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纳米粒子/聚合物复合光热平台的构筑和应用

高分子学报 2015年第2期25卷 133-146页

作者：林敏王丹丹刘树威周鼎张皓刘畅孙宏晨吉林大学超分子结构与材料国家重点实验室长春130012 吉林大学口腔医学院病理科长春130021 吉林大学口腔医学院口腔正畸科长春130021

叙述了一系列增强纳米粒子光热性能的方法,包括通过自组装方法调控纳米粒子的空间排列,进而优化电子结构和光热转化性能;在纳米粒子及其组装结构外表面进一步包覆具有光热性质的聚合物等.这些手段能够有效地增强光热试剂在近红外光区的... 详细信息

叙述了一系列增强纳米粒子光热性能的方法,包括通过自组装方法调控纳米粒子的空间排列,进而优化电子结构和光热转化性能;在纳米粒子及其组装结构外表面进一步包覆具有光热性质的聚合物等.这些手段能够有效地增强光热试剂在近红外光区的消光能力,达到增强光热性能的目的.另外,包覆聚合物壳层后,纳米粒子的胶体稳定性、光稳定性以及生物兼容性都能得到进一步提高,为后续的体外细胞实验和动物体内肿瘤模型实验提供了可能.

关键词：光热治疗纳米平台自组装纳米粒子复合物

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特高含水油藏综合调整效果的模糊评价方法

中国石油大学学报（自然科学版） 2007年第4期31卷 70-73,89页

作者：侯健陈月明赵红兵郭振海孙新敏中国石油大学石油工程学院山东东营257061 中国石化胜利油田分公司胜利采油厂山东东营257051

建立了特高含水开发期油藏综合调整效果评价指标体系,分为注采状态评价指标、开发动态评价指标、经济效益评价指标等3大类,包括井网密度变化率、注采对应率变化值、水驱储量控制程度变化值、含水率评价系数降低值、存水率评价系数降低... 详细信息

建立了特高含水开发期油藏综合调整效果评价指标体系,分为注采状态评价指标、开发动态评价指标、经济效益评价指标等3大类,包括井网密度变化率、注采对应率变化值、水驱储量控制程度变化值、含水率评价系数降低值、存水率评价系数降低值、平均年增油程度、采收率增加值、耗水量降低值、产出投入比等9项子指标。基于模糊综合评判原理和层次分析法,提出了综合调整效果的模糊综合评判方法。对胜坨油田'十五'期间12个综合调整单元的调整效果进行了模糊评价,结果表明,该方法能综合反映多方面的调整效果。

关键词：特高含水油藏综合调整模糊评价胜坨油田

植物叶际好氧反硝化细菌的筛选及其脱氮性能研究

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微生物学报 2024年第5期64卷 1521-1537页

作者：张建云谷立坤王亚西李潇扬宁志琪孙淼焜张欣白志辉河南工程学院环境与生物工程学院河南郑州451191 中国科学院生态环境研究中心北京100085

【目的】探索叶际微生物协同植物削减大气氮氧化物的机制,了解叶际可培养好氧反硝化细菌的存在及多样性,获得高效的叶际好氧反硝化细菌资源。【方法】采用富集培养结合格里斯试剂检测、溴百里酚蓝(bromothymol blue,BTB)培养基筛选的方... 详细信息

