关键词： Discrepancy Adenoma High grade dyspla-sia Endoscopic mucosal resection Endoscopic submu-cosal dissection

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Analysis of Worm Cutting Characteristics in Whirling Process

Analysis of Worm Cutting Characteristics in Whirling Process

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第五届国际材料与热加工物理模拟及数值模拟学术会议

作者： Young-moon Lee Won-Sik Choi Jae-Hwan Son Kyung-Jun Oh sun-Il Kim Geon-Woo Park Hee-Chul Jung School of Mechanical Engineering Kyungpook National University Daegu S. Korea School of Biosystems Engineering Pusan National University Miryang S. Korea Daegu Machinery Institute of Component & Materials Foundation Daegu S. Korea Daehan Machinery Corporation (DMC) Daegu S. Korea Graduate School of Mechanical Engineering Kyungpook National University Daegu S. Korea

Improved geometrical accuracy and better surface finish of worms are required, especially in automobile industry. To meet this requirement, whirling process has been used in the manufacture of worm. Whirling process is a cutting process in which a series of cutting edges on the whirling ring remove material by turning over the rotating workpiece. In this study, cutting characteristics of the worm in whirling process has been analyzed. The undeformed chip models of front and side cutting edges were established. Using the undeformed chip models and DEFORM software, cutting force analyses are carried out. The calculated cutting force imposed on the tool is nearly the same as the sum of the forces calculated which are separately imposed on the front and side cutting edges.

关键词： Whirling process Undeformed chip model Cutting force DEFORM software

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Research on End-force Output of 8-cable Driven Parallel Manipulator

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International Journal of Automation and computing 2020年第3期17卷 378-389页

作者： Sen-Hao Hou Xiao-Qiang Tang Ling Cao Zhi-Wei Cui Hai-Ning sun Ying-Wei Yan State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Lab of Precision/Ultra-precision Manufacturing Equipments and Control Tsinghua UniversityBeijing 100084China Postal Scientific Research and Planning Academy Beijing 100096China

The return capsule needs to be launched to the moon and return back to earth in the third stage of the Chinese lunar exploration ***,it is necessary to perform simulations on the *** paper presents an 8-cable-driven parallel manipulator to achieve end-force output in a low-gravity ***-force output refers to the vector sum of the external force on the end-effector.A model of end-force output is established based on a kinematics model,a dynamic model,and a force analysis of an 8-cable driven parallel *** obtain end-force output in a low-gravity environment,the cable force has to be controlled to counteract *** addition,a force-position mix control strategy is proposed to proactively control the cable force according to the force optimal distribution given by the closed-form force distribution ***,a suitable choice for an end-force output is obtained by modeling the effect of cable force on end-force *** results show that the actual cable force agrees well with the calculated force distribution,indicating that it is feasible to realize end-force output in a low gravity environment.

关键词： Cable driven parallel manipulators low gravity environment end force output cable force control mix control strategy

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The Taylor moon

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Acta Geochimica 2016年第1期35卷 14-14页

作者： Wei-dong sun CAS Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of Geochemistry Chinese Academy of Sciences CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences

The formation of the moon remains obscure after＊400 years since Galileo saw that the moon was mountainous in *** current hypothesis is that the moon formed through a low-angle collision between the Earth and Mar-size... 详细信息

关键词： Galileo collision obscure Giant hypothesis mountainous sufficiently giant likely volatile

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