检索结果-南通市图书馆

MANIFOLDS WITH POINTWISE PINCHED RICCI CURVATURE

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2010年第3期30卷 819-829页

作者：顾会玲 Department of Mathematics Sun Yat-sen University

In this article, the author proves a compactness result about Riemannian manifolds with an arbitrary pointwisely pinched Ricci curvature tensor.

关键词： Ricci pinching condition Yamabe flow asymptotic behavior

Correlation analysis between loss of heterozygosity at chromosome 18q and prognosis in the stage-Ⅱ colon cancer patients

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2010年第8期29卷 761-767页

作者： Wei Wang1,2. Yuan-Fang Li1,2. Xiao-Wei sun1,2. Gong Chen1,3, You-Qing Zhan1,2. Chun-Yu Huang1,2. De-sen Wan1,3, Zhi-Zhong Pan1,3, Zhi-Wei Zhou1,2.1 State Key Labortary of Oncology in South {2., guangzhou, Guangdong 510060, P. R. {2. 2.Department of Gasrtic and Pancreatic Surgery, sun Yat-sen university Cancer Center, guangzhou, Guangdong 510060, P. R. {2. 3 Department of Colorectal Surgery, sun Yat-sen university Cancer Center, guangzhou, Guangdong 510060, P. R. {2. Department of Gasrtic and Pancreatic Surgery Sun Yat-sen University Cancer Center State Key Labortary of Oncology in South China Guangdong Guangzhou 510060 Department of Colorectal Surgery Sun Yat-sen University Cancer Center State Key Labortary of Oncology in South China Guangdong Guangzhou 510060

Background and Objective: Colorectal cancer is one of the most common malignant cancers in the world. Although the clinicopathologic staging is the golden criterion for the prognosis at present, the optimum prognostic criteria for colorectal cancer should be a combination of the clinicopathologic staging and the molecular markers. However, there are currently no molecular markers available for the prognosis of colorectal cancer. Several tumor-suppressor genes associated with colorectal cancer have been mapped at the 18q2.-2. region. In this study we detected the frequency of loss of heterozygosity (LOH) at chromosome 18q and investigated the relationship between LOH and clinicopathologic features and its prognostic value for patients with stage Ⅱ colon cancer. Methods: A total of 106 samples of tumor tissues and corresponding normal mucosa from patients with sporadic stage-Ⅱ colon cancer were included in this study. All the samples were formalin-fixed and paraffin-embedded. DNA was extracted from tumor tissues and LOH of D18S474, D18S55, D18S58, D18S61 and D18S64 at chromosome 18q was analyzed using polymerase chain reaction (PCR), polyacrylamide gel-electrophoresis, and DNA sequencing method. Multivariate analysis for association between LOH and prognosis in colon cancer patients was performed with Cox proportional hazards regression model. Results: The median follow-up time was 68 months. For 106 patients, 5-year survival rate was 83.6%, which was associated with age and gross tumor type (P = 0.011 and 0.034, respectively). Among 102.patients who were eligible for LOH information, the overall frequency of LOH is 49.0% (50/102., and that of LOH at 5 microsatellite loci of D18S474, D18S55, D18S58, D18S61, and D18S64 was 30.2. (2./86), 2..4% (18/77), 2..6% (2./70), 35.0% (2./80), and 2..8%(15/72., respectively. The occurrence of LOH was significantly associated with tumor location and histopathologic grade (P = 0.02., 0.016 and 0.005, respectively). LOH was more freq

关键词：大肠癌染色体杂合性预后患者相关分析聚丙烯酰胺凝胶电泳临床病理

RNomics:The New Frontier in the post-genomic era

在线全文

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2009年第3期52卷 193-194页

作者： Liang-Hu Qu College of Life Sciences,sun Yan-sen {2.,guangzhou 5102.5,china 1. College of Life Sciences Sun Yan-Sen University Guangzhou 510275 China

It has been shown that whenever there is breakthrough in DNA structure there follows a bloom period of RNA research.

