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北京市161名新生儿脐带血中邻苯二甲酸酯代谢物含量与出生指标的关联分析

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中华预防医学杂志 2020年第7期54卷 768-773页

作者：苗宏健张磊赖建强孙亮赵云峰李敬光国家食品安全风险评估中心化学实验室国家卫生健康委食品安全风险评估重点实验室北京100021 中国疾病预防控制中心营养与健康所北京100050 岛津企业管理(中国)有限公司技术服务部北京100020

目的分析北京市新生儿脐带血中邻苯二甲酸酯代谢物含量与新生儿出生指标的关联。方法于2015年2—7月,在北京市海淀区妇幼保健医院招募符合标准的待产孕妇及其新生儿为研究对象,共纳入161对孕妇及新生儿。问卷调查孕妇年龄、吸烟、饮酒... 详细信息

目的分析北京市新生儿脐带血中邻苯二甲酸酯代谢物含量与新生儿出生指标的关联。方法于2015年2—7月,在北京市海淀区妇幼保健医院招募符合标准的待产孕妇及其新生儿为研究对象,共纳入161对孕妇及新生儿。问卷调查孕妇年龄、吸烟、饮酒等人口学信息,并在分娩后采集脐带血。采用超高效液相色谱‐三重四极杆质谱仪测定脐带血邻苯二甲酸酯代谢物含量,并采用多元线性回归模型分析其与新生儿体重、身长和出生体重指数的关联。结果161名孕妇年龄为(30.3±3.0)岁;161名婴儿体重为(3447.2±413.0)kg,身长为(50.2±1.1)cm,出生体重指数为(26.7±2.2)kg/m3,男婴占51.6%(83名)。脐带血中检出的7种邻苯二甲酸酯代谢物:邻苯二甲酸甲酯、邻苯二甲酸异丁酯、邻苯二甲酸丁酯、邻苯二甲酸单‐2‐乙基己酯、邻苯二甲酸单(2‐乙基‐5‐氧己基)酯、邻苯二甲酸单(2‐乙基‐5‐羧基戊基)酯和邻苯二甲酸乙酯含量分别为(3.50±0.28)、(2.65±0.47)、(4.31±0.55)、(6.26±0.57)、(1.71±0.13)、(1.10±0.09)、(0.47±0.06)ng/ml。多元线性回归模型分析结果显示,7种邻苯二甲酸酯代谢物含量与新生儿体重、身长和出生体重指数均无关联(P值均>0.05)。结论北京市新生儿脐带血中邻苯二甲酸酯代谢物的含量较低,与新生儿体重、身长和出生体重指数无关联。

关键词：胎血横断面研究邻苯二甲酸酯代谢物

Structural effects of sulfonamides on the proliferation dynamics of sulfonamide resistance genes in the sequencing batch reactors and the mechanism

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Journal of Environmental Sciences 2024年第1期135卷 161-173页

作者： Ligui Wu Mingyu Wang Lingling Rong Wenbiao Wang Linwei Chen Qiaofeng Wu Haoyu sun Xiangfeng Huang Xiaoming Zou College of Environmental Science and Engineering Tongji UniversityShanghai 200092China School of Life Science Jinggangshan UniversityJi’an 343009China Key Laboratory of Organic Compound Pollution Control Engineering(MOE) School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Fuzhou Urban and Rural Construction Group Co.Ltd. Fuzhou 350007China

Antibiotic resistance genes(ARGs)can be easily promoted by antibiotics,however,the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in,especially,activated sludge sequencing batch *** the present study,the effects of 9 sulfonamides(SAs)with different structures on the proliferation dynamic of sulfonamide resistance genes(Suls)in the activated sludge sequencing batch reactors and the corresponding mechanisms were determined(30 days),and the results showed that the largest proliferation value(ΔA^(R))of Suls dynamic for SAs(sulfachloropyridazine)was approximately 2.9 times than that of the smallest one(sulfadiazine).The proliferation of Suls was significantly related to the structural features(minHBint6,SssNH,SHBd and SpMax2_Bhm)that represent the biological activity of *** interpret the phenomenon,a mechanistic model was developed and the results indicated that the biodegradation of SAs(T_(1/2))rather than conjugative transfer frequency or mutation frequency tends to be the key process for affecting Suls proliferation.T_(1/2)was proved to be dependent on the interactions between SAs and receptors(E_(binding)),the cleavage mode(bond dissociation energy),and the site of nucleophilic ***,the metagenomic analysis showed that SAs posed significant effect on antibiotic resistome and Tnp31 played a vital role in the proliferation of ***,our findings provide important insight into a theoretical basis for understanding the structural effects of SAs on the proliferation of ARGs in SBR systems.