【目的】探索叶际微生物协同植物削减大气氮氧化物的机制,了解叶际可培养好氧反硝化细菌的存在及多样性,获得高效的叶际好氧反硝化细菌资源。【方法】采用富集培养结合格里斯试剂检测、溴百里酚蓝(bromothymol blue,BTB)培养基筛选的方法从景观植物叶际分离筛选好氧反硝化细菌,对好氧反硝化细菌的16SrRNA基因序列进行系统发育分析,并选取其中一株高效好氧反硝化细菌进行脱氮性能研究。【结果】从6种景观植物石楠、女贞、木樨、樟树、卫矛冬青、荷花玉兰的叶际中分离到好氧反硝化细菌13株,经16SrRNA基因序列分析发现,13株细菌分别属于4门7科7属,其中4株为肠杆菌属(Enterobacter),3株为无色杆菌属(Achromobacter),2株为假单胞菌属(Pseudomonas),其余4株分别属于鞘氨醇杆菌属(Sphingobacterium)、不动杆菌属(Acinetobacter)、微杆菌属(Microbacterium)和假节杆菌属(Pseudarthrobacter)。定量分析发现菌株SF的反硝化效果较好。通过单因素试验和响应面设计试验,对菌株SF的脱氮性能进行了一系列研究,探究了碳源、温度、初始pH、碳氮比和转速等因素对菌株SF脱氮效果的影响。结果表明,菌株SF的最佳脱氮条件:碳源为葡萄糖,初始pH值为7.5,碳氮比为9.7,转速180 r/min,温度为33.5℃。在此条件下,当初始硝酸盐浓度为361 mg/L时,72 h总氮去除率可达到93.3%。【结论】景观植物叶际中存在较多种类的可培养好氧反硝化细菌,丰富了叶际氮循环相关微生物的类型,为探索叶际微生物协同削减大气氮氧化物的机制奠定了基础。通过高效脱氮菌株的筛选,为进一步应用微生物协同植物削减空气氮氧化物污染提供了候选菌株。

关键词：叶际好氧反硝化细菌分离与鉴定脱氮反硝化特性

腰椎间盘突出症克氏针定位经皮内镜内侧椎间孔椎间盘切除

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中国矫形外科杂志 2024年第6期32卷 500-505页

作者：刘欢丁其瑞葛运如孙鹏王守国费昊东南京医科大学附属淮安第一医院骨科江苏淮安223300

[目的]探讨克氏针锚定定位经皮内镜内侧椎间孔椎间盘切除术(percutaneous endoscopic medial foraminal discectomy,PEMFD)治疗腰椎间盘突出症(lumbar disc herniation,LDH)的临床疗效。[方法]回顾性分析2019年6月—2022年1月本院脊柱外科应用可视化环锯行PEMFD治疗的93例LDH患者的临床资料,依据医患沟通结果,48例采用克氏针锚定定位结合可视化环锯PEMFD,另外45例行常规可视化环锯PEMFD。比较两组围手术期、随访和影像资料。[结果]两组患者均顺利完成手术,均未发生严重并发症。锚定组在手术时间[(44.9±3.2)min vs(54.3±3.3)min,P0.05)。所有患者均获随访12~18个月,平均(14.4±5.0)个月,两组患者恢复完全负重活动的时间差异无统计学意义(P>0.05)。随时间推移,两组患者VAS评分、ODI评分均显著下降(P0.05)。末次随访时按改良Macnab分级,两组间临床结果优良率差异无统计学意义(89.6%vs 88.9%,P>0.05)。影像方面,两组术后椎管面积较术前均显著增大(P0.05);相应时间点,两组患者间上述影像测量指标的差异均无统计学意义(P>0.05)。与术前相比,末次随访时两组患者手术椎间盘的Pfirrmann评级无显著变化(P>0.05),相应时间点两组间Pfirrmann评级的差异无统计学意义(P>0.05)。[结论]在后路内镜技术治疗LDH术中采用克氏针锚定定位椎板间内镜椎间盘切除术可显著提升手术效率。

关键词：克氏针锚定腰椎间盘突出症椎板间入路可视化环锯

Al_2O_3-TiO_2 composite oxide films on etched aluminum foil fabricated by electrodeposition and anodization

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Science China Chemistry 2011年第10期54卷 1558-1564页

作者： BU JunFu sun Lan WU Qi WANG MengYe LIN ChangJian Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China State Key Laboratory of Physical Chemistry of Solid Surfaces Xiamen University Xiamen 361005 China

Ti species have been deposited on low-voltage etched aluminum foils by a simple electrochemical method using a Ti anode as Ti source in a Ti-free I2-dissolved acetone solution. After annealing at 500-600℃ in air, an Al2O3-TiO2 composite oxide film was formed on the surface of the etched aluminum foil by anodizing galvanostatically in an ammonium adipate solution. The effects of I2 concentration in the acetone solution, applied anode voltage, electrolysis time, and annealing temperature on the specific capacitance of the aluminum anode foils were investigated. The TiO2-deposited specimens prepared by applying a po-tential of 50V for 3 min in 2.5m MI2-added acetone solution followed by annealing at 550℃ after anodization exhibited the highest specific capacitance, with an enhancement of 22% compared with pure etched aluminum foil specimens. The electro-deposition process and the change of the anode voltage during the anodization were analyzed.