关键词： RNomics RNA

Blindness as A Challenging Medical and Social Problem in china

在线全文

学校读者我要写书评

暂无评论

Eye Science 2002年第1X期18卷 4-8页

作者： Shixing HuZhongshan Ophthalmic Center, sun Yat-sen {2., guangzhou 510060, china Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

china, a country with about one fifth of the world' s population, has been gaining a rapideconomic growth since 1980s. This country has around 5 million blind people, accountingfor 18% of the blind in the world. The major causes of blindness include cataract,corneal diseases, trachoma, glaucoma, vitreoretinopathy and a number of factorscontributing to blindness in children. The principal cause of blindness in china was nolonger trachoma but cataracts. Vitamin A deficiency remains a public health problem inthe under-developed ***-related conditions in china, such as vision loss due tocataract and retinal disorders, will increase accordingly if no preventive meaunes aretaken. Glaucoma and diabetic retinopathy appear to be predominant induction of thedevastating blind. In this fast developing country blindness is not only a medical orhealth, but also a social problem. Developed strategies have been adopted simultaneouslyby national efforts under the leadership of the government, international agencies,nongovernmental organizations, as well as private sectors in their every-day work toprevent and treat blindness.

关键词：预防盲中国健康保健

Large animal models for Huntington's disease research

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 275-283页

作者： Bofeng Han Weien Liang Xiao-Jiang Li Shihua Li sen Yan Zhuchi Tu Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan university Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no ***,the development of appropriate disease models is critical to thoroughly investigate disease *** genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT *** HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain *** models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic *** to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD *** models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment *** have explored the advantages of utilizing large animal models,particularly pigs,in previous *** then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of *** the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic *** also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and *** objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs

Effects of cyclooxygenase 2.inhibitors on biological traits of nasopharyngeal carcinoma cells

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第7期25卷 97-103页

作者： Pei-yi CHEN1, Qi-cai LONG2.Institute of ClinicalPharmacology, School of Pharmaceutical Sciences, sun Yat-sen {2., guangzhou 510080, china1 Now in Inspection, Evaluation and Certification Committee forDrug, Guangdong Province Drug Administration, guangzhou510080, china. Institute of Clinical Pharmacology School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510080 Chin

AIM: To investigate effects of cyclooxygenase 2.(COX-2. inhibitors on nasopharyngeal carcinoma (NPC) cells and on angiogenesis in vitro. METHODS: Human NPC cell lines (CNE1, CNE2.and sunE) were treated with nimesulide or celecoxib. MTT assay and colony formation assay were performed to observe antiproliferation activity of COX-2.inhibitors to NPC cell lines. Cell cycle arrest and apoptosis of NPC cell strains were tested by flow cytometry assay, microscopic morphology observation, and DNA fragmentation assay. The effect of COX- 2.inhibitor on angiogenesis was tested by chick chorioallantoic membrane (CAM) model. RESULTS: Nimesulide (Nim) and celecoxib (Cel) could antiproliferate NPC cell lines with IC50 182.μmol/LNim-sunE, 78 μmol/LNim-CNE1, 175 μmol/LNim-CNE2. 7.2.μmol/LCel-sunE, 8.1 μmol/LCel-CNE1, and 7.6 μmol/LCel-CNE2. The antiproliferation presented dose- dependent (Nim5-400 μmol/L, Cel 0.5-80μmol/L) and time-dependent manner (Nim IC50 562.μmol/L2. , 316 μmol/L48 , h h 50.1 μmol/L2.0 ). Nim and Cel arrested sunE and CNE1 cell cycle at phase G2.M (cell aggregation rate 2..9 %- h 45.1 %Nim 2.-2.0μmol-12.h-sunE , 18.9%-2..2.%Nim 2.-2.0μmol-2. h-sunE ,2..8 %-35.6%Nim 2.-2.0 μmol-48 h-sunE ,30.4 %-16.4%Cel 2.-100μmol-12.h-sunE , 2..2.%-19.7 %Cel 2.-100 μmol-2. h-sunE, 31.1 %-19.9 %Cel 2.-100 μmol-2. h-sunE, 2..5 %-34.1 %Nim2.-2.0 μmol-12.h-CNE1, 2..2.%- 2..9 %Nim 2.-2.0 μmol-2. h-CNE1 , 11.5 %-7.1 %Nim 2.-2.0 μmol-48 h-CNE1). Apoptosis shape and apoptosis strap displayed in NPC cells after treatment with Nim and Cel. Nim had a feature of anti-angiogenesis on CAM model. CONCLUSION: Nim and Cel could suppress proliferation of squamous epithelium NPC cell (sunE, CNE1 and CNE2. through blocking cell cycle and inducing cell apoptosis. Nim could apparently suppress CAM angiogenesis induced by