关键词： Activated sludge Sulfonamides Suls Proliferation Mechanism

Advanced cervix cancer patient with chemotherapy-induced grade IV myelosuppression achieved complete remission with cadonilimab:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1510-1516页

作者： Rui Zhu Tian-Ze Chen Meng-Ting sun Chun-Rong Zhu Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND The prognosis for patients with advanced metastatic cervix cancer(MCC)is poor,and this disease continues to pose a considerable therapeutic *** the administration of first-line regimens consisting of cisplatin,paclitaxel,and bevacizumab,survival rates for patients with metastasis remain *** emergence of bispecific antibodies(BsAbs)offers a novel treatment option for patients diagnosed with *** SUMMARY In this report,we present a patient with MCC who was treated with cadonilimab monotherapy at a dose of 6 mg/kg every two weeks after chemotherapy was proven to be *** patient exhibited a sustained complete response for a duration of 6 months,demonstrating an optimistic *** This case illustrates the considerable efficacy of cadonilimab for treating advanced ***,BsAb therapy is a promising strategy for effectively treating patients with advanced MCC and should be considered as an option when patients are intolerant to standard chemotherapy.

关键词： Cadonilimab Complete response Bispecific antibodies Recurrent or metastatic cervical cancer Programmed death protein 1 Cytotoxic T-lymphocyteassociated antigen-4 Case report

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循环荷载作用下广西红黏土动力特性试验研究

地震工程学报 2015年第2期37卷 487-493页

作者：穆坤郭爱国柏巍孙志亮臧濛中国科学院武汉岩土力学研究所岩土力学与工程国家重点试验室湖北武汉430071

针对广西上林县原状红黏土开展一系列循环加载动三轴试验,分析天然含水率、围压与固结应力比等对红黏土动力特性,包话动应力-动应变关系、动弹性模量以及阻尼比等的影响来研究循环荷载作用下红黏土的动力特性。试验结果表明：广西原状... 详细信息

针对广西上林县原状红黏土开展一系列循环加载动三轴试验,分析天然含水率、围压与固结应力比等对红黏土动力特性,包话动应力-动应变关系、动弹性模量以及阻尼比等的影响来研究循环荷载作用下红黏土的动力特性。试验结果表明：广西原状红黏土动应力-动应变关系曲线接近双曲线;由于初始剪应力的影响,达到相同的动应变,在均压固结下所需的动应力比在偏压固结下所需动应力要小;动弹性模量随着动应变的增加而减小,且减小幅度随应变增加逐渐减小,初始应力状态对动弹性模量的影响最为显著;固结应力比、围压、含水率和振动次数等对阻尼比均有影响,综合反映在阻尼比随动应变增加而减小,阻尼比离散性较大,取值范围在0.05-0.20之间。利用Konder双曲线模型对试验数据进行拟合,得到相关参数,可为广西地区原状红黏土动力特性设计和数值计算提供一定的理论和参数支持。

关键词：红黏土动弹性模量阻尼比土动力学双曲线模型

Natural Products Improve Organ Microcirculation Dysfunction Following Ischemia/Reperfusion-and Lipopolysaccharide-Induced Disturbances:Mechanistic and Therapeutic Views

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Engineering 2024年第7期38卷 77-99页

作者： Jingyan Han Quan Li Kai sun Chunshui Pan Jian Liu Ping Huang Juan Feng Yanchen Liu Gerald A.Meininger Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China Tasly Microcirculation Research Center Peking University Health Science CenterBeijing 100191China Key Laboratory of Stasis and Phlegm State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaBeijing 100191China Beijing Laboratory of Integrative Microangiopathy Peking University Health Science CenterBeijing 100191China Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology University of MissouriColumbiaMO 65211USA