关键词： electrodeposition titanium oxide composite film aluminum electrolytic capacitor anodization

Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4338-4345页

作者： Yunpeng Yang Jie min Nong Yang Qitao Yu Ying Cheng Yanqiu Zhao Manxiang Li hong Chen Shou’an Ren Jianying Zhou Wu Zhuang Xintian Qin Lejie Cao Yan Yu Jian Zhang Jianxing He Jifeng Feng Hao Yu Li Zhang Wenfeng Fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Oncology The Second Affiliated Hospital of Air Force Medical UniversityXi’an 710038China Department of Medical Oncology Lung Cancer and Gastrointestinal UnitHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Department of Medical Oncology of Respiratory Affiliated Tumor Hospital of Guangxi Medical UniversityGuangxiNanning 530021China Department of Thoracic Medical Oncology Jilin Provincial Cancer HospitalChangchun 130012China Department of Medical Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Respiratory First Affiliated Hospital of Xian Jiaotong UniversityXi’an 710061China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400050China Department of Respiratory The First Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Respiratory Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Medical Oncology Fujian Cancer HospitalFuzhou 350014China The First Department of Oncology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510699China Department of Respiratory and Critical Care Medicine Anhui Provincial HospitalHefei 230000China Department of Respiratory Medicine Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150000China Department of Respiratory Medicine The First Affiliated Hospital of Air Force Medical UniversityXi’an 710032China Department of Cardiothoracic Surgery The First Affiliated Hospital of Guangzhou Medical CollegeGuangzhou Research Institute of Respiratory Disease and China State Key Laboratory of Respiratory DiseaseGuangzhou 510120China Department

Anaplastic lymphoma kinase(ALK)rearrangements are present in about 5–6%of non-small cell lung cancer(NSCLC)cases and associated with increased risks of central nervous system(CNS)***,a novel ALK inhibitor,demonstrated promising anti-tumor activity and safety in advanced ALK-positive NSCLC in the first-in-human phase I *** phase III trial(*** NCT04009317)investigated the efficacy and safety of first-line envonalkib in advanced ALK-positive NSCLC *** 264 participants were randomized 1:1 to receive envonalkib(n=131)or crizotinib(n=133).Median independent review committee(IRC)-assessed progression-free survival(PFS)times were 24.87(95%confidence interval[CI]:15.64–30.36)and 11.60(95%CI:8.28–13.73)months in the envonalkib and crizotinib groups,respectively(hazard ratio[HR]=0.47,95%CI:0.34–0.64,p<0.0001).IRC-assessed confirmed objective response rate(ORR)was higher(81.68%vs.70.68%,p=0.056)and duration of response was longer(median,25.79[95%CI,16.53–29.47]vs.11.14[95%CI,9.23–16.59]months,p=0.0003)in the envonalkib group compared with the crizotinib *** participants with baseline brain target lesions,IRC-assessed CNS-ORR was improved with envonalkib compared with crizotinib(78.95%vs.23.81%).Overall survival(OS)data were immature,and median OS was not reached in either group(HR=0.84,95%CI:0.48–1.47,p=0.5741).The 12-month OS rates were 90.6%(95%CI,84.0%–94.5%)and 89.4%(95%CI,82.8%–93.6%)in the envonalkib and crizotinib groups,***≥3 treatment-related adverse events were observed in 55.73%and 42.86%of participants in the envonalkib and crizotinib groups,*** significantly improved PFS and delayed brain metastasis progression in advanced ALK-positive NSCLC.

关键词： crizotinib randomized cancer

Karyotypes of nineteen species of Asteraceae in the Hengduan Mountains and adjacent regions

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Plant Diversity 2017年第4期39卷 194-201页

作者： Wenguang sun Xiangguang Ma Jianwen Zhang Fuming Su Yonghong Zhang Zhimin Li School of Life Science Engineering Research Center of Sustainable Development and Utilization of Biomass Energy Yunnan Normal University Yunnan Kunming 650500 China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China University of Chinese Academy of Sciences Beijing 100049 China

The Hengduan Mountains region is a biodiversity hotspot. In this study, we report the karyotypes of 19 species(21 populations) of Asteraceae from this region, 14 of which are reported for the first time. We also examined polyploidy in Asteraceae plants and summarized karyotype data in the literature for 69 congeneric taxa. In these genera, there were five different ploidy levels in the region, though the most dominant was diploid(73.08%). There is no direct evidence that ploidy level and karyotype asymmetry are associated with the distribution of recorded Asteraceae species from the Hengduan Mountains. This suggests that polyploidy(26.92%) may not play an important role in the evolutionary history of these plants, even though, among these genera, the ratio of paleopolyploidy was high(46.15%).