关键词： cyclooxygenase inhibitors nimesulide celecoxib nasopharyngeal neoplasms apoptosis cell cycle angiogenesis inhibitors

Particles attrition of binary mixtures in the coal-fueled chemical looping system based on fluidized bed

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第3期86卷 281-290页

作者： Heyu Li Zhe sun Yan Cao guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China university of Chinese Academy of Sciences Bejing 100049China CAS Key Laboratory of Renewable Energy Guangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640China College of Chemistry and Chemical Engineering Anhui UniversityHefei230601China

In this work,a reactive air jet attrition device with auto-recording and collection of elutriated fines was *** established insights into the physiochemical interaction and further correlated attrition behaviors between char and oxygen carriers under various operation *** attrition rate increased by over 110% upon the introduced CO_(2.,which brought in the significant effect of thermo-chemical stress,similarly in effects of the increased char addition ratio and the decreased sizes of char or hematite in different *** the char-hematite co-attrition process,the elutriated carbon loss of char with poor mechanical strength was found to be over 10%,while the reactive iron loss of hematite was found to be 6.3%,and was enriched in elutriated *** reaction-derived thermochemical stress and the collision-derived mechanical stress jointly controls the particle attrition during the cyclic transformation of oxygen carrier particles in coal-fueled chemical looping fluidization,especially sig-nificant in its reduction stage.

关键词： Attrition Binary species Chemical looping Oxygen carrier CO_(2.capture

Molecular characterization and expression analysis of caveolin-1 in pig tissues

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2008年第7期51卷 655-661页

作者： WANG Chong1,MEI YingJie 1,LI Li 1,MO DeLin 2.LI JiaQi 1,ZHANG Hao 1,TIAN XingGuo 1 &CHEN YaoSheng2.1College of Animal Science,South china Agricultural university,{2. 510642.china 2.chool of Life Science,sun Yat-sen university,{2. 510006,china 1. College of Animal Science South China Agricultural University Guangzhou 510642 China 2. School of Life Science Sun Yat-Sen University Guangzhou 510006 China

Members of the caveolin family played important roles during fundamental cellular processes,such as regulation of cell morphology,migration,and gene expression in muscle *** this study,caveolin-1 (Cav-1),one of the caveolins,was identified from longissimus dorsi muscle of Large Yorkshire pig and Chinese indigenous Lantang pig based on the results of mRNA differential display *** deduced amino acids sequence of the porcine Cav-1 contained a caveolin domain,and was very conservative among different *** Cav-1 mRNA was widely expressed in the eight tissues in this study,including heart,liver,kidney,encephalon,spleen,lung,longissimus dorsi muscle,and back fat, and the highest expression quantity was found in back fat of the two pig *** expression quantity of porcine Cav-1 in back fat and longissimus dorsi muscle of Lantang pig was significantly higher than that of Large Yorkshire(P<0.01,and P<0.05,respectively).These results suggested that the Cav-1 might be a candidate gene for carcass traits,and might provide valuable information for understanding the mechanism of caveolae signaling in fat deposition by using the animal model of pig.

关键词： caveolin family clone expression analysis real-time quantify PCR

An adaptive spatial clustering method for automatic brain MR image segmentation

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2009年第10期19卷 1373-1382页

作者： Jingdan Zhang,Daoqing Dai Center for Computer Vision and Department of Mathematics,sun Yat-sen(Zhongshan) {2.,guangzhou 5102.5,china [a]Center for Computer Vision and Department of Mathematics Sun Yat-Sen (Zhongshan) University Guangzhou 510275 China

In this paper,an adaptive spatial clustering method is presented for automatic brain MR image segmentation,which is based on a competitive learning algorithm-self-organizing map(SOM).We use a pattern recognition approach in terms of feature generation and classifier ***,a multi-dimensional feature vector is constructed using local spatial ***,an adaptive spatial growing hierarchical SOM(ASGHSOM) is proposed as the classifier,which is an extension of SOM,fusing multi-scale segmentation with the competitive learning clustering algorithm to overcome the problem of overlapping grey-scale intensities on boundary ***,an adaptive spatial distance is integrated with ASGHSOM,in which local spatial information is considered in the clustering process to reduce the noise effiect and the classification *** proposed method is validated by extensive experiments using both simulated and real MR data with varying noise level,and is compared with the state-of-the-art algorithms.

关键词： Self-organizing map Growing hierarchical SOM Adaptive spatial distance Image segmentation MR images