Microcirculatory disturbances are complex processes caused by many factors,including abnormal vasomotor responses,decreased blood flow velocity,vascular endothelial cell injury,altered leukocyte and endothelial cell interactions,plasma albumin leakage,microvascular hemorrhage,and *** disturbances involve multiple mechanisms and interactions among mechanisms that can include energy metabolism,the mitochondrial respiratory chain,oxidative stress,inflammatory factors,adhesion molecules,the cytoskeleton,vascular endothelial cells,caveolae,cell junctions,the vascular basement membrane,neutrophils,monocytes,and *** clinical practice,aside from drugs that target abnormal vasomotor responses and platelet adhesion,there continues to be a lack of multi-target drugs that can regulate the complex mechanistic links and interactions underlying microcirculatory *** products have demonstrated obvious positive therapeutic effects in treating ischemia/reperfusion(I/R)-and lipopolysaccharide(LPS)-induced microcirculatory *** recent years,numerous research papers on the improvement of microcirculatory function by natural products have been published in international *** 2008 and 2017,the first listed author of this review was invited to publish reviews in the journal of Pharmacology&Therapeutics on the improvement of microcirculatory disturbances and organ injury induced by I/R using Salvia miltiorrhiza ingredients and other natural components of compounded Chinese medicine,*** review systematically summarizes the effects,targets of action,and mechanisms of natural products regarding improving I/R-and LPSinduced microcirculatory disturbances and tissue *** on this summary,scientific proposals are suggested for the discovery of new drugs to improve microcirculatory disturbances in disease.

关键词： Ischemia/reperfusion Lipopolysaccharide Natural products Leukocyte activation Hyperpermeability

一种轴径双向分离式电磁线圈驱动装置的结构响应特性

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物理学报 2024年第13期73卷 44-51页

作者：丛源涛王秋良程军胜熊玲孙建中国科学院电工研究所北京100190 中国科学院大学电子电气与通信工程学院北京100049

为了避免传统一体化驱动结构在运行过程中容易出现骨架断裂失效等不稳定现象.本文根据典型一体化驱动结构在运行过程中的应力应变,结合加速实验后出现内壁裂痕的一体化驱动结构的耐压放电测试,分析确定一体化驱动结构存在的不稳定因素,... 详细信息

为了避免传统一体化驱动结构在运行过程中容易出现骨架断裂失效等不稳定现象.本文根据典型一体化驱动结构在运行过程中的应力应变,结合加速实验后出现内壁裂痕的一体化驱动结构的耐压放电测试,分析确定一体化驱动结构存在的不稳定因素,初步设计了一种轴径双向分离式模块化的新型驱动结构,对新结构在运行过程中的电磁及结构响应等展开有限元仿真分析.在相同激励条件下,新型驱动结构内壁上的应力应变远小于一体化结构,同时一体化驱动结构的内壁上的最大形变约为10-2m量级,而新型驱动结构在运行过程中内壁上的最大形变降低至10^(-5)—10^(-6)m量级.结果表明新结构能够在保证推进性能的前提下,降低内壁和相间隔板的应力应变及变形程度,提高了结构的可靠性,能够为电磁线圈驱动结构的设计优化提供一定参考和借鉴.

关键词：电磁推进线圈推进结构响应有限元分析

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Enhancing the peroxidase-like activity of MoS_(2)-based nanozymes by introducing attapulgite for antibacterial application and sensitive detection of glutathione

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Nano Research 2024年第8期17卷 7415-7426页