关键词： Polyploidy Karyotype morphology Asteraceae Chromosome number Hengduan Mountains

A new method for high precsion instantaneous speedmeasurement of hydraulic system

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Journal of Measurement Science and Instrumentation 2019年第4期10卷 307-314页

作者： LIU Jia-min GU Li-chen sun Yu School of Mechatronic Engineering Xi’an University of Architecture and TechnologyXi’an 710055China

The instantaneous speed of a hydraulic system contains a wealth of operational information,and its accurate extraction is the basis for condition monitoring and fault *** order to solve the problem of high hardware requirement for instantaneous speed measurement based on data acquisition card,a new method of high precision measurement is *** this method,the time-displacement information of each tooth is obtained from the pulsed square wave signal of the gear disk collected by magnetoelectric *** time-displacement curve is interpolated by the cubic spline interpolation method,and then the instantaneous speed is calculated by the five-point digital differential *** experimental results show that the method improves the speed measurement resolution and reduces the quantization *** high precision instantaneous speed signal can also be acquired by hardware devices with less teeth and low sampling *** related research results provide a theoretical basis and a method for improving the accuracy of instantaneous speed measurement.

关键词： instantaneous speed measurement variable speed hydraulic system cubic spline interpolation five-point digital differentiation

烧伤患者围手术期焦虑状态评估及其影响因素分析

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解放军医学杂志 2024年第7期49卷 754-760页

作者：任舒婷李萌萌边雅楠徐雯顾国鑫孙雨冉明梓山西医科大学麻醉学院山西太原030000 解放军总医院第四医学中心麻醉科北京100048

目的评估烧伤患者围手术期焦虑状态并分析其影响因素。方法选择2022年2-8月解放军总医院第四医学中心拟在全身麻醉下择期手术的烧伤患者110例,术前1 d及术后1 d对患者进行焦虑自评量表(SAS)、焦虑视觉模拟量表(VAS-a)、疼痛视觉模拟量表... 详细信息

目的评估烧伤患者围手术期焦虑状态并分析其影响因素。方法选择2022年2-8月解放军总医院第四医学中心拟在全身麻醉下择期手术的烧伤患者110例,术前1 d及术后1 d对患者进行焦虑自评量表(SAS)、焦虑视觉模拟量表(VAS-a)、疼痛视觉模拟量表(VAS-p)、简易精神状态检查量表(MMSE)和Ramsay镇静评分评估,并记录入院时(T_(0))、麻醉诱导前(T_(1))、插管后2 min(T_(2))、手术开始后15 min(T_(3))、术中(T_(4))、手术结束(T_(5))和离开手术室即刻(T_(6))的平均动脉压(MAP)和心率(HR),分析烧伤患者围手术期焦虑发生情况,并采用单因素及多因素logistic回归分析烧伤患者围手术期焦虑状态的影响因素。结果烧伤患者术前及术后焦虑发生率为29.1%和22.3%。单因素logistic回归分析结果显示,性别(P=0.002)、烧伤时间(P=0.046)、烧伤面积(P=0.005)、烧伤部位(P=0.035)及术前疼痛程度(P=0.001)与烧伤患者术前焦虑状态有关;烧伤时间(P=0.030)、烧伤面积(P=0.001)、烧伤部位(P=0.016)、术前疼痛程度(P=0.021)及术前焦虑状态(P0.05),但HR均加快(P<0.05),且术中舒芬太尼、瑞芬太尼及丙泊酚用量明显增加(P<0.05)。结论烧伤患者术前焦虑发生率明显高于术后,焦虑患者术中麻醉药物用量增加,但与手术类型、手术次数无关;性别、术前疼痛程度及术前焦虑状态为烧伤患者围手术期焦虑状态的独立影响因素,针对相关因素进行早期干预,有利于患者快速康复。

关键词：烧伤围手术期焦虑疼痛