作者： Feng Feng Yihe Zhang Xiao Zhang Bin Mu Jiahe Zhang Wenjie Qu Wangshu Tong Minmin liang Qi An Zhanjun Guo Lu Zhao Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastesNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Clay Mineral Applied Research of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Experimental Center of Advanced Materials School of Materials Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Nanozymes are next-generation of nanomaterials with enzyme-like *** particular,nanozymes with peroxidase(POD)-like activity have been utilized in various fields,including antibacterial,detection,degradation,***,their extensive applications were limited by their low catalytic activity ***,we have presented a composite nanozyme based on attapulgite(ATP)(Fe-ATP-MoS_(2)(FAM)),which exhibited enhanced POD-like activity(185.33 U·mg^(−1)),4.25 times higher than that of Fe-MoS_(2)(FM)(43.63 U·mg^(−1)).The density functional theory(DFT)calculations indicated that the addition of ATP increased the electron density of metal centers(Mo and Fe).More importantly,Michaelis–Menten kinetics revealed that the introduction of ATP significantly enhanced the binding affinities of substrates through the pores of ATP,forming a highly concentrated substrate microenvironment and thus promoting its POD-like ***,from molecular size and kinetic analysis,we proposed that the changes in substrate size before and after oxidation also significantly affected its Michaelis-constant(Km)***,we utilized FAM in the applications of highly effective antibacterial application and sensitive detection of glutathione(GSH).In conclusion,this work provides a novel approach for designing a highly efficient nanozyme based on natural mineral composites.

关键词： attapulgite peroxidase electron density affinity antibacterial

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甜樱桃果实NCED基因的克隆及其表达

园艺学报 2010年第6期37卷 891-898页

作者：任杰吴洁芳冷平孙亮赵胜利中国农业大学农学与生物技术学院北京100193

为了进一步研究ABA在甜樱桃果实成熟过程中的作用,通过RT-PCR以及RACE-PCR方法从甜樱桃果实克隆得到了ABA合成关键酶NCED基因片段PacNCED1及其3′末端序列,从乙烯利处理果实中克隆得到了乙烯合成关键酶ACO基因片段PacACO1。推测的PacNC... 详细信息

为了进一步研究ABA在甜樱桃果实成熟过程中的作用,通过RT-PCR以及RACE-PCR方法从甜樱桃果实克隆得到了ABA合成关键酶NCED基因片段PacNCED1及其3′末端序列,从乙烯利处理果实中克隆得到了乙烯合成关键酶ACO基因片段PacACO1。推测的PacNCED1和PacACO1氨基酸序列与其它物种的NCEDs和ACOs氨基酸序列具有很高的同源性。通过半定量RT-PCR及定量RT-PCR方法分析了PacNCED1和PacACO1的表达模式,发现PacNCED1在甜樱桃果实发育的整个过程以及不同部位都有表达,在果肉和种子中的表达不断增加,在果实成熟之前达到最高峰,而在果柄中的表达则在果实完熟时达到最大。PacNCED1在未失水的叶片和根中有微弱表达,但在失水叶片中的表达急剧上升,表现出与失水的相关性。外源ABA和乙烯利能促进PacNCED1在果实中的表达,而NDGA和IAA对PacNCED1在果实中的表达没有显著影响。在甜樱桃果实发育过程中并没有检测到PacACO1的表达信号,但是外源乙烯利和ABA处理能诱导其在果实中的表达。

关键词：甜樱桃 NCED ACO ABA 基因克隆表达

A Deep Deterministic Policy Gradient-Based Method for Enforcing Service Fault-Tolerance in MEC

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Chinese Journal of Electronics 2024年第4期33卷 899-909页

作者： Tingyan LONG Peng CHEN Yunni XIA Yong MA Xiaoning sun Jiale ZHAO Yifei LYU College of Computer Science Chongqing University School of Computer and Software Engineering Xihua University School of Computer and Information Engineering Jiangxi Normal University School of Computer and Information Science Chongqing Normal University

Mobile edge computing(MEC) provides edge services to users in a distributed and on-demand *** to the heterogeneity of edge applications, deploying latency and resource-intensive applications on resourceconstrained devices is a key challenge for service providers. This is especially true when underlying edge infrastructures are fault and error-prone. In this paper, we propose a fault tolerance approach named DFGP, for enforcing mobile service fault-tolerance in MEC. It synthesizes a generative optimization network(GON) model for predicting resource failure and a deep deterministic policy gradient(DDPG) model for yielding preemptive migration *** show through extensive simulation experiments that DFGP is more effective in fault detection and guaranteeing quality of service, in terms of fault detection accuracy, migration efficiency, task migration time, task scheduling time,and energy consumption than other existing methods.

关键词： Fault tolerance Multi-access edge computing Processor scheduling Fault detection Image edge detection Fault tolerant systems Quality